LOCUS       NM_019571               3168 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus tetraspanin 5 (Tspan5), transcript variant 1, mRNA.
ACCESSION   NM_019571 XM_916979 XM_924597 XM_924599
VERSION     NM_019571.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Colbert,J.D., Cruz,F.M., Baer,C.E. and Rock,K.L.
  TITLE     Tetraspanin-5-mediated MHC class I clustering is required for
            optimal CD8 T cell activation
  JOURNAL   Proc Natl Acad Sci U S A 119 (42), e2122188119 (2022)
   PUBMED   36215490
  REMARK    GeneRIF: Tetraspanin-5-mediated MHC class I clustering is required
            for optimal CD8 T cell activation.
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Moretto,E., Longatti,A., Murru,L., Chamma,I., Sessa,A., Zapata,J.,
            Hosy,E., Sainlos,M., Saint-Pol,J., Rubinstein,E., Choquet,D.,
            Broccoli,V., Schiavo,G., Thoumine,O. and Passafaro,M.
  TITLE     TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine
            Maturation through Neuroligin-1 Clustering
  JOURNAL   Cell Rep 29 (5), 1130-1146 (2019)
   PUBMED   31665629
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Saint-Pol,J., Billard,M., Dornier,E., Eschenbrenner,E., Danglot,L.,
            Boucheix,C., Charrin,S. and Rubinstein,E.
  TITLE     New insights into the tetraspanin Tspan5 using novel monoclonal
            antibodies
  JOURNAL   J Biol Chem 292 (23), 9551-9566 (2017)
   PUBMED   28428248
  REMARK    GeneRIF: two TspanC8-specific motifs in the large extracellular
            domain of Tspan5 that are important for ADAM10 interaction and exit
            from the endoplasmic reticulum. One of the anti-Tspan5 mAbs does
            not recognize Tspan5 associated with ADAM10, providing a convenient
            way to measure the fraction of Tspan5 not associated with ADAM10.
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Zhou,J., Fujiwara,T., Ye,S., Li,X. and Zhao,H.
  TITLE     Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits
            osteoclastogenesis in vitro
  JOURNAL   Calcif Tissue Int 95 (3), 209-217 (2014)
   PUBMED   24935633
  REMARK    GeneRIF: Tspan-5 and Tspan-10, are up-regulated during osteoclast
            differentiation and knockdown of their expression dramatically
            inhibits osteoclastogenesis
REFERENCE   5  (bases 1 to 3168)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   6  (bases 1 to 3168)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   7  (bases 1 to 3168)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., de Lecea,L. and Soriano,E.
  TITLE     Pattern of expression of the tetraspanin Tspan-5 during brain
            development in the mouse
  JOURNAL   Mech Dev 106 (1-2), 207-212 (2001)
   PUBMED   11472858
  REMARK    GeneRIF: This protein is expressed during brain development from
            embryonic stages to adulthood.
REFERENCE   8  (bases 1 to 3168)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., de Lecea,L. and
            Soriano,E.
  TITLE     Mouse Tspan-5, a member of the tetraspanin superfamily, is highly
            expressed in brain cortical structures
  JOURNAL   Neuroreport 11 (14), 3181-3185 (2000)
   PUBMED   11043545
REFERENCE   9  (bases 1 to 3168)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3168)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114621.8, BC058695.1, AC110574.9 and AI447898.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_019571.6.
            
            On Jun 11, 2014 this sequence version replaced NM_019571.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF121344.1, BC058695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC114621.8         47716-47760         c
            46-460              BC058695.1         17-431
            461-461             AC110574.9         62092-62092         c
            462-3161            BC058695.1         433-3132
            3162-3168           AI447898.1         15-21               c
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.42 cM"
     gene            1..3168
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /note="tetraspanin 5"
                     /db_xref="GeneID:56224"
                     /db_xref="MGI:MGI:1928096"
     exon            1..453
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1179
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /note="transmembrane 4 superfamily member 9; tetraspanin
                     Tspan-5; tetraspan NET-4"
                     /codon_start=1
                     /product="tetraspanin-5"
                     /protein_id="NP_062517.1"
                     /db_xref="CCDS:CCDS17870.1"
                     /db_xref="GeneID:56224"
                     /db_xref="MGI:MGI:1928096"
                     /translation="MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEK
                     GVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIF
