LOCUS       NM_172449               7633 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TSPO associated protein 1 (Tspoap1), mRNA.
ACCESSION   NM_172449
VERSION     NM_172449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7633)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   3  (bases 1 to 7633)
  AUTHORS   Mencacci,N.E., Brockmann,M.M., Dai,J., Pajusalu,S., Atasu,B.,
            Campos,J., Pino,G., Gonzalez-Latapi,P., Patzke,C., Schwake,M.,
            Tucci,A., Pittman,A., Simon-Sanchez,J., Carvill,G.L., Balint,B.,
            Wiethoff,S., Warner,T.T., Papandreou,A., Soo,A., Rein,R.,
            Kadastik-Eerme,L., Puusepp,S., Reinson,K., Tomberg,T., Hanagasi,H.,
            Gasser,T., Bhatia,K.P., Kurian,M.A., Lohmann,E., Ounap,K.,
            Rosenmund,C., Sudhof,T.C., Wood,N.W., Krainc,D. and Acuna,C.
  TITLE     Biallelic variants in TSPOAP1, encoding the active-zone protein
            RIMBP1, cause autosomal recessive dystonia
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33539324
  REMARK    GeneRIF: Biallelic variants in TSPOAP1, encoding the active-zone
            protein RIMBP1, cause autosomal recessive dystonia.
REFERENCE   4  (bases 1 to 7633)
  AUTHORS   Sclip,A., Acuna,C., Luo,F. and Sudhof,T.C.
  TITLE     RIM-binding proteins recruit BK-channels to presynaptic release
            sites adjacent to voltage-gated Ca2+-channels
  JOURNAL   EMBO J 37 (16) (2018)
   PUBMED   29967030
REFERENCE   5  (bases 1 to 7633)
  AUTHORS   Luo,F., Liu,X., Sudhof,T.C. and Acuna,C.
  TITLE     Efficient stimulus-secretion coupling at ribbon synapses requires
            RIM-binding protein tethering of L-type Ca2+ channels
  JOURNAL   Proc Natl Acad Sci U S A 114 (38), E8081-E8090 (2017)
   PUBMED   28874522
REFERENCE   6  (bases 1 to 7633)
  AUTHORS   Grauel,M.K., Maglione,M., Reddy-Alla,S., Willmes,C.G.,
            Brockmann,M.M., Trimbuch,T., Rosenmund,T., Pangalos,M., Vardar,G.,
            Stumpf,A., Walter,A.M., Rost,B.R., Eickholt,B.J., Haucke,V.,
            Schmitz,D., Sigrist,S.J. and Rosenmund,C.
  TITLE     RIM-binding protein 2 regulates release probability by fine-tuning
            calcium channel localization at murine hippocampal synapses
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11615-11620 (2016)
   PUBMED   27671655
REFERENCE   7  (bases 1 to 7633)
  AUTHORS   Acuna,C., Liu,X. and Sudhof,T.C.
  TITLE     How to Make an Active Zone: Unexpected Universal Functional
            Redundancy between RIMs and RIM-BPs
  JOURNAL   Neuron 91 (4), 792-807 (2016)
   PUBMED   27537484
REFERENCE   8  (bases 1 to 7633)
  AUTHORS   Acuna,C., Liu,X., Gonzalez,A. and Sudhof,T.C.
  TITLE     RIM-BPs Mediate Tight Coupling of Action Potentials to
            Ca(2+)-Triggered Neurotransmitter Release
  JOURNAL   Neuron 87 (6), 1234-1247 (2015)
   PUBMED   26402606
REFERENCE   9  (bases 1 to 7633)
  AUTHORS   Shrestha,A., Carraro,G., El Agha,E., Mukhametshina,R., Chao,C.M.,
            Rizvanov,A., Barreto,G. and Bellusci,S.
  TITLE     Generation and Validation of miR-142 Knock Out Mice
  JOURNAL   PLoS One 10 (9), e0136913 (2015)
   PUBMED   26327117
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7633)
  AUTHORS   Galiegue,S., Jbilo,O., Combes,T., Bribes,E., Carayon,P., Le Fur,G.
            and Casellas,P.
