LOCUS       NM_028735               4182 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 21A (Ttc21a), mRNA.
ACCESSION   NM_028735 XM_135216
VERSION     NM_028735.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4182)
  AUTHORS   Bumann,E.E., Hahn Leat,P., Wang,H.H., Hufft-Martinez,B.M., Wang,W.
            and Tran,P.V.
  TITLE     Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial
            Bone
  JOURNAL   J Dev Biol 10 (2), 17 (2022)
   PUBMED   35645293
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4182)
  AUTHORS   Allard,B.A., Wang,W., Pottorf,T.S., Mumtaz,H., Jack,B.M.,
            Wang,H.H., Silva,L.M., Jacobs,D.T., Wang,J., Bumann,E.E. and
            Tran,P.V.
  TITLE     Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog
            signaling in postnatal skeletogenesis
  JOURNAL   Cell Mol Life Sci 78 (7), 3743-3762 (2021)
   PUBMED   33683377
  REMARK    GeneRIF: Thm2 interacts with paralog, Thm1, and sensitizes to
            Hedgehog signaling in postnatal skeletogenesis.
REFERENCE   3  (bases 1 to 4182)
  AUTHORS   Wang,W., Allard,B.A., Pottorf,T.S., Wang,H.H., Vivian,J.L. and
            Tran,P.V.
  TITLE     Genetic interaction of mammalian IFT-A paralogs regulates cilia
            disassembly, ciliary entry of membrane protein, Hedgehog signaling,
            and embryogenesis
  JOURNAL   FASEB J 34 (5), 6369-6381 (2020)
   PUBMED   32167205
REFERENCE   4  (bases 1 to 4182)
  AUTHORS   Liu,W., He,X., Yang,S., Zouari,R., Wang,J., Wu,H., Kherraf,Z.E.,
            Liu,C., Coutton,C., Zhao,R., Tang,D., Tang,S., Lv,M., Fang,Y.,
            Li,W., Li,H., Zhao,J., Wang,X., Zhao,S., Zhang,J., Arnoult,C.,
            Jin,L., Zhang,Z., Ray,P.F., Cao,Y. and Zhang,F.
  TITLE     Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in
            Humans and Mice
  JOURNAL   Am J Hum Genet 104 (4), 738-748 (2019)
   PUBMED   30929735
  REMARK    GeneRIF: bi-allelic mutations in TTC21A can induce
            asthenoteratospermia with defects of the sperm flagella and
            head-tail conjunction
REFERENCE   5  (bases 1 to 4182)
  AUTHORS   Tran,P.V., Haycraft,C.J., Besschetnova,T.Y., Turbe-Doan,A.,
            Stottmann,R.W., Herron,B.J., Chesebro,A.L., Qiu,H., Scherz,P.J.,
            Shah,J.V., Yoder,B.K. and Beier,D.R.
  TITLE     THM1 negatively modulates mouse sonic hedgehog signal transduction
            and affects retrograde intraflagellar transport in cilia
  JOURNAL   Nat Genet 40 (4), 403-410 (2008)
   PUBMED   18327258
REFERENCE   6  (bases 1 to 4182)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Ttc21a is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029952.1, AC124662.10 and BC133699.1.
