LOCUS       NP_084112                677 aa            linear   ROD 12-JUN-2025
DEFINITION  testis-specific Y-encoded-like protein 2 isoform a [Mus musculus].
ACCESSION   NP_084112
VERSION     NP_084112.1
DBSOURCE    REFSEQ: accession NM_029836.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 677)
  AUTHORS   Sui,M., Yan,S., Zhang,P., Li,Y., Chen,K., Li,Y., Lu,H., Li,Y.,
            Zhao,W. and Zeng,L.
  TITLE     The role of Testis-Specific Protein Y-encoded-Like 2 in kidney
            injury
  JOURNAL   iScience 27 (5), 109594 (2024)
   PUBMED   38665207
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 677)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 677)
  AUTHORS   Zhuge,R., Wang,C., Wang,J., Yu,S., Liao,L. and Zheng,X.
  TITLE     hCINAP regulates the differentiation of embryonic stem cells by
            regulating NEDD4 liquid-liquid phase-separation-mediated YAP1
            activation
  JOURNAL   Cell Rep 42 (1), 111935 (2023)
   PUBMED   36640330
  REMARK    GeneRIF: hCINAP regulates the differentiation of embryonic stem
            cells by regulating NEDD4 liquid-liquid phase-separation-mediated
            YAP1 activation.
REFERENCE   4  (residues 1 to 677)
  AUTHORS   Liu,H., Peng,L., So,J., Tsang,K.H., Chong,C.H., Mak,P.H.S.,
            Chan,K.M. and Chan,S.Y.
  TITLE     TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons
  JOURNAL   Mol Neurobiol 56 (4), 2640-2652 (2019)
   PUBMED   30051352
  REMARK    GeneRIF: TSPYL2 is recruited to promoters of specific EZH2 target
            genes in neurons.
REFERENCE   5  (residues 1 to 677)
  AUTHORS   Li,J., Huynh,P., Dai,A., Wu,T., Tu,Y., Chow,B., Kiriazis,H.,
            Du,X.J., Bach,L.A., Wilkinson-Berka,J.L., Biros,E., Walker,P.,
            Nataatmadja,M., West,M., Golledge,J., Allen,T.J., Cooper,M.E. and
            Chai,Z.
  TITLE     Diabetes Reduces Severity of Aortic Aneurysms Depending on the
            Presence of Cell Division Autoantigen 1 (CDA1)
  JOURNAL   Diabetes 67 (4), 755-768 (2018)
   PUBMED   29311219
  REMARK    GeneRIF: The identification that diabetes is associated with
            upregulation of vascular CDA1 and that CDA1 deletion in diabetic
            mice promotes aneurysm formation provides evidence that CDA1 plays
            a role in diabetes to reduce susceptibility to aneurysm formation.
REFERENCE   6  (residues 1 to 677)
  AUTHORS   Filippova,G.N., Cheng,M.K., Moore,J.M., Truong,J.P., Hu,Y.J.,
            Nguyen,D.K., Tsuchiya,K.D. and Disteche,C.M.
  TITLE     Boundaries between chromosomal domains of X inactivation and escape
            bind CTCF and lack CpG methylation during early development
  JOURNAL   Dev Cell 8 (1), 31-42 (2005)
   PUBMED   15669143
REFERENCE   7  (residues 1 to 677)
  AUTHORS   Wang,G.S., Hong,C.J., Yen,T.Y., Huang,H.Y., Ou,Y., Huang,T.N.,
            Jung,W.G., Kuo,T.Y., Sheng,M., Wang,T.F. and Hsueh,Y.P.
  TITLE     Transcriptional modification by a CASK-interacting nucleosome
            assembly protein
  JOURNAL   Neuron 42 (1), 113-128 (2004)
   PUBMED   15066269
  REMARK    Erratum:[Neuron. 2004 Aug 5;43(3):437]
REFERENCE   8  (residues 1 to 677)
  AUTHORS   Ozbun,L.L., Martinez,A., Angdisen,J., Umphress,S., Kang,Y.,
            Wang,M., You,M. and Jakowlew,S.B.
