LOCUS       NP_081568                162 aa            linear   ROD 27-APR-2025
DEFINITION  translocator protein 2 [Mus musculus].
ACCESSION   NP_081568 XP_001003074
VERSION     NP_081568.1
DBSOURCE    REFSEQ: accession NM_027292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 162)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 162)
  AUTHORS   Kiatpakdee,B., Sato,K., Otsuka,Y., Arashiki,N., Chen,Y.,
            Tsumita,T., Otsu,W., Yamamoto,A., Kawata,R., Yamazaki,J.,
            Sugimoto,Y., Takada,K., Mohandas,N. and Inaba,M.
  TITLE     Cholesterol-binding protein TSPO2 coordinates maturation and
            proliferation of terminally differentiating erythroblasts
  JOURNAL   J Biol Chem 295 (23), 8048-8063 (2020)
   PUBMED   32358067
  REMARK    GeneRIF: Cholesterol-binding protein TSPO2 coordinates maturation
            and proliferation of terminally differentiating erythroblasts.
REFERENCE   3  (residues 1 to 162)
  AUTHORS   Fan,J., Rone,M.B. and Papadopoulos,V.
  TITLE     Translocator protein 2 is involved in cholesterol redistribution
            during erythropoiesis
  JOURNAL   J Biol Chem 284 (44), 30484-30497 (2009)
   PUBMED   19729679
  REMARK    GeneRIF: identify the TSPO2 family of proteins as mediators of
            cholesterol redistribution-dependent erythroblast maturation during
            mammalian erythropoiesis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK011003.1.
            
            On May 4, 2006 this sequence version replaced XP_001003074.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011003.1, BY710385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 24.12 cM"
     Protein         1..162
                     /product="translocator protein 2"
                     /note="benzodiazapine receptor, peripheral-like 1;
                     peripheral-type benzodiazepine receptor-like protein 1"
                     /calculated_mol_wt=18155
     Site            3..23
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRZ8.2)"
     Site            order(7..8,10..11,13..14,17,64,77,79..81,83..84,86..88,
                     90..91,94..95,114)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:320706"
     Region          8..153
                     /region_name="TspO_MBR"
                     /note="TspO/MBR family; pfam03073"
                     /db_xref="CDD:460795"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRZ8.2)"
     Site            79..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRZ8.2)"
     Site            103..123
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRZ8.2)"
     Site            129..149
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRZ8.2)"
     CDS             1..162
                     /gene="Tspo2"
                     /gene_synonym="2510027D20Rik; Bzrpl1"
                     /coded_by="NM_027292.2:258..746"
                     /db_xref="CCDS:CCDS28869.1"
                     /db_xref="GeneID:70026"
                     /db_xref="MGI:MGI:1917276"
ORIGIN      
        1 mqlqgpvfvg vpllgpilic mlihqpssrc ederklpwcp phkvillvwv tiysvmgyas
       61 ylvwkelggg frwplalplg lysfqlalsw tflvlflaad spglalldll llyglvaslv
      121 fiwqpinkla allllpylaw ltvttaityr lwrdslcpty qp
//
