LOCUS       NM_001403358            1614 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus tetraspanin 4 (Tspan4), transcript variant 6, mRNA.
ACCESSION   NM_001403358 XM_030242865
VERSION     NM_001403358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Pham,A.H., Emori,C., Ishikawa-Yamauchi,Y., Tokuhiro,K.,
            Kamoshita,M., Fujihara,Y. and Ikawa,M.
  TITLE     Thirteen Ovary-Enriched Genes Are Individually Not Essential for
            Female Fertility in Mice
  JOURNAL   Cells 13 (10), 802 (2024)
   PUBMED   38786026
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Zheng,Y., Lang,Y., Qi,B. and Li,T.
  TITLE     TSPAN4 and migrasomes in atherosclerosis regression correlated to
            myocardial infarction and pan-cancer progression
  JOURNAL   Cell Adh Migr 17 (1), 14-19 (2023)
   PUBMED   36513632
  REMARK    GeneRIF: TSPAN4 and migrasomes in atherosclerosis regression
            correlated to myocardial infarction and pan-cancer progression.
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Jiao,H., Jiang,D., Hu,X., Du,W., Ji,L., Yang,Y., Li,X., Sho,T.,
            Wang,X., Li,Y., Wu,Y.T., Wei,Y.H., Hu,X. and Yu,L.
  TITLE     Mitocytosis, a migrasome-mediated mitochondrial quality-control
            process
  JOURNAL   Cell 184 (11), 2896-2910 (2021)
   PUBMED   34048705
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 1614)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Banerjee,H., Hawkins,Z., Johnson,T., Eley,S., Alikhan,A.,
            Mcdaniel,M., Singh,I. and Raymond,J.
  TITLE     Identification of a mouse orthologue of the CED-6 gene of
            Caenorhabditis elegans
  JOURNAL   Plasmid 49 (1), 30-33 (2003)
   PUBMED   12583998
REFERENCE   7  (bases 1 to 1614)
  AUTHORS   Wylin,T., Baes,M., Brees,C., Mannaerts,G.P., Fransen,M. and Van
            Veldhoven,P.P.
  TITLE     Identification and characterization of human PMP34, a protein
            closely related to the peroxisomal integral membrane protein PMP47
            of Candida boidinii
  JOURNAL   Eur J Biochem 258 (2), 332-338 (1998)
   PUBMED   9874197
REFERENCE   8  (bases 1 to 1614)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
REFERENCE   9  (bases 1 to 1614)
  AUTHORS   Tachibana,I., Bodorova,J., Berditchevski,F., Zutter,M.M. and
            Hemler,M.E.
  TITLE     NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that
            complexes with integrins and other TM4SF proteins
  JOURNAL   J Biol Chem 272 (46), 29181-29189 (1997)
   PUBMED   9360996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158224.6.
