LOCUS       NM_001379136            4583 bp    mRNA    linear   ROD 31-JAN-2025
DEFINITION  Mus musculus tetraspanin 9 (Tspan9), transcript variant 6, mRNA.
ACCESSION   NM_001379136 XM_006505330
VERSION     NM_001379136.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Jiao,H., Jiang,D., Hu,X., Du,W., Ji,L., Yang,Y., Li,X., Sho,T.,
            Wang,X., Li,Y., Wu,Y.T., Wei,Y.H., Hu,X. and Yu,L.
  TITLE     Mitocytosis, a migrasome-mediated mitochondrial quality-control
            process
  JOURNAL   Cell 184 (11), 2896-2910 (2021)
   PUBMED   34048705
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Haining,E.J., Matthews,A.L., Noy,P.J., Romanska,H.M., Harris,H.J.,
            Pike,J., Morowski,M., Gavin,R.L., Yang,J., Milhiet,P.E.,
            Berditchevski,F., Nieswandt,B., Poulter,N.S., Watson,S.P. and
            Tomlinson,M.G.
  TITLE     Tetraspanin Tspan9 regulates platelet collagen receptor GPVI
            lateral diffusion and activation
  JOURNAL   Platelets 28 (7), 629-642 (2017)
   PUBMED   28032533
  REMARK    GeneRIF: Tspan9 regulates platelet collagen receptor GPVI lateral
            diffusion and activation.
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Kotha,J., Zhang,C., Longhurst,C.M., Lu,Y., Jacobs,J., Cheng,Y. and
            Jennings,L.K.
  TITLE     Functional relevance of tetraspanin CD9 in vascular smooth muscle
            cell injury phenotypes: a novel target for the prevention of
            neointimal hyperplasia
  JOURNAL   Atherosclerosis 203 (2), 377-386 (2009)
   PUBMED   18799160
  REMARK    GeneRIF: tetraspanin CD9 has a role in determining vascular smooth
            muscle cell injury phenotypes
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Protty,M.B., Watkins,N.A., Colombo,D., Thomas,S.G., Heath,V.L.,
            Herbert,J.M., Bicknell,R., Senis,Y.A., Ashman,L.K.,
            Berditchevski,F., Ouwehand,W.H., Watson,S.P. and Tomlinson,M.G.
  TITLE     Identification of Tspan9 as a novel platelet tetraspanin and the
            collagen receptor GPVI as a component of tetraspanin microdomains
  JOURNAL   Biochem J 417 (1), 391-400 (2009)
   PUBMED   18795891
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135355.3.
            
            On Mar 24, 2020 this sequence version replaced XM_006505330.4.
            
            Transcript Variant: This variant (6) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.166303.1,
                                           SRR9219383.33194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-897               AC135355.3         18677-19573
            898-1089            AC135355.3         86467-86658
            1090-1164           AC135355.3         86936-87010
            1165-1266           AC135355.3         87256-87357
            1267-1398           AC135355.3         87909-88040
            1399-1482           AC135355.3         88418-88501
            1483-4583           AC135355.3         89240-92340
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.73 cM"
     gene            1..4583
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /note="tetraspanin 9"
                     /db_xref="GeneID:109246"
                     /db_xref="MGI:MGI:1924558"
     exon            1..897
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1554
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /note="isoform a is encoded by transcript variant 6;
                     tetraspan NET-5"
                     /codon_start=1
                     /product="tetraspanin-9 isoform a"
