LOCUS       NM_080442               1034 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus testis-specific serine kinase 3 (Tssk3), mRNA.
ACCESSION   NM_080442 NM_021479
VERSION     NM_080442.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1034)
  AUTHORS   Nozawa,K., Garcia,T.X., Kent,K., Leng,M., Jain,A., Malovannaya,A.,
            Yuan,F., Yu,Z., Ikawa,M. and Matzuk,M.M.
  TITLE     Testis-specific serine kinase 3 is required for sperm morphogenesis
            and male fertility
  JOURNAL   Andrology 11 (5), 826-839 (2023)
   PUBMED   36306217
  REMARK    GeneRIF: Testis-specific serine kinase 3 is required for sperm
            morphogenesis and male fertility.
REFERENCE   2  (bases 1 to 1034)
  AUTHORS   Nayyab,S., Gervasi,M.G., Tourzani,D.A., Caraballo,D.A., Jha,K.N.,
            Teves,M.E., Cui,W., Georg,G.I., Visconti,P.E. and Salicioni,A.M.
  TITLE     TSSK3, a novel target for male contraception, is required for
            spermiogenesis
  JOURNAL   Mol Reprod Dev 88 (11), 718-730 (2021)
   PUBMED   34623009
REFERENCE   3  (bases 1 to 1034)
  AUTHORS   Li,Y., Sosnik,J., Brassard,L., Reese,M., Spiridonov,N.A.,
            Bates,T.C., Johnson,G.R., Anguita,J., Visconti,P.E. and
            Salicioni,A.M.
  TITLE     Expression and localization of five members of the testis-specific
            serine kinase (Tssk) family in mouse and human sperm and testis
  JOURNAL   Mol Hum Reprod 17 (1), 42-56 (2011)
   PUBMED   20729278
REFERENCE   4  (bases 1 to 1034)
  AUTHORS   Bucko-Justyna,M., Lipinski,L., Burgering,B.M. and Trzeciak,L.
  TITLE     Characterization of testis-specific serine-threonine kinase 3 and
            its activation by phosphoinositide-dependent kinase-1-dependent
            signalling
  JOURNAL   FEBS J 272 (24), 6310-6323 (2005)
   PUBMED   16336268
  REMARK    GeneRIF: PDK1-induced phosphorylation increased in vitro TSSK3
            kinase activity, suggesting that TSSK3 can be regulated in the same
            way as AGC kinase family members. The peptide sequence RRSSSY
            containing Ser5 is identified as a target for TSSK3 phosphorylation
REFERENCE   5  (bases 1 to 1034)
  AUTHORS   Visconti,P.E., Hao,Z., Purdon,M.A., Stein,P., Balsara,B.R.,
            Testa,J.R., Herr,J.C., Moss,S.B. and Kopf,G.S.
  TITLE     Cloning and chromosomal localization of a gene encoding a novel
            serine/threonine kinase belonging to the subfamily of
            testis-specific kinases
  JOURNAL   Genomics 77 (3), 163-170 (2001)
   PUBMED   11597141
REFERENCE   6  (bases 1 to 1034)
  AUTHORS   Zuercher,G., Rohrbach,V., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel member of the testis specific serine kinase family, tssk-3,
            expressed in the Leydig cells of sexually mature mice
  JOURNAL   Mech Dev 93 (1-2), 175-177 (2000)
   PUBMED   10781952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019840.1.
            
            On or before Oct 15, 2004 this sequence version replaced
            NM_021479.1, NM_080442.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019840.1, BC048470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AK019840.1         2-1035
FEATURES             Location/Qualifiers
     source          1..1034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..1034
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /note="testis-specific serine kinase 3"
                     /db_xref="GeneID:58864"
                     /db_xref="MGI:MGI:1929914"
     exon            1..309
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..971
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 22C (spermiogenesis
                     associated); spermiogenesis associated serine/threonine
                     kinase 22D; testis-specific serine/threonine kinase 3b;
                     testis-specific kinase 3; serine/threonine-protein kinase
                     22C"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     3"
                     /protein_id="NP_536690.1"
                     /db_xref="CCDS:CCDS18693.1"
                     /db_xref="GeneID:58864"
                     /db_xref="MGI:MGI:1929914"
                     /translation="MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKM
                     GGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLN
                     GGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPK
                     SRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKM
                     LWQQQKGVSFPTHLGISTECQDLLKRLLEPDMILRPSIEEVSWHPWLAST"
     exon            310..1034
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      996..1001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /note="hexamer: AATAAA"
     polyA_site      1028
                     /gene="Tssk3"
                     /gene_synonym="1700014N07Rik; 4930594I21Rik; Stk22c;
                     Stk22d; Tsk-3; Tssk-3; Tssk3b"
                     /note="major polyA site"
ORIGIN      
        1 accacctgtg gctgtgtcca gacggagaat gttctagccc tggaggcagc tgtgaatgaa
       61 gtccttgggg ggaaaagaag caggccgagg gcgatggtgg agtagagctg cctcgcagag
      121 gcagcatgag ctgagagggt gacaagaagg aggcgctaca cagcatggag gactttctac
      181 tctccaatgg gtatcagctg ggcaagacca ttggggaagg gacctactca aaagtcaaag
      241 aagcattttc caaaaaacat caaagaaaag tggcaattaa aattatagac aagatgggag
      301 ggccagaaga gtttatccag agattcctgc ctcgtgagct ccagattgtc cgtaccctgg
      361 accacaaaaa catcatccag gtgtatgaga tgctggagtc agcagatgga aaaatctacc
      421 tggtgatgga actggctgag ggaggggatg tctttgactg tgtgctgaac ggagggccac
      481 ttcccgagag ccgggccaag gccctcttcc gccagatggt tgaggctatt cgctattgcc
      541 atggctgtgg cgtggcccac cgggacctta agtgtgagaa cgccttgttg cagggcttca
      601 acctgaagct gaccgacttt ggctttgcca aggtgctacc caagtcacgc agggagctga
      661 gccagacctt ctgtggcagc acagcctatg ccgcccctga ggtgctacag ggcatacccc
      721 atgatagcaa gaaaggtgat gtctggagca tgggtgtggt cctgtatgta atgctctgtg
      781 caagtctacc ttttgatgac acagatatcc ccaagatgct gtggcagcag cagaaggggg
      841 tgtccttccc cactcatttg ggcatctcaa ccgaatgcca ggacctgctc aagcggctcc
      901 tggaaccaga catgatactc cggccttcaa tcgaagaagt tagttggcac ccatggctag
      961 caagcacttg ataaaagcaa tggcaagtcc tccccaataa agtaggggga gaaagcaaac
     1021 tgaaaaaacc cgct
//
