LOCUS       NM_183180               3773 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tetraspanin 18 (Tspan18), mRNA.
ACCESSION   NM_183180 XM_001004200 XM_001004204
VERSION     NM_183180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Gavin,R.L., Koo,C.Z. and Tomlinson,M.G.
  TITLE     Tspan18 is a novel regulator of thrombo-inflammation
  JOURNAL   Med Microbiol Immunol 209 (4), 553-564 (2020)
   PUBMED   32447449
  REMARK    GeneRIF: Tspan18 is a novel regulator of thrombo-inflammation.
            Review article
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Noy,P.J., Gavin,R.L., Colombo,D., Haining,E.J., Reyat,J.S.,
            Payne,H., Thielmann,I., Lokman,A.B., Neag,G., Yang,J., Lloyd,T.,
            Harrison,N., Heath,V.L., Gardiner,C., Whitworth,K.M., Robinson,J.,
            Koo,C.Z., Di Maio,A., Harrison,P., Lee,S.P., Michelangeli,F.,
            Kalia,N., Rainger,G.E., Nieswandt,B., Brill,A., Watson,S.P. and
            Tomlinson,M.G.
  TITLE     Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von
            Willebrand factor release in endothelial cells
  JOURNAL   Haematologica 104 (9), 1892-1905 (2019)
   PUBMED   30573509
  REMARK    GeneRIF: The findings identify Tspan18 as a novel regulator of
            endothelial cell Orai1/Ca2+ signaling and von Willebrand factor
            release in response to inflammatory stimuli.
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 3773)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   9  (bases 1 to 3773)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   10 (bases 1 to 3773)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB659903.1, BC052169.1 and AL691472.6.
            
            On Oct 27, 2007 this sequence version replaced NM_183180.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.398519.1,
                                           SRR12282455.37866310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BB659903.1         2-38
            38-2234             BC052169.1         1-2197
            2235-2320           AL691472.6         8053-8138           c
            2321-3773           BC052169.1         2198-3650
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.37 cM"
     gene            1..3773
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /note="tetraspanin 18"
                     /db_xref="GeneID:241556"
                     /db_xref="MGI:MGI:1917186"
     exon            1..216
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            217..297
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            298..379
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            380..452
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1136
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /note="tspan-18"
                     /codon_start=1
                     /product="tetraspanin-18"
                     /protein_id="NP_899003.1"
                     /db_xref="CCDS:CCDS38182.1"
                     /db_xref="GeneID:241556"
                     /db_xref="MGI:MGI:1917186"
                     /translation="MEGDCLSCMKYLMFVFNFFVFLGGACLLGVGIWVLVDPTGFREI
                     VATNPLLTTGAYIVLAMGGLLFLLGFLGCCGAVRENRCLLLFFFLFILIIFLVELSAA
                     ILAFIFREHLTREFFTKELTKHYQGDNDTDVFSATWNSVMITFGCCGVNGPEDFKLAS
                     VFRLLTLDTEEVPKACCRREPQTRDGVVLSREECQLGRNPFINKQGCYTVILNTFETY
                     VYLAGAFAIGVLAIELFLMVFAMCLFRGIQ"
     exon            453..647
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            648..722
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            723..821
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1004
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1088
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..3751
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /note="hexamer: TATAAA"
     polyA_site      3751
                     /gene="Tspan18"
                     /gene_synonym="2610042G18Rik; 6720430O15"
                     /note="major polyA site"
ORIGIN      
        1 gtctcagggg ctgcaagctg caggcggacg caacgctgtg cgattccgaa gcccagccac
       61 gccaggccgc ccggccctgg cccccagcgg gcgtcgccgc tccttgtcgc tttgacgcct
      121 agcccagcgc cgcggcgcag gactaccggt gccccgcaag ttgcgagcgc actctgcgcc
      181 tggggaaact ttaccccgcg gccgagcctc tgccagagtt gccccaaagc tgtcatcagg
      241 agacttcaaa aggatctctc cgttccttcc cagaaaggaa aaggacagct ggaagaggac
