LOCUS       NM_009440                819 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus testis specific X-linked gene (Tsx), transcript
            variant 1, mRNA.
ACCESSION   NM_009440
VERSION     NM_009440.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 819)
  AUTHORS   Bao,J., Wu,J., Schuster,A.S., Hennig,G.W. and Yan,W.
  TITLE     Expression profiling reveals developmentally regulated lncRNA
            repertoire in the mouse male germline
  JOURNAL   Biol Reprod 89 (5), 107 (2013)
   PUBMED   24048575
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 819)
  AUTHORS   Kobayashi,S., Totoki,Y., Soma,M., Matsumoto,K., Fujihara,Y.,
            Toyoda,A., Sakaki,Y., Okabe,M. and Ishino,F.
  TITLE     Identification of an imprinted gene cluster in the X-inactivation
            center
  JOURNAL   PLoS One 8 (8), e71222 (2013)
   PUBMED   23940725
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 819)
  AUTHORS   Anguera,M.C., Ma,W., Clift,D., Namekawa,S., Kelleher,R.J. 3rd and
            Lee,J.T.
  TITLE     Tsx produces a long noncoding RNA and has general functions in the
            germline, stem cells, and brain
  JOURNAL   PLoS Genet 7 (9), e1002248 (2011)
   PUBMED   21912526
  REMARK    GeneRIF: Tsx performs general functions in multiple cell types and
            links the noncoding locus to stem and germ cell development,
            learning, and behavior in mammals.
REFERENCE   4  (bases 1 to 819)
  AUTHORS   Beyret,E. and Lin,H.
  TITLE     Pinpointing the expression of piRNAs and function of the PIWI
            protein subfamily during spermatogenesis in the mouse
  JOURNAL   Dev Biol 355 (2), 215-226 (2011)
   PUBMED   21539824
REFERENCE   5  (bases 1 to 819)
  AUTHORS   Unhavaithaya,Y., Hao,Y., Beyret,E., Yin,H., Kuramochi-Miyagawa,S.,
            Nakano,T. and Lin,H.
  TITLE     MILI, a PIWI-interacting RNA-binding protein, is required for germ
            line stem cell self-renewal and appears to positively regulate
            translation
  JOURNAL   J Biol Chem 284 (10), 6507-6519 (2009)
   PUBMED   19114715
REFERENCE   6  (bases 1 to 819)
  AUTHORS   Deng,W. and Lin,H.
  TITLE     miwi, a murine homolog of piwi, encodes a cytoplasmic protein
            essential for spermatogenesis
  JOURNAL   Dev Cell 2 (6), 819-830 (2002)
   PUBMED   12062093
REFERENCE   7  (bases 1 to 819)
  AUTHORS   Chureau,C., Prissette,M., Bourdet,A., Barbe,V., Cattolico,L.,
            Jones,L., Eggen,A., Avner,P. and Duret,L.
  TITLE     Comparative sequence analysis of the X-inactivation center region
            in mouse, human, and bovine
  JOURNAL   Genome Res 12 (6), 894-908 (2002)
   PUBMED   12045143
REFERENCE   8  (bases 1 to 819)
  AUTHORS   Debrand,E., Chureau,C., Arnaud,D., Avner,P. and Heard,E.
  TITLE     Functional analysis of the DXPas34 locus, a 3' regulator of Xist
            expression
  JOURNAL   Mol Cell Biol 19 (12), 8513-8525 (1999)
   PUBMED   10567576
REFERENCE   9  (bases 1 to 819)
  AUTHORS   Cunningham,D.B., Segretain,D., Arnaud,D., Rogner,U.C. and Avner,P.
  TITLE     The mouse Tsx gene is expressed in Sertoli cells of the adult
            testis and transiently in premeiotic germ cells during puberty
  JOURNAL   Dev Biol 204 (2), 345-360 (1998)
   PUBMED   9882475
REFERENCE   10 (bases 1 to 819)
  AUTHORS   Simmler,M.C., Cunningham,D.B., Clerc,P., Vermat,T., Caudron,B.,
            Cruaud,C., Pawlak,A., Szpirer,C., Weissenbach,J., Claverie,J.M. and
            Avner,P.
  TITLE     A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT
            rich region containing a new testis specific gene Tsx
  JOURNAL   Hum Mol Genet 5 (11), 1713-1726 (1996)
   PUBMED   8922998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048493.1 and AV265136.1.
            
            On Jan 24, 2017 this sequence version replaced NM_009440.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048493.1, X99796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-815               BC048493.1         1-815
            816-819             AV265136.1         231-234
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.12 cM"
     gene            1..819
                     /gene="Tsx"
                     /note="testis specific X-linked gene"
                     /db_xref="GeneID:22127"
                     /db_xref="MGI:MGI:108118"
     exon            1..180
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..521
                     /gene="Tsx"
                     /note="testis-specific X-linked protein"
                     /codon_start=1
                     /product="testis-specific protein TSX"
                     /protein_id="NP_033466.1"
                     /db_xref="CCDS:CCDS41090.1"
                     /db_xref="GeneID:22127"
                     /db_xref="MGI:MGI:108118"
                     /translation="MSEKQSPKTSEAECSAMDLPEFEDEENWLFKVLGFQPGPSSALD
                     DDTDDQADEPLSAAEFLHLQDILQEDRVSSTDDEDTCQAGCTEDDETSHSDRDIDNNV
                     KVITGNIKASPSMYMEMFTDQNPQADQDLEETESDGAMNPTD"
     exon            181..216
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     exon            217..253
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     exon            254..335
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     exon            336..436
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     exon            437..495
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     exon            496..819
                     /gene="Tsx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsx"
                     /note="hexamer: AATAAA"
     polyA_site      819
                     /gene="Tsx"
                     /note="major polyA site"
ORIGIN      
        1 caggccttta ttcacagcac ccacctagac ttgggtatca gctccaccaa caaggtctcc
       61 ctccacagaa gccgaatccc ggagctatgt ctgaaaagca aagccccaag acctctgaag
      121 cagaatgcag tgcaatggac ttgccagaat tcgaggatga agaaaactgg cttttcaaag
      181 ttctgggatt ccagcctggg ccgtcctctg ctctggatga tgacaccgac gatcaggcag
      241 atgagccact gagcgctgcc gaatttcttc acctgcaaga tattcttcag gaggacagag
      301 tcagcagtac cgatgatgag gacacttgcc aagctggatg tactgaagat gatgaaacca
      361 gtcacagtga cagagacata gacaataatg tgaaagtcat cactggcaac attaaagcaa
      421 gcccctccat gtatatggag atgttcactg atcagaaccc acaagctgac caagacctgg
      481 aagaaactga atcagatggt gccatgaacc caactgatta agcaggcagg cagaaacgtg
      541 tcaccatcag ctaccattgt gccctcatgc ataaatgaag tcctgatgga aaacagacaa
      601 acaaacaaac aaacaaacat ctctacacac taagccgaaa acaaatctat accaaactgc
      661 taaaataaat ggaaaatact taatttgagc ctggctgttt tgaaaattgg aaatccttct
      721 tcaaaatgaa aatcaccgca aaacaatcta aagtcatcta caggccaact agggtgtttg
      781 ttgcttgcca aacttccaat aaattctgct tgaaacctt
//