  TITLE     Cloning and characterization of PRAX-1. A new protein that
            specifically interacts with the peripheral benzodiazepine receptor
  JOURNAL   J Biol Chem 274 (5), 2938-2952 (1999)
   PUBMED   9915832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043747.1, BY233070.1, CN460580.1, CB249809.1, CD348883.1,
            CO429655.1, CA317177.1, BQ769688.1, CN525117.1, EL605892.1 and
            BC055691.1.
            
            On Oct 5, 2007 this sequence version replaced NM_172449.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               AK043747.1         2-934
            934-1884            AK043747.1         936-1886
            1885-1956           BY233070.1         198-269
            1957-2540           CN460580.1         69-652
            2541-2848           CB249809.1         281-588
            2849-3373           CD348883.1         141-665
            3374-3944           CO429655.1         79-649
            3945-4391           CA317177.1         160-606
            4392-4706           BQ769688.1         206-520
            4707-5080           CN525117.1         1-374
            5081-5730           EL605892.1         19-668              c
            5731-7633           BC055691.1         482-2384
FEATURES             Location/Qualifiers
     source          1..7633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.21 cM"
     gene            1..7633
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /note="TSPO associated protein 1"
                     /db_xref="GeneID:207777"
                     /db_xref="MGI:MGI:2450877"
     exon            1..1188
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             862..6402
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /note="benzodiazapine receptor associated protein 1;
                     peripheral benzodiazepine receptor-associated protein 1;
                     PBR-IP; RIM-BP1; RIMS-binding protein 1; peripheral
                     benzodiazepine receptor-interacting protein;
                     benzodiazepine receptor associated protein 1"
                     /codon_start=1
                     /product="peripheral-type benzodiazepine
                     receptor-associated protein 1"
                     /protein_id="NP_766037.2"
                     /db_xref="CCDS:CCDS48879.1"
                     /db_xref="GeneID:207777"
                     /db_xref="MGI:MGI:2450877"
                     /translation="MEQLTTLPRLGDLGAMEPWALPAWQHWTQGQGCKPGDASPSIAG
                     TPTALQVKGLRFEESSKPEGAHSPGPVGNTDPEATETGLPKLGQQAESPGYSCSGLEE
                     EEAQAYKAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPETEEKVRRL
                     KRKNAELAVIAKRLEERAQKLQETNMRVVSAPVPRPGSSLELCRKALARQRARDLSET
                     ASALLAKDKQIAALQRECRELQARLSLVGKEGPQWLHMRDFDRLLRESQREVLRLQRQ
                     IALRNQREPLRPARSPGPTAPSRVGAPAPGAPGEAVLQDDVESPQVVLREPEKQQRVQ
                     QLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRATEK
                     EQVEWENSELKGQLLGVTQERDSALLKSQGLQSKLESLEQVLKHMREVAQRRQQLEVE
                     HEQARLSLQEKQEEVRRLQQAQAEAKREHEGAVQLLESTLDSMQARVRELEGQCRSQT
                     ERFSLLAQELQAFRLHPGPLDLLTSALGCSALGDHPPPHCCCSIPQPCQGSGPKDLDL
                     PPGSPGRCTPKSSEPALTTLTGIPRRTAKKAESLSNSSRSESIHNSPKSCPTPEVDTA
