LOCUS       NM_016909               2363 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus translin-associated factor X (Tsnax), mRNA.
ACCESSION   NM_016909 XM_916765
VERSION     NM_016909.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Wang,S.H., Cheng,J.Y., Tsai,H.H., Lo,T.C., Hung,J.T., Lin,C.C.,
            Lee,C.W., Ho,Y.H., Kuo,H.H., Yu,A.L. and Yu,J.
  TITLE     Conformational alteration in glycan induces phospholipase Cbeta1
            activation and angiogenesis
  JOURNAL   J Biomed Sci 29 (1), 105 (2022)
   PUBMED   36517806
  REMARK    GeneRIF: Conformational alteration in glycan induces phospholipase
            Cbeta1 activation and angiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Fu,X., Shah,A.P., Keighron,J., Mou,T.M., Ladenheim,B., Alt,J.,
            Fukudome,D., Niwa,M., Tamashiro,K.L., Tanda,G., Sawa,A.,
            Cadet,J.L., Rais,R. and Baraban,J.M.
  TITLE     Elevated body fat increases amphetamine accumulation in brain:
            evidence from genetic and diet-induced forms of adiposity
  JOURNAL   Transl Psychiatry 11 (1), 427 (2021)
   PUBMED   34392304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Park,A.J., Shetty,M.S., Baraban,J.M. and Abel,T.
  TITLE     Selective role of the translin/trax RNase complex in hippocampal
            synaptic plasticity
  JOURNAL   Mol Brain 13 (1), 145 (2020)
   PUBMED   33172471
  REMARK    GeneRIF: Selective role of the translin/trax RNase complex in
            hippocampal synaptic plasticity.
            Erratum:[Mol Brain. 2021 Mar 5;14(1):48. doi:
            10.1186/s13041-021-00761-2.. PMID: 33673835]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Fu,X., Shah,A.P., Li,Z., Li,M., Tamashiro,K.L. and Baraban,J.M.
  TITLE     Genetic inactivation of the translin/trax microRNA-degrading enzyme
            phenocopies the robust adiposity induced by Translin (Tsn) deletion
  JOURNAL   Mol Metab 40, 101013 (2020)
   PUBMED   32408014
  REMARK    GeneRIF: Genetic inactivation of the translin/trax
            microRNA-degrading enzyme phenocopies the robust adiposity induced
            by Translin (Tsn) deletion.
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Tuday,E., Nomura,Y., Ruhela,D., Nakano,M., Fu,X., Shah,A.,
            Roman,B., Yamaguchi,A., An,S.S., Steenbergen,C., Baraban,J.M.,
            Berkowitz,D.E. and Das,S.
  TITLE     Deletion of the microRNA-degrading nuclease, translin/trax,
            prevents pathogenic vascular stiffness
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H1116-H1124 (2019)
   PUBMED   31625778
  REMARK    GeneRIF: Deletion of the TN/TX complex selectively increases aortic
            miR-181b and prevents increased vascular stiffness caused by
            ingestion of high-salt water.
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Chennathukuzhi,V.M., Kurihara,Y., Bray,J.D. and Hecht,N.B.
  TITLE     Trax (translin-associated factor X), a primarily cytoplasmic
            protein, inhibits the binding of TB-RBP (translin) to RNA
  JOURNAL   J Biol Chem 276 (16), 13256-13263 (2001)
   PUBMED   11278549
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Devon,R.S., Taylor,M.S., Millar,J.K. and Porteous,D.J.
  TITLE     Isolation and characterization of the mouse translin-associated
            protein X (Trax) gene
  JOURNAL   Mamm Genome 11 (5), 395-398 (2000)
   PUBMED   10790540
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672234.27.
