LOCUS       NM_021367               1143 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus thymic stromal lymphopoietin (Tslp), transcript
            variant 1, mRNA.
ACCESSION   NM_021367
VERSION     NM_021367.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1143)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1143)
  AUTHORS   Song,C., Sun,J., Zhao,Z., Zhang,X., Ding,X., Liang,X., Bai,J.,
            Xing,L., Gong,L., Li,C. and Lin,B.
  TITLE     Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells
            Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis
  JOURNAL   Balkan Med J 41 (3), 174-185 (2024)
   PUBMED   38700313
  REMARK    GeneRIF: Thymic Stromal Lymphopoietin Activates Mouse Dendritic
            Cells Through the JAK/SYK Pathway in Promoting Th17 Response in
            Psoriasis.
REFERENCE   3  (bases 1 to 1143)
  AUTHORS   Kurihara,Y., Tashiro,H., Konomi,Y., Sadamatsu,H., Ihara,S.,
            Takamori,A., Kimura,S., Sueoka-Aragane,N. and Takahashi,K.
  TITLE     Thymic stromal lymphopoietin contributes to ozone-induced
            exacerbations of eosinophilic airway inflammation via granulocyte
            colony-stimulating factor in mice
  JOURNAL   Allergol Int 73 (2), 313-322 (2024)
   PUBMED   38145912
  REMARK    GeneRIF: Thymic stromal lymphopoietin contributes to ozone-induced
            exacerbations of eosinophilic airway inflammation via granulocyte
            colony-stimulating factor in mice.
REFERENCE   4  (bases 1 to 1143)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1143)
  AUTHORS   Cha,J., Kim,T.G., Bhae,E., Gwak,H.J., Ju,Y., Choe,Y.H., Jang,I.H.,
            Jung,Y., Moon,S., Kim,T., Lee,W., Park,J.S., Chung,Y.W., Yang,S.,
            Kang,Y.K., Hyun,Y.M., Hwang,G.S., Lee,W.J., Rho,M. and Ryu,J.H.
  TITLE     Skin microbe-dependent TSLP-ILC2 priming axis in early life is
            co-opted in allergic inflammation
  JOURNAL   Cell Host Microbe 32 (2), 244-260 (2024)
   PUBMED   38198924
REFERENCE   6  (bases 1 to 1143)
  AUTHORS   Osborn,M.J., Ryan,P.L., Kirchhof,N., Panoskaltsis-Mortari,A.,
            Mortari,F. and Tudor,K.S.
  TITLE     Overexpression of murine TSLP impairs lymphopoiesis and
            myelopoiesis
  JOURNAL   Blood 103 (3), 843-851 (2004)
   PUBMED   14512322
  REMARK    GeneRIF: The arrest in lymphopoiesis and the expansion of myeloid
            progenitor cells in TSLP transgenic mice suggest that TSLP has
            negative and positive regulatory effects on lymphoid and myeloid
            development, respectively.
REFERENCE   7  (bases 1 to 1143)
  AUTHORS   Taneda,S., Segerer,S., Hudkins,K.L., Cui,Y., Wen,M., Segerer,M.,
            Wener,M.H., Khairallah,C.G., Farr,A.G. and Alpers,C.E.
  TITLE     Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin
            transgenic mice
  JOURNAL   Am J Pathol 159 (6), 2355-2369 (2001)
   PUBMED   11733384
REFERENCE   8  (bases 1 to 1143)
  AUTHORS   Quentmeier,H., Drexler,H.G., Fleckenstein,D., Zaborski,M.,
            Armstrong,A., Sims,J.E. and Lyman,S.D.
  TITLE     Cloning of human thymic stromal lymphopoietin (TSLP) and signaling
            mechanisms leading to proliferation
  JOURNAL   Leukemia 15 (8), 1286-1292 (2001)
   PUBMED   11480573
REFERENCE   9  (bases 1 to 1143)
  AUTHORS   Sims,J.E., Williams,D.E., Morrissey,P.J., Garka,K., Foxworthe,D.,
            Price,V., Friend,S.L., Farr,A., Bedell,M.A., Jenkins,N.A.,
            Copeland,N.G., Grabstein,K. and Paxton,R.J.
