LOCUS       NM_197996               3605 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tetraspanin 15 (Tspan15), mRNA.
ACCESSION   NM_197996 XM_286253
VERSION     NM_197996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3605)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3605)
  AUTHORS   Koo,C.Z., Harrison,N., Noy,P.J., Szyroka,J., Matthews,A.L.,
            Hsia,H.E., Muller,S.A., Tushaus,J., Goulding,J., Willis,K.,
            Apicella,C., Cragoe,B., Davis,E., Keles,M., Malinova,A.,
            McFarlane,T.A., Morrison,P.R., Nguyen,H.T.H., Sykes,M.C., Ahmed,H.,
            Di Maio,A., Seipold,L., Saftig,P., Cull,E., Pliotas,C.,
            Rubinstein,E., Poulter,N.S., Briddon,S.J., Holliday,N.D.,
            Lichtenthaler,S.F. and Tomlinson,M.G.
  TITLE     The tetraspanin Tspan15 is an essential subunit of an ADAM10
            scissor complex
  JOURNAL   J Biol Chem 295 (36), 12822-12839 (2020)
   PUBMED   32111735
  REMARK    GeneRIF: The tetraspanin Tspan15 is an essential subunit of an
            ADAM10 scissor complex.
REFERENCE   3  (bases 1 to 3605)
  AUTHORS   Shah,J., Rouaud,F., Guerrera,D., Vasileva,E., Popov,L.M.,
            Kelley,W.L., Rubinstein,E., Carette,J.E., Amieva,M.R. and Citi,S.
  TITLE     A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to
            Promote alpha-Toxin Cytotoxicity
  JOURNAL   Cell Rep 25 (8), 2132-2147 (2018)
   PUBMED   30463011
REFERENCE   4  (bases 1 to 3605)
  AUTHORS   Seipold,L., Altmeppen,H., Koudelka,T., Tholey,A., Kasparek,P.,
            Sedlacek,R., Schweizer,M., Bar,J., Mikhaylova,M., Glatzel,M. and
            Saftig,P.
  TITLE     In vivo regulation of the A disintegrin and metalloproteinase 10
            (ADAM10) by the tetraspanin 15
  JOURNAL   Cell Mol Life Sci 75 (17), 3251-3267 (2018)
   PUBMED   29520422
  REMARK    GeneRIF: Data show that tetraspanin15 (Tspan15) is abundantly
            expressed in brain, where it specifically interacts with endogenous
            a disintegrin and metalloproteinase 10 (ADAM10).
REFERENCE   5  (bases 1 to 3605)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   6  (bases 1 to 3605)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
REFERENCE   7  (bases 1 to 3605)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX206586.1, CN455615.1 and AC127417.3.
            
            On Jul 14, 2006 this sequence version replaced NM_197996.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172169.1, SRR17784643.1121730.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               CX206586.1         1-575
            576-872             CN455615.1         465-761
            873-3605            AC127417.3         120563-123295       c
FEATURES             Location/Qualifiers
     source          1..3605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.36 cM"
     gene            1..3605
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="tetraspanin 15"
                     /db_xref="GeneID:70423"
                     /db_xref="MGI:MGI:1917673"
     exon            1..199
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..988
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="transmembrane 4 superfamily member 15; tspan-15"
                     /codon_start=1
                     /product="tetraspanin-15"
                     /protein_id="NP_932113.2"
                     /db_xref="CCDS:CCDS56705.1"
                     /db_xref="GeneID:70423"
                     /db_xref="MGI:MGI:1917673"
                     /translation="MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGGLVLSVGIY
                     AEAERQKYKTLESAFLAPAIILILLGVVMFIVSFIGVLASLRDNLCLLQSFMYILGIC
                     LVMELIGGIVALIFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDY
                     RDWSKNQYHDCSAPGPLACGVPYTCCIRNTTDVVNTMCGYKTIDKERLNAQNIIHVRG
                     CTNAVLIWFMDNYTIMAGLLLGILLPQFLGVLLTLLYITRVEDIILEHSVTDGLLGPG
                     AKSRTDTAGTGCCLCYPD"
     exon            200..385
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            386..460
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            461..556
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            557..673
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            674..721
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            722..838
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     exon            839..3605
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="major polyA site"
     regulatory      3115..3120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="hexamer: ATTAAA"
     polyA_site      3138
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
     regulatory      3584..3589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
