LOCUS       NP_062767                253 aa            linear   ROD 05-JUN-2024
DEFINITION  tetraspanin-3 [Mus musculus].
ACCESSION   NP_062767
VERSION     NP_062767.3
DBSOURCE    REFSEQ: accession NM_019793.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 253)
  AUTHORS   Xing,W., Pourteymoor,S., Kesavan,C., Gomez,G.A. and Mohan,S.
  TITLE     Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced
            Trabecular Bone Mass Caused by Decreased Osteoblast Functions
  JOURNAL   Cells 11 (6), 977 (2022)
   PUBMED   35326428
  REMARK    GeneRIF: Mice with Targeted Knockout of Tetraspanin 3 Exhibit
            Reduced Trabecular Bone Mass Caused by Decreased Osteoblast
            Functions.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 253)
  AUTHORS   Lindsey,R.C., Xing,W., Pourteymoor,S., Godwin,C., Gow,A. and
            Mohan,S.
  TITLE     Novel Role for Claudin-11 in the Regulation of Osteoblasts via
            Modulation of ADAM10-Mediated Notch Signaling
  JOURNAL   J Bone Miner Res 34 (10), 1910-1922 (2019)
   PUBMED   31112308
REFERENCE   3  (residues 1 to 253)
  AUTHORS   Seipold,L., Damme,M., Prox,J., Rabe,B., Kasparek,P., Sedlacek,R.,
            Altmeppen,H., Willem,M., Boland,B., Glatzel,M. and Saftig,P.
  TITLE     Tetraspanin 3: A central endocytic membrane component regulating
            the expression of ADAM10, presenilin and the amyloid precursor
            protein
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (1), 217-230 (2017)
   PUBMED   27818272
  REMARK    GeneRIF: Tspan3 is a central endocytic membrane component
            regulating the expression of ADAM10, presenilin and the amyloid
            precursor protein.
REFERENCE   4  (residues 1 to 253)
  AUTHORS   Kwon,H.Y., Bajaj,J., Ito,T., Blevins,A., Konuma,T., Weeks,J.,
            Lytle,N.K., Koechlein,C.S., Rizzieri,D., Chuah,C., Oehler,V.G.,
            Sasik,R., Hardiman,G. and Reya,T.
  TITLE     Tetraspanin 3 Is Required for the Development and Propagation of
            Acute Myelogenous Leukemia
  JOURNAL   Cell Stem Cell 17 (2), 152-164 (2015)
   PUBMED   26212080
  REMARK    GeneRIF: Tspan3 is an important regulator of aggressive leukemias.
REFERENCE   5  (residues 1 to 253)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   6  (residues 1 to 253)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   7  (residues 1 to 253)
  AUTHORS   Tokoro,Y., Shibuya,K., Osawa,M., Tahara-Hanaoka,S., Iwama,A.,
            Kitamura,T., Nakauchi,H. and Shibuya,A.
  TITLE     Molecular cloning and characterization of mouse Tspan-3, a novel
            member of the tetraspanin superfamily, expressed on resting
            dendritic cells
  JOURNAL   Biochem Biophys Res Commun 288 (1), 178-183 (2001)
   PUBMED   11594770
REFERENCE   8  (residues 1 to 253)
  AUTHORS   Tiwari-Woodruff,S.K., Buznikov,A.G., Vu,T.Q., Micevych,P.E.,
            Chen,K., Kornblum,H.I. and Bronstein,J.M.
  TITLE     OSP/claudin-11 forms a complex with a novel member of the
            tetraspanin super family and beta1 integrin and regulates
            proliferation and migration of oligodendrocytes
  JOURNAL   J Cell Biol 153 (2), 295-305 (2001)
   PUBMED   11309411
REFERENCE   9  (residues 1 to 253)
  AUTHORS   Puls,K.L. and Wright,M.D.
  TITLE     The molecular characterisation of mouse tspan-3
  JOURNAL   DNA Seq 11 (3-4), 271-275 (2000)
   PUBMED   11092739
REFERENCE   10 (residues 1 to 253)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855376.1, AK159418.1 and BC043072.1.
            
            On Jul 18, 2009 this sequence version replaced NP_062767.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043072.1, AK159324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     Protein         1..253
                     /product="tetraspanin-3"
                     /EC_number="2.7.10.2"
                     /note="transmembrane 4 superfamily member 8; tetraspanin
                     TM4-A homolog; H41D4 protein; OAP-1; OSP-associated
                     protein 1"
                     /calculated_mol_wt=27918
     Region          9..235
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Site            12..32
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            51..71
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            86..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY33.1)"
     Region          104..210
                     /region_name="TM4SF8_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), TM4SF8_like subfamily.
                     Tetraspanins are trans-membrane proteins with 4
                     trans-membrane segments. Both the N- and C-termini lie on
                     the intracellular side of the membrane. This alignment...;
                     cd03163"
                     /db_xref="CDD:239416"
     Site            order(106,111,115,117..118,121,137,140..141,144..145)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239416"
     Site            127
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            152
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            183
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QY33.1)"
     Site            213..233
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY33.1)"
     CDS             1..253
                     /gene="Tspan3"
                     /gene_synonym="1700055K04Rik; TM4-A; Tm4sf8"
                     /coded_by="NM_019793.3:209..970"
                     /db_xref="CCDS:CCDS23207.1"
                     /db_xref="GeneID:56434"
                     /db_xref="MGI:MGI:1928098"
ORIGIN      
        1 mgqcgitssk tvlvflnlif wgaagilcyv gayvfitydd ydhffedvyt lfpavviiav
       61 gallfiigli gccatiresr cglatfvfil llvfvtevvv vvlgyvyrak venevdrsiq
      121 kvyktyngtn sdaasraidy vqrqlhccgi hnysdwentd wfketknqsv plsccretak
      181 scngslanps dlyaegceal vvkklqeilm hviwaalafa aiqllgmlca civlcrrsrd
      241 payellitgg tya
//