            
            On Mar 21, 2009 this sequence version replaced NM_028735.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029952.1, DQ011665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AK029952.1         4-44
            42-42               AC124662.10        42969-42969         c
            43-2066             BC133699.1         1-2024
            2067-4182           AK029952.1         2071-4186
FEATURES             Location/Qualifiers
     source          1..4182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..4182
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /note="tetratricopeptide repeat domain 21A"
                     /db_xref="GeneID:74052"
                     /db_xref="MGI:MGI:1921302"
     exon            1..145
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..4063
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /note="tetratricopeptide repeat-containing hedgehog
                     modulator 2; TPR repeat protein 21A"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 21A"
                     /protein_id="NP_083011.2"
                     /db_xref="CCDS:CCDS40805.1"
                     /db_xref="GeneID:74052"
                     /db_xref="MGI:MGI:1921302"
                     /translation="MSSDDSSLMASIIYYSQEKYFHHVLQAANVGLERYSSDPALQFF
                     RAYGILGEDHIHDAISELEGIQSHPDTSLCAVIALLSAHKSCDTIDIEAVQELESSLK
                     EIRRSASSTALYYASLFLWFMGHHDKAREYVDHMLKVSSGSKEGYVLKGWVDLTSSKP
                     HVVKKSIKYLEQGTQDTKDVLGLMGKATYFMTQQNFSGALEVANQVTLACSNFLPALV
                     LKMKLFLARQDWDQTIETGQRILEKDENNIDAWQILAVHELVKEGNTDRAADRVRNLI
                     KALETGEPHNPNLHLKKILVISRLCGRHQVVHRLVSGFLERIFMATPSCALVATELGY
                     LFILHQQVKEACLWYKEAMKLEENRLAALAGSIWCQILQGQLEEAAHQLEFLKEVQQS
                     LGKSELLVFLQALVAAKKQRLEQEATALLKEAVEVHFSSMQGLALSPEYFEKLDPLFL
                     VCIAKEYLHFCPKQPRSPGQLVSPLLKQVAMILSPVVKVAPAMMEPLYVTAQVKFLSG
                     ELENAQSTLQRCLELDPTFVDAHLLMSQIYLAQGNFAMCSHCLELGVSHNFQVRDHPL
                     YHFIKARALNKTGDYAEAIKTLKMIIKVPTSKAEEGRKSQSPSVRPSERASILLELVE
                     ALRLNGELHEATKIMQDAINEFSGTPEEMRITVANVDLALSKGNVDLALNMLRGITPK
                     QPCYTEAKEKMASIYLHTRKDVRLYIGCYVELCEHLPGPHSSLLLGDAFMNIQEPEKA
                     LEVYDEAYRKNPHDASLVSRIGQAYVKTHQYAKAINYYEAAQKISGQDFLCCELAELL
                     LKLKKYHKAEKVLKQALERDSGVKDIPSMINEVKCLLLLAKVYKSHKKEEVMETLNLA
                     LDLQSRILKRVPLEQSEMIPFQNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSP
                     TDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYETAIN
                     LYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSRVPLEPGFNYCQGI
                     YFWHIGQPNEALRFLNKARKDSTWGQLATCYMVQICLNPDNEIVGGEAFESLVGDSNS
                     ASRKESQQHGVRTAEKLLREFYPHSESGQTQLRLLQNLCLLATREKANVEVALGAFIE
                     MAQAEKDSIPALLAMAQAYILLKQVPKARTQLKRLAKVPWTVDEAEDLEKSWLLLADI
                     YCQGGKFDLALELLRRCLQYNKSCCRAYEYMGFIMEKEQSYKDAATNYELAWKYSHQA
                     NPAIGFKLAFNYLKDKKFVDAIEVCHSVLTEHPKYPKIREEILEKAQGSLRP"
     exon            146..275
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..386
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..553
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..676
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..834
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..919
