LOCUS       NM_133795               1467 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 1 (Ttc1), mRNA.
ACCESSION   NM_133795
VERSION     NM_133795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669911.16 and AL732633.6.
            
            On Jan 23, 2019 this sequence version replaced NM_133795.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010236.1, AK077715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL669911.16        14214-14300         c
            88-450              AL669911.16        11377-11739         c
            451-511             AL669911.16        8053-8113           c
            512-624             AL669911.16        6009-6121           c
            625-661             AL669911.16        5089-5125           c
            662-810             AL669911.16        4159-4307           c
            811-865             AL669911.16        2711-2765           c
            866-1467            AL732633.6         93995-94596         c
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.81 cM"
     gene            1..1467
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /note="tetratricopeptide repeat domain 1"
                     /db_xref="GeneID:66827"
                     /db_xref="MGI:MGI:1914077"
     exon            1..87
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..450
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..999
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /note="TPR repeat protein 1"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 1"
                     /protein_id="NP_598556.1"
                     /db_xref="CCDS:CCDS24561.1"
                     /db_xref="GeneID:66827"
                     /db_xref="MGI:MGI:1914077"
                     /translation="MEEKSEDCKVPEDLFNGLKVADPQEGESASPMVSDPKGQHCQSK
                     LPKAAEAHPQDDHVEEECFHDCSASFEEEQPGAHVAGSKASDDSSSELDEEYLIELEK
                     NMPEEEKQKRREESAKLKEEGNERFKRGDYMEAESSYSQALQMCPACFQKDRSVLFSN
                     RAAARMKQDKKETAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSVLEK
                     DPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSS
                     TGSYSINFVQNPNNNR"
     exon            451..511
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..624
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..661
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..810
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..865
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1467
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /note="hexamer: AATAAA"
     polyA_site      1467
                     /gene="Ttc1"
                     /gene_synonym="4833412C19Rik; TPR1"
                     /note="major polyA site"
ORIGIN      
        1 aggaggaagt agaaggactc ggaggcagga gcggtggaga gaggagctgg gaggttgtga
       61 agcccatcgt gggtctcgcg gcgttcgaca tttagccgta cctccctccc tgaactcagc
      121 atggaggaaa agtcagaaga ctgtaaggtc ccagaagatc tgttcaatgg tctgaaagtc
      181 gcagatcctc aagaaggaga gtctgccagc cccatggttt ctgatcccaa gggtcagcac
      241 tgccagagca agctgccgaa ggctgctgaa gcccatccac aggacgacca tgttgaagag
      301 gaatgttttc atgactgtag tgcctcgttt gaggaggaac agccaggggc gcacgtggca
      361 gggagcaaag ccagcgatga ttctagttct gaactggatg aagaatacct aattgaactg
      421 gaaaaaaaca tgccagaaga agagaaacag aaaagaagag aggagagcgc taaactaaag
      481 gaggagggga atgagcggtt taagagagga gattacatgg aagctgagag ttcttacagt
      541 caagcccttc agatgtgccc agcctgtttc cagaaagatc gatctgttct gttttcaaat
      601 agagctgctg cgaggatgaa acaggacaag aaggagacgg ccatcactga ctgcagcaaa
      661 gcaattcagt taaaccccac ctatatccgt gcaatactga ggagagctga attatatgag
      721 aaaacagaca aactagatga agcactggaa gattataaat cagtattaga aaaagatcca
      781 tcagtacatc aagcaagaga agcttgtatg agattaccta agcaaattga agaacgtaat
      841 gaaaggttaa aagaggagat gttaggtaaa ctaaaagatc ttggcaactt ggttctgcga
      901 ccttttgggc tctccacaga aaatttccag atcaagcagg attcttctac tggctcctac
      961 tccatcaatt ttgttcaaaa tccgaataat aatagataac agaaataaca gtcttaaagg
     1021 ctgactggga ggccatgaac tgttcacaag gagcacggct ctgcaggcgt tgaatattta
     1081 aaagcatcta tctaagaaag gctgtgtagt agaaccagag gcgccttctt gctcttgttt
     1141 tatgatcagg gtggaatgtg cctcctgatg tatgagcctc attaatttcc attttaaggt
     1201 ggtgtctgtg cagccgtgtc cctggttctg gctgttttct gtctggtgga gaagcctgct
     1261 tgtcaaagct gacctcttag agccgcacag atgtgctagc caccaaaaac ctcctgtaac
     1321 catgcaagcc tgtagttgag tgatgaccat acatatggac agggtcccct cctgctgtcc
     1381 ctccctgctc acacttgctc agatgctgca gtgcaggggc ttcagcattc ttgagttcct
     1441 ccgtgttaat aaaaacatcc tgtgaca
//
