LOCUS       NM_020285               1394 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tumor-suppressing subchromosomal transferable fragment
            4 (Tssc4), transcript variant 1, mRNA.
ACCESSION   NM_020285
VERSION     NM_020285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Bogutz,A.B., Oh-McGinnis,R., Jacob,K.J., Ho-Lau,R., Gu,T.,
            Gertsenstein,M., Nagy,A. and Lefebvre,L.
  TITLE     Transcription factor ASCL2 is required for development of the
            glycogen trophoblast cell lineage
  JOURNAL   PLoS Genet 14 (8), e1007587 (2018)
   PUBMED   30096149
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Oh-McGinnis,R., Bogutz,A.B. and Lefebvre,L.
  TITLE     Partial loss of Ascl2 function affects all three layers of the
            mature placenta and causes intrauterine growth restriction
  JOURNAL   Dev Biol 351 (2), 277-286 (2011)
   PUBMED   21238448
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Mohammad,F., Mondal,T., Guseva,N., Pandey,G.K. and Kanduri,C.
  TITLE     Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by
            interacting with Dnmt1
  JOURNAL   Development 137 (15), 2493-2499 (2010)
   PUBMED   20573698
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Oh-McGinnis,R., Bogutz,A.B., Lee,K.Y., Higgins,M.J. and Lefebvre,L.
  TITLE     Rescue of placental phenotype in a mechanistic model of
            Beckwith-Wiedemann syndrome
  JOURNAL   BMC Dev Biol 10, 50 (2010)
   PUBMED   20459838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Shin,J.Y., Fitzpatrick,G.V. and Higgins,M.J.
  TITLE     Two distinct mechanisms of silencing by the KvDMR1 imprinting
            control region
  JOURNAL   EMBO J 27 (1), 168-178 (2008)
   PUBMED   18079696
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Engemann,S., Strodicke,M., Paulsen,M., Franck,O., Reinhardt,R.,
            Lane,N., Reik,W. and Walter,J.
  TITLE     Sequence and functional comparison in the Beckwith-Wiedemann
            region: implications for a novel imprinting centre and extended
            imprinting
  JOURNAL   Hum Mol Genet 9 (18), 2691-2706 (2000)
   PUBMED   11063728
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Paulsen,M., El-Maarri,O., Engemann,S., Strodicke,M., Franck,O.,
            Davies,K., Reinhardt,R., Reik,W. and Walter,J.
  TITLE     Sequence conservation and variability of imprinting in the
            Beckwith-Wiedemann syndrome gene cluster in human and mouse
  JOURNAL   Hum Mol Genet 9 (12), 1829-1841 (2000)
   PUBMED   10915772
  REMARK    GeneRIF: The orthologous gene pair, Tssc4/TSSC4, shows difference
            in imprinting between mouse and human. Mouse Tssc4 gene is
            imprinted, with preferential expression from the maternal allele in
            placenta, whereas, human TSSC4 gene is not imprinted.
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Yatsuki,H., Watanabe,H., Hattori,M., Joh,K., Soejima,H., Komoda,H.,
            Xin,Z., Zhu,X., Higashimoto,K., Nishimura,M., Kuratomi,S.,
            Sasaki,H., Sakaki,Y. and Mukai,T.
  TITLE     Sequence-based structural features between Kvlqt1 and Tapa1 on
            mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann
            syndrome region on human 11p15.5: long-stretches of unusually well
            conserved intronic sequences of kvlqt1 between mouse and human
  JOURNAL   DNA Res 7 (3), 195-206 (2000)
   PUBMED   10907850
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Day,C.D., Smilinich,N.J., Fitzpatrick,G.V., deJong,P.J., Shows,T.B.
            and Higgins,M.J.
  TITLE     The imprinted domain in mouse distal Chromosome 7: reagents for
            mutagenesis and sequencing
  JOURNAL   Mamm Genome 10 (2), 182-185 (1999)
   PUBMED   9922400
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB038011.1.
