LOCUS       NM_029836               2775 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TSPY-like 2 (Tspyl2), transcript variant 1, mRNA.
ACCESSION   NM_029836
VERSION     NM_029836.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Zhuge,R., Wang,C., Wang,J., Yu,S., Liao,L. and Zheng,X.
  TITLE     hCINAP regulates the differentiation of embryonic stem cells by
            regulating NEDD4 liquid-liquid phase-separation-mediated YAP1
            activation
  JOURNAL   Cell Rep 42 (1), 111935 (2023)
   PUBMED   36640330
  REMARK    GeneRIF: hCINAP regulates the differentiation of embryonic stem
            cells by regulating NEDD4 liquid-liquid phase-separation-mediated
            YAP1 activation.
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Liu,H., Peng,L., So,J., Tsang,K.H., Chong,C.H., Mak,P.H.S.,
            Chan,K.M. and Chan,S.Y.
  TITLE     TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons
  JOURNAL   Mol Neurobiol 56 (4), 2640-2652 (2019)
   PUBMED   30051352
  REMARK    GeneRIF: TSPYL2 is recruited to promoters of specific EZH2 target
            genes in neurons.
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Li,J., Huynh,P., Dai,A., Wu,T., Tu,Y., Chow,B., Kiriazis,H.,
            Du,X.J., Bach,L.A., Wilkinson-Berka,J.L., Biros,E., Walker,P.,
            Nataatmadja,M., West,M., Golledge,J., Allen,T.J., Cooper,M.E. and
            Chai,Z.
  TITLE     Diabetes Reduces Severity of Aortic Aneurysms Depending on the
            Presence of Cell Division Autoantigen 1 (CDA1)
  JOURNAL   Diabetes 67 (4), 755-768 (2018)
   PUBMED   29311219
  REMARK    GeneRIF: The identification that diabetes is associated with
            upregulation of vascular CDA1 and that CDA1 deletion in diabetic
            mice promotes aneurysm formation provides evidence that CDA1 plays
            a role in diabetes to reduce susceptibility to aneurysm formation.
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Filippova,G.N., Cheng,M.K., Moore,J.M., Truong,J.P., Hu,Y.J.,
            Nguyen,D.K., Tsuchiya,K.D. and Disteche,C.M.
  TITLE     Boundaries between chromosomal domains of X inactivation and escape
            bind CTCF and lack CpG methylation during early development
  JOURNAL   Dev Cell 8 (1), 31-42 (2005)
   PUBMED   15669143
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Wang,G.S., Hong,C.J., Yen,T.Y., Huang,H.Y., Ou,Y., Huang,T.N.,
            Jung,W.G., Kuo,T.Y., Sheng,M., Wang,T.F. and Hsueh,Y.P.
  TITLE     Transcriptional modification by a CASK-interacting nucleosome
            assembly protein
  JOURNAL   Neuron 42 (1), 113-128 (2004)
   PUBMED   15066269
  REMARK    Erratum:[Neuron. 2004 Aug 5;43(3):437]
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Ozbun,L.L., Martinez,A., Angdisen,J., Umphress,S., Kang,Y.,
            Wang,M., You,M. and Jakowlew,S.B.
  TITLE     Differentially expressed nucleolar TGF-beta1 target (DENTT) in
            mouse development
  JOURNAL   Dev Dyn 226 (3), 491-511 (2003)
   PUBMED   12619135
  REMARK    GeneRIF: DENTT may play multiple roles in modulating
            transcriptional responses suggesting new roles for the TTSN
            superfamily during embryogenesis and differentiation.
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Martinez,A., Ozbun,L.L., Angdisen,J. and Jakowlew,S.B.
  TITLE     Expression of differentially expressed nucleolar transforming
            growth factor-beta1 target (DENTT) in adult mouse tissues
  JOURNAL   Dev Dyn 224 (2), 186-199 (2002)
   PUBMED   12112471
  REMARK    GeneRIF: DENTT may play a role in development of the endocrine
            tissues, nervous system, lung, oocytes, and thecal cells, and
            testis [DENTT]
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Tsuchiya,K.D. and Willard,H.F.
