LOCUS       NM_009775                871 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus translocator protein (Tspo), mRNA.
ACCESSION   NM_009775
VERSION     NM_009775.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Firth,W., Robb,J.L., Stewart,D., Pye,K.R., Bamford,R.,
            Oguro-Ando,A., Beall,C. and Ellacott,K.L.J.
  TITLE     Regulation of astrocyte metabolism by mitochondrial translocator
            protein 18 kDa
  JOURNAL   J Neurochem 168 (7), 1374-1401 (2024)
   PUBMED   38482552
  REMARK    GeneRIF: Regulation of astrocyte metabolism by mitochondrial
            translocator protein 18 kDa.
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Zhai,D.S., Wang,X.S., Yang,L., Jiang,Y.L., Jin,Y.C., Yan,Y.X.,
            Song,D.K., Zhang,K., Han,Z.K., Liu,M.Y., Wu,Y.M., Ma,X., Qi,J.Y.,
            Yang,F., Tian,F., Li,X.B. and Liu,S.B.
  TITLE     TOM40 mediates the effect of TSPO on postpartum depression
            partially through regulating calcium homeostasis in microglia
  JOURNAL   J Affect Disord 348, 283-296 (2024)
   PUBMED   38159656
  REMARK    GeneRIF: TOM40 mediates the effect of TSPO on postpartum depression
            partially through regulating calcium homeostasis in microglia.
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 871)
  AUTHORS   Tang,Q., Cheng,Z., Liu,S., Niu,J., Xu,J., Huang,J., Pan,J., Lu,F.
            and Chen,D.
  TITLE     FGF1DeltaHBS ameliorates retinal inflammation via suppressing TSPO
            signal in a type 2 diabetes mouse model
  JOURNAL   Biochem Pharmacol 221, 116039 (2024)
   PUBMED   38301966
  REMARK    GeneRIF: FGF1[DeltaHBS] ameliorates retinal inflammation via
            suppressing TSPO signal in a type 2 diabetes mouse model.
REFERENCE   5  (bases 1 to 871)
  AUTHORS   Pradhan,A.K., Neumuller,T., Klug,C., Fuchs,S., Schlegel,M.,
            Ballmann,M., Tartler,K.J., Pianos,A., Garcia,M.S., Liere,P.,
            Schumacher,M., Kreuzer,M., Rupprecht,R. and Rammes,G.
  TITLE     Chronic administration of XBD173 ameliorates cognitive deficits and
            neuropathology via 18 kDa translocator protein (TSPO) in a mouse
            model of Alzheimer's disease
  JOURNAL   Transl Psychiatry 13 (1), 332 (2023)
   PUBMED   37891168
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 871)
  AUTHORS   Letts,V.A., Valenzuela,A., Kirley,J.P., Sweet,H.O., Davisson,M.T.
            and Frankel,W.N.
  TITLE     Genetic and physical maps of the stargazer locus on mouse
            chromosome 15
  JOURNAL   Genomics 43 (1), 62-68 (1997)
   PUBMED   9226373
REFERENCE   7  (bases 1 to 871)
  AUTHORS   Yakovlev,A.G., Ruffo,M., Jurka,J. and Krueger,K.E.
  TITLE     Comparison of repetitive elements in the third intron of human and
            rodent mitochondrial benzodiazepine receptor-encoding genes
  JOURNAL   Gene 155 (2), 201-205 (1995)
   PUBMED   7721091
REFERENCE   8  (bases 1 to 871)
  AUTHORS   Taketani,S., Kohno,H., Okuda,M., Furukawa,T. and Tokunaga,R.
  TITLE     Induction of peripheral-type benzodiazepine receptors during
            differentiation of mouse erythroleukemia cells. A possible
            involvement of these receptors in heme biosynthesis
  JOURNAL   J Biol Chem 269 (10), 7527-7531 (1994)
   PUBMED   8125973
REFERENCE   9  (bases 1 to 871)
  AUTHORS   Garnier,M., Dimchev,A.B., Boujrad,N., Price,J.M., Musto,N.A. and
            Papadopoulos,V.
