LOCUS       NM_146010               1522 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus tetraspanin 8 (Tspan8), transcript variant 1, mRNA.
ACCESSION   NM_146010
VERSION     NM_146010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Zhu,Y., Saint-Pol,J., Nguyen,V., Rubinstein,E., Boucheix,C. and
            Greco,C.
  TITLE     The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme
            ECE1 and Regulates Its Activity
  JOURNAL   Cancers (Basel) 15 (19), 4751 (2023)
   PUBMED   37835445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Min,J., Yang,S., Cai,Y., Vanderwall,D.R., Wu,Z., Li,S., Liu,S.,
            Liu,B., Wang,J., Ding,Y., Chen,J., Jiang,C., Wren,J.D., Csiszar,A.,
            Ungvari,Z., Greco,C., Kanie,T., Peng,J. and Zhang,X.A.
  TITLE     Tetraspanin Tspan8 restrains interferon signaling to stabilize
            intestinal epithelium by directing endocytosis of interferon
            receptor
  JOURNAL   Cell Mol Life Sci 80 (6), 154 (2023)
   PUBMED   37204469
  REMARK    GeneRIF: Tetraspanin Tspan8 restrains interferon signaling to
            stabilize intestinal epithelium by directing endocytosis of
            interferon receptor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Liu,Y., Fan,J., Xu,T., Ahmadinejad,N., Hess,K., Lin,S.H., Zhang,J.,
            Liu,X., Liu,L., Ning,B., Liao,Z. and Hu,T.Y.
  TITLE     Extracellular vesicle tetraspanin-8 level predicts distant
            metastasis in non-small cell lung cancer after concurrent
            chemoradiation
  JOURNAL   Sci Adv 6 (11), eaaz6162 (2020)
   PUBMED   32195353
  REMARK    GeneRIF: Extracellular vesicle tetraspanin-8 level predicts distant
            metastasis in non-small cell lung cancer after concurrent
            chemoradiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1522)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   7  (bases 1 to 1522)
  AUTHORS   Kobielak,A. and Fuchs,E.
  TITLE     Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma
            in skin
  JOURNAL   Proc Natl Acad Sci U S A 103 (7), 2322-2327 (2006)
   PUBMED   16452166
REFERENCE   8  (bases 1 to 1522)
  AUTHORS   Lu,J., Izvolsky,K.I., Qian,J. and Cardoso,W.V.
  TITLE     Identification of FGF10 targets in the embryonic lung epithelium
            during bud morphogenesis
  JOURNAL   J Biol Chem 280 (6), 4834-4841 (2005)
   PUBMED   15556938
REFERENCE   9  (bases 1 to 1522)
  AUTHORS   Gu,G., Wells,J.M., Dombkowski,D., Preffer,F., Aronow,B. and
            Melton,D.A.
  TITLE     Global expression analysis of gene regulatory pathways during
            endocrine pancreatic development
  JOURNAL   Development 131 (1), 165-179 (2004)
   PUBMED   14660441
REFERENCE   10 (bases 1 to 1522)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126270.4, DV060937.1, AK077301.1 and AC153364.4.
            
            On Dec 12, 2009 this sequence version replaced NM_146010.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029808.1, DV060937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC126270.4         6081-6357           c
            278-924             DV060937.1         111-757
            925-1249            AK077301.1         833-1157
            1250-1522           AC153364.4         118590-118862       c
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 63.51 cM"
     gene            1..1522
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /note="tetraspanin 8"
                     /db_xref="GeneID:216350"
                     /db_xref="MGI:MGI:2384918"
     exon            1..377
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1025
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /note="transmembrane 4 superfamily member 3; tspan-8"
                     /codon_start=1
                     /product="tetraspanin-8"
                     /protein_id="NP_666122.1"
                     /db_xref="CCDS:CCDS24181.1"
                     /db_xref="GeneID:216350"
                     /db_xref="MGI:MGI:2384918"
                     /translation="MAGVSSCLKYSMFFFNFLFWVCGTLILGLAIWVRVSKDGKEIIT
                     SGDSSTNPFIAVNILIAVGSIIMVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAA
                     GILGAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAAD
                     WGNNFVEAKESCQCTGTDCATYQGSSVYPKTCLSLIKDLFEKNIIIVIGIAFGLAVIE
                     ILGLVFSMVLYCQIGSK"
     exon            378..440
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..578
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            579..653
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..761
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..887
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            888..971
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1522
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="Tspan8"
                     /gene_synonym="E330007O21Rik; Tm4sf3"
                     /note="major polyA site"
ORIGIN      
        1 cgggctttga gaagccatca taaatatcct gacctaatgc cttagcagcc ataagaagga
       61 aaagaatgta ctcgcctgaa gataacgttt gagatattta aaggtgtggg ttaatttttt
      121 atccactcca ataactgttg gttttttttt ttttcttttt tttctgttcc ttctgtctac
      181 ttctttgctc tctatttcta cccccgaagc tgcaggcaca cggatctctg caggcaaaat
      241 ccgtcagagc ctacgcagga cagccttcta cggacttctt cattccactg taacttggtg
      301 gctgcccctt ctccgaaatg gcaggtgtga gcagctgttt aaagtattct atgtttttct
      361 tcaacttctt gttctgggta tgtggtacac tgatcttggg actggccata tgggtgagag
      421 taagcaaaga tggaaaagag atcatcacgt caggagactc tagcacgaac cccttcattg
      481 ctgtgaatat cttgattgca gttgggtcta tcatcatggt tctaggtttc ctgggatgct
      541 gtggagctgt gaaagaaagc cggtgcatgc ttctcttgtt ttttatcggc ttgctgctga
      601 ttctgattct gcaagtggca gcaggcatcc taggagccgc tttcaaacct gagtataacc
      661 gaattctgaa tgaaacgcta tatgaaaatg ctaagcttct gtcggacaac actgatgagg
      721 caaaagactt ccagaaggcc atgattgtgt ttcagtcgga gttcaagtgc tgtggcttgg
      781 agaatggagc tgccgactgg ggaaataatt ttgtggaggc aaaagagtca tgtcaatgta
      841 caggaactga ctgtgcaact tatcagggga gttccgttta cccaaagacc tgtctttctt
      901 tgatcaaaga tctgtttgaa aagaacatta ttattgtcat tggaattgct tttggactgg
      961 ccgttattga gattctcggt ttggtgtttt ctatggtgct atactgccag attggaagca
     1021 agtgaacctg aggatttacc tagtcatcat aaacaccatt tgagtttttg ctttggcttc
     1081 atgactttaa atactcgaat actgtaaata aatgttattg aagtatctca ctgaggcagt
     1141 ctacagatat cttcacaggt attcactgta tttaactgtg aaggacataa tacaaatggt
     1201 tgtgtatttt tttttttctc tcacaataaa aagtgttggt gttgatgctt ttttgctgtc
     1261 tggccattgt gtccaagtgg ctctgtgtct ctagagatga tcatctggag cgtcccagtg
     1321 gaataagcac gtttctaagt gacaagatca cagactctag ggcagtgaat ctgggatctg
     1381 ggattttttt ttttttcttt ttctttttca aaaacacagc tctgtttcat caggtatgtc
     1441 aacagctgat gatgagattg tttaaaggtg aaatacttaa cgatgtgtaa atcaccatat
     1501 tataaaatat ttgtttacct tt
//