  TITLE     Chromosomal domains and escape from X inactivation: comparative X
            inactivation analysis in mouse and human
  JOURNAL   Mamm Genome 11 (10), 849-854 (2000)
   PUBMED   11003698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066847.1, BY008032.1, BC054393.1 and AW046203.1.
            
            On Dec 1, 2017 this sequence version replaced NM_029836.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000279.1, BC054393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CJ066847.1         2-43
            43-112              BY008032.1         16-85
            113-2758            BC054393.1         33-2678
            2759-2775           AW046203.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..2775
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /note="TSPY-like 2"
                     /db_xref="GeneID:52808"
                     /db_xref="MGI:MGI:106244"
     exon            1..945
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2193
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     differentially expressed nucleolar TGF-beta1 target;
                     nucleolar TGF-beta1 target protein; testis-specific
                     Y-encoded-like protein 2; cell division autoantigen 1
                     nucleolar protein; CASK interacting nucleosome assembly
                     protein; TSPY-like protein 2"
                     /codon_start=1
                     /product="testis-specific Y-encoded-like protein 2 isoform
                     a"
                     /protein_id="NP_084112.1"
                     /db_xref="CCDS:CCDS30474.1"
                     /db_xref="GeneID:52808"
                     /db_xref="MGI:MGI:106244"
                     /translation="MDRPDEGPPAKTPRLSSSEPRQRDLPPPPPPPLQRLPLPPPQQR
                     PRPQEETEAAQVLADMRGVGPTLPPPLPYVILEEGGIRAYFTLSAESPGWDHAMESGF
                     GEAPSTGIMETLPSSEISGGSLAIDFQVAEPSSLGEKALETCSLGGWGPQMLVGPKRK
                     EEAIIIVEDEDEDDKESVRRRQRRRRRRRKQRKAKESRERSAQRMESILQALESIQMD
                     LEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINQR
                     DRDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTP
                     IRWHRGQEPQAYNRRSHDTRESFFNWFSNHSLPEADRIAEIIKNDLWVNPVRYYMRRG
                     GYRSSRKKQHGKERAKNQYEMVIMEDAHDHYAIEDILSDISEIDEITDNETIHDIKIS
                     DFMETTDYFETTDNEVTDANENLCDSENPDHSEGYNTKITDNKGSVAANPDDNSDDPE
                     EKNTYDSEDSNSEKADGDNTTLRDNQQVTNIQDSSDSDNGDEGSDDEDDDGNEGDNEG
                     SDDDDDDNEGSDDDDRDIRYYKNGPEVFDKALDNRTNQNDYEEEVELISEDSVEEEEE
                     TSEEASQLSEDSYEDERIYGEERSEVNSEDSDIQEVLPVPKAWASLGKKGKIG"
     exon            946..1023
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1135
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1281
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1376
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2044
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2759
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2755
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcgctgtg ggagtggggc aggcgctgtg ggaggggacg tcagagcgag gtggtgagca
       61 gagctggtcg cgtgaggtgt ggcggctccg cttcaagtgt gactggtggc tacggccttg
      121 tctgagagcc gcagagccag tgttgtgagt gcggtcacca tggaccgccc ggacgagggg
