LOCUS       NM_019656               1763 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus tetraspanin 6 (Tspan6), mRNA.
ACCESSION   NM_019656
VERSION     NM_019656.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Humbert,P.O., Pryjda,T.Z., Pranjic,B., Farrell,A., Fujikura,K., de
            Matos Simoes,R., Karim,R., Kozieradzki,I., Cronin,S.J.F.,
            Neely,G.G., Meyer,T.F., Hagelkruys,A., Richardson,H.E. and
            Penninger,J.M.
  TITLE     TSPAN6 is a suppressor of Ras-driven cancer
  JOURNAL   Oncogene 41 (14), 2095-2105 (2022)
   PUBMED   35184157
  REMARK    Erratum:[Oncogene. 2022 Apr;41(14):2138. doi:
            10.1038/s41388-022-02265-2. PMID: 35292775]
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Andrijes,R., Hejmadi,R.K., Pugh,M., Rajesh,S., Novitskaya,V.,
            Ibrahim,M., Overduin,M., Tselepis,C., Middleton,G.W., Gyorffy,B.,
            Beggs,A.D. and Berditchevski,F.
  TITLE     Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer
  JOURNAL   Proc Natl Acad Sci U S A 118 (39) (2021)
   PUBMED   34521767
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Guix,F.X., Sannerud,R., Berditchevski,F., Arranz,A.M., Horre,K.,
            Snellinx,A., Thathiah,A., Saido,T., Saito,T., Rajesh,S.,
            Overduin,M., Kumar-Singh,S., Radaelli,E., Corthout,N.,
            Colombelli,J., Tosi,S., Munck,S., Salas,I.H., Annaert,W. and De
            Strooper,B.
  TITLE     Tetraspanin 6: a pivotal protein of the multiple vesicular body
            determining exosome release and lysosomal degradation of amyloid
            precursor protein fragments
  JOURNAL   Mol Neurodegener 12 (1), 25 (2017)
   PUBMED   28279219
  REMARK    GeneRIF: Results shows that TSPAN6 is a crucial player in Amyloid
            Precursor Protein-C-terminal fragment turnover
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Salas,I.H., Callaerts-Vegh,Z., Arranz,A.M., Guix,F.X., D'Hooge,R.,
            Esteban,J.A., De Strooper,B. and Dotti,C.G.
  TITLE     Tetraspanin 6: A novel regulator of hippocampal synaptic
            transmission and long term plasticity
  JOURNAL   PLoS One 12 (2), e0171968 (2017)
   PUBMED   28207852
  REMARK    GeneRIF: Tspan6 KO mice show normal locomotor behaviour and no
            defects in hippocampus-dependent memory tests.
            Erratum:[PLoS One. 2017 Jul 7;12(7):e0178016. doi:
            10.1371/journal.pone.0178016. PMID: 28686613]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Zhou,P., Zhang,Y., Ma,Q., Gu,F., Day,D.S., He,A., Zhou,B., Li,J.,
            Stevens,S.M., Romo,D. and Pu,W.T.
  TITLE     Interrogating translational efficiency and lineage-specific
            transcriptomes using ribosome affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15395-15400 (2013)
   PUBMED   24003143
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Cai,J., Ash,D., Kotch,L.E., Jabs,E.W., Attie-Bitach,T., Auge,J.,
            Mattei,G., Etchevers,H., Vekemans,M., Korshunova,Y., Tidwell,R.,
            Messina,D.N., Winston,J.B. and Lovett,M.
  TITLE     Gene expression in pharyngeal arch 1 during human embryonic
            development
  JOURNAL   Hum Mol Genet 14 (7), 903-912 (2005)
   PUBMED   15703188
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA458002.1, AK167384.1 and AV351536.1.
            
            On Feb 9, 2007 this sequence version replaced NM_019656.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003733.1, AK146673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AA458002.1         1-106
            107-1761            AK167384.1         3-1657
            1762-1763           AV351536.1         251-252
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.47 cM"
     gene            1..1763
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /note="tetraspanin 6"
                     /db_xref="GeneID:56496"
                     /db_xref="MGI:MGI:1926264"
     exon            1..222
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            223..411
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            412..486
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            487..585
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            586..720
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            721..804
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            805..909
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1763
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /note="hexamer: AGTAAA"
     polyA_site      1095
                     /gene="Tspan6"
                     /gene_synonym="6720473L21Rik; T245; Tm4sf; Tm4sf6;
                     TSPAN-6"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctgtt tccggttctt ctcagttgca gatactcgtg agttttcggc agtttccgtg
       61 gaaactcgga aactctcgcg cctggcaagc tcgagccgat cgcccggtgc ataggcgcag
      121 ggtctccggg tagtcatggc gtccccatct cggaggctgc agactaagcc ggtcattact
      181 tgtttgaaaa gcgttctctt gatctacact ttcatctttt ggatcactgg tgttatcctt
      241 cttgccgttg gcatttgggg caaggtgagc ctggaaaatt atttttccct cttaaatgag
      301 aaggccacca atgtgccttt tgtgctcatt ggcacaggca ctgtcattat tctcttgggc
      361 acctttggtt gtttcgctac ctgtcgagcc tccgcctgga tgctgaaact gtacgcgatg
      421 tttctgacac tcattttttt ggtcgaacta gttgccgcca ttgttggatt tgttttcaga
      481 catgagatta agaacagctt taaaagtaac tatgaaaacg ctctgaagga gtacaactcc
      541 acaggagact atagaagtga agctgtagac aagatccaaa gtacgttgca ttgttgcggt
      601 gtcaccaatt acggagattg gaaaggtacg aactattact cagaaacagg atttcccaag
      661 agctgctgta aactggaggg ctgttatcca cagagagatg cagataaagt caacgaagag
      721 ggttgtttca taaaggtaat gacaactata gagtcagaaa tgggagtcgt tgctggaatt
      781 tcttttggag ttgcttgctt tcagctaatt ggaatctttc ttgcctactg cctgtctcgt
      841 gccataacga ataaccagta tgagatagta taatcactac acacgggctc atatctcctc
      901 agttttaagg ttacctttgt gagttataac agcgcctgga tggagactga catctgctta
      961 gcctgaaaag ctacaccagt aggctgattc aatcaagata cttgtgtatt gtattctgtg
     1021 tccactttct gtcctattct tacacccctg tatctctgaa acactggaag tgctagtaaa
     1081 ttgtaaatga aataataccc tgtttccctt ggatttgatt tctcagtgta ggaattgtga
     1141 gaagtgctgt gaacttgcca tttccctaac agtgtcactg gtggaacttt aacccctatg
     1201 aatttgtcgt tgatgtagtg tgatagaaaa ttggtctcct tgagtgggcc ttgtactagt
     1261 caagattgtc tggcttgatt atataatatc caaaaaaagg aaaacatttc cttagcctct
     1321 gctggtaggc agagttgcat tgtataattt catcccagct ggtcatcaga tggtgcccat
     1381 caatggcgtt cctgcatggt ggtaccagtc tcaggctttg ggtgcaaagg acagagacta
     1441 agagccacca cttgtattct gtgatacatc agctttcagc acacaatgta tgtgctttta
     1501 tcaccaaact aaggcattca tacggattct actttattat ttgaaaggtt ataattactt
     1561 taatggcatc agaactcttg tattttcctt atgaatttac tggaacttac ttgattaact
     1621 ttagctagct attcctcacc aagcaaatca tacttaatac caactgtcag cattttggtt
     1681 aattttaata gtattcattt tgttttgtat ccttgattaa taaatataaa tcctttacac
     1741 aataaatact gcatttcctc taa
//
