LOCUS       NM_011650               3257 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus translin (Tsn), transcript variant 1, mRNA.
ACCESSION   NM_011650
VERSION     NM_011650.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Akiyoshi,K., Fujimori,T., Fu,X., Shah,A.P., Yamaguchi,A.,
            Steenbergen,C., Santhanam,L., Berkowitz,D., Tuday,E., Baraban,J.M.
            and Das,S.
  TITLE     Adenosine A2A Receptor Regulates microRNA-181b Expression in Aorta:
            Therapeutic Implications for Large-Artery Stiffness
  JOURNAL   J Am Heart Assoc 12 (14), e028421 (2023)
   PUBMED   37421280
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Fu,X., Shah,A.P., Keighron,J., Mou,T.M., Ladenheim,B., Alt,J.,
            Fukudome,D., Niwa,M., Tamashiro,K.L., Tanda,G., Sawa,A.,
            Cadet,J.L., Rais,R. and Baraban,J.M.
  TITLE     Elevated body fat increases amphetamine accumulation in brain:
            evidence from genetic and diet-induced forms of adiposity
  JOURNAL   Transl Psychiatry 11 (1), 427 (2021)
   PUBMED   34392304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Oyama,K., Baba,T. and Kashiwabara,S.I.
  TITLE     Functional characterization of testis-brain RNA-binding protein,
            TB-RBP/Translin, in translational regulation
  JOURNAL   J Reprod Dev 67 (1), 35-42 (2021)
   PUBMED   33268667
  REMARK    GeneRIF: Functional characterization of testis-brain RNA-binding
            protein, TB-RBP/Translin, in translational regulation.
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Park,A.J., Shetty,M.S., Baraban,J.M. and Abel,T.
  TITLE     Selective role of the translin/trax RNase complex in hippocampal
            synaptic plasticity
  JOURNAL   Mol Brain 13 (1), 145 (2020)
   PUBMED   33172471
  REMARK    GeneRIF: Selective role of the translin/trax RNase complex in
            hippocampal synaptic plasticity.
            Erratum:[Mol Brain. 2021 Mar 5;14(1):48. doi:
            10.1186/s13041-021-00761-2. PMID: 33673835]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Fu,X., Shah,A.P., Li,Z., Li,M., Tamashiro,K.L. and Baraban,J.M.
  TITLE     Genetic inactivation of the translin/trax microRNA-degrading enzyme
            phenocopies the robust adiposity induced by Translin (Tsn) deletion
  JOURNAL   Mol Metab 40, 101013 (2020)
   PUBMED   32408014
  REMARK    GeneRIF: Genetic inactivation of the translin/trax
            microRNA-degrading enzyme phenocopies the robust adiposity induced
            by Translin (Tsn) deletion.
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Aoki,K., Ishida,R. and Kasai,M.
  TITLE     Isolation and characterization of a cDNA encoding a Translin-like
            protein, TRAX
  JOURNAL   FEBS Lett 401 (2-3), 109-112 (1997)
   PUBMED   9013868
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Han,J.R., Yiu,G.K. and Hecht,N.B.
  TITLE     Testis/brain RNA-binding protein attaches translationally repressed
            and transported mRNAs to microtubules
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9550-9554 (1995)
   PUBMED   7568171
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Han,J.R., Gu,W. and Hecht,N.B.
  TITLE     Testis-brain RNA-binding protein, a testicular translational
            regulatory RNA-binding protein, is present in the brain and binds
            to the 3' untranslated regions of transported brain mRNAs
  JOURNAL   Biol Reprod 53 (3), 707-717 (1995)
   PUBMED   7578697
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Aoki,K., Suzuki,K., Sugano,T., Tasaka,T., Nakahara,K., Kuge,O.,
            Omori,A. and Kasai,M.
  TITLE     A novel gene, Translin, encodes a recombination hotspot binding
            protein associated with chromosomal translocations
  JOURNAL   Nat Genet 10 (2), 167-174 (1995)
   PUBMED   7663511
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Kwon,Y.K. and Hecht,N.B.