                     SEVEELEVDSVSLLPAAPESHSGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYI
                     YIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLSTLPRELADSSHSSGPELSF
                     LSGGGGGCSSGGQSSGGRSQPRPEEEAAGDELSLSPPPEGLGEPLAVPYPRHITVLKQ
                     LAHSVVLAWELPPERVDLRGFHIFVNGELRQALGPGVPPKAVLENMDLRTGPLHVSVQ
                     ALTSKGSSDPLRCCLAVGAGAGVVPSQLRIHRLTATSAEIAWVPGNSNLAHAIYLNGE
                     ECPPARPSTYWATFCNLRPGTLYQARVEAQIPSQGPWEPGWERPEQRAATLQFTTLPA
                     GLPDAPLDVQAEPGPSPGILMISWLPVTIDAAGTSNGVRVTGYAIYADGQKIMEVASP
                     TAGSVLVEVSQLQLLQACHEVTVRTMSPHGESSDSIPAPVAPALASACQPARMSCLSP
                     RPSPEVRTPLASVSPGLGDTSFPLRHPVPHGTQDFSASLSIEMSKGPQEEPPVPCSQE
                     EAGAAVRSISEEKRAIEPTLGQEGPEPVAPSLAKQEVECTSGDAGPVPCSTQGELTQK
                     KPSIEACHGGDLDSGLKLRSEKEDMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEEE
                     EEELGSRPCSSQKQVAGNSIRENGAKPQPDPFCETDSDEEILEQILELPLQRLCSKKL
                     FSIPEEEEEEEEEEGLEKPGPSRTSQDPSQPELALLGPGCDSSQPQGPGLCPLSPELS
                     GVREHLEDVLGVVGGNGRRRGGGSPEKLPNRKRPQDPREHCSRLLGNGGPQASARPVP
                     PRERGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDS
                     EDEQEAGSGGVSINSSCYPTDGEAWGTAAVGRPRGPPKVNPGPNAYLRLPAWEKGEPE
                     RRGRSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVPRSGTTELAPPRSPQEA
                     PPHQDLPVRVFVALFDYDPVSMSPNPDAGEEELPFKEGQLLKVFGDKDADGFYRGESG
                     GRTGYIPCNMVAEVAVDSPAGRQQLLQRGFLPPNVLTEASGNGPSVYSSAHTPGPPPK
                     PRRSKKVELEGPTQLCPGPPKLIHSAAQKTSRPMVAAFDYNPRENSPNMDVEAELPFR
                     AGDVITVFGNMDDDGFYYGELNGQRGLVPSNFLEGPGPESGSLESGTSQAESQRTRRR
                     RVQC"
     exon            1189..1296
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1425
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1605
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1791
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1869
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1953
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2043
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2166
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2271
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2322
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2343
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2548
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2721
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2837
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2947
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3778
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3930
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4296
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4536
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4725
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4726..5565
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5665
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5666..5817
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5818..5986
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5987..6058
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6059..6091
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6092..6195
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6196..6267
