LOCUS       NP_766037               1846 aa            linear   ROD 27-APR-2025
DEFINITION  peripheral-type benzodiazepine receptor-associated protein 1 [Mus
            musculus].
ACCESSION   NP_766037
VERSION     NP_766037.2
DBSOURCE    REFSEQ: accession NM_172449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1846)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1846)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   3  (residues 1 to 1846)
  AUTHORS   Mencacci,N.E., Brockmann,M.M., Dai,J., Pajusalu,S., Atasu,B.,
            Campos,J., Pino,G., Gonzalez-Latapi,P., Patzke,C., Schwake,M.,
            Tucci,A., Pittman,A., Simon-Sanchez,J., Carvill,G.L., Balint,B.,
            Wiethoff,S., Warner,T.T., Papandreou,A., Soo,A., Rein,R.,
            Kadastik-Eerme,L., Puusepp,S., Reinson,K., Tomberg,T., Hanagasi,H.,
            Gasser,T., Bhatia,K.P., Kurian,M.A., Lohmann,E., Ounap,K.,
            Rosenmund,C., Sudhof,T.C., Wood,N.W., Krainc,D. and Acuna,C.
  TITLE     Biallelic variants in TSPOAP1, encoding the active-zone protein
            RIMBP1, cause autosomal recessive dystonia
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33539324
  REMARK    GeneRIF: Biallelic variants in TSPOAP1, encoding the active-zone
            protein RIMBP1, cause autosomal recessive dystonia.
REFERENCE   4  (residues 1 to 1846)
  AUTHORS   Sclip,A., Acuna,C., Luo,F. and Sudhof,T.C.
  TITLE     RIM-binding proteins recruit BK-channels to presynaptic release
            sites adjacent to voltage-gated Ca2+-channels
  JOURNAL   EMBO J 37 (16) (2018)
   PUBMED   29967030
REFERENCE   5  (residues 1 to 1846)
  AUTHORS   Luo,F., Liu,X., Sudhof,T.C. and Acuna,C.
  TITLE     Efficient stimulus-secretion coupling at ribbon synapses requires
            RIM-binding protein tethering of L-type Ca2+ channels
  JOURNAL   Proc Natl Acad Sci U S A 114 (38), E8081-E8090 (2017)
   PUBMED   28874522
REFERENCE   6  (residues 1 to 1846)
  AUTHORS   Grauel,M.K., Maglione,M., Reddy-Alla,S., Willmes,C.G.,
            Brockmann,M.M., Trimbuch,T., Rosenmund,T., Pangalos,M., Vardar,G.,
            Stumpf,A., Walter,A.M., Rost,B.R., Eickholt,B.J., Haucke,V.,
            Schmitz,D., Sigrist,S.J. and Rosenmund,C.
  TITLE     RIM-binding protein 2 regulates release probability by fine-tuning
            calcium channel localization at murine hippocampal synapses
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11615-11620 (2016)
   PUBMED   27671655
REFERENCE   7  (residues 1 to 1846)
  AUTHORS   Acuna,C., Liu,X. and Sudhof,T.C.
  TITLE     How to Make an Active Zone: Unexpected Universal Functional
            Redundancy between RIMs and RIM-BPs
  JOURNAL   Neuron 91 (4), 792-807 (2016)
   PUBMED   27537484
REFERENCE   8  (residues 1 to 1846)
  AUTHORS   Acuna,C., Liu,X., Gonzalez,A. and Sudhof,T.C.
  TITLE     RIM-BPs Mediate Tight Coupling of Action Potentials to
            Ca(2+)-Triggered Neurotransmitter Release
  JOURNAL   Neuron 87 (6), 1234-1247 (2015)
   PUBMED   26402606
REFERENCE   9  (residues 1 to 1846)
  AUTHORS   Shrestha,A., Carraro,G., El Agha,E., Mukhametshina,R., Chao,C.M.,
            Rizvanov,A., Barreto,G. and Bellusci,S.
  TITLE     Generation and Validation of miR-142 Knock Out Mice
  JOURNAL   PLoS One 10 (9), e0136913 (2015)
   PUBMED   26327117
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1846)
  AUTHORS   Galiegue,S., Jbilo,O., Combes,T., Bribes,E., Carayon,P., Le Fur,G.
            and Casellas,P.
  TITLE     Cloning and characterization of PRAX-1. A new protein that
            specifically interacts with the peripheral benzodiazepine receptor
  JOURNAL   J Biol Chem 274 (5), 2938-2952 (1999)
   PUBMED   9915832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043747.1, BY233070.1, CN460580.1, CB249809.1, CD348883.1,
            CO429655.1, CA317177.1, BQ769688.1, CN525117.1, EL605892.1 and
            BC055691.1.