  TITLE     Binding of a phosphoprotein to the 3' untranslated region of the
            mouse protamine 2 mRNA temporally represses its translation
  JOURNAL   Mol Cell Biol 13 (10), 6547-6557 (1993)
   PUBMED   8413253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121531.10 and CX243508.1.
            
            [WARNING] On Jan 4, 2025 this sequence was replaced by NM_011650.5.
            
            On Feb 16, 2018 this sequence version replaced NM_011650.3.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding variant.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF234179.1, AK165598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC121531.10        19074-19227
            155-823             CX243508.1         1-669
            824-908             CX243508.1         671-755
            909-3257            AC121531.10        29558-31906
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.14 cM"
     gene            1..3257
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /note="translin"
                     /db_xref="GeneID:22099"
                     /db_xref="MGI:MGI:109263"
     exon            1..346
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..967
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /note="testis/brain-RNA-binding protein; component 3 of
                     promoter of RISC"
                     /codon_start=1
                     /product="translin"
                     /protein_id="NP_035780.1"
                     /db_xref="CCDS:CCDS35690.1"
                     /db_xref="GeneID:22099"
                     /db_xref="MGI:MGI:109263"
                     /translation="MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQG
                     VHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLA
                     AFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVT
                     AGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFN
                     KETAAACGEK"
     exon            347..440
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            441..537
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            538..653
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            654..733
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            734..3257
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /note="hexamer: AATAAA"
     polyA_site      3254
                     /gene="Tsn"
                     /gene_synonym="2610034C24Rik; C3PO; TB-RBP"
                     /note="major polyA site"
ORIGIN      
        1 ctacgtgcgg gcggcaggcg aggctcggcc ctgccgtcgg gattctgggc aagagcgcgg
       61 cacgggactg tgcgcgcggc gcttcaggca ttgcggcggg cagcccgggc tccggtgcgc
      121 cgcgggtgtg ggaagacccc ggcgccagcc ttggcgcaag ggctagtgga cgcggcagtg
      181 gcgacggcga cgggcgttgc gagcgagtcc gctacttgtt tgtgggtcgt acttcttcgg
      241 cggtgctccg gtgctgactg attgtagggc agccagcgcc atgtctgtga gcgagatctt
      301 cgtggagctg cagggctttt tggctgccga gcaggacatc cgagaggaaa tacgaaaagt
      361 tgtacagagt ttagaacaaa ctgctcgaga gattttgacc ctacttcaag gggtccacca
      421 gggtactgga tttcaggaca ttccaaagag gtgcttgaaa gcgagagaac atttcagtac
      481 agtaaaaaca catctcacgt ccctgaagac caagttcccc gctgagcagt attacaggtt
      541 tcatgagcat tggcggttcg tgcttcagcg cctggtcttc ctggcagcat ttgtggtata