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6372
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6373..6423
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6424..7616
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7591..7596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /note="hexamer: AATAAA"
     polyA_site      7612
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /note="major polyA site"
ORIGIN      
        1 attctgaggc tctgccctcc ttcgtgccca ccatctcatt tggggagctc cgggaccgcg
       61 agggaccctt gcagtccctc gagctgagac tagctgaggc agagactatg aggcaagccg
      121 cccatcgacc caggcctcct taggaccgcc cagccaccca gcaagcaact gatcggcggc
      181 agccagcgga gagaaaagct ggagataaag gaccacagtg gatcactggg gatcattccc
      241 aggaactcct gcggaccctt tccaggcaga gtggtcgtga tgggtggcca gactcacaga
      301 cactgaaaga cacacgccac tacagataca ccgggcttta caacactgag acaggaccgg
      361 cgacagcatc acacactgcc acagccctgc aatacagaca gcccctaccc ccacgcagaa
      421 acaactggta actcttaaat aggcacagac agtgacacat agcaccaccc ttctcaacat
      481 acacaagtcg gagtattcat cctccaatca cataataaaa catcactgac ctgcagggac
      541 agacctggag gcacacgtac atatatacct tcagccaggc actcctggtg gtggtctctc
      601 acccccccac acacaccccg tacacacaca cacacacaca caagagagag agagagaacc
      661 atgagcaaac cccagctcca gtctggcaac cccgatacct tctgaaccct ccttcgtggg
      721 tgggaagagc tcagccaacc tctgatggac tcggtgaagc caaacactta cagggagaat
      781 ggtctagtct ggcatgaccc ttgtcagtct tcccgctggt gatgtcccca ggtccaggtt
      841 cgggggcccc ttgccgaaac catggagcaa ctgacaaccc tcccacggct tggagacctt
      901 ggagccatgg agccatgggc actgcctgcc tggcagcact ggactcaggg ccaggggtgc
      961 aaacctggag atgcatctcc aagcattgct ggtactccga cagctctgca ggttaaagga
     1021 ttgaggtttg aagagagttc caagcctgag ggagctcata gccctggacc tgtcggaaat
     1081 actgatcctg aagcaacaga gaccgggctg cctaagctgg ggcagcaagc agagagccct
     1141 gggtacagct gttccgggct ggaggaggag gaggcacagg cttataaggc caagttcaac
     1201 ataggcttcg gggacaggcc taatctggag ctgctaaggg ccctgggaga gctgcagcag
     1261 cgctgtacca tcctgaagga ggaaaaccag atgctgagaa aaagcagctt cccagagacg
     1321 gaggagaagg tacggaggct gaagcggaag aatgctgaac tggcagtcat tgccaagcgc
     1381 ctggaggaga gggcacagaa gctgcaggaa acgaacatga gggtggtgag tgcccctgtg
     1441 ccccgacccg gatccagttt ggagttgtgc cgtaaggctc tagctcgcca gcgagcccga
     1501 gacctcagtg agacagccag tgcactgttg gccaaggaca aacagattgc tgccttgcag
     1561 cgggagtgca gggagctgca ggccagactc tctctggtgg gcaaggaagg tccccagtgg
     1621 ctgcatatgc gggacttcga ccggttgctg cgcgagtccc aacgggaggt gctgcggctg
     1681 cagaggcaga tcgccctgcg caaccagcgg gagccgctcc ggcctgcccg gtccccgggt
     1741 cctactgccc catctagagt aggggcgccg gcccccgggg ccccgggaga ggccgtactt
     1801 caggatgatg tggagagccc acaggtagtc ctaagggaac cagagaagca gcaaagggtg
     1861 cagcagctgg agtctgagct ctgcaagaag cgaaagaaat gcgagagtct ggagcaggaa
     1921 gccaggaaaa agcagaggcg atgtgaggag ctggagctac agctgagggc agcccagaat
     1981 gaaaatgccc gcctggtgga ggagaactct cggctcagtg ggagagccac agagaaggag
     2041 caggtggaat gggagaattc ggagctgaag ggacagctcc tgggggtgac acaagagagg
     2101 gactcggccc ttcttaagag ccagggcctg caaagcaagc tggagagcct ggagcaggtg
     2161 ctgaagcata tgcgggaggt ggcccagcgc cggcagcagc tggaggtgga gcatgagcag
     2221 gctaggctca gcctgcagga gaagcaggag gaggtccgga ggctgcagca ggcccaggca