            
            On Mar 4, 2008 this sequence version replaced NM_020285.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 3
            both encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038011.1, BI651089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 10915772
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.11 cM"
     gene            1..1394
                     /gene="Tssc4"
                     /gene_synonym="ESTM671070"
                     /note="tumor-suppressing subchromosomal transferable
                     fragment 4"
                     /db_xref="GeneID:56844"
                     /db_xref="MGI:MGI:1861712"
     exon            1..146
                     /gene="Tssc4"
                     /gene_synonym="ESTM671070"
                     /inference="alignment:Splign:2.1.0"
     exon            147..242
                     /gene="Tssc4"
                     /gene_synonym="ESTM671070"
                     /inference="alignment:Splign:2.1.0"
     exon            243..1394
                     /gene="Tssc4"
                     /gene_synonym="ESTM671070"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1217
                     /gene="Tssc4"
                     /gene_synonym="ESTM671070"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein TSSC4; U5 small nuclear ribonucleoprotein TSSC4"
                     /codon_start=1
                     /product="U5 small nuclear ribonucleoprotein TSSC4 isoform
                     1"
                     /protein_id="NP_064681.1"
                     /db_xref="CCDS:CCDS40195.1"
                     /db_xref="GeneID:56844"
                     /db_xref="MGI:MGI:1861712"
                     /translation="MAETEAGLEADEPTEDDTLPSDTVSLSDSDSDLSLPSGVEVQVL
                     SPERLSEEGQEDSGPEDPPSPPTGTLTTAVQPFHLRGMSSTFSQRSHSIFDCLESAAR
                     QAPCSAPQTSVSDNGSFRRPVTPPSQTPARGLSRVHGNTGPTRVLPVPDYVSHPERWT
                     KYSLEDVSEASEQSNRDAALAFLSSRSQVSHTDYVPSFNQDPSSCGEGRVVFTKPVRD
                     SEARAERKRVLKKGVGSGAGGEAAVELAHLAGPEAEEWSGHQGQPEVVVPSEAAHPES
                     SSGPIGVKAVGFHGSKKRSRDHFRNRDGNPGGPGSERGPSV"
ORIGIN      
        1 gggcgctgaa gccacgaaaa tctgatcgcc cgagactcgg tttcccagga acccgagcga
       61 gactggacag gaccgaatcc cggggaactg gcgggacgct gcgagaaagg cggcagggta
      121 ttgaggcgtg tacggacgct ggaacgctcc tgtatctgtg cgcgctagga taccctttaa
      181 ccacccagct tcgcgaggcc tcccgtccgg ctgtgagtag aggcacttga cacatagtgg
      241 aggtgggacg ggtgtcaggt cgtatggcgg agacagaggc tggcctggag gctgatgaac
      301 ccaccgagga tgacaccctg ccttctgaca ccgtctccct cagcgactcg gactcggacc
      361 ttagcttacc tagtggtgtg gaggtccaag tgttgtcccc agagaggctt tcggaggagg
      421 gccaggagga ctccggccct gaggaccctc catcgccccc cacgggcacc ctcaccactg
      481 cagtgcagcc attccacctc cgaggcatga gttctacctt ctcccagcgc agccacagca
      541 tctttgattg tctggagagt gcagcccggc aggcaccgtg ctctgctccc caaaccagtg
      601 tgagtgacaa tggcagcttc aggcggcccg tgactccccc aagtcagact ccagcaaggg
      661 gcctgagcag agtgcatggg aacactggcc cgactagggt actcccagtc cctgactatg
      721 tgtcacaccc tgagcgttgg accaaataca gtctggagga tgtgtctgaa gccagtgagc
      781 agagcaatcg tgatgctgcc ctggccttcc tgagctctcg aagccaggtg tcccacacag
      841 actatgtgcc ttctttcaac caggacccct ctagctgtgg ggagggaaga gtggtcttca
      901 ccaaaccagt gagggacagt gaggctaggg ctgagaggaa gagggtccta aagaaggggg
      961 ttgggtcagg tgcggggggt gaggccgctg tggagctagc ccatctcgct ggacctgagg
     1021 ctgaggaatg gagtggccac cagggacagc cagaggtggt ggtaccttca gaagctgccc
     1081 atcctgagtc ctcatcaggc cccataggtg tgaaggctgt tggtttccat ggcagcaaga
     1141 agcggagcag agaccacttc cggaacaggg acggtaaccc tggggggccg gggtctgaga
     1201 gaggaccctc agtttgactg cagtgctatc actctacccc tcacctgcta gtccaagtgg
     1261 gaaggtgtgg gctgtctgtg gtagggggat gtgtgcagcc gctctggcag agactgtggg
     1321 aattgtgggt caggggacct cgaaggcctt tgtgccccag tgtttaggat gaataataaa
     1381 cgtttggaat attt
//