      181 cctccggcca agaccccccg cctgagcagc tcggaacccc gtcagcgcga cctgccgccc
      241 ccgccacccc caccgctcca gcgactgccc ctgcctccac cccagcagcg tccgagaccc
      301 caggaagaaa ccgaggctgc acaggtgctg gctgacatga ggggggtggg ccccacgctg
      361 cccccaccac tgccctatgt cattcttgag gaagggggga tccgcgcgta tttcaccctg
      421 agtgctgaga gtcccggatg ggatcacgca atggagtcag ggttcgggga ggccccttcc
      481 acagggatca tggaaacgct cccatcttca gaaatctctg ggggaagcct ggcaattgac
      541 tttcaggttg cagagcccag cagcctcgga gagaaggccc tagaaacctg tagcttagga
      601 gggtgggggc cccagatgtt agttggtccg aagaggaagg aggaggctat cataatagtg
      661 gaagatgagg atgaggatga caaggagagt gtgaggaggc ggcagcgtcg gaggaggagg
      721 agaaggaagc agaggaaggc gaaggagagc cgagagagga gtgcccagag gatggagagc
      781 atactgcagg ccctggagag cattcaaatg gacctggagg cggtgaacat caaggcaggc
      841 aaggccttct tgcgtctcaa gcgcaaattc atccagatgc gaaggccctt tttggagcgc
      901 agagacctca tcatccagca tatcccaggc ttctgggtca aagcattcct caaccacccc
      961 agaatttcaa tcttgatcaa ccaacgtgac agagacattt tccgctactt gaccaatctt
     1021 caggtacagg acctcagaca tatctccatg ggctacaaaa tgaagctgta cttccagaca
     1081 aacccatact ttacaaacat ggtgatcgtc aaggagttcc agcgcaaccg ctcaggccgg
     1141 ttggtgtctc attctacccc aatacgttgg caccggggcc aggaacccca ggcctataat
     1201 cgcaggagcc atgacaccag agaaagcttc ttcaactggt tttccaatca cagcctccca
     1261 gaagctgaca gaattgctga gatcatcaag aacgacctgt gggttaaccc agtacgctac
     1321 tatatgagac gaggtggcta cagatcaagc agaaagaagc aacacggaaa ggaaagagcc
     1381 aagaatcaat atgaaatggt gatcatggaa gatgctcatg accattatgc aattgaagac
     1441 attctcagtg acatctcaga aattgatgag atcactgaca atgagaccat tcacgacatc
     1501 aagatctctg acttcatgga gaccaccgac tacttcgaga ctactgataa tgaggtgacc
     1561 gatgccaatg agaacctgtg cgacagtgag aatcctgacc acagtgaagg ctacaacacc
     1621 aagatcactg acaacaaagg gagcgttgcc gcaaatccag atgacaacag tgatgaccca
     1681 gaggaaaaga atacctatga cagtgaggat tccaacagcg agaaagctga tggtgataac
     1741 acaaccctac gtgacaacca gcaggttact aatatccagg acagcagtga tagtgacaat
     1801 ggagatgagg gcagtgatga tgaagatgat gatggtaatg agggggacaa tgagggcagt
     1861 gatgatgatg atgatgacaa tgagggcagt gatgatgatg acagggacat tagatactat
     1921 aagaatggcc ctgaagtctt tgacaaggct ctggataacc gcaccaacca gaatgactat
     1981 gaggaggagg tagaactcat ctctgaagac tcagttgaag aagaggaaga gaccagtgag
     2041 gaagccagcc agctaagtga ggacagctat gaagatgagc gaatctatgg ggaggaaaga
     2101 agtgaggtga actccgaaga ttctgatatt caggaagtgc tgccggtccc aaaagcttgg
     2161 gccagcctgg ggaagaaagg gaaaatcgga taaacatctt gccctctagg ggctctctat
     2221 atatacccct atgccctctc ccatttgccc tcctcttcag ctagggctgt gcggccccat
     2281 attgcacttc tggggggaga cagacttatt acacgggttt aaagtttatt tttatggttt
     2341 agtaattgca gagttcttat ttggaggagg gaccacgctc cccttcggcc ctcctccact
     2401 gcaggcttct gtgtgctgct aatcttattt attgtgatgc cttggtcagg gcccctctag
     2461 cccccttctc gtgagcttag gcccaagccc ctctctccgt gctgcgtgga catcctatct
     2521 ctaagcgaga agggccgctg tgaccttcgt cacaattgca ctgtggcctc agactctgct
     2581 accccttctc cagagttact ctgcaactcc tttcttccct tcaacagccc tgactgctag
     2641 cccgcctcag tgtctttgca aggcagcttc gcctttgtgg gattcctgct ccccagaagc
     2701 cccgcccctt tccccgtgac cctcaacgag cctaataaaa ctgagcaaat tcaaagtgca
     2761 aaaaaaaaaa aaaaa
//