     2281 gaagccaaga gggaacatga gggagccgtt cagctgctgg agtctacctt ggattccatg
     2341 caggcccggg ttcgagagct tgagggccag tgccgaagcc agactgagcg tttcagcctt
     2401 ctggctcagg agctccaggc cttccgtctg cacccaggcc ctctggatct gcttacttca
     2461 gccttgggct gtagtgccct tggggaccac ccgccccccc actgctgctg ctctatccct
     2521 cagccctgcc aggggtccgg ccccaaagat cttgacctcc caccgggctc cccaggacgc
     2581 tgcaccccca aatcttctga acctgctctc accaccctta ctggaatccc tcgaaggaca
     2641 gctaagaagg ccgagtctct ttctaattct tctcgctcag agtccatcca caacagcccc
     2701 aagtcatgtc ccacaccaga ggtggacaca gccagtgagg tggaggaact ggaggtagac
     2761 agtgtttccc tgctcccagc agctccggag agtcactcgg gaggagccag aatccaggtc
     2821 ttcctagcac gctatagcta caaccccttt gagggtccca atgagaatcc agaggccgag
     2881 cttcctctga cagcgggcga gtatatctac atctatggta acatggacga ggatggcttt
     2941 tttgaagggg agctcatgga tggccgaagg ggcctggtcc cttccaactt tgtagagcgc
     3001 gtgtctgatg atgatcttct gtccaccctc cctcgggagc tggctgattc gtcgcacagc
     3061 tcaggccccg agctcagttt cctgagtgga ggcgggggtg gttgcagtag tgggggccag
     3121 agcagcgggg gacgtagcca gcccagacca gaggaggagg ccgcaggaga tgaactcagt
     3181 ctgagccccc caccagaggg acttggcgag cctctggctg tgccttaccc ccgacacatc
     3241 acggttctca agcagttagc ccacagtgtg gtgctggcct gggagttgcc tcctgagaga
     3301 gtagatctgc gtggcttcca tatctttgtc aatggggaac tccgtcaggc cttggggcct
     3361 ggggtgcccc ccaaagctgt gcttgaaaac atggacctgc ggactgggcc tctccatgtg
     3421 tctgtccagg ccctaaccag caagggcagc tcagaccctc tgcgctgttg cctggctgtg
     3481 ggtgccgggg ctggggtggt acccagccag ctgcggatcc atcggctgac agccacatct
     3541 gctgagatcg cctgggtgcc ggggaatagc aacttggccc atgccatcta cctcaatgga
     3601 gaagagtgcc cacctgctcg ccccagcaca tattgggcaa ccttttgtaa cctgagacct
     3661 ggcacactct atcaggcccg agtggaggct cagatcccat ctcaggggcc ttgggaacca
     3721 ggctgggaga ggccagagca gagagctgct accttgcagt tcaccacact tccagcaggt
     3781 ctgcctgatg ccccactgga tgtacaggct gaaccaggac cctctcctgg aatcttgatg
     3841 atcagttggc tccctgtcac cattgatgct gctggtacct ccaatggtgt ccgggttaca
     3901 ggctatgcca tctatgctga tgggcagaag attatggagg tggcttcccc cacagcaggc
     3961 agtgtgctgg tggaggtgtc ccagctgcag ctgttgcagg cctgccatga ggtgactgta
     4021 cgcactatgt caccccatgg cgagtccagt gactccatcc cggcccccgt tgccccagcc
     4081 ctggcttctg cctgccagcc agccaggatg tcctgtctct caccacgacc aagcccagag
     4141 gtcagaacac cccttgcttc agtctcccca gggcttgggg ataccagctt tcccctccgg
     4201 catcctgtcc cccatggaac tcaagatttc tctgcaagtc tttccataga gatgtccaaa
     4261 ggaccccagg aggaacctcc agtcccttgc tctcaggaag aggctggggc agctgtgcgg
     4321 agcatctcag aagagaagag ggctatcgag ccaactctgg gccaggaagg ccctgagcct
     4381 gtggctcctt ccctggctaa gcaggaagtg gagtgcactt caggagatgc tggccctgta
     4441 ccttgctcca cccaaggaga gctgacccag aagaagccaa gtattgaagc ctgccatggg
     4501 ggagatctgg actccgggct gaaacttaga tctgagaaag aagatatgtc agagcttgga
     4561 gttcacctgg tgaattccct tgtggatcac agccgcaact cagacttatc agacatccag
     4621 gaagaagagg aagaggagga agaagaggaa gaggaactgg gttccaggcc ttgttcctcc
     4681 cagaagcagg ttgctggcaa cagcatcagg gagaatggag ccaagcccca gccagacccc
     4741 ttttgtgaga ctgacagcga cgaggagatc ttggagcaga tactggagtt gcctctccag
     4801 cggctctgca gcaagaagct gttcagcatc cctgaggagg aagaggagga ggaagaggag
     4861 gaagggctgg agaaaccagg gcccagccgc acttcccaag accctagcca gcctgaactt
     4921 gcgttgctag ggccgggctg tgatagcagt cagccccagg gacctggcct gtgtcccttg