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1018
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1211
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1309
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1510
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1640
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1798
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2014
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2253
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2326
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2437
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2576
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2683
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2872
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2983
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3065
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3216
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3378
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3571
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3796
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3917
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..3985
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4182
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4137..4142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /note="hexamer: AGTAAA"
     polyA_site      4169
                     /gene="Ttc21a"
                     /gene_synonym="4921538N17Rik; Thm2"
                     /note="major polyA site"
ORIGIN      
        1 agccaggttg ccaaggacgc gcgcgcctta gacttccggc cgtgagctgg gctgcgaatt
       61 gggcggccag agctgggaat cccgctcagc cggtcatcac ctgagccggg ctgcagccat
      121 gagcagcgat gactcctctc tcatggcttc gatcatttac tacagccagg aaaagtactt
      181 ccaccatgtg ctgcaggctg cgaatgtggg cctagagagg tacagcagcg acccagccct
      241 gcagttcttc agagcgtatg gaatccttgg ggaagaccac atccacgatg ccatcagcga
      301 gctggaaggc atccaaagcc acccagacac gtccctgtgc gcggtcatcg ccctgctttc
      361 tgctcacaaa tcctgcgaca ccatcgacat agaagcagtt caggaactgg agagcagctt
      421 gaaggaaatt cgcaggtcag ccagcagcac tgctctgtac tacgccagcc tcttcctctg
      481 gttcatgggt caccacgaca aggccaggga gtatgttgac cacatgttga aggtctccag
      541 cggctccaaa gagggctatg tgctcaaagg ctgggtggac cttacctcca gtaaacccca
      601 cgttgtgaag aaatccatca agtacctgga acaaggaact caagacacca aagatgtgct
      661 agggctcatg ggcaaggcaa cgtacttcat gacacaacag aacttctctg gggccctgga
      721 ggtggcgaac caggtcacct tggcctgcag caacttcctg cccgctttag tcctgaagat
      781 gaagctgttc ctggctcggc aggattggga tcagacgata gaaaccggac aaagaatcct
      841 tgaaaaagac gaaaacaata ttgatgcctg gcaaattcta gctgtgcacg agctggtgaa
      901 agaagggaac acggacagag ctgccgaccg ggtcagaaac ctcatcaagg cgctagagac
      961 tggagagccc cacaatccaa acctacatct taagaagatc cttgtaatca gcaggctgtg
     1021 tgggaggcac caggtggtcc atcggcttgt gagcggcttc ctggagcgca tctttatggc
     1081 cacaccttcc tgtgcccttg tggccacaga gctgggctac ctcttcatcc tacaccaaca
     1141 agtgaaggaa gcctgtctgt ggtacaagga ggccatgaag ctggaggaga acaggctggc
     1201 tgccttggca gggagcatct ggtgccagat cctacagggc cagctggagg aggctgctca
     1261 ccagctggag ttcctcaagg aggtgcagca gtcccttggg aagtctgagt tgctggtttt
     1321 cctgcaagcc ctcgtagcag ctaagaagca aaggctggag caggaggcca cggcgctcct
     1381 gaaggaggcg gtggaagtgc acttctccag catgcagggt ctggccctga gccccgagta