            
            On Oct 5, 2007 this sequence version replaced NP_766037.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.21 cM"
     Protein         1..1846
                     /product="peripheral-type benzodiazepine
                     receptor-associated protein 1"
                     /note="benzodiazapine receptor associated protein 1;
                     peripheral benzodiazepine receptor-associated protein 1;
                     PBR-IP; RIM-BP1; RIMS-binding protein 1; peripheral
                     benzodiazepine receptor-interacting protein;
                     benzodiazepine receptor associated protein 1"
                     /calculated_mol_wt=199798
     Region          57..97
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          152..>519
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          281..318
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          560..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          653..713
                     /region_name="SH3_RIM-BP_1"
                     /note="First Src homology 3 domain of Rab3-interacting
                     molecules (RIMs) binding proteins; cd12014"
                     /db_xref="CDD:212947"
     Site            order(658,660,663,673,692..693,707,709..710)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212947"
     Region          726..785
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          881..943
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1084..1107
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          1163..1219
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          1243..1302
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          1322..1476
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          <1339..1730
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1492..1617
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          1620..1681
                     /region_name="SH3_RIM-BP_2"
                     /note="Second Src homology 3 domain of Rab3-interacting
                     molecules (RIMs) binding proteins; cd12012"
                     /db_xref="CDD:212945"
     Site            order(1625,1627,1630,1642,1661..1662,1675,1677..1678)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212945"
     Region          1704..1755
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     Region          1760..1819
                     /region_name="SH3_RIM-BP_3"
                     /note="Third Src homology 3 domain of Rab3-interacting
                     molecules (RIMs) binding proteins; cd12013"
                     /db_xref="CDD:212946"
     Site            order(1764,1766,1769,1780,1799..1800,1813,1815..1816)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212946"
     Region          1812..1846
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNF8.2)"
     CDS             1..1846
                     /gene="Tspoap1"
                     /gene_synonym="Bzrap1; D230016K05; mKIAA0612; PRAX-1"
                     /coded_by="NM_172449.2:862..6402"
                     /db_xref="CCDS:CCDS48879.1"
                     /db_xref="GeneID:207777"
                     /db_xref="MGI:MGI:2450877"
ORIGIN      
        1 meqlttlprl gdlgamepwa lpawqhwtqg qgckpgdasp siagtptalq vkglrfeess
       61 kpegahspgp vgntdpeate tglpklgqqa espgyscsgl eeeeaqayka kfnigfgdrp
      121 nlellralge lqqrctilke enqmlrkssf peteekvrrl krknaelavi akrleeraqk
      181 lqetnmrvvs apvprpgssl elcrkalarq rardlsetas allakdkqia alqrecrelq
      241 arlslvgkeg pqwlhmrdfd rllresqrev lrlqrqialr nqreplrpar spgptapsrv
      301 gapapgapge avlqddvesp qvvlrepekq qrvqqlesel ckkrkkcesl eqearkkqrr
      361 ceelelqlra aqnenarlve ensrlsgrat ekeqvewens elkgqllgvt qerdsallks
      421 qglqsklesl eqvlkhmrev aqrrqqleve heqarlslqe kqeevrrlqq aqaeakrehe
      481 gavqllestl dsmqarvrel egqcrsqter fsllaqelqa frlhpgpldl ltsalgcsal
      541 gdhppphccc sipqpcqgsg pkdldlppgs pgrctpksse palttltgip rrtakkaesl
      601 snssrsesih nspkscptpe vdtaseveel evdsvsllpa apeshsggar iqvflarysy
      661 npfegpnenp eaelpltage yiyiygnmde dgffegelmd grrglvpsnf vervsdddll
      721 stlprelads shssgpelsf lsgggggcss ggqssggrsq prpeeeaagd elslspppeg
      781 lgeplavpyp rhitvlkqla hsvvlawelp pervdlrgfh ifvngelrqa lgpgvppkav
      841 lenmdlrtgp lhvsvqalts kgssdplrcc lavgagagvv psqlrihrlt atsaeiawvp
      901 gnsnlahaiy lngeecppar pstywatfcn lrpgtlyqar veaqipsqgp wepgwerpeq
      961 raatlqfttl paglpdapld vqaepgpspg ilmiswlpvt idaagtsngv rvtgyaiyad
     1021 gqkimevasp tagsvlvevs qlqllqache vtvrtmsphg essdsipapv apalasacqp
     1081 armsclsprp spevrtplas vspglgdtsf plrhpvphgt qdfsaslsie mskgpqeepp
     1141 vpcsqeeaga avrsiseekr aieptlgqeg pepvapslak qevectsgda gpvpcstqge
     1201 ltqkkpsiea chggdldsgl klrsekedms elgvhlvnsl vdhsrnsdls diqeeeeeee
     1261 eeeeelgsrp cssqkqvagn sirengakpq pdpfcetdsd eeileqilel plqrlcskkl
     1321 fsipeeeeee eeeeglekpg psrtsqdpsq pelallgpgc dssqpqgpgl cplspelsgv
     1381 rehledvlgv vggngrrrgg gspeklpnrk rpqdprehcs rllgnggpqa sarpvpprer
     1441 gslpviegtr vgqepggrgr pglsrrcprg papesslvsc lspkcleisi eydsedeqea
     1501 gsggvsinss cyptdgeawg taavgrprgp pkvnpgpnay lrlpawekge perrgrsaig
     1561 rtkeppsrat etgesrgqdn sgrrgpqrrg arvprsgtte lapprspqea pphqdlpvrv
     1621 fvalfdydpv smspnpdage eelpfkegql lkvfgdkdad gfyrgesggr tgyipcnmva
     1681 evavdspagr qqllqrgflp pnvlteasgn gpsvyssaht pgpppkprrs kkvelegptq
     1741 lcpgppklih saaqktsrpm vaafdynpre nspnmdveae lpfragdvit vfgnmdddgf
     1801 yygelngqrg lvpsnflegp gpesgslesg tsqaesqrtr rrrvqc
//