  TITLE     In vitro reconstitution of a functional peripheral-type
            benzodiazepine receptor from mouse Leydig tumor cells
  JOURNAL   Mol Pharmacol 45 (2), 201-211 (1994)
   PUBMED   8114671
REFERENCE   10 (bases 1 to 871)
  AUTHORS   Bucan,M., Gatalica,B., Nolan,P., Chung,A., Leroux,A.,
            Grossman,M.H., Nadeau,J.H., Emanuel,B.S. and Budarf,M.
  TITLE     Comparative mapping of 9 human chromosome 22q loci in the
            laboratory mouse
  JOURNAL   Hum Mol Genet 2 (8), 1245-1252 (1993)
   PUBMED   8401507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA472650.1, AK153273.1 and AI841615.1.
            
            On Dec 21, 2007 this sequence version replaced NM_009775.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA472650.1, BQ938533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AA472650.1         1-19
            20-849              AK153273.1         4-833
            850-871             AI841615.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     gene            1..871
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /note="translocator protein"
                     /db_xref="GeneID:12257"
                     /db_xref="MGI:MGI:88222"
     exon            1..72
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /inference="alignment:Splign:2.1.0"
     exon            73..283
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..611
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /note="isoquinoline-binding protein; PKBS; mitochondrial
                     benzodiazepine receptor; peripheral-type benzodiazepine
                     receptor; benzodiazepine receptor, peripheral"
                     /codon_start=1
                     /product="translocator protein"
                     /protein_id="NP_033905.3"
                     /db_xref="CCDS:CCDS27705.1"
                     /db_xref="GeneID:12257"
                     /db_xref="MGI:MGI:88222"
                     /translation="MPESWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHP
                     PRWTLAPIWGTLYSAMGYGSYIVWKELGGFTEDAMVPLGLYTGQLALNWAWPPIFFGA
                     RQMGWALADLLLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATVLNYYVWRDNSG
                     RRGGSRLPE"
     exon            284..422
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..856
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      831..836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /note="hexamer: AATAAA"
     polyA_site      849
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcggct accaacctct gtgcgcagtg tccttcacgg aacaaccagc gactgcgtga
       61 gcggggctgt ggatctttcc agaacatcag ttgcaatcac catgcctgaa tcctgggtgc
      121 ctgccgtggg cctcactctg gtgcccagcc tggggggctt catgggagcc tactttgtac
      181 gtggcgaggg cctccggtgg tatgctagct tgcagaaacc ctcttggcat ccgcctcgct
      241 ggacactggc tcccatctgg ggcacactgt attcagccat ggggtatggc tcctacatag
      301 tctggaaaga gctgggaggt ttcacagagg acgctatggt tcccttgggt ctctacactg
      361 gtcagctggc tctgaactgg gcgtggcccc ccatcttctt tggtgcccgg cagatgggct
      421 gggccttggc cgatcttctg cttgtcagtg gggtggcgac tgccacaacc ctggcttggc
      481 accgagtgag cccgccggct gcccgcttgc tgtaccctta cctggcctgg ctggcttttg
      541 ccaccgtgct caactactat gtatggcgtg ataactctgg ccggcgaggg ggctcccggc
      601 tcccagagtg aaggcaccca gccatcagga atgcagccct gccagccagg caccatgggt
      661 ggcagccatc atgcttttat gaccattggg cctgctggtc tacctggtct tagcccagga
      721 agccaccagg taggttaggg tggtcagtgc cgagtctcct gcagacacag ttatacctgc
      781 ctttctgcac tgctccaggc atgcccttag agcatggtgt tttaaagcta aataaagtct
      841 ctaacttcat gtgtaaaaaa aaaaaaaaaa a
//