     1441 ctttgaaaag ctggaccccc tctttctggt ctgcatcgcc aaggagtatc tgcatttctg
     1501 ccccaagcag ccccggtcac ccggccagct cgtatctcca cttcttaaac aagtcgccat
     1561 gatcttgagt cctgtggtga aggtggcccc ggccatgatg gagccactgt atgtaacggc
     1621 tcaggtcaag ttcctctcag gagagctgga aaatgcgcag agcaccctgc agcgctgcct
     1681 ggagctggac cccacatttg tggatgctca cctcctcatg tcccagatct acctggccca
     1741 gggcaacttc gccatgtgct cccattgcct agagctgggt gtcagccaca acttccaggt
     1801 ccgagaccat cccctctacc acttcatcaa agccagggcc ctcaataaga cgggcgacta
     1861 tgccgaggcc ataaagacct taaaaatgat cataaaggtt cccacctcga aggcagaaga
     1921 gggcaggaag tcccaaagcc cctccgttcg gcccagcgag cgggcatcca tcctgctaga
     1981 gctagtagag gctctccgac tgaatgggga actgcacgag gccaccaaga tcatgcagga
     2041 cgccatcaat gagttcagcg gcacgccaga ggagatgcgc atcacggtcg ccaacgtgga
     2101 cttggctctg agcaagggca acgtggacct ggcgctgaac atgttaagag gtatcacacc
     2161 caagcaaccc tgctacacag aagccaagga gaagatggcc agtatctacc tgcacactcg
     2221 caaggacgtg cgcctctaca ttggctgcta cgtggagctt tgtgaacatc tgcccggccc
     2281 ccacagcagc ctgctactgg gtgacgcttt catgaacatt caggagcctg agaaggccct
     2341 ggaggtgtat gacgaggcct atagaaagaa ccctcacgat gcctccttgg tcagcaggat
     2401 cggacaggcc tacgtgaaga cccaccagta cgccaaggcc attaattact acgaggctgc
     2461 ccagaagatc agcgggcagg acttcctgtg ctgcgagctg gccgagctcc tcctcaagct
     2521 gaagaaatac cacaaggcag agaaggtgct gaagcaggcc ttggagcgag actcaggggt
     2581 caaggacatc ccatccatga taaatgaggt caagtgcttg cttttgttgg caaaggttta
     2641 caagagccac aagaaggaag aggtgatgga aaccctgaat ctggccttgg acctccagtc
     2701 ccggatactg aagcgggttc ctttggagca atcagaaatg atccccttcc agaatcagct
     2761 ggcagcctcc atctgcatcc agattgggga acatcacctg gcggagaaag attacgacag
     2821 cgccctgaaa tcctataagg acgccctcgc ctactcgccc acagacagta aggtggtgct
     2881 ggagctggcc catctctacc tgcttctggg tcagctggac ctgtgtgaac agcgctgtgc
     2941 ccccctctta gagatggagc agacccacga gagagccgct gtgatgctgg ccgacctgat
     3001 gtttagaaga caaaactatg aaactgccat caatctctac caccaagtgc tggagaaagc
     3061 tccagacaat tttttggtat tgaataaact ggtcgatctg ctacgacgga gcggcaagct
     3121 tgaagaggcc cctgctttct ttgaactggc caagaaggtg tctagccggg tgcctttgga
     3181 gccagggttt aactactgcc aaggcattta cttctggcac attggacagc ccaatgaagc
     3241 cttgaggttt ctgaacaaag cccgaaagga cagcacttgg ggccagcttg ccacctgtta
     3301 catggtacag atctgtctga accctgacaa tgagattgtc ggtggagagg cttttgagag
     3361 cctggtgggt gacagcaact ctgccagtag aaaggagtct cagcagcacg gggtgcgcac
     3421 tgcagagaag ctacttcggg aattttaccc acactcggaa tccgggcaga cccagctgcg
     3481 gctgctgcag aatctctgcc tgctggccac cagggagaag gcgaatgtag aggtggctct
     3541 gggagccttt atcgagatgg cccaggctga gaaggacagc atccctgcac tgctggccat
     3601 ggcgcaggcc tacatactcc tgaagcaagt ccccaaggcc cgaacgcagc tgaagcgcct
     3661 ggccaaagtc ccatggacgg tcgacgaggc cgaagacctg gaaaagagct ggcttctgtt
     3721 ggcagatatc tattgccaag gcggcaagtt cgacctggcc ttggagctac tgcgccgatg
     3781 cctgcagtat aacaagtctt gctgccgggc ctatgagtac atgggcttca tcatggagaa
     3841 agagcagtca tacaaggatg cagcaaccaa ctacgagctg gcctggaagt acagtcatca
     3901 ggccaacccc gccattggtt tcaaactggc tttcaactac ctgaaagaca agaagttcgt
     3961 agatgccatt gaagtctgtc acagcgtcct gacggagcac cccaagtacc ccaagatcag
     4021 ggaggagatt ttggagaaag cccaagggtc cttgaggccc tagctgtggc tggaaggggc
     4081 ttgggcaggg agaagcatca gtctatagac gacgacggtt caggggggga gtaggaagta
     4141 aaaccgtgga gaggcaagtg agaaacgcat actctccccg tt
//