                     FLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGAD
                     DWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYT
                     KGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW"
     exon            454..504
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            505..651
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            652..822
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            823..948
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            949..996
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1113
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..3168
                     /gene="Tspan5"
                     /gene_synonym="2810455A09Rik; 4930505M03Rik; NET-4;
                     Tm4sf9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggcggg cggagcgagc ggcgggagga gcgagcggtg ggaggcgcgc gagcgggcgg
       61 cgggcagcgt ctccgccggc atctgcgcgg ccgcctctgc ccggagcccg gggaccgagc
      121 gccggacccg ccgcctggcg caccgacgcg gagctcccgc tttgtgctcc gtgccggttc
      181 gaggaggctt cccggaggct gcggccaccg cgccccggcg gcctcggagg cccgcggctg
      241 gaggtgccgg agctgctcgg tccgcgcggc tgagccccgc gtgccccact gctcgccggg
      301 ctgctccgag ccggggtgct ccggggctcc aaactcgggc tggcggggca agtgtcttca
      361 tgaacccaga ggatgtccgg gaagcactac aagggtcctg aagtcagttg ttgcatcaaa
      421 tacttcattt ttggcttcaa tgtcatattt tggtttttgg gaataacgtt tcttggaatc
      481 ggactgtggg cgtggaatga aaaaggtgtc ctctccaaca tctcgtccat caccgacctc
      541 ggtggctttg acccagtgtg gcttttcctt gtggtgggag gagtgatgtt cattctgggg
      601 tttgcagggt gcatcggagc acttcgggaa aacacctttc ttctcaagtt tttttctgtg
      661 ttcctgggga ttattttctt cctggaactc actgctgggg tgttggcatt tgttttcaaa
      721 gactggatca aagaccagct gtatttcttt attaacaaca acatcagagc ctacagagat
      781 gacattgatc tacagaacct catagacttc acccaggaat attggcagtg ctgtggggct
      841 tttggagctg atgattggaa cctaaatatt tacttcaatt gcacagattc caatgcaagc
      901 cgagagcgat gcggtgtgcc attttcctgc tgcactaaag accccgcgga agatgtcatc
      961 aacactcagt gtggctatga tgccaggcag aaaccagaag ttgaccaaca gattgtaatc
     1021 tacacaaaag gctgtgtgcc ccagtttgag aagtggctac aggacaattt aaccatcgtg
     1081 gctggtattt tcataggcat tgcattgcta cagatttttg ggatatgcct ggcacagaat
     1141 ttggtgagtg acattgaagc tgtcagggct agctggtaga cccctgcgac cactgctgtc
     1201 agacactgga ctgatccccc ctcactgact gaccctctgt gcgccggccg gctgatggcg
     1261 ggctgtagag gcctggtcac aggcctacag tctcacctga tggagctgcc aagaacttaa
     1321 ctttctgtgg gggtagaact gggaaatgct gctcacagac ggaacttgga aaaagaaaaa
     1381 caaaacaagt gcgcaacttg ctgagtcaac gtgcagtgaa tctctactgt agccgtggat
     1441 tggtggtcgg atggatgcta ccagaagggg gaagggggga ggttgggcac ggcatgtact
     1501 tgaatttttg gagaatacag tgctgtacac atcttggcta aaacttgggc ccttagccgt
     1561 cagggccagg tgtcttgaaa tctctcaaac cctttgcatc tgtcctccag agaagaaacc
     1621 agctgccccc tgtgttcaga ttctgagaga ggtggagcgg gtcacgatac agcatgcgcc
     1681 cttcatcctg agtttgccct taagagaact gggcgtttgc agtaaactag ggtgccagag
     1741 gctgagctcc acatttccac aggactgctc tttcctctga gtggccagcc cgagcctgag
     1801 ctctgtcaat gacatccaag gagaaaatga ggttaatgag agacattaat taaacactcc
     1861 ctcaccccac cgcaccaaac cagttgggtt cttctgatat tctggaatac tctgggctat
     1921 gttttatgtt ttatttcttt tttaatcggt tgttattttg gttctttttt tttttctttc
     1981 tttctttttt ctttttgtct cccaaaggag gctatgacac agttctcttg gtttcttatt
     2041 cagcttgaat agtaagtttt tgtagacttg tcacctgcat gtactgtaac cccaccccca
     2101 cccccaaatc caccatgttc ttttcagaga gacatttgag cgtgttcctt agtgtttatg
     2161 tcctaggtat ccagccttga gtggttgtgg agtgttgtcc tagccgcatc tttgtatgcc
     2221 cctcaggctc tctgtctctc ctggcatcca attcagcttc tgtccattcg ccattgagtg
     2281 gtagaaaagc ccagctccaa agcagggttg acacagtcaa aaagcatttc atgaggtttt
     2341 tctttctttt ctttttcctc cctttttgca actttagttt tgtcgtatat taaataaaaa
     2401 accaagccta gtatagtgca tgtgctcgct gaggtgacct cggggtggtt acaaagcaca
     2461 aatatttgag gggctgcgcc gaagcccagc cagggttcag tgacgctagg tggaaaacca
     2521 ccttcaggtt cttctcctgc ctcgtgccca ctgggagggt ggactttagc cccagatccc
     2581 cccaccccca gcttgtgata acccctggat gttgctttca cggggagcag atttagtttg
     2641 tgggtttgct gggaaggccc cagcctctgc gaaaagcagc tccccattgg ccagccagca
     2701 gtctgcgtca tgcagcccgg ttttccattt ccgcagcacg tgtgcgttgc cgtggctgat
     2761 gggcgctgtc tgctcagagg gaggtcaggc actccttggg tttacgtggc tctgcatgtt
     2821 tgtatcggtg tctgttttta ggtagagata gtcattccat acgtggatgc gaggtcacgt
     2881 gacttcaccc ctgtccatac cacagccgtc gcttgtgatg tccttcaaca tggacactcg
     2941 tgctctcgga ttggcacttc tgtcttcttt attacctcat tctccagtga actgcatctg
     3001 gccaattgat tcagaatcag acaggatccc caccccgtgg cacatccagt gaaagccaaa
     3061 acacaagccc aagcgagttt taaattttaa tcacccttta ttttttacac tcgagagtga
     3121 ttgtaataaa agctgtcatt aataaactcg gttctacctt acatggga
//
