LOCUS       NM_028841               1567 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tetraspanin 17 (Tspan17), mRNA.
ACCESSION   NM_028841
VERSION     NM_028841.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Mearini,G., Gedicke,C., Schlossarek,S., Witt,C.C., Kramer,E.,
            Cao,P., Gomes,M.D., Lecker,S.H., Labeit,S., Willis,M.S.,
            Eschenhagen,T. and Carrier,L.
  TITLE     Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different
            mechanisms
  JOURNAL   Cardiovasc Res 85 (2), 357-366 (2010)
   PUBMED   19850579
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY734818.1, AK008761.1, AI019499.1 and CD740983.1.
            
            On Dec 3, 2009 this sequence version replaced NM_028841.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010346.1, AK171691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY734818.1         1-56
            57-832              AK008761.1         2-777
            833-928             AI019499.1         304-399
            929-1549            AK008761.1         874-1494
            1550-1567           CD740983.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.41 cM"
     gene            1..1567
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /note="tetraspanin 17"
                     /db_xref="GeneID:74257"
                     /db_xref="MGI:MGI:1921507"
     exon            1..277
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1003
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /EC_number="3.6.5.3"
                     /note="F-box only protein 23; transmembrane 4 superfamily
                     member 17; tspan-17; tetraspan protein SB134"
                     /codon_start=1
                     /product="tetraspanin-17"
                     /protein_id="NP_083117.2"
                     /db_xref="CCDS:CCDS26536.1"
                     /db_xref="GeneID:74257"
                     /db_xref="MGI:MGI:1921507"
                     /translation="MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWG
                     EKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGL
                     IFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDLDLQNLIDFAQEYWSCCGARG
                     PNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQQGSI
                     YTKGCVGQFEKWLQDNLIVVAGVLVGIALLQIFGLCLAQNLVSDIKAVKANW"
     exon            278..328
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            329..475
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            476..646
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            647..772
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            773..820
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            821..937
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1556
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /note="hexamer: AATAAA"
     polyA_site      1556
                     /gene="Tspan17"
                     /gene_synonym="2210021G21Rik; Fbxo23; Tm4sf17"
                     /note="major polyA site"
ORIGIN      
        1 actccgggtg tggctgtccg agcgccgtgg gcggtgccac agcgggcggg gcagccggtg
       61 agctgtgtgg ctttgaccat gaagccgcag ccaccgggct aggcccgggg ctgctccagg
      121 cctgggcggc ccgcagaggg ctgggccggt caccggctcg ggttcccggg acggcaggtg
      181 gccgctcacc atgcccggca agcaccagca attccaggac cctgaggtcg gctgctgcgg
      241 gaaatacttc ctgtttggct tcaacattgt cttctgggtg ctgggagccc tgttcctggc
      301 cattggcctc tgggcctggg gtgagaaggg cgttctctcc aacatctcgg cgctgacaga
      361 tctgggcggt cttgaccccg tgtggctgtt tgtggtggtg gggggagtca tgtcagtgtt
      421 gggcttcgcc ggctgcattg gggccctccg ggaaaacacc ttcctgctca agttcttctc
      481 tgtgttcctc ggcctcatct tcttcctgga gctggccgcg gggatcctgg ccttcgtctt
      541 caaggattgg atccgagacc aacttaatct cttcatcaac aacaatgtca aagcctaccg
      601 ggatgatctc gaccttcaga accttatcga ctttgctcag gaatactggt cttgctgtgg
      661 tgcccgaggg cccaatgact ggaacctcaa tatctacttc aactgcactg acttgaaccc
      721 aagccgtgag cgctgtgggg tgcccttttc ctgctgtgtt agggacccag cggaagatgt
      781 cctcaatacc cagtgtggct atgacatccg actcaaactg gagctcgagc agcagggctc
      841 catctacacc aaaggctgtg tgggccagtt tgagaagtgg ctacaagaca acctgatcgt
      901 ggtggccggg gtcttggtgg ggatcgccct cctccagata tttggcctct gcttggccca
      961 gaacctcgtg agtgacatca aggcggtgaa ggccaactgg tgaggctgcc aggggtgatg
     1021 gccatgtgcc tggcccgtgg ggctctagtg ggggcctccc aggacactct gcctcgctca
     1081 caatggcaag gcctgtggga cgtctgttac gacctgagcc ggaggttttg tgaccttggt
     1141 gctcattacc cactgaggaa accattgggg actagactgg ggctgtttgc cacagagctc
     1201 tgtgtcgggg gtgtgtacct gtgtgtgtgc atgcacactc gtaagtgcac ctggagtctc
     1261 taccctgctg ctgtgaggtg gtggcccttc cagagctcgt gggggggggg cagatggagg
     1321 gtagggcagg cacctgtgtc ccctggtcta ctgtgggatg tatctgtgtg tggcttagga
     1381 gcctgctgtc tcagacctct ccatactcac catgactttg agcctgcctg gagcttgtct
     1441 tggcctcagt gtcacagcct ctgaaatggg tccaagaatt ctctctctcg cttgcctctc
     1501 aggatcacac ttggcgatgg ctacaaacga ctcaataaac aacactttga aaaacaaaaa
     1561 aaaaaaa
//
