LOCUS       NM_009437               1102 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus thiosulfate sulfurtransferase, mitochondrial (Tst),
            mRNA.
ACCESSION   NM_009437
VERSION     NM_009437.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Luo,Y., Chatre,L., Melhem,S., Al-Dahmani,Z.M., Homer,N.Z.M.,
            Miedema,A., Deelman,L.E., Groves,M.R., Feelisch,M., Morton,N.M.,
            Dolga,A. and van Goor,H.
  TITLE     Thiosulfate sulfurtransferase deficiency promotes oxidative
            distress and aberrant NRF2 function in the brain
  JOURNAL   Redox Biol 68, 102965 (2023)
   PUBMED   38000344
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Carter,R.N., Gibbins,M.T.G., Barrios-Llerena,M.E., Wilkie,S.E.,
            Freddolino,P.L., Libiad,M., Vitvitsky,V., Emerson,B., Le Bihan,T.,
            Brice,M., Su,H., Denham,S.G., Homer,N.Z.M., Mc Fadden,C.,
            Tailleux,A., Faresse,N., Sulpice,T., Briand,F., Gillingwater,T.,
            Ahn,K.H., Singha,S., McMaster,C., Hartley,R.C., Staels,B.,
            Gray,G.A., Finch,A.J., Selman,C., Banerjee,R. and Morton,N.M.
  TITLE     The hepatic compensatory response to elevated systemic sulfide
            promotes diabetes
  JOURNAL   Cell Rep 37 (6), 109958 (2021)
   PUBMED   34758301
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Lainscek,D., Sustar,U., Carter,R.N., Morton,N.M. and Horvat,S.
  TITLE     Tst gene mediates protection against palmitate-induced inflammation
            in 3T3-L1 adipocytes
  JOURNAL   Biochem Biophys Res Commun 527 (4), 1008-1013 (2020)
   PUBMED   32444140
  REMARK    GeneRIF: Tst gene mediates protection against palmitate-induced
            inflammation in 3T3-L1 adipocytes.
REFERENCE   5  (bases 1 to 1102)
  AUTHORS   Beltram,J., Morton,N.M., Kunej,T. and Horvat,S.
  TITLE     Construction of an integrative regulatory element and variation map
            of the murine Tst locus
  JOURNAL   BMC Genet 17 (1), 77 (2016)
   PUBMED   27287690
  REMARK    GeneRIF: Results identified two regulatory variants between fat and
            lean mice: one overlaps an evolutionary constrained Tst intronic
            element and the other resides in the seed region of a predicted
            3'UTR miRNA binding site.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1102)
  AUTHORS   Moran,J.L., Johnston,S.H., Rauskolb,C., Bhalerao,J., Bowcock,A.M.
            and Vogt,T.F.
  TITLE     Genomic structure, mapping, and expression analysis of the
            mammalian Lunatic, Manic, and Radical fringe genes
  JOURNAL   Mamm Genome 10 (6), 535-541 (1999)
   PUBMED   10341080
REFERENCE   7  (bases 1 to 1102)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   8  (bases 1 to 1102)
  AUTHORS   Aita,N., Ishii,K., Akamatsu,Y., Ogasawara,Y. and Tanabe,S.
  TITLE     Cloning and expression of human liver rhodanese cDNA
  JOURNAL   Biochem Biophys Res Commun 231 (1), 56-60 (1997)
   PUBMED   9070219
REFERENCE   9  (bases 1 to 1102)
  AUTHORS   Nagahara,N. and Nishino,T.
  TITLE     Role of amino acid residues in the active site of rat liver
            mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression,
            and site-directed mutagenesis
  JOURNAL   J Biol Chem 271 (44), 27395-27401 (1996)
   PUBMED   8910318
REFERENCE   10 (bases 1 to 1102)
  AUTHORS   Dooley,T.P., Nair,S.K., Garcia,R.E. 4th and Courtney,B.C.
  TITLE     Mouse rhodanese gene (Tst): cDNA cloning, sequencing, and
            recombinant protein expression
  JOURNAL   Biochem Biophys Res Commun 216 (3), 1101-1109 (1995)
   PUBMED   7488186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL583893.17.
            
            On Jul 6, 2018 this sequence version replaced NM_009437.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005644.2, AK003953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               AL583893.17        176366-176992       c
            628-1102            AL583893.17        170683-171157       c
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.47 cM"
     gene            1..1102
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /note="thiosulfate sulfurtransferase, mitochondrial"
                     /db_xref="GeneID:22117"
                     /db_xref="MGI:MGI:98852"
     exon            1..627
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..926
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /EC_number="2.8.1.1"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase"
                     /protein_id="NP_033463.1"
                     /db_xref="CCDS:CCDS27614.1"
                     /db_xref="GeneID:22117"
                     /db_xref="MGI:MGI:98852"
                     /translation="MVHQVLYRALVSTKWLAESIRSGRLGPSLRVLDASWYSPGTRQA
                     RKEYQERHVPGASFFDIEECRDTTSPYEMMLPSEAHFGDYVGNLGISNDTHVVVYDGD
                     DLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLNLS
                     LLKTYEQVLENLQSKRFQLVDSRAQGRYLGTQPEPDIVGLDSGHIRGSVNMPFMDFLT
                     KDGFEKSPEELRAIFQDKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSW
                     SEWFRRAPPETRVSQGKSGKA"
     exon            628..1102
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /note="hexamer: AATAAA"
     polyA_site      1102
                     /gene="Tst"
                     /gene_synonym="rhodanese"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcgcca ggtgactcgc agaactgaca ctatggtaca tcaggtgctc taccgggcgc
       61 tggtatccac caagtggctg gcggaatcca ttcggtctgg ccgcctgggg cccagccttc
      121 gggtgctgga cgcgtcttgg tactcacccg ggacccgcca ggcacgcaaa gagtaccagg
      181 agcgacacgt gcctggcgcg tccttctttg atatagagga atgccgggac acgacttcgc
      241 cttatgagat gatgctgccc agtgaggccc actttgggga ctatgtgggc aacctgggca
      301 taagcaacga cacacatgtg gtggtatacg atggagatga cctgggcagc ttctatgcac
      361 ccagagtctg gtggatgttt cgtgtgtttg gccaccgcac agtgtcagtg ctcaatggtg
      421 gcttccggaa ctggctgaag gagggccacc cggtgacatc tgagccctcg aggccagagc
      481 cagccgtttt caaagccaca ctgaatctct ccctgctcaa gacctatgag caggtcctag
      541 agaatctcca gtctaaaagg ttccagctgg tggactctcg ggcccaagga cggtacctgg
      601 gcacacaacc ggagccggat atagtaggac tagactcggg ccacatccgt ggctcagtca
      661 acatgccctt catggacttc ctgacgaaag atggcttcga gaagagccca gaggagctgc
      721 gtgccatatt ccaggacaag aaggtggacc tctcacagcc cctcattgcc acgtgccgca
      781 agggggtcac tgcctgtcac gttgccctgg ctgcctacct ttgtggcaaa cccgatgtgg
      841 ctgtttacga tggctcctgg tcagagtggt tccgcagggc acccccagag acccgtgtgt
      901 cccaggggaa gagtgggaag gcctgagtgt gtgcagcctc ctcctctgcc cacccaatcc
      961 agccagttcc cttcagggag gttggtgtga cctgctgtag gttcaccttt taggctacgg
     1021 atattgacag ggttttagaa ttgctcttgg tgcctccctc cctccctccc tctacattgg
     1081 aataaagtgc cttttctcag aa
//
