LOCUS       NM_009435               1466 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus testis-specific serine kinase 1 (Tssk1), mRNA.
ACCESSION   NM_009435
VERSION     NM_009435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Pedroza,M., Welschhans,R.L. and Agarwal,S.K.
  TITLE     Targeting of cadherin-11 decreases skin fibrosis in the tight
            skin-1 mouse model
  JOURNAL   PLoS One 12 (11), e0187109 (2017)
   PUBMED   29112946
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1466)
  AUTHORS   MacLeod,G., Shang,P., Booth,G.T., Mastropaolo,L.A.,
            Manafpoursakha,N., Vogl,A.W. and Varmuza,S.
  TITLE     PPP1CC2 can form a kinase/phosphatase complex with the
            testis-specific proteins TSSK1 and TSKS in the mouse testis
  JOURNAL   Reproduction 147 (1), 1-12 (2013)
   PUBMED   24088291
  REMARK    GeneRIF: In mouse testis, PPP1CC2 can form a complex with TSSK1
            mediated by the direct interaction of each with the kinase
            substrate protein TSKS. Interaction between PPP1CC2 and TSKS is
            mediated through an RVxF docking motif on the TSKS surface.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1466)
  AUTHORS   Jha,K.N., Coleman,A.R., Wong,L., Salicioni,A.M., Howcroft,E. and
            Johnson,G.R.
  TITLE     Heat shock protein 90 functions to stabilize and activate the
            testis-specific serine/threonine kinases, a family of kinases
            essential for male fertility
  JOURNAL   J Biol Chem 288 (23), 16308-16320 (2013)
   PUBMED   23599433
  REMARK    GeneRIF: HSP90 function abolished the catalytic activities of TSSK4
            and -6 but did not significantly alter the specific activities of
            TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK
            ubiquitination and proteasomal degradation
REFERENCE   5  (bases 1 to 1466)
  AUTHORS   Yang,M.H., Su,J.Z., Liu,J. and Li,Y.H.
  TITLE     [Cloning and expression of Tssk1 & Tssk2 in mice and the presence &
            localization of them in mature sperm]
  JOURNAL   Dongwuxue Yanjiu 33 (4), 381-388 (2012)
   PUBMED   22855445
  REMARK    GeneRIF: Tssk1 and Tssk2 play an important role in the regulation
            of sperm function.
REFERENCE   6  (bases 1 to 1466)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
REFERENCE   7  (bases 1 to 1466)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   8  (bases 1 to 1466)
  AUTHORS   Reeves,R.H., Rue,E.E., Citron,M.P. and Cabin,D.E.
  TITLE     High-resolution recombinational map of mouse chromosome 16
  JOURNAL   Genomics 43 (2), 202-208 (1997)
   PUBMED   9244437
REFERENCE   9  (bases 1 to 1466)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
REFERENCE   10 (bases 1 to 1466)
  AUTHORS   Bielke,W., Blaschke,R.J., Miescher,G.C., Zurcher,G., Andres,A.C.
            and Ziemiecki,A.
  TITLE     Characterization of a novel murine testis-specific serine/threonine
            kinase
  JOURNAL   Gene 139 (2), 235-239 (1994)
   PUBMED   8112611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006517.1, BC050772.1 and U01840.1.