      301 aagctgggct gctgagagac atacctgaga ccctctaact aagagattgc atcctgttga
      361 ctcctgaaga gctgcccagg tgaagaacca tggagggcga ctgtctgagc tgcatgaagt
      421 atctgatgtt tgttttcaat ttcttcgttt ttctgggagg cgcttgcctg ctaggtgttg
      481 gcatctgggt cctggtggac cccaccggct tccgagaaat cgtggctacc aaccccctgc
      541 tgaccaccgg tgcctacatc gtactggcca tgggtggtct gctgtttctt ctgggcttcc
      601 tgggctgctg cggggctgtc cgagagaaca ggtgtctgct gctatttttc ttcctgttta
      661 tcctgatcat cttcctggta gagctctcag cagccatcct ggccttcatc ttcagagaac
      721 acctcacccg agagttcttc accaaggagc ttaccaagca ctaccaaggc gataacgata
      781 cggatgtttt ctctgccacc tggaattcag tcatgatcac atttggctgc tgtggggtca
      841 acggacctga agacttcaag ctggcctccg tgtttcggct gctgacgctg gacactgagg
      901 aggtgcccaa ggcttgctgt cggagggaac cccagactcg agatggagtg gtgctgagca
      961 gggaggagtg ccagctggga cggaatccgt tcataaacaa gcagggctgt tatacagtga
     1021 tcctcaacac cttcgaaacc tatgtctacc tggccggagc ctttgccatt ggagtactgg
     1081 ctattgagct cttcctcatg gtctttgcca tgtgcctctt ccggggcatc cagtaggcct
     1141 tggcctgaag acactcagcc caccactgcc cagaagccag ccccttctct tccctgtcct
     1201 ctggccccag gggcggaagc aaggccagcc caaacggcca gaagcataga gctaattttt
     1261 aaataaacaa acaaacaaac aaaaaagaca gacatgaagg ggcctcacct aggctctaaa
     1321 gcaaggggca tgggctctac aaggacctag ggctggcctg ggaccagctg ttcctgagac
     1381 caaaggttca tcagcctcag agccccttgg ccctgtcaga ctggagtgtc ccttggcccg
     1441 gatcacctct cttagcattt ccaggatcag agcaaccagg aggtagaaac acatcctgga
     1501 ggaggagccc ggtcctcagg ccccaaggag ccggcttttc acaacacaag gacagactct
     1561 gcagcaccat ctgctggaga gcgaagcggt ccctgctccc gctggctgag ggtggctgtg
     1621 tgtggacact ggatcagaag gtggcccttt catttccgtc cagtcacaca gcatgtgcat
     1681 gacaaggtca tctccaggct gctgtcgctc cagccaggac tccaccccga tgtaaactgg
     1741 ccaggaactg cctgcatcca gctctacagt ccgtactgtg tccactctgc cctgcttgta
     1801 cctctgtcag agatccaact gtgatacatc acctgtcccc gtgggccatg ccccacccct
     1861 gttctcccag gtggaagaca ccccagtatt gttcatttct ctctttctac ccagagctga
     1921 ggcttgaatg tgttcttcaa ggtccctgcc aagaattcac ccctgcatcc ctccacatac
     1981 ggatggatct cactacctcc caactcagcc tcctgccttc agatgctctg atgtcaccat
     2041 cacctccgca gacagaaggg gtttccattt ttccgtctgt gtaccccttc actctctctc
     2101 ctttctagag gttaaggtca tgcctcttgt ctgcagactt aaccccacag catctcctac
     2161 cgtgacacct tctgaccttt tgctgaacat ttattttgtt agtctctcta ggctcagatt
     2221 acccagacta ataggttcac aaccaaccaa ccaaccaaca gacacacaca cacacacaca
     2281 cacacacaca cacacacaca caaacacccc agactaatag gttcacaacc aaccaaccaa
     2341 ccaacagaca cacacacaca cacacacaca cacacacaca aacaaacacc ccagactaat
     2401 aggttcacaa ccaaccaacc aaccaacacc cccccacaca cacacacaca cacacacaaa
     2461 cttgaactgc aggctaggtt agcaactagt tgcaagatgc ctgaccctgc caggaccgtg
     2521 ttgaatccat tagtgttgtc tgtcaggatc tcaaatttga ttaattatgt ctgccaaggg
     2581 cacaaaaggg gaacagtggt ggaaggaaca gctaggtgtc tgctctcctc tctcagatgg
     2641 aagagcctga cctgaactcc agccttcctt tgcccttctg ccacctggga gtcatagcca
     2701 tagcctgttc tattctgctg tctgggtgca aggggggcta cttctcccat tttctctcct
     2761 ctttatgtgg tcctcaccca gcctggcctt ccggggagtg ggtgtctctg aatgctatac
     2821 ggaagttgtc tttatgacag cttaattggc atccccatag taagctccct agaggctgag
     2881 tcaccagatc agggggcccc tctgctggct tgcaccccca gactaagagg acccaggctg
     2941 actcagaacc cagcacgtac tggactccaa ctgtctagga aggcaaatgg cttggctatt
     3001 gattggaagt tcatggctag gttgaggact tagcccaacc acagcggctg ccacccagaa
     3061 ctagcccagg cttccagaga tgggcagggc tgggacaggg agggactgag aagccagata
     3121 tggagcctag gcaattccag ggcagatcag agtccctcac cagaactttc cacacttacg
     3181 ctgaagcgct cccaagtagc cctgattcaa cccagcttct cagcatcctc atggggccag
     3241 acagacacag tcttcaccct ctgagcttgc tggtagccat tgcaaggctg tctgaggtca
     3301 tcctggtggg gcttggtgag ctgctctgtg tactcccaga ggaatggagg ggagctcttc
     3361 cttcacccca agatgcctca gccagtagtg agcagaacag ccacttcctg tcccagagca
     3421 gtggcctaag ggacagctgt atctgacagg cgaggagcta agactggacc tgtggctcat
     3481 gctccccatt atcctgtccc aagcccctgg cctacctggg ttctgaaccc agcaccttca
     3541 tccccaggaa ctctgataca cacacacaca cacacacaca cacacacaca cacacacaca
     3601 cacacacgtc atatgctaaa gtctattttg gaatttgtaa atgtcccttg cagtaggaaa
     3661 cagagctaat ttatcattgt atctcccaag tctccccttt ttatattcta tattaagaga
     3721 aattttgtaa tataaaacag gacaccacgc aaaaaaaaaa aaaaaaaaaa aaa
//