                     /note="hexamer: AATAAA"
     polyA_site      3605
                     /gene="Tspan15"
                     /gene_synonym="1110036D12Rik; 2700063A19Rik; Tm4sf15"
ORIGIN      
        1 gggagagagc gcgggtggcg ggccaggccg cgggacagcc gcaggtgggg cctggagcgg
       61 tggccggatc gaggcagccc cgcagccccg cgcgggagcc aagatgcctc gcggggactc
      121 ggagcaggtg cgctactgcg cgcgcttctc ctatctttgg ctcaagttct ctctcatcat
      181 ctactccacc gtgttctggc tgattggggg cctggtcctg tcagtgggga tctacgcaga
      241 ggcagagcgg cagaaataca aaaccctgga gagtgccttc ctggcccccg ccatcatcct
      301 catcctcctg ggggtggtca tgttcatcgt ctccttcatc ggggtgctgg cttccctccg
      361 ggacaacctg tgccttctgc agtcgtttat gtatatcctg gggatctgcc tggtcatgga
      421 gcttattggt ggcatagtgg ctttgatctt ccggaaccag actattgact ttctgaacga
      481 caacatccgg agaggaatcg agaattacta cgatgatctg gacttcaaga acatcatgga
      541 ctttgttcag aagaagttca agtgctgtgg cggggaggac tacagagact ggagcaaaaa
      601 ccagtaccat gactgcagcg cccccgggcc cctggcctgc ggggtgccct acacctgctg
      661 catcaggaac acgacagatg ttgtcaacac catgtgtggc tacaaaacaa tcgacaagga
      721 gcgcctgaat gcacagaaca tcattcacgt gcggggctgc accaacgccg tgttgatatg
      781 gttcatggac aactatacca tcatggcggg ccttttactg ggcatcctgc ttcctcagtt
      841 tcttggtgtg ctgctgaccc tactgtacat cacccgtgtg gaggacatta tcttggagca
      901 ctctgtcacg gatggattgc tgggacctgg tgccaagtcc agaacggaca cagcaggcac
      961 tggatgctgc ctgtgctatc ccgattagct atgctgattg agctatcctg gcccggcaca
     1021 gcagctccca gccggactgt actgcaaagt gcatctaaga ctacacaagc tggacaggac
     1081 cagctgcagc tcctctgccc acccacggcg ctgaccaaag cccagggtgt atgtacctgc
     1141 gtatagtgtc tgatggccac tcctcctagg ggaaagctga accctgtggg atcccgggaa
     1201 cagggatagc ccagctccgg ttctgagtcc tggagaaggc agctcagggc tccgtgtggg
     1261 ctctttttct ttctggcagt gccttggcca gtggtcatta tgccccttca agggcagttt
     1321 tgcagtgatt atttttaaag gcaagaaggg agtgtatctg ttctataggg aagtcctggg
     1381 tgcagccctg gtacactact ctagatgtga cgttggactg tgtctcaaat tcccaggtgc
     1441 cttgagtcct ctgtaaggct cctgctttgc ccacccattt tctacatatg ttttttttct
     1501 tttttttttt aataaccgtg ttttgtatac aattaacaag agtttctggc tattcaaaac
     1561 tagccacccc tgaccgagtc cactcacccc tccccgttag ttcattaatt gaacaataaa
     1621 tatgtgtttt ggggggtggt cttttatttg tgttgtttgg aagtctcttg tcagattgag
     1681 agaaggctgc cccggggtga agattggtat aacttggggc gctggggtca gggagaaaga
     1741 atggacagca ttcgtatttc acactctatg ggaaactaat agtaagactt aagagtccat
     1801 ggttacatgg agaagtagct gagtccaggg ctcctgtagg agaatggtat cacaagtcta
     1861 cccgtgttat agaaagtaac cgaggtaggg ctctgtaggg acccatgcca aacaaagctt
     1921 ggtgcttgcc gccccctgct ggagacatcc ggccttgcag gagcagtcgg tccaagtgtc
     1981 accccaaccc tacctgggtt tctaggtttt tctgtgagag ttttagacag ggcaatagat
     2041 ataaaacaag aatctcagac ccagctaagc ctgggttagg gaattcccct caccagggaa
     2101 gcttgtgttc catatgagga agggtggagg cggggcttta aaaagaacac catgaccatg
     2161 aacacaccag aggccagacc taaacattca gcatagacag aaactcttgg tgctcacagc
     2221 tgtttgtggt catccctgta acctcagttt tgtatggaaa cagaggcaca gttaaccaac
     2281 atgttgaggc atgggactgt gtatgaagaa cctctgcttg agttgcgtct gtgtatagac
     2341 agactctccc aggtgtgcga aaccaggcat ggctgggact gctgctcccg tgctccctaa
     2401 ctaatccccc tttggttgtt gagacggggt ctcacgtagc ccaggctggc ctccagctca
     2461 ctgtgtagct gaggatatcc ttaagctcct gattcctggg ctgctttctc gtgaatgctg
     2521 ggatcacggt gagtcccacc actccccgtt tatggaattt ggggcctgaa agctctttat
     2581 ctcgtggctc cactgagccc ctttgatcag ggcacagggc tgggtggtga gccttctggc
     2641 cctggctcta gccatcctca gaatcctgta gtatagcagt atggctgggg cactcagagg
     2701 ggatcagagg ctggtgactc tgtcattctc cctctctctg ccatcaggga tgggggttgg
     2761 tgcctaccca gacccgagtt tctatatgcc ctctgaatga caaagctgtc tcttgcctct
     2821 caagaaaaat aaaaccacag agctttgcca gccggtctcg ggggtcacct gctatggcac
     2881 gtttctgtta cccaatgcca agggtaccat cttgccacct tgtctctcaa gaatagagaa
     2941 taacttcaag gggttggaga gatggctcag tggttaagag cactgactgc tcttccagag
     3001 gtcctgagtt caatccctag cagccacgtg gtggctcaca accatctgta acaggatccg
     3061 atgccttctt ctggtgcatc tgaagacagc gacagtgtat tcataaataa aataattaaa
     3121 tattttctaa aaacccaaca gaatgaccct caaaattagt ccctttcttc actcttcagt
     3181 ttttgaagat ttttgttaca agaaaaatgt gggggctgga gagatggctc agcggttaag
     3241 agcactgact gctctttccg aggtcctgag ttcaattccc agcaaccaca tggtggctca
     3301 caaccatctg taatggacac ccaccctgtt ctggtgtgtc tgaagacagc tacagagtac
     3361 acatatacat aaaataaata aatcttaaaa agaaaaatgt gtttaggaac cctggtttcc
     3421 tgtgaaaatt taaaaaaaaa aaaactgttg aagaaacttc cttttgaaat atgcacagca
     3481 caagtaaata gtaatttgct gagcatgggg gctgatccat gcctgtaatc cagcactcag
     3541 ggggtggagg caggaggatt gtgaggtcaa aacatggacc aaaaataaac cctttcttaa
     3601 attgc
//
