LOCUS       NM_145363               2064 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tetraspanin 10 (Tspan10), mRNA.
ACCESSION   NM_145363
VERSION     NM_145363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Zhou,J., Fujiwara,T., Ye,S., Li,X. and Zhao,H.
  TITLE     Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits
            osteoclastogenesis in vitro
  JOURNAL   Calcif Tissue Int 95 (3), 209-217 (2014)
   PUBMED   24935633
  REMARK    GeneRIF: Tspan-5 and Tspan-10, are up-regulated during osteoclast
            differentiation and knockdown of their expression dramatically
            inhibits osteoclastogenesis
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Garcia-Espana,A., Chung,P.J., Sarkar,I.N., Stiner,E., Sun,T.T. and
            Desalle,R.
  TITLE     Appearance of new tetraspanin genes during vertebrate evolution
  JOURNAL   Genomics 91 (4), 326-334 (2008)
   PUBMED   18291621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK625019.1, AK148326.1 and BY479111.1.
            
            On Sep 28, 2009 this sequence version replaced NM_145363.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript data. The updated start codon appears to be restricted
            to mouse and rat, and it has a weak Kozak signal. It is possible
            that ribosomal leaky scanning may allow the better conserved
            downstream start codon to be used some of the time. There is no
            experimental evidence indicating which start codon is
            preferentially used in vivo.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148326.1, BC019991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               CK625019.1         1-629
            630-1873            AK148326.1         566-1809
            1874-1876           BY479111.1         325-327
            1877-2062           AK148326.1         1810-1995
            2063-2064           BY479111.1         515-516
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.13 cM"
     gene            1..2064
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /note="tetraspanin 10"
                     /db_xref="GeneID:208634"
                     /db_xref="MGI:MGI:2384781"
     exon            1..187
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1147
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /note="oculospanin; tspan-10"
                     /codon_start=1
                     /product="tetraspanin-10"
                     /protein_id="NP_663338.2"
                     /db_xref="CCDS:CCDS25733.2"
                     /db_xref="GeneID:208634"
                     /db_xref="MGI:MGI:2384781"
                     /translation="MMKEEECSPLLSQDTAGREHPLTRNSPPTANIPCPAPWENQKGS
                     WGCRCCPGAKRQASGEGQASSLPLSTGSNCVKYLIFLSNFLFSLPSLLALAAGLWGLT
                     VKRSQGIGWGGPVPTDPMLMLVLGGLVVSVVSLSGCLGAFCENSCLLHWYCGAVLFCL
                     ALEALAGVLMVTLWKPLQDSLKYTLHAAIIHYWDDPDLHFLLDQVQLGLQCCGAVSYQ
                     DWQQNLYFNCSSPGVQACSLPASCCINPQEDGAVVNTQCGFGALGLDQNVAGQVVFLQ
                     GCWPALQEWLRGNTGAIGDCAVAVVMIQGTELLLAACLLRALAVHEAAEDIEAGPL"
     exon            188..819
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /inference="alignment:Splign:2.1.0"
     exon            820..2064
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1648
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /note="major polyA site"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
                     /note="hexamer: AGTAAA"
     polyA_site      1697
                     /gene="Tspan10"
                     /gene_synonym="Ocsp"
ORIGIN      
        1 cactggagga ggagcttgca gctctccagc tctggcttat acagttcaca gagaagccaa
       61 gggacaccgg gacaccgtta ttttaggact gtaacctgtt cagagagacc ctggccactg
      121 ctctccgtgg ttttctccaa ttgtgtggat gatgaaggaa gaagaatgca gccccttgct
      181 gtctcaggac actgctggcc gagagcaccc actcaccagg aacagtccac ctaccgcaaa
      241 tattccatgt ccagcaccct gggagaatca gaaggggtcc tggggctgca ggtgctgtcc
      301 tggagcaaag cgccaggcct caggggaagg ccaggcctcc tccctccccc tttccacagg
      361 gagcaactgt gtcaaatatc tgattttcct ctctaacttc ctcttctcct tgccgtctct
      421 gctggcccta gctgcagggc tctggggcct gactgttaaa aggtctcagg ggattggctg
      481 gggtggaccc gtgcctacag accctatgct gatgctggtg ctgggaggcc tggtggtcag
      541 cgtggtgagc ctgtctggat gtctgggtgc tttctgtgag aatagctgcc tgttgcactg
      601 gtactgtggg gctgtcctct tttgtctggc actggaagcc ctggcagggg ttctcatggt
      661 aaccctctgg aagccactgc aagatagcct gaagtataca cttcatgcag ccatcattca
      721 ctactgggat gacccagacc tgcacttcct cctcgaccaa gtccagctgg ggctgcaatg
      781 ctgtggggca gtatcctacc aggactggca acagaacctg tactttaact gcagctctcc
      841 cggggtgcaa gcctgcagcc ttccagcctc ttgctgcatc aacccccagg aagacggagc
      901 tgtagtgaac acccaatgtg gtttcggagc actgggcctg gaccagaatg tggctggaca
      961 agtagtattc ctgcagggct gctggcctgc gctgcaagaa tggctgcggg ggaatactgg
     1021 tgccataggt gactgtgctg tggccgttgt catgatccaa gggactgaac tcctgttggc
     1081 tgcctgcctg ctaagggccc tggctgtcca cgaggcggca gaggacatag aagcaggccc
     1141 cttgtgagct gctagcacta ccctccccac cgaacagatc tgagaagact gcactgcaga
     1201 gttccaagct tctcctcacc ttccagggaa ggtgacagtg cttcctctcc tggccctggc
     1261 ttctttgcta caactgggat atcagtcccc atgactcacc tagacggcct ctgtgctgct
     1321 ctaatctcac aatttcactc ccgactcctc aggacccagc taagcccagg gctgtctttt
     1381 gcaaaggcca ccctggcagt ctgtgtcaca catacctgcc ttgtgtcccg ctacatggca
     1441 ggagcagcca gggctggggt cttctggttc cagcctcacc caccttccct gatctatctc
     1501 acgctgacta gctctgggtc cccatttcat cactactggc ttttcatggg cctcctcttg
     1561 cttgctggtc ttcggtaaga attagggtaa tgcccagggt ggacttgccc tgtggaaaat
     1621 ttttctggta aaaggaagac tttgcttatt ggtgtgtgca ttcttatttg tatagtaaac
     1681 tacagatctc acactgactg ggactgtctt tccaaaatca aaatggagac aattcctagt
     1741 ttcccagcta gggctgactg cttgcagcag gcaacacagc tctggtttta tctgtagagt
     1801 ttacatgctc agtttatggc tgtctcataa gtggagtctt ttttcttttc tttctatttt
     1861 tttttttttt ttttttggac agagcctcag gtatcgcagg ctagccttga actccctaca
     1921 tagctcagga tgatctgtct tcagcactct cctgcctcca gctctccagt gctcagatta
     1981 caagtgtgga ccaccatgcc tagcacagag ggtccttctg agagtcattt tctggtcatg
     2041 cccaaagaat aaacatttac cctg
//