                     /protein_id="NP_001366065.1"
                     /db_xref="GeneID:109246"
                     /db_xref="MGI:MGI:1924558"
                     /translation="MEKSSSEDSSIHRSPSLDSKDSDFAKPSTSGRPFGRGFTAGAFY
                     GTAGSRGQSRTEAGIKTDKYNAPKGSKYVVFYLDLSFVFLLEFKKCNMARGCLCCLKY
                     TMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGF
                     LGCLGAIKENKCLLLSFFIVLLIILLAELILIILFFVYMDKVNENAKQDLKEGLLLYN
                     TENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNSTTPL
                     WRTGCYEKVKLWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQHIHRTGKKYDA"
     exon            898..1089
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1164
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1266
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1398
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1482
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..4583
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4556..4561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /note="hexamer: AATAAA"
     polyA_site      4583
                     /gene="Tspan9"
                     /gene_synonym="6720474K14Rik; 9430079M16Rik; Tspan-9"
                     /note="major polyA site"
ORIGIN      
        1 gagagtcagg gctggaattt cgcagggcaa gcccagcggt tgcagctgca gcggatccga
       61 ggctctctgc ccgcggcgca cccgggcagc ccagggccgg cagcggctcc gcaaagtcgc
      121 ggagcaaggg aggccgagcg cccgcaaagt ggtggggctc cgggttggaa gaggcgtgcc
      181 tgcggagctt ggatcccagc gccctttcgc ctcgagtgct gcgtccggtc ggtggtgcag
      241 ccgcccggga aagagcagtc aaattgcagc ctccctaaag aagcctagtt acgcaggcga
      301 gccggctccc caagcgtgct tataacagtg ccgcagagcc ctcccgggcc agcgggctaa
      361 ggctgggagc ggggcgccgt cccagaggca gtgaaccccc ggcagttggt tgctccgcta
      421 ttgctcgcgg gtgcagagag ggggcgtgcg aagctccaac agccagcttg ctcagaaccc
      481 gtgcccgacc ggggtgcccc ctccgtccca ctctgggagc aatgcccccc gcccctcgtg
      541 ccccccggga acgaggcgag catggagaag tcgagtagcg aggattcttc gatccaccgg
      601 agtccatctt tggacagcaa ggactcggac tttgccaagc cgtccacctc tggccgcccg
      661 ttcggccgcg gcttcacggc tggcgccttc tacggcaccg cgggttcgcg gggtcagagc
      721 cgcacggagg ccggcattaa gactgacaag tacaatgcac ccaaaggcag caagtacgtg
      781 gtgttttacc tggacctgtc ctttgtgttc ctcctagaat ttaagaagtg caacatggcc
      841 aggggctgtc tctgctgctt gaagtacacg atgttcctct tcaatttgat attctggctc
      901 tgtggctgtg ggctgcttgg agtgggcatc tggctctctg tgtcccaagg caacttcgcc
      961 accttctccc ccagcttccc ctcactgtcc gcagccaacc tcgtcatcgc catcggcacc
     1021 atcgtcatgg tgacgggctt cctgggctgc ctgggggcca tcaaggagaa caagtgtctg
     1081 cttctcagct tcttcatcgt gctgttgatc atcctgctgg cagagttgat tctgatcatc
     1141 ctcttcttcg tctacatgga caaggtgaac gagaatgcca agcaggacct gaaagagggg
     1201 ctgctgctct acaacacaga gaacaacgtg gggctcaaga acgcctggaa catcatccag
     1261 gccgagatgc ggtgttgtgg ggtcactgac tacacagact ggtatccggt gctcggggag
     1321 aacacagttc ctgacagatg ctgcatggag aattcccagg gctgtgggcg caacagcacc
     1381 acccccttgt ggagaacggg ctgctacgaa aaagtgaagc tgtggtttga tgacaacaag
     1441 cacgtgctag gcaccgtggg catgtgcatc ctcatcatgc agatcctggg aatggccttt
     1501 tccatgacac tgttccagca catccaccgg acaggtaaaa agtacgacgc ctgaggctgc
     1561 ggcagcgcct ggctccaccc ggacactgcg tgtgccaggg aagaggaccc gagtcatgtc
     1621 tcctgcctgc tctccgatgg ccaccctgca ccacctgccg gcctgccctc ccctgcccac
     1681 atccttggcc ttagacctca tggagggcag aggcccaggg atgaggcatc atgcagagac
     1741 ctcagggctt gggcaactgg attcctgcac ctgcagactt gccaaagatg ccggggcggg