  TITLE     Differentially expressed nucleolar TGF-beta1 target (DENTT) in
            mouse development
  JOURNAL   Dev Dyn 226 (3), 491-511 (2003)
   PUBMED   12619135
  REMARK    GeneRIF: DENTT may play multiple roles in modulating
            transcriptional responses suggesting new roles for the TTSN
            superfamily during embryogenesis and differentiation.
REFERENCE   9  (residues 1 to 677)
  AUTHORS   Martinez,A., Ozbun,L.L., Angdisen,J. and Jakowlew,S.B.
  TITLE     Expression of differentially expressed nucleolar transforming
            growth factor-beta1 target (DENTT) in adult mouse tissues
  JOURNAL   Dev Dyn 224 (2), 186-199 (2002)
   PUBMED   12112471
  REMARK    GeneRIF: DENTT may play a role in development of the endocrine
            tissues, nervous system, lung, oocytes, and thecal cells, and
            testis [DENTT]
REFERENCE   10 (residues 1 to 677)
  AUTHORS   Tsuchiya,K.D. and Willard,H.F.
  TITLE     Chromosomal domains and escape from X inactivation: comparative X
            inactivation analysis in mouse and human
  JOURNAL   Mamm Genome 11 (10), 849-854 (2000)
   PUBMED   11003698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066847.1, BY008032.1, BC054393.1 and AW046203.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000279.1, BC054393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     Protein         1..677
                     /product="testis-specific Y-encoded-like protein 2 isoform
                     a"
                     /note="differentially expressed nucleolar TGF-beta1
                     target; nucleolar TGF-beta1 target protein;
                     testis-specific Y-encoded-like protein 2; cell division
                     autoantigen 1 nucleolar protein; CASK interacting
                     nucleosome assembly protein; TSPY-like protein 2"
                     /calculated_mol_wt=77540
     Region          1..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H2G4; propagated from
                     UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Region          175..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Region          220..389
                     /region_name="PTZ00007"
                     /note="(NAP-L) nucleosome assembly protein -L;
                     Provisional; cl08298"
                     /db_xref="CDD:471807"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H2G4; propagated from
                     UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Region          469..658
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Site            648
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Site            652
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TQI8.1)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TQI8.1)"
     CDS             1..677
                     /gene="Tspyl2"
                     /gene_synonym="CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E;
                     E130307F10Rik"
                     /coded_by="NM_029836.4:160..2193"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30474.1"
                     /db_xref="GeneID:52808"
                     /db_xref="MGI:MGI:106244"
ORIGIN      
        1 mdrpdegppa ktprlsssep rqrdlppppp pplqrlplpp pqqrprpqee teaaqvladm
       61 rgvgptlppp lpyvileegg irayftlsae spgwdhames gfgeapstgi metlpsseis
      121 ggslaidfqv aepsslgeka letcslggwg pqmlvgpkrk eeaiiivede deddkesvrr
      181 rqrrrrrrrk qrkakesrer saqrmesilq alesiqmdle avnikagkaf lrlkrkfiqm
      241 rrpflerrdl iiqhipgfwv kaflnhpris ilinqrdrdi fryltnlqvq dlrhismgyk
      301 mklyfqtnpy ftnmvivkef qrnrsgrlvs hstpirwhrg qepqaynrrs hdtresffnw
      361 fsnhslpead riaeiikndl wvnpvryymr rggyrssrkk qhgkeraknq yemvimedah
      421 dhyaiedils diseideitd netihdikis dfmettdyfe ttdnevtdan enlcdsenpd
      481 hsegyntkit dnkgsvaanp ddnsddpeek ntydsedsns ekadgdnttl rdnqqvtniq
      541 dssdsdngde gsddedddgn egdnegsddd dddnegsddd drdiryykng pevfdkaldn
      601 rtnqndyeee velisedsve eeeetseeas qlsedsyede riygeersev nsedsdiqev
      661 lpvpkawasl gkkgkig
//
