LOCUS       NM_019793               1747 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tetraspanin 3 (Tspan3), mRNA.
ACCESSION   NM_019793
VERSION     NM_019793.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Xing,W., Pourteymoor,S., Kesavan,C., Gomez,G.A. and Mohan,S.
  TITLE     Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced
            Trabecular Bone Mass Caused by Decreased Osteoblast Functions
  JOURNAL   Cells 11 (6), 977 (2022)
   PUBMED   35326428
  REMARK    GeneRIF: Mice with Targeted Knockout of Tetraspanin 3 Exhibit
            Reduced Trabecular Bone Mass Caused by Decreased Osteoblast
            Functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Lindsey,R.C., Xing,W., Pourteymoor,S., Godwin,C., Gow,A. and
            Mohan,S.
  TITLE     Novel Role for Claudin-11 in the Regulation of Osteoblasts via
            Modulation of ADAM10-Mediated Notch Signaling
  JOURNAL   J Bone Miner Res 34 (10), 1910-1922 (2019)
   PUBMED   31112308
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Seipold,L., Damme,M., Prox,J., Rabe,B., Kasparek,P., Sedlacek,R.,
            Altmeppen,H., Willem,M., Boland,B., Glatzel,M. and Saftig,P.
  TITLE     Tetraspanin 3: A central endocytic membrane component regulating
            the expression of ADAM10, presenilin and the amyloid precursor
            protein
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (1), 217-230 (2017)
   PUBMED   27818272
  REMARK    GeneRIF: Tspan3 is a central endocytic membrane component
            regulating the expression of ADAM10, presenilin and the amyloid
            precursor protein.
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Kwon,H.Y., Bajaj,J., Ito,T., Blevins,A., Konuma,T., Weeks,J.,
            Lytle,N.K., Koechlein,C.S., Rizzieri,D., Chuah,C., Oehler,V.G.,
            Sasik,R., Hardiman,G. and Reya,T.
  TITLE     Tetraspanin 3 Is Required for the Development and Propagation of
            Acute Myelogenous Leukemia
  JOURNAL   Cell Stem Cell 17 (2), 152-164 (2015)
   PUBMED   26212080
  REMARK    GeneRIF: Tspan3 is an important regulator of aggressive leukemias.
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Tokoro,Y., Shibuya,K., Osawa,M., Tahara-Hanaoka,S., Iwama,A.,
            Kitamura,T., Nakauchi,H. and Shibuya,A.
  TITLE     Molecular cloning and characterization of mouse Tspan-3, a novel
            member of the tetraspanin superfamily, expressed on resting
            dendritic cells
  JOURNAL   Biochem Biophys Res Commun 288 (1), 178-183 (2001)
   PUBMED   11594770
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Tiwari-Woodruff,S.K., Buznikov,A.G., Vu,T.Q., Micevych,P.E.,
            Chen,K., Kornblum,H.I. and Bronstein,J.M.
  TITLE     OSP/claudin-11 forms a complex with a novel member of the
            tetraspanin super family and beta1 integrin and regulates
            proliferation and migration of oligodendrocytes
  JOURNAL   J Cell Biol 153 (2), 295-305 (2001)
   PUBMED   11309411
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Puls,K.L. and Wright,M.D.
  TITLE     The molecular characterisation of mouse tspan-3
  JOURNAL   DNA Seq 11 (3-4), 271-275 (2000)
   PUBMED   11092739
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855376.1, AK159418.1 and BC043072.1.
            
            On Jul 18, 2009 this sequence version replaced NM_019793.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043072.1, AK159324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BB855376.1         2-58
            58-1727             AK159418.1         2-1671
            1728-1747           BC043072.1         1706-1725
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..1747
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /note="tetraspanin 3"
                     /db_xref="GeneID:56434"
                     /db_xref="MGI:MGI:1928098"
     exon            1..271
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            272..463
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            464..538
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            539..640
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            641..793
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            794..877
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1729
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1708..1713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /note="hexamer: AATAAA"
     polyA_site      1729
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggga cttagttgcc tgggaacggc ctagggggcc tgcggcgggc tgcacgcagc
       61 tgcgaggtgc ttgctggggc ggcgcggggg tctgcgggaa cgcggctcgg gcccagcagt
      121 tctcagcaga gccgccggcg ccattgcctt ctcgctcggt gagcgccgct ccgctcgccc
      181 agccgggcct ccgccggccg ccggcaccat gggccaatgc ggcatcacct cctctaagac
      241 cgtgctggtc ttcctcaacc tcatcttctg gggggcagct ggcatcctct gctacgtggg
      301 agcctatgtc ttcatcacct atgacgacta tgaccacttc ttcgaggatg tgtacacgct
      361 cttccctgcc gtggtgatca tagctgtagg agccttgctt ttcatcattg gcctgatcgg
      421 ctgctgtgct acaatccggg agagccgctg tggacttgcc acgtttgtct tcatcctgct
      481 cttggttttc gtcacagaag tggttgttgt ggttttggga tacgtgtaca gagcaaaggt
      541 ggagaacgag gttgatcgca gcattcagaa agtgtataag acctacaacg ggaccaactc
      601 cgacgctgcc agccgtgcta ttgactatgt gcagagacag ttgcactgtt gtggaattca
      661 taactattca gactgggaaa atacagattg gttcaaagaa acaaaaaacc agagtgtccc
      721 tcttagctgc tgcagagaga ctgccaaaag ctgtaacggc agcctggcca acccctctga
      781 cctctacgcc gagggctgtg aggctcttgt tgtgaagaag ctacaagaaa tcttgatgca
      841 tgttatctgg gcagcgttgg cctttgcagc tattcagctg ctgggcatgc tgtgcgcatg
      901 catcgtgttg tgcagacgga gtagagatcc tgcctatgag ctcctcatca ctggcggaac
      961 ctacgcgtag cggacagcac gtgcctgagc taatttgtag tatccttgtt ctgattcaga
     1021 aggtgaattg agcaggcctg cagcagttgg ctcctgagtt catctagtca aagcacacgt
     1081 acactggtgt tgactagcag gttggcattt catgtaccca ccttcctacc tgcccctctg
     1141 gctttcttac ccttgttcta gatgattctc catgccctta atttcagaac catttacaag
     1201 ttctgtaatg tggtagagct ataggagggt gtggcctgct tctgtcacct ctgaggagta
     1261 atggactgtg ttgtggtatc actgggccct tttcgtcttc ataacgagaa ctcttggcca
     1321 aaggtttgag ggtaaagagg gaggacgcca gctgtctggt gccgcacacc agtgtccttt
     1381 taaagaatat atactgtagt acaataatat agcaattgta caaaatggct aacatagatt
     1441 ttagaatcaa acagtatgtg tctttgttca tcttcaaaat cagagactga tctttgaaat
     1501 tagtggtttt taatcaaagc tggctttata ggaagactat aatgtatgca ctactgtttt
     1561 aaagcagttg gtgtgagtgt gtgcgtttct ctgtgtgatt gaacccattc atcataagtc
     1621 ttacactcgt tagagataat gtacccatgg agactagcaa aatagtatgt agatgtgatc
     1681 tcaattgtaa atagaaaaat ttaattcaat aaactctgta tcagccctaa aaaaaaaaaa
     1741 aaaaaaa
//
