LOCUS       NM_028360               3430 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus tetratricopeptide repeat domain 19 (Ttc19), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_028360
VERSION     NM_028360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Radaelli,E., Assenmacher,C.A., Verrelle,J., Banerjee,E., Manero,F.,
            Khiati,S., Girona,A., Lopez-Lluch,G., Navas,P. and Spinazzi,M.
  TITLE     Mitochondrial defects caused by PARL deficiency lead to arrested
            spermatogenesis and ferroptosis
  JOURNAL   Elife 12, e84710 (2023)
   PUBMED   37505079
  REMARK    Erratum:[Elife. 2024 Sep 13;13:e103278. doi: 10.7554/eLife.103278..
            PMID: 39268597]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Spinazzi,M., Radaelli,E., Horre,K., Arranz,A.M., Gounko,N.V.,
            Agostinis,P., Maia,T.M., Impens,F., Morais,V.A., Lopez-Lluch,G.,
            Serneels,L., Navas,P. and De Strooper,B.
  TITLE     PARL deficiency in mouse causes Complex III defects, coenzyme Q
            depletion, and Leigh-like syndrome
  JOURNAL   Proc Natl Acad Sci U S A 116 (1), 277-286 (2019)
   PUBMED   30578322
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Bottani,E., Cerutti,R., Harbour,M.E., Ravaglia,S., Dogan,S.A.,
            Giordano,C., Fearnley,I.M., D'Amati,G., Viscomi,C.,
            Fernandez-Vizarra,E. and Zeviani,M.
  TITLE     TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis
            of Mitochondrial Respiratory Complex III
  JOURNAL   Mol Cell 67 (1), 96-105 (2017)
   PUBMED   28673544
  REMARK    GeneRIF: UQCRFS1 produces N-terminal polypeptides, which remain
            bound to holocomplex III. We show that, in normal conditions, these
            UQCRFS1 fragments are rapidly removed, but when TTC19 is absent
            they accumulate within complex III, causing its structural and
            functional impairment.
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Ghezzi,D., Arzuffi,P., Zordan,M., Da Re,C., Lamperti,C., Benna,C.,
            D'Adamo,P., Diodato,D., Costa,R., Mariotti,C., Uziel,G.,
            Smiderle,C. and Zeviani,M.
  TITLE     Mutations in TTC19 cause mitochondrial complex III deficiency and
            neurological impairment in humans and flies
  JOURNAL   Nat Genet 43 (3), 259-263 (2011)
   PUBMED   21278747
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596110.15.
            
            On Dec 29, 2022 this sequence version replaced NM_028360.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034075.1, SRR7974084.3704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL596110.15        106797-107017       c
            222-325             AL596110.15        106602-106705       c
            326-436             AL596110.15        104783-104893       c
            437-475             AL596110.15        104321-104359       c
            476-532             AL596110.15        103431-103487       c
            533-594             AL596110.15        102605-102666       c
            595-689             AL596110.15        96272-96366         c
            690-841             AL596110.15        79297-79448         c
            842-1004            AL596110.15        75312-75474         c
            1005-3430           AL596110.15        72055-74480         c
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.02 cM"
     gene            1..3430
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /note="tetratricopeptide repeat domain 19"
                     /db_xref="GeneID:72795"
                     /db_xref="MGI:MGI:1920045"
     exon            1..221
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1138
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 19, mitochondrial; TPR
                     repeat protein 19"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 19,
                     mitochondrial isoform 1"
                     /protein_id="NP_082636.3"
                     /db_xref="CCDS:CCDS36177.1"
                     /db_xref="GeneID:72795"
                     /db_xref="MGI:MGI:1920045"
                     /translation="MFRLLRWRLGRTLLRAAGRRCGGCTARLLPERTGDAGTGAERLR
                     TRGAPARGHGVLPLLAALAWFSRPAATAEQPGEDASDEAEAEIIQLLKQAKLSIMKDE
                     PEAAELILHDALRLAYESDNRKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGG
                     GMKQEDNAIIEISLKLANIYAAQNKQEFALAGYEFCISTLEGKIEREKELAEDIMSEE
                     TANTYLLLGMCLDSCARYLLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLA
                     TTLDAQGHFDDAYIYMQRASDLAREINHPELHMVLSNLAAILIHRERYTQAKEIYQEA
                     LKRAELKRDEVSVQHIREELAELSRKSRRLT"
     exon            222..325
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..436
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            437..475
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..532
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..594
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..689