     4981 tctcctgagc tctctggggt cagggagcac ctggaggatg tgctgggagt cgttggtgga
     5041 aacggcagga ggagaggagg tggctccccg gagaaactcc caaaccgcaa gcgacctcag
     5101 gacccccgag aacattgcag ccggcttctt ggcaatggcg ggccccaggc ctctgcacgg
     5161 ccggtccctc cacgggagag gggcagcctc cctgtgattg agggcaccag ggttggacag
     5221 gagcccggtg ggagagggcg gccgggtctt tcccggaggt gtccccgtgg ccctgctcca
     5281 gaatccagct tagtcagctg cctctctcca aagtgtttgg agatcagtat tgaatatgat
     5341 tctgaggatg agcaggaggc gggcagcggg ggtgtcagca tcaacagctc ctgctacccc
     5401 acagatgggg aggcctgggg cacagcggca gtaggaaggc ccaggggacc tccgaaggtc
     5461 aatccaggcc ccaacgccta cctgcgcctc ccagcctggg agaaagggga gccagagcgg
     5521 agaggccgca gtgcgattgg cagaaccaag gagccaccct cccgggcaac agaaactggg
     5581 gagtccagag ggcaggacaa ctctgggcgg agaggacccc agaggagagg ggcccgggtg
     5641 cctaggtctg gtaccactga gctggcccct ccaaggagcc cccaagaagc accacctcat
     5701 caggacctgc ctgtgagggt ctttgtggct ctgtttgact atgaccctgt atcaatgtca
     5761 ccgaaccctg atgccggaga agaggaactg ccctttaagg agggccaact cctcaaggtg
     5821 tttggagaca aggacgctga tggtttctac cggggtgaga gtgggggccg tacaggctac
     5881 atcccctgca acatggtggc tgaggtggct gtggacagtc cagcagggag acaacagctg
     5941 ctccagcggg gtttcttgcc cccaaatgtt ctcaccgagg cctcaggaaa tggtccctct
     6001 gtgtactcct cagcacacac acccgggcct ccccccaagc ctcgtcggtc caagaaagtg
     6061 gagctggaag gtcctacaca gctctgtcca ggtcctccta agctgattca ttctgctgcc
     6121 cagaaaacct cccgacctat ggtggctgca tttgactata atcctcggga gaactccccc
     6181 aatatggatg tggaggcaga gctgcccttc agagcagggg atgtcattac tgtgtttggg
     6241 aacatggacg atgatggttt ctactatggg gagctgaatg gacaaagggg cctggttcca
     6301 tccaacttcc tggaaggccc tgggcctgag tcaggcagcc tagagtctgg gacatctcaa
     6361 gccgagagtc agagaacgag gaggagaaga gtccagtgct agatggagct agtgtagaga
     6421 catgacccca gaatcaccat acaagggcct ccagtgcccc caggctggca ctgtgccctc
     6481 agctctggaa gttcctccag gaccaaactg ggggagtcac agagcatagc tgagaagaag
     6541 cagggtctcc tcgccaaagc aaaggaactt ctcaaaaggc tgggctccag gaaagactga
     6601 ggctgccgtc cgtctgtcct gcagacagaa gtggccctgg atcaactcac tggctggaca
     6661 gggaaaccca actcctgatc tctgagcaga ctggcactca aaggagccca ggggacctgg
     6721 tgagggtggg gttacctgca cccttagtga ggagtcctct agatgggctc ttccagaggg
     6781 aactgagccc cagagtaagt aatcaagcac caagcactgt cagatcagga ctggacccac
     6841 gcctctggat tcccagtctg ttctcatcta ctcctgcttt gctaccacgc tctgtaggtc
     6901 ccttcttggc cttccctgct ccaaggatag gccctgggtg gagataggga ccactctaac
     6961 gatggctctg gctgtcctcc cgatggatcg tttgcactgg actgtcccct ggggcggggg
     7021 cagagccatg tacatactca gtgtatatat gtccatactc agtgcatata tgtacatact
     7081 cagtgtatat atgtacatac tcagtgcctc agtccaggtc ctccctctgc ttcaccgcac
     7141 aggccagggg aggagaaagg ccatgccaaa gcgggcctga ccccgcccca tagtgctcca
     7201 cccctccctg cccaggccac ctggcctctg tgtgatccca tcctctcaga cccaggggac
     7261 cagggggcag aaagcaggag ttgggtttgc cttattttgc tcattggatt caacttctct
     7321 cttgcatcat tttcttccag tccctgttgg gtccaggggc tgagggaaag gacggattta
     7381 tgcagctatt ttcatacatt ccctgttcag agtgggtagg ggtgtctccc ctcactctaa
     7441 ccatcccatc cttcacccct tgtctgggcg agtctctttg catgttttct tcgctgtggt
     7501 gggagatgtt tgattgaacc ctcgccccct accctggtct ccaggggtgt gggatagtgg
     7561 gggcatttgt ttaaaaagac attttactat aataaagtct attttcacaa aattgaaaaa
     7621 aaaaaaaaaa aaa
//