            
            On Feb 7, 2019 this sequence version replaced NM_016909.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF187040.1, BC004611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AL672234.27        154721-154892
            173-277             AL672234.27        155190-155294
            278-392             AL672234.27        157335-157449
            393-523             AL672234.27        166187-166317
            524-651             AL672234.27        170448-170575
            652-2363            AL672234.27        174177-175888
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 73.1 cM"
     gene            1..2363
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /note="translin-associated factor X"
                     /db_xref="GeneID:53424"
                     /db_xref="MGI:MGI:1855672"
     exon            1..172
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1029
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /codon_start=1
                     /product="translin-associated protein X"
                     /protein_id="NP_058605.1"
                     /db_xref="CCDS:CCDS22778.1"
                     /db_xref="GeneID:53424"
                     /db_xref="MGI:MGI:1855672"
                     /translation="MNGKEGPGGFRKRKHDTFPHNQRREGKDASLSSPVMLAFKSFQQ
                     ELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEEILTESESKLDGVRQKIL
                     QVAQELSGEDMHQFHRAVTTGLQEYVEAVSFQHFIKTRSLISMEEINKQLTFTAEDSG
                     KESKTPPAEGQEKQLVTWRLKLTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVS
                     QFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVF
                     SVKTDMIDQEESIS"
     exon            173..277
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            278..392
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            393..523
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            524..651
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            652..2363
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /note="hexamer: AATAAA"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /note="hexamer: AATACA"
     polyA_site      2350
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /note="major polyA site"
     polyA_site      2363
                     /gene="Tsnax"
                     /gene_synonym="Trax"
ORIGIN      
        1 aggctgcgtg aaggatccgc ttccggcggc cgcctactgc gaccagggtg gtgtgcgctg
       61 tcacccacgg gctcagcgcg gcgtcccgcg acggcctttc gctgagctgg cccggcggct
      121 gcgatccctg cgcgtgcaag ccgaggcccc gcggccatga acggcaaaga aggaccagga
      181 gggttcagga agaggaagca tgacaccttc ccacataacc aaaggagaga ggggaaggat
      241 gccagtttgt cttcgccggt gatgctggcc ttcaaatcat ttcagcagga gctggacgcc
      301 aggcacgaca aatatgagag actcgtgaag ctaagccggg atattactgt ggagagtaag
      361 aggacaattt ttcttctcca taggattaca agtgctcctg atatggagga gatactgact
      421 gaatcagaaa gtaagctgga tggtgtcaga cagaagatcc tgcaggtagc ccaagagctg
      481 tcgggggaag acatgcacca gttccatcga gccgtcacca caggactgca ggaatacgtg
      541 gaggctgtct cttttcaaca cttcatcaaa actcgttcat tgatcagtat ggaagagatt
      601 aacaagcagt tgacatttac agcagaagac agtgggaaag agagcaagac tcctcccgcg
      661 gaaggacaag agaagcagct ggttacatgg agactgaagc tcacccctgt tgactacctg
      721 ctgggcgtgg ccgacctaac tggagagttg atgcggatgt gtattaacag tgtggggaac
      781 ggggacatcg acaccccctt tgaagtgagc cagtttttac gccaggttta cgatgggttc
      841 tcgttcattg gcaacactgg gccctatgag gtctctaaga agctgtacac cttgaaacag
      901 agcctggcca aagtggagaa cgcttgctat gcccttaaag tccggggttc tgagattcct
      961 aagcacatgc tggcagatgt gttttcagtt aaaacagaca tgattgatca ggaagagagc
     1021 atttcttaag cagccccact ctgctctcta aggagctcct gggcgaccag ttggtgagac
     1081 tgttctgagt gtgcatctga gtttattgtg gcttctgtag acgttccaag ttgtactagt
     1141 ttgaagttgt aaacagctgt atataagttt gtccacaggg aggttgtttc ttacactccc
     1201 gcgcatttgc atacagtgtt tgtatatgtg ctcgctctat tgttgtgtga acgtgcttcc
     1261 gattgcactt tctgccacac ctactttagt tcactttgaa cttggagtga cattttgggt
     1321 ggaaggaagt ctcttaagtg ggtgattctg tctatggagg gaaaagtgtg gagaagcttc
     1381 ctgcgtgcct acgttcctca gcaggatcat ggcaggcctt taacgtggct cagtacgtga
     1441 aacagcagtt taaatatgga agttatcagt gttttctaag tgcaagtttt ggtggtggta
     1501 taatgagaat tcacttaaaa ttctggtcaa gtttaggtcg ttttgaattc gtaggaagca
     1561 gttttcctga agagttgatg ggtatctgga tgttcacttt cccacgttgt cttttccttt
     1621 ctcaccgatg tgggaaggaa ggagctgaca ctggtcatca ctggtgacgc tgagtaactg
     1681 actccacact cgtgtgtagg ttgtgagcag ccaggccctt tgtcgtgtgt taggtgtggt
     1741 gcacttgtct accccagccg tcctgggacc ccagaggagc agccacagtg ctcccagtgc
     1801 tgacaaccca agccttgacc ctgcccttgg tgtgagctag cgatgttgcc aaagaaaaag
     1861 aattgtgagt aattcagcaa taagacgatg gccaacactg gagggagcgt cgggcgtggg
     1921 ttcatctccc cagtcagtca gagtcatctg tggtgagagc ctggcttgag cgtggcctgc
     1981 ggctgtcaac gccacatgct ttcaacgagt tctgtgactt ttcacaactt agatactggg
     2041 ctttattttt ggaaagaata tctatttgta aggctggttc tttgaaagtg taattttcca
     2101 aaaagtctca ccaaaagtaa aataaagtgt gtacatgcct ggtaagttag acttgttgtc
     2161 ctggtggtga tgaggcttcg ccttcctgta gtaagatgga ctcctgagct gtagtcagtc
     2221 ctggtacctg ctctgtctgt ctggtttttt tcagctactt caagtggaat ttataatgtt
     2281 aaaataatgg attgaagaat gttttacaga aatttaaagc aaactttaaa taaaatatta
     2341 aaatacagca gccctctggt taa
//