     1801 cagggtgtca gcgaggaagc cccttcaacg atgggtgtct gcccctggcc ttcctcacac
     1861 tgacacttgt tcctatgtgg ggtggagagt ctgccccatg gaggccactg ccgtccatgg
     1921 ctgcccagcc agagagcctg ccagggtgca gtgtggcacc gccaggtcag gccccctgga
     1981 gcaccctgcc cgggttttta tactatagtg taactttttt ttttatttta ctctgattat
     2041 gattattcag gaatattatc tctcagataa gtttagggtt agctctctga tttataactt
     2101 tttactgtgt tgatttccat aatggtttga gtttcctttt cctgtgggtg gggatgggta
     2161 gagagagagg acctccgtcc acgttcagtc aggacacacc actgtgcaac actcacgagg
     2221 ctggaggtag ggtgagaagt gccagccgtt tttccaggac tcaccttgag ggagagggtg
     2281 aggccatgat acggggccct gccaggcctg gagaccatgg atgaaggcca gaagaggctg
     2341 gtggcataca cagcatgggc catgctactc tggggtgaga ggatgctgcc tgaaccaggg
     2401 agccacatca gcagggcatg cttaggtcag gggacagtga aacgctttgc cgggaggagt
     2461 ggcagtcaga acactgtggc atttcctctt cctccctcgg tcctccgtgg gctttgaccc
     2521 gcgagcatcc tgcatcccga atggtcactc tcacacattc ctgctgctgc aaattcctct
     2581 ggttcagacc ccgctctcct caccctgatc cggagagtgg aagcagacat gttcctctgc
     2641 ccagactgaa acagagtctc aggacaaccc aggaagggag gcagacccca ccagactcac
     2701 tcagttgctt actgccctgc tgaggggaaa ggaaagggcc atgtgggtct caggaccatt
     2761 cctccttagg atccattgct gtccacactg gggggcagac actgtagccc atgtaacctc
     2821 aaagacaaga tacagaaact ctgagaagtc aggcttccac tgcccccaca gcattgggga
     2881 gaagaccctt gttagatgcc cagtgctagg ccaagcagtc ttgccaacac tgatacccaa
     2941 cacatgtcct tccgtaaaga caggggcctg tggaactgac tgagcaccta tctgggatcc
     3001 agatcctcac tctctctcgg gccttcacgt ggtagctgct tttctcgtgc tatttggctc
     3061 tttacgctgt ttcccaccag gccaggtgtt ctctggtcta gcaatgacat ccaaccaacc
     3121 taaaacccct ctgaccacct tgaataacag tgatgaccag gatgtggaac tttcagtacg
     3181 ttcaggattc aagttttggg ggtgagagag gatagcgggg agctctcggc agattggtcc
     3241 cacaagttgc cagttccagg agatggaatt gtggtgttat tggaggaatg acagctatct
     3301 tcccccaagg tgcagagttc aggtagaaac aaacagaaag caagcatggc gcctgctgca
     3361 ttatgagtgt ggatgggtag ggtgggtttg tttatgccta tctatgggtg tttaaacctt
     3421 cattaacttc aacattgagg tcccactacc ctaggaggca cttcgcctcc ctgcctcgtc
     3481 acatctgtag agtgcttcag ggtggtgctg gttcctggag ccttagctga agtcctccct
     3541 cctcaccaac ctcacctcac ctgtctgttc agcagagcca gatcataagt cccaaactgc
     3601 cttttttgtt ttagctgtgt gtggttgcat agtcatctgc agagtcttca cggcacagag
     3661 gtctccatgc acagagtgga tgtcctgaga ccctcactta tcgtggggca atggccctca
     3721 catgctagaa gaccacaccg agtaaggcta ggggagatgg ctcagctctt ctctgacact
     3781 cttgggtctg agttcactga ggtcctgcca tgaaatctcc cttacctgcg gcctcccttg
     3841 cctaaggcag agccgtttcc ttcaggtacc acacaagcaa tttgcagacc tgactcagaa
     3901 agtcctcttg gtttgcaggt gacctcaagg aaatgcctgg cgcagcctct ggcatttctc
     3961 cacagccagc tgcctcagtg gggctcagag ggtagggtct ggacaggtgt ctggtgcagg
     4021 tctccttgcg cctctgtact ctgcgctggc acattgtcat cctgtctccg ccagcctgga
     4081 ccagcacctc agctgtcccc cttgcacatg ctctggcctg acttaagagt taagtggtca
     4141 agcccccagc tcacttcagg tggatggaat tggttgtccc ctcctctctg gacccctgcc
     4201 caccctctgg tggaggtgct aactagcagg gacatggcac aggacaggga gctgggtgcc
     4261 agatgcttgg ggtctgttct ttgccccacg gcccctggca tcccttctca tgttcccgtt
     4321 ctctcatctc cctcccctcc tccatgatgg tggcattctg gcctcacctt cctgagtggg
     4381 cattctgagg ggagaggcct ttgggcctcc acttgccttg ctgtcccttg gtggccagag
     4441 agccaggagt gcacgctatt ggtttcgaat gcactttctg cttgcaatgc cttgtctgca
     4501 tttccttcat cccaggtccc gctttaacga acaccatgtt tttagcatgt ttttaaataa
     4561 aaactgatca tgtgtcaaaa gca
//
