LOCUS       NM_175146               3805 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus TSR2 20S rRNA accumulation (Tsr2), transcript variant
            2, mRNA.
ACCESSION   NM_175146
VERSION     NM_175146.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ072126.1, AK044504.1, AL805937.11 and AI098563.1.
            
            On Sep 3, 2009 this sequence version replaced NM_175146.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1,
            resulting in an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044504.1, SRR11927932.3632120.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CJ072126.1         3-27
            26-1275             AK044504.1         2-1251
            1276-3337           AL805937.11        166107-168168       c
            3338-3805           AI098563.1         1-468               c
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..3805
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /note="TSR2 20S rRNA accumulation"
                     /db_xref="GeneID:69499"
                     /db_xref="MGI:MGI:1916749"
     exon            1..115
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..610
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pre-rRNA-processing protein TSR2 homolog; TSR2, 20S rRNA
                     accumulation, homolog"
                     /codon_start=1
                     /product="pre-rRNA-processing protein TSR2 homolog isoform
                     2"
                     /protein_id="NP_780355.2"
                     /db_xref="CCDS:CCDS30468.2"
                     /db_xref="GeneID:69499"
                     /db_xref="MGI:MGI:1916749"
                     /translation="MMAGAAEDVRVLFGAAVRAALEAWPALQIAVENGFGGVHSQEKA
                     EWLGGAVEDYFIANADLELEEIEDFLGELMTTEFDTVVEDGSLPQVSQQLQTMFHHFQ
                     KGDGAALQEMTSQINQKKCKVTATPLMTAKETDVAEDDVDSVEEMEVTATNDGATTDE
                     VCPQPQPSDPDTQTIKEEDIVEDGWTIVRRKK"
     exon            116..206
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            207..298
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..475
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..3796
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1384..1389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /note="major polyA site"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="Tsr2"
                     /gene_synonym="2310007F12Rik"
ORIGIN      
        1 gggctgcctg ggagccacgt gatctaaacg gatgatggcg ggcgccgctg aagatgtgcg
       61 tgtgctcttc ggagctgcag tccgagctgc gctggaggct tggcctgctt tacagatcgc
      121 tgtggagaat ggcttcgggg gcgtgcacag ccaggagaag gccgagtggc tagggggtgc
      181 agtggaggat tacttcatcg ccaatgctga cttggagctg gaagagatag aagattttct
      241 tggggagctg atgaccactg agtttgatac agttgtggaa gatgggagtc tgccccaggt
      301 gagccaacag ctacagacca tgttccacca cttccagaag ggtgatgggg ctgctcttca
      361 ggagatgacc tctcagatca accaaaaaaa gtgcaaagtc acggctaccc cacttatgac
      421 agccaaagaa actgatgtgg ctgaagatga tgtggacagc gtggaagaaa tggaggtgac
      481 agctactaat gatggggcca caactgacga ggtctgccca cagcctcaac cctctgatcc
      541 agacacccag actattaagg aagaggatat agttgaagac ggttggacca ttgtccggag
      601 aaagaaatga gcagggcagt acatgttttg ggccctcgtt tgttaaatgt tatgagactt
      661 ataggagctg tttgggggct atacacctct gttctggaaa ccataaccct tctttgttcc
      721 cctgtccttc ccttcaggag aaggaaagcc ctagttgtgg ggttgatggg acctattcca
      781 gccccttgaa tcttaaggta ccatatgaga gctaagagca ggtttcccag catagtacct
      841 cctaggtgca gtgactatga agacggctga caagtgtggg tgtggttgta gaccagactt
      901 gtggaaaact ggcaggtaca tttgtggaaa ggaccagaat tccacagtgg taggctggct
