LOCUS       NM_019634               1791 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tetraspanin 7 (Tspan7), mRNA.
ACCESSION   NM_019634
VERSION     NM_019634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Kim,M., Lin,J., Huh,J.E., Park,J.H., Go,M., Lee,H., Hwang,D.,
            Kim,H.S., Kim,T., Lee,D. and Lee,S.Y.
  TITLE     Tetraspanin 7 regulates osteoclast function through association
            with the RANK/alphavbeta3 integrin complex
  JOURNAL   J Cell Physiol 237 (1), 846-855 (2022)
   PUBMED   34407208
  REMARK    GeneRIF: Tetraspanin 7 regulates osteoclast function through
            association with the RANK/alphavbeta3 integrin complex.
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Murru,L., Ponzoni,L., Longatti,A., Mazzoleni,S., Giansante,G.,
            Bassani,S., Sala,M. and Passafaro,M.
  TITLE     Lateral habenula dysfunctions in Tm4sf2-/y mice model for
            neurodevelopmental disorder
  JOURNAL   Neurobiol Dis 148, 105189 (2021)
   PUBMED   33227491
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Murru,L., Vezzoli,E., Longatti,A., Ponzoni,L., Falqui,A., Folci,A.,
            Moretto,E., Bianchi,V., Braida,D., Sala,M., D'Adamo,P., Bassani,S.,
            Francolini,M. and Passafaro,M.
  TITLE     Pharmacological Modulation of AMPAR Rescues Intellectual
            Disability-Like Phenotype in Tm4sf2-/y Mice
  JOURNAL   Cereb Cortex 27 (11), 5369-5384 (2017)
   PUBMED   28968657
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Zemni,R., Bienvenu,T., Vinet,M.C., Sefiani,A., Carrie,A.,
            Billuart,P., McDonell,N., Couvert,P., Francis,F., Chafey,P.,
            Fauchereau,F., Friocourt,G., des Portes,V., Cardona,A., Frints,S.,
            Meindl,A., Brandau,O., Ronce,N., Moraine,C., van Bokhoven,H.,
            Ropers,H.H., Sudbrak,R., Kahn,A., Fryns,J.P., Beldjord,C. and
            Chelly,J.
  TITLE     A new gene involved in X-linked mental retardation identified by
            analysis of an X;2 balanced translocation
  JOURNAL   Nat Genet 24 (2), 167-170 (2000)
   PUBMED   10655063
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Hosokawa,Y., Ueyama,E., Morikawa,Y., Maeda,Y., Seto,M. and Senba,E.
  TITLE     Molecular cloning of a cDNA encoding mouse A15, a member of the
            transmembrane 4 superfamily, and its preferential expression in
            brain neurons
  JOURNAL   Neurosci Res 35 (4), 281-290 (1999)
   PUBMED   10617319
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238972.1, AK004776.1 and AI854904.1.
            
            On Jan 10, 2006 this sequence version replaced NM_019634.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058603.1, AK004776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               BY238972.1         1-412
            413-1772            AK004776.1         373-1732
            1773-1791           AI854904.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.85 cM"
     gene            1..1791
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /note="tetraspanin 7"
                     /db_xref="GeneID:21912"
                     /db_xref="MGI:MGI:1298407"
     exon            1..123
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..792
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /note="transmembrane 4 superfamily member 2; tspan-7;
                     TALLA homolog; cell surface glycoprotein A15"
                     /codon_start=1
                     /product="tetraspanin-7"
                     /protein_id="NP_062608.2"
                     /db_xref="CCDS:CCDS30016.1"
                     /db_xref="GeneID:21912"
                     /db_xref="MGI:MGI:1298407"
                     /translation="MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTL
                     GTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAE
                     LVAGISGFVFRHEIKDTFLRTYTDAMQNYNGNDERSRAVDHVQRSLSCCGVQNYTNWS
                     SSPYFLDHGIPPSCCMNETDCNPLDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAG
                     VAFGIAFSQLIGMLLACCLSRFITANQYEMV"
     exon            124..312
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..387
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..483
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..639
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..723
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..799
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1774
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1754..1759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /note="hexamer: AATAGA"
     polyA_site      1774
                     /gene="Tspan7"
                     /gene_synonym="1200014P11Rik; A15; Cd231; Mxs1; PE31;
                     TALLA; Tm4sf2"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccgcc cgccgccact gccgccgccg gagctgagta gtatggcatc gaggagaatg
       61 gagaccaaac ctgtgataac ctgtctcaaa accctcctca tcatctactc cttcgtcttc
      121 tggatcactg gggtgatcct gttggccgtt ggagtctggg gaaagctgac tttgggaacc
      181 tatatctccc tgattgctga gaactccaca aatgctccct atgtgctcat tggaaccggc
      241 accaccatcg tggtttttgg cctctttgga tgctttgcta catgccgtgg tagtccatgg
      301 atgctgaaac tgtatgccat gttcctgtcc ctggtgttcc tggctgagct tgttgctggc
      361 atttctggat ttgtgtttcg tcatgagatc aaggacacct tcctgaggac ttacacggat
      421 gccatgcaga actacaatgg caatgatgag aggagccggg ctgtggacca tgtgcagcgc
      481 agcctgagct gctgtggcgt gcagaactac accaactgga gcagcagccc ctacttcctg
      541 gaccatggca tcccccccag ttgctgcatg aacgaaactg actgcaatcc cctggatctg
      601 cacaatctga ctgtggccgc caccaaagtt aatcagaagg gctgttatga tctggtgacc
      661 agttttatgg agactaacat ggggatcatt gctggagtgg catttggaat tgcgttctcc
      721 cagttgattg gcatgctgct ggcttgctgt ctgtcccggt tcatcactgc caatcagtat
      781 gagatggtgt aaagagaagt ctttcaagaa ctttggaata agaggcctgt ttttaaaaag
      841 gaactgccgc aatctctgaa agacttccaa agaacgttag agcacagtac atactatccc
      901 tgccctgctc ccacccccag ctccctgcag cccctccccc tacgtgcaac tgacactcct
      961 acccagtcaa agctctgcct ttcagcccac gtcatacgta gtgtccatct tgtgaagccc
     1021 tgttgtgccc cacagtgtag ccaggccccc tgcagctagt catagtgaag cccaccctaa
     1081 ggccctgtga gcgccagctc cctcacatgt acttggtcca actgtaggtg actggttatc
     1141 acatcttcac tggcccctgt ggccctgcat gtagtagggg aggcttcagt cagcccctca
     1201 ctgtggtcca agaatgccac acacctttcc gtagatatgc cgatggtaat tatcttttct
     1261 tttggcttaa tccgatttgg tttggttttt ccctttccct ggattctttc ctaccttctt
     1321 caggctgtca agcacgggag aggagacaca gtgggaggga ttcataagga gaaaacagcg
     1381 tctggcaggc atggcagaaa gtgctgttaa gcattagctg gcttccttgt tcattgttcc
     1441 aagagatggg tgtggagaga cggcttagtg taggatcctc tcgaatgaag cctgtgtaat
     1501 cctgttacag gttgtgttgt tacttccctg atttgcccca actacttact attatttcgc
     1561 tttcgttttc ctgtattttt ttcttgcatt gacattattg acgttgagga cctcatcaga
     1621 tcaatttaaa agtgagtgtg gaagggaaac gaaagtcaac atatttttaa aagatcttaa
     1681 aaataatgcc tctgtctagc atgccaacaa gaatgcattg atattgtgaa catttgtgat
     1741 acatgtatta ataaatagag caattaaaaa tggcaaaaaa aaaaaaaaaa a
//