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..841
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1004
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..3430
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2225..2230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2245
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /note="major polyA site"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3421
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
     polyA_site      3430
                     /gene="Ttc19"
                     /gene_synonym="2010204O13Rik; 2810460C24Rik"
ORIGIN      
        1 agccgtggct tagtggatct ctgagggagg acccgtcggc atgttccggt tgcttcgctg
       61 gcgtctgggt cgaaccctgc tgcgggccgc gggccggcgg tgtgggggtt gtacggcgcg
      121 cctgctgccg gagcggacgg gcgacgcggg gacgggcgcg gagcggctgc ggacccgagg
      181 cgcgccggcg cgggggcacg gggtgctgcc gctgttggca gctctcgcct ggttctcgcg
      241 acccgcggcg acggccgagc agccgggaga ggacgcgtca gacgaggcgg aggccgagat
      301 catccagctg ctgaagcaag ccaagttgag catcatgaaa gacgagccag aagcggccga
      361 gctgattttg catgacgctc ttcgccttgc gtatgagagt gacaacagga aggccatcac
      421 gtacacttat gacctgatgg ccaacttagc atttatacga gggcagcttg aaaatgcaga
      481 acagcttttt aaagcaacga tgagttatct gcttggagga ggcatgaagc aggaagacaa
      541 tgcaataatt gaaatctctc tgaaactggc caacatctat gctgctcaga ataaacagga
      601 atttgccctt gctggctatg aattctgcat ttcaactcta gaggggaaaa ttgaaagaga
      661 aaaggaatta gcagaagata ttatgtcaga agaaacagcc aatacttacc tcctccttgg
      721 tatgtgctta gactcttgtg cacgctatct gctattctcc aagcagctat cacaggcaca
      781 aaggatgtat gaaaaagccc tgcagatttg tcaagaaata caaggagaaa gacacccaca
      841 gaccattgtg ctgatgagtg acttggctac tactctggat gcacagggcc actttgatga
      901 tgcctacatt tatatgcaga gggcgtcaga tctggcaaga gagataaatc accctgagct
      961 gcacatggta ctcagcaatc tggctgccat tttgatacac agagagcgat acacacaagc
     1021 aaaggagatc taccaggaag cgctgaagcg agcagagctg aaaagagatg aggtttctgt
     1081 tcagcacatc agggaagaat tggctgaact gtcaagaaaa agtagacgtt tgacttaatt
     1141 ttgttaagct atagaagttc attttgttgt agagagggta acctctgata tcccaaagga
     1201 gtaactgttc cttcgttgtc tggacctcaa tcagtgtgta aatcattgtt gaaattcaac
     1261 gttcgtcaac tcggcttcgg agaaggacaa gttgcataca ctgccacttt tgtttctaaa
     1321 tttattttac tttgagatgg gtatctctat gggtaggctg gcctggaaat cactatatgc
     1381 ttgaagttgg cctccaactt ggagtactac tcctccctcg gcttcgaaag tgcctggccc
     1441 tacttttgtt tttaaaggtg aaacagcttt taccctgtac tgactgtata taaggtacag
     1501 tccatgctca tctgagaaat ttacagacta cagttggcca agttcctcac catatggtca
     1561 ttataccttc cataagattt tgattcatgc ttacttttct gtatccattt ctggcaaaca
     1621 agttacttgt atcatgacac aggaggattt tagttagctc tcttacacac tattttattg
     1681 atgcattatg agatttaatg actatgaagg ggaatgataa ttctagttgg ccatcattgg
     1741 cagcacttac tactaaagtg gaagtgagac atttggactg tatatctgtt tgtatgtata
     1801 taactactaa aaatgatggt ggcagaagga atgaagccct catcagcact gtctgaacac
     1861 agggcttcct ttataaccac aggcacagag tggagtaaag ttatgcttac agcacccatg
     1921 tgctcagggt aatgtgcagc ctctgatctg gatcctagtt agctctactt ttttattttg
     1981 caatctctga agtctgaaac caattagatt gtttgtctga tgactttatc actgcctcag
     2041 agtatataaa tatatgatgc atggatggat gcttttacct ttgcagtctg gcaaatggct
     2101 ttttgcctaa gagaaaacac atttttctgg gtgccacgaa ggaaccctgg tggtagaggt
     2161 aggcggtgtg agtacgattg ccagtggact ttggttcatg tgtttgttct gggagaatct
     2221 ctataataaa ctagagacta cgcaattgta tggattctaa taatcttgga atcatagaaa
     2281 aataatggcc aagttactag acagacatac taaggtccaa gtcctcagag ctaagagcta
     2341 ccgcagagtc tgtgttgtgt ggggagagcc ccacattctg tttgagttca tttaccattc
     2401 acttcctaac cacatgtgat cttcccgcta accatgaata accaggtaag agttcagtta
     2461 cctttgcttt gaaaatgttt tttacttttt cacaattcca gagttaccca agttagctgt
     2521 taggcttttt aatgttccat ggtgactgac ctcatgtcct gtggctgggg acacagtctg
     2581 tgtatgttcc cagcagcatt cgtttgcact attataaaaa aggcagtgag acaaagggac
     2641 tcatctcctt ttactgatta caactttaaa caatttacat ttaatttcat attaaagttt
     2701 taaactagac catgttacta gggttttcag ggcttaagtg tttgtaagac aatcacagca
     2761 tatgaaaatt taaagtgtag tataaaattt ctcactaagt agactggaaa attgtcagaa
     2821 tattacctct gctggaagac cttgatttag ttgcatgtgc atgtgttaca gatatagtgc
     2881 tggcccgcct tgatttgcag ctgaggtcgc agactcagta cttgctgctg cccgcgtcgg
     2941 taagccggcc tccacctctc taggtaaact gtggggttct gttctgttct gaagtaagaa
     3001 acgattctgg acttcatgtt gtgttgtcgt gaacacagat agcacaagca gtctgcagga
     3061 ggagctacaa gagtaggtga ccaagctcga ttgactgaca cagtaagaca gggccaatca
     3121 tcatcatcat cattttttgg gctagttgac aaagtgactt actaataaga tctagactta
     3181 tgtgactata acttggcagg gggacacttt cagcagtaaa tctaatcaga acacttagtc
     3241 ttcattatgt ttgtgactat tgtaaaggta atgactttac aagtgataag aatcctgttc
     3301 tggctggtcc agaactcatc ttgtaatcca gactagcctt gtactcttag tgatccgcct
     3361 gcctctgcct cctgagtgct gggattaaag gtgtgtgcta tgatgcatag ctaaagttta
     3421 agatctcaaa
//