            
            On Aug 18, 2006 this sequence version replaced NM_009435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               AK006517.1         2-823
            823-1449            BC050772.1         796-1422
            1450-1466           U01840.1           1354-1370
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.09 cM"
     gene            1..1466
                     /gene="Tssk1"
                     /gene_synonym="Stk22a; TSK-1; Tsk1; Tssk; Tssk1b"
                     /note="testis-specific serine kinase 1"
                     /db_xref="GeneID:22114"
                     /db_xref="MGI:MGI:1347557"
     exon            1..1451
                     /gene="Tssk1"
                     /gene_synonym="Stk22a; TSK-1; Tsk1; Tssk; Tssk1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1248
                     /gene="Tssk1"
                     /gene_synonym="Stk22a; TSK-1; Tsk1; Tssk; Tssk1b"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 22A (spermiogenesis
                     associated); TSSK-1; testis-specific kinase 1;
                     serine/threonine-protein kinase 22A; testis-specific
                     serine/threonine kinase"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     1"
                     /protein_id="NP_033461.2"
                     /db_xref="CCDS:CCDS28011.1"
                     /db_xref="GeneID:22114"
                     /db_xref="MGI:MGI:1347557"
                     /translation="MDDAAVLKRRGYIMGINLGEGSYAKVKSAYSERLKFNVAVKIID
                     RKKAPSDFLEKFLPREIEILAMLNHRSIVKTYEIFETSDGKVYIVMELGVQGDLLEFI
                     KTRGALQEDDARKKFHQLSSAIKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKR
                     CLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDD
                     SNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYRMLQPDVNRRLHIDEILNHCWVQPKA
                     RGLSSGAINKEGESSRATEPSWIPEPGADKKSATKLEPREEARSEARSESKPQEDTLQ
                     VVRQSENVGLSSELNRDTEEGHPQQPSETHT"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tssk1"
                     /gene_synonym="Stk22a; TSK-1; Tsk1; Tssk; Tssk1b"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="Tssk1"
                     /gene_synonym="Stk22a; TSK-1; Tsk1; Tssk; Tssk1b"
                     /note="major polyA site"
ORIGIN      
        1 gctagagtct tgggcctctt aggaggcagg gacagcaggc ctggacagct cagaggactc
       61 tctgtccaca gtgtaaatga ggacactgct ggcccatgtc tggcagggat gtagagggca
      121 gcctcggagg cactgggcac tcccggcacc atggatgacg ctgccgtcct caagcgacga
      181 ggctacatca tggggataaa cttgggagag ggctcatatg ccaaagtcaa atccgcttac
      241 tctgagcgcc taaagttcaa cgtggcggtc aagatcatcg atcgcaagaa agccccctca
      301 gacttcctgg agaaattcct tccccgggag attgagattc tggccatgct aaaccaccgc
      361 tctattgtca agacctatga gatctttgag acatcagatg gcaaggtcta cattgtcatg
      421 gagcttgggg tccagggtga cctcctcgag ttcatcaaaa ccagaggagc cctgcaagag
      481 gatgatgctc gaaagaagtt ccaccagctc tcctcggcca tcaagtactg ccacgacctg
      541 gatgtcgtcc accgagacct caaatgtgag aaccttctgc ttgacaagga cttcaacatc
      601 aaactgtctg acttcggctt ctccaagcgc tgcttgcggg atgatagtgg tcgactgata
      661 ttaagcaaga ccttctgtgg gtcagcagct tatgcggccc ccgaggtgct gcagggcatc
      721 ccctaccagc ccaaggtgta tgacatctgg agcctgggtg tgattctcta catcatggtc
      781 tgtggctcca tgccctacga tgactccaac atcaaaaaga tgctgcgcat ccagaaggag
      841 caccgtgtca actttccacg ctctaaacac ctgactggtg agtgcaagga cctcatctac
      901 agaatgttac agccagatgt caaccgccgg ctgcacatcg atgagatcct taaccactgc
      961 tgggtgcagc ccaaggcacg aggtctgtcc tctggagcca tcaacaagga gggggaaagc
     1021 tcccgggcca ctgagccctc atggatccct gaacctggtg ctgataagaa gtctgccacc
     1081 aagttggagc ctagggaaga ggcacgatct gaggcccggt ctgagtcaaa accccaggaa
     1141 gatactttgc aggtggtcag gcagtcagag aacgtgggcc tcagcagcga actgaacagg
     1201 gacacagagg aagggcaccc ccaacagcct tcagagacac atacttagtg agcctcttgc
     1261 agcccagggg gccagcaggg aatgaggcag agctcatggc ttgaagcctg agcctagaag
     1321 tcaagggacg agagagagaa ggaagacact cccggatgag ctattttcgt cactttcttc
     1381 tccccccctt tgaacttggt aactcacacg gctaaagaag caataaatca ctatattggt
     1441 gcacacccta aaaaaaaaaa aaaaaa
//