      601 tttggaaaca gagaccctgg tgacccgaga ggctgttaca gagattcttg gcattgaacc
      661 agatcgggaa aaagggtttc atctggatgt ggaagattat ctctcaggag ttttaattct
      721 tgccagtgaa ctgtcgaggc tgtctgtcaa cagtgtcact gctggagact actctcggcc
      781 ccttcacatt tctactttca tcaatgagct ggattctggt tttcgtcttc tcaatctgaa
      841 aaatgactcc ctgaggaagc gctacgacgg cttgaagtac gatgtgaaga aagtagagga
      901 ggtggtctat gacctttcca tccgaggctt caataaggag acagcagcgg cttgtggtga
      961 aaaataggag cttttccctg gggctggcct tgctggcgcc gcagttgcca gggagggcta
     1021 gctcagtgcc tcttcctgta gttagcacac cagttgctaa acactgcgct ttattttcgt
     1081 aaccagctgt gtgctgtgag tgtcagaatt gaaatacttt ttggatctaa acaaaaaaaa
     1141 aaaaaagaaa aagaaacctt tccacggatg gggttttttt gttgattttc agtgcacttg
     1201 ccgtgccgtg ttgtcgtcgt attaccattt tgtcaacagt gtgaatgttg gtcccttggt
     1261 aaaagtcctt tcttgcttac ctgactgttg atgtactgac tgacaggttt gttgtcttgt
     1321 ttgtaatttc tcccacaagt aaacaatgat gttttctagg tccagattag tcctccattt
     1381 ccagctatag cctggatgca gtgtgagaat aaaatggttg acaagcaagg gaactttatt
     1441 ttgcccatct taagtcttgt aagtgagttg aattttttgc ctaggaaatt tgaggccccg
     1501 actctgtccc tgctactaaa acagagcaga tgaaactgta cagttcaacc cagcaaggtc
     1561 aaggtagaaa gagcctctgg aaaagcgttg tgatgtcttg tgttgggtta gagcatctgt
     1621 tttctgacat caccttacac cccggctgcc gtagcagtta gtctttacac ctgcctagag
     1681 ctaacacctg tgtgctgtat ttgtaaacat ggagaccttt tctcagcagc cagctagaac
     1741 tggtctggga gtagaaagcc atcctcatgt attcactcct tatctgtact gaggagtggc
     1801 ttcttagaga catcagtgct gtttggagta gaagaaagta aaatttggct ttaaaaaatt
     1861 catgtgattg gcagtatttt ttggaataag aaattgaagg ttgtgattct gtcagtacat
     1921 ttaaaatgta tagtttaggg tagtcatgta aactttgggc tcctctatgc cctctccttt
     1981 tcagatcgca taagaattca tatgtggcca ttcttggggt agaactgaaa ttattaaagt
     2041 caaggctggt gatgtagctt ttagtgatag acttgcttgg caatgtgagg caatggtcca
     2101 tcctaggact tcaaaaaact gaaagaaaaa aagaaaaaaa aaacccaaca aaaatagtgt
     2161 aggttttttt tttttttgca ccctctgaca ggaagctgct gccattacta gtgtaatagg
     2221 aagtactcag gggtgtcacc ctttctttct tggtagcatt ttgggcttca tgtttgtgca
     2281 gtgggatctt tgacactggc ttttatcagg ccatggttag agactaactg gaaagtgggg
     2341 cctgaaagtg caggcttgtg ctcccaggta cacaggaggc tgaggcagga gattggcaaa
     2401 ttcaaggctt caggggtagc ctgtctaact gagtgagatc ctgtgacaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaagacca cccaccccca cacacacaca caagcaaaaa acaaaaaaca
     2521 ccaaccaaaa aggctggggg tatgtttcag tgactttccc tcgcatgttt gaggccttgg
     2581 gttcaaccct tcgttgtgca gcgagcgggg tggcaggagg ctgactctaa tttcccatcc
     2641 tgaggaatga gctgtgattg ctgtatattg ttggacatgt agactagctt tcttcatggt
     2701 tctttttgca gggttagagt aaggtattag gcaatttttg ttagtttacc atttgagaca
     2761 gggttttgct ggtagtccag gctggcctgg aactcgcacc tctgtttccg tttcctgagt
     2821 acaggattag actcttgaaa gtgtctggga aggtagaagg cttttcagtt gcatggtagt
     2881 ttcacaggct cttgcctgtt cttgtgggtt ctgctagaca tcattaaagc tcttgtcaaa
     2941 agtttcatat tttcctcttt agagacagag gttgtaatgt cctgcctgta gtgttgtcta
     3001 ggctggtctc aacctcctgg gctgaagctc tcctcttgcc tcagcctgtg agcagctggg
     3061 actctaggtc attgccacca tacataactc ttgaaattca gtttcagatg caatgaacaa
     3121 attgcactta aaagtgaagg agtatgttct agtgttgtga ttctacttga gagtttagaa
     3181 gtgtcatgtt gataattagt tgtgttcgtt actggcttgt aaagcaataa aactgttttt
     3241 ggtctctttg taaagta
//