  TITLE     Molecular cloning and biological characterization of a novel murine
            lymphoid growth factor
  JOURNAL   J Exp Med 192 (5), 671-680 (2000)
   PUBMED   10974033
REFERENCE   10 (bases 1 to 1143)
  AUTHORS   Ray,R.J., Furlonger,C., Williams,D.E. and Paige,C.J.
  TITLE     Characterization of thymic stromal-derived lymphopoietin (TSLP) in
            murine B cell development in vitro
  JOURNAL   Eur J Immunol 26 (1), 10-16 (1996)
   PUBMED   8566050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140983.4, AK087266.1 and CJ198416.1.
            
            On Jan 15, 2010 this sequence version replaced NM_021367.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF232937.1, BC130230.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC140983.4         61232-61252
            22-161              AC140983.4         61417-61556
            162-197             AC140983.4         62299-62334
            198-1131            AK087266.1         202-1135
            1132-1143           CJ198416.1         362-373
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.12 cM"
     gene            1..1143
                     /gene="Tslp"
                     /note="thymic stromal lymphopoietin"
                     /db_xref="GeneID:53603"
                     /db_xref="MGI:MGI:1855696"
     exon            1..21
                     /gene="Tslp"
                     /inference="alignment:Splign:2.1.0"
     exon            22..161
                     /gene="Tslp"
                     /inference="alignment:Splign:2.1.0"
     exon            162..197
                     /gene="Tslp"
                     /inference="alignment:Splign:2.1.0"
     exon            198..332
                     /gene="Tslp"
                     /inference="alignment:Splign:2.1.0"
     exon            333..1133
                     /gene="Tslp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      436..441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tslp"
                     /note="hexamer: AATAAA"
     polyA_site      468
                     /gene="Tslp"
                     /note="major polyA site"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tslp"
                     /note="hexamer: AATAAA"
     polyA_site      1133
                     /gene="Tslp"
                     /note="major polyA site"
ORIGIN      
        1 cacgttcagg cgacagcatg gttcttctca ggagcctctt catcctgcaa gtactagtac
       61 ggatggggct aacttacaac ttttctaact gcaacttcac gtcaattacg aaaatatatt
      121 gtaacataat ttttcatgac ctgactggag atttgaaagg ggctaagttc gagcaaatcg
      181 aggactgtga gagcaagcca gcttgtctcc tgaaaatcga gtactatact ctcaatccta
      241 tccctggctg cccttcactc cccgacaaaa catttgcccg gagaacaaga gaagccctca
      301 atgaccactg cccaggctac cctgaaactg agagaaatga cggtactcag gaaatggcac
      361 aagaagtcca aaacatctgc ctgaatcaaa cctcacaaat tctaagattg tggtattcct
      421 tcatgcaatc tccagaataa aattagcttt cagcttctgc tatgaaaatc tctatcttgg
      481 ttttagtgga cagaatacta agggtgtgac acttagagga ccactggtgt ttattcttta
      541 attacagaag ggattcttaa cttatttttt ggcatatcgc ttttttcagt ataggtgctt
      601 taaatgggaa atgagcaata gaccgttaat ggaaatatct gtactgttaa tgaccagctt
      661 ctgagaagtc tttctcacct cccctgcaca caccttactc tagggcaaac ctaactgtag
      721 taggaagaga attgaaagta gaaaaaaaaa attaaaacca atgacagcat ctaaaccctg
      781 tttaaaaggc aaggattttt ctacctgtaa tgattcttct aacattccta tgctaagatt
      841 ttaccaaaga agaaaatgac agttcgggca gtcactgcca tgatgaggtg gtctgaaaga
      901 agattgtgga atctgggaga aactgctgag atcatattgc aaatccagct gtcaaagggt
      961 tcagacccag gacagtacaa ttcgtgagca gatctcaaga gccttgcaca tctacgagat
     1021 atatatttaa agttgtagat aatgaatttc taatttattt tgtgagcact tttggaaata
     1081 tacatgctac tttgtaatga atacatttct gaataaagta attctcaagt ttgaaaaaaa
     1141 aaa
//