      961 ggattggtaa tccagccagg ataagcatac agttggaaga gagaaaagat gtagacatct
     1021 ctacattccc caatgtcccc accctagcct ccctcagaac aaccctcatc ctgcccagaa
     1081 tttgcatcct cctgggaatg ctccctgttt gaataccctt gagagtttga aggacttgac
     1141 taaaagtggt gaacttgaga aagttgggct gttttaagtc cagggatgag gcttaagacc
     1201 ttaataacat ataacatttt cttgtttaat ccatgattta accttggaat cagctttctg
     1261 caagctgagc ttcaaaattt ggcaagagag tagtttctgt accctcccat ctcccttagt
     1321 agcctgggac tttggacaaa cggacggacc atagcagtgc tctgaaagtt actgtatgcc
     1381 tgaaataaac tgtatttttc tttaaaaaac agtatccatt gtcctccccc cccctccccc
     1441 attcccgtcc tgcccagtgg ccctgccatg gatctggacg ataaaatact ggattgcttt
     1501 ggggctaggt agaagctata agccatggga aaggcaagaa gggtctagtc accaccccat
     1561 gtaaggtcat acatgtgaag acactggctg aggaggaaag ggtgggttgg ggtcccaggg
     1621 tcagtagcag agctggcact tgaatccagg tctcctgcct ctggtacttt tgtggggagc
     1681 tgggtggaag tggggtactg ggaggaaact aattcaagtg agtctagcaa ttagctcccg
     1741 ccctccctgg ggacagggat ttaaaaaatt aacatcaatg taggaatagt tttttttttt
     1801 tttttaaaaa gcccaccttt tgtgaaaaga tgaattaaaa aacccatgac ccagcattcg
     1861 ggattgaaag tgcccttgat gggaattcaa gtattgactg cattgggagt gggctggagc
     1921 ccccaattga acatgggcag ctggagtgtg gggcagaaac tcccagttcc ccccaaaccc
     1981 tctaggtctt gtctcgggtc tgggaggctt caggaggttc agcagtggct cctgaggctg
     2041 ccactggtgt ctcctccatc tccttgtcct cagacagtgt gggccctggg cagaatgtgt
     2101 ccccacggcc cgccctgccg agaacagcca tccagcgccg ctggagttct tctgtctctg
     2161 ggctgaagta ccagcttagg tggctttgtg tgatcttgaa gacatgcctc ctgtctggcc
     2221 gctctcctgc ctcaggaggc cccacctcaa agccaatgag gggcaggctg cgctgggctt
     2281 tcacatcctg gagagaagga acagagaact agtgtcatct aggggctagg cagtatcctc
     2341 tgcccagtca aactgctctg ttctgctgtt tccctctgct gaagaacact gatttcactg
     2401 taatgaacag gaagatatct gaactgggac tagaaggcag gctggtttac atggctatct
     2461 cctcccatgc ccaaatcaac tattatagat tcagtccttt ggctagttcc tctatctgcc
     2521 tattctgttc tacttaagtg tcagacctag aggtgcctgt ctattctact gttttctcca
     2581 gaaagccaga cttcccacct caccctcatt gtccccatac cttggcctcc aaactcttct
     2641 acctacctat tctgtcacat aaggataggg gttttaattt tcccctttgc taggctcacc
     2701 ctgcccccaa aggacaagga gaggagcagc ccagctttgt cagatggctg gaaaaacctg
     2761 aaggagtggg atgcacacct gaggggctcc atagatgtac agcaccaagg gttcattctc
     2821 aggaaccaca aaccatgcct tgtgccatcc tttcccaccc ttctccatgt agtgcaggaa
     2881 gctgcagatg acgctgttct cagcagcgac cgaggcctgt ttctgtgatc agagacacag
     2941 gacagggaac atcaatgttg atggaaggct ttgctcttgg ctttaacagc cccatagtgt
     3001 atggactatg tctcagacaa cggtagccaa gctgtgcaaa tcatagctga aatgatttag
     3061 ccttcatcat ggagataaaa caaagcaagg cttggctgct gctgactctt aacaacaagt
     3121 ataaggggtg tgcagatctc agtggggaca gtgaaatgct ggccactctt aaggctaagg
     3181 gactttcaca gctaaccctt ttcatctttc ataatatact cattgcctgc tctgagaaag
     3241 tccttctaac attatgatta atgggatgag taggtggcta acaccatctg tctcgatcct
     3301 aacaatagat gaaaatgcag gacttgtgag aagagcacag agggtgttta tgagattgaa
     3361 attagcataa gcaaggcatt taaaatagtt ctggtacaga gtaagctccc ttacatttgg
     3421 gataccttgg ttttgttgaa aaaacaatca ccccaaatat gtgtatattc atggtcctaa
     3481 aaagatagga tcagtattaa cagtggcaac ttctgggtaa aggaatatgt cttatgtttc
     3541 cttatcctat ttcataattt taaaaatgca cttggttcat taaaaagaaa aacctatagg
     3601 ctagcttagg ctatgcagtg agactttgtc tcagataaaa tgatccctag aagtgttttt
     3661 ctggttgtat aacttagtca aatatcctct ctgggtttta gtttcttcct atgtaaacta
     3721 agggtaagag ttgagcagtt actgtaagag ttaagtgtgt aaagttctgt aataaaaagt
     3781 atccttttaa cccgtaaaaa aaaaa
//