            
            On Mar 29, 2022 this sequence version replaced XM_030242865.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.1442661.1,
                                           SRR17784646.112581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               AC158224.6         131310-131795
            487-678             AC158224.6         138781-138972
            679-753             AC158224.6         139991-140065
            754-855             AC158224.6         140801-140902
            856-987             AC158224.6         141003-141134
            988-1071            AC158224.6         141209-141292
            1072-1614           AC158224.6         142114-142656
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.83 cM"
     gene            1..1614
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /note="tetraspanin 4"
                     /db_xref="GeneID:64540"
                     /db_xref="MGI:MGI:1928097"
     exon            1..486
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1140
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /note="isoform b is encoded by transcript variant 6;
                     transmembrane 4 superfamily member 7; novel antigen 2;
                     tetraspan TM4SF"
                     /codon_start=1
                     /product="tetraspanin-4 isoform b"
                     /protein_id="NP_001390287.1"
                     /db_xref="GeneID:64540"
                     /db_xref="MGI:MGI:1928097"
                     /translation="MRRSSTDESTYRRSPSPESKEPGFARGGPFRRCSSLYGRAGAGD
                     AGDAGGGFFGLHSNPGPKAAQARYTTPKGNKYVVFYLDLSFIFLLELKRCSMARGCLQ
                     GVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGNFATLSSSFPSLSAANLLIVTGTFVM
                     AIGFVGCIGALKENKCLLLTFFVLLLLVFLLEATIAVLFFAYSDKIDSYAQQDLKKGL
                     HLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSDSCGLHE
                     PGTWWKSPCYETVKAWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA"
     exon            487..678
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..753
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     exon            754..855
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     exon            856..987
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1071
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1614
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1555..1560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /note="hexamer: AATAAA"
     polyA_site      1609
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /note="major polyA site"
     polyA_site      1614
                     /gene="Tspan4"
                     /gene_synonym="D130042I01Rik; NAG-2; Tm4sf7; Tspan-4"
                     /note="major polyA site"
ORIGIN      
        1 gctgctaccg cgggtccggg gaggtgcggg agctcgccgg cgtggtgcgg atggagcgtc
       61 cggtagccac gggtgcagag cgctgacaac gactgtagcc agtgagcgtg gcggcggggg
      121 cccagcctcc ccaccgcgat gcgccgctcc agcacggacg aatccacgta ccggcgcagc
      181 ccttctccgg agagcaagga gccaggcttt gcgcgcggcg gcccctttcg gcgctgcagc
      241 agcctgtatg ggcgcgcggg cgccggggac gcgggggatg ctggcggcgg cttcttcggc
      301 ctgcactcga acccgggccc caaggcagcc caggcgcgct atacaacgcc caagggcaac
      361 aagtatgtgg tcttctacct agacctctcc ttcatcttcc ttctagagct gaagcgctgc
      421 agcatggcgc gcggctgcct ccagggcgtc aagtacctca tgttcgcctt caacctgctc
      481 ttctggctgg gtggctgtgg tgtcctgggt gttggcatct ggttggctgc cacacaggga
      541 aactttgcca ccttatcatc ctcatttcca tccttgtcgg ctgccaacct gctcatcgtc
      601 accgggacct tcgtcatggc catcggcttc gtgggctgca ttggggccct caaggagaac
      661 aagtgcctac tgctcacttt ctttgtgctg ctgctgctag tgttcctgct ggaagccacc
      721 attgctgtgc tcttctttgc ctacagtgac aagattgaca gttatgccca acaagacctg
      781 aagaagggcc tgcatctgta tggcacacag ggcaacgtgg gcctcaccaa tgcctggagc
      841 atcatccaga ctgatttccg atgctgtgga gtttccaatt acactgattg gtttgaggta
      901 tacaatgcca ctcgtgtgcc tgactcctgc tgtctggagt tcagtgatag ctgtgggtta
      961 catgaacctg gtacctggtg gaagtcgccc tgttatgaga cagtgaaggc ctggctccag
     1021 gagaacctgc tagctgtggg catctttgga ctgtgcacgg cactggtgca gattctgggc
     1081 ctcaccttcg ctatgaccat gtactgccag gtggtaaagg cggacaccta ctgtgcatag
     1141 gtctcacagc ctctgcttct ctgccaaagg acccgcccac gggaaggaag atgtccaaac
     1201 ccgctccccc tgcaggactg gtgttctgct gaatgcaggg ggaagagctg gaggccagag
     1261 cacccagcat ccatccctgc acctgagggc actctgcttg ggtggcagca gacaccagac
     1321 tatagagttg gtgccaaatg gcacccaggg ctaagggccc agggaacttt gacacttttt
     1381 atatccatat ataccttcca gtgttcacac aggatggggt tcccagcctt gcatggttgc
     1441 taggttgggg gcaggcccag tctgctcaag gcccacgatg atcttggtgc tccaggcagg
     1501 gccaggtccc atgatccaca ttccatgaca gtgtcgtggt tccagatgca tcttaataaa
     1561 gtgtgtgagc agactgtggg tcttgccaac acacaaaggt tgtacagcct tcaa
//
