LOCUS       NM_172298               5098 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus teashirt zinc finger family member 3 (Tshz3), mRNA.
ACCESSION   NM_172298
VERSION     NM_172298.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5098)
  AUTHORS   Kesdiren,E., Martens,H., Brand,F., Werfel,L., Wedekind,L.,
            Trowe,M.O., Schmitz,J., Hennies,I., Geffers,R., Gucev,Z.,
            Seeman,T., Schmidt,S., Tasic,V., Fasano,L., Brasen,J.H.,
            Kispert,A., Christians,A., Haffner,D. and Weber,R.G.
  TITLE     Heterozygous variants in the teashirt zinc finger homeobox 3
            (TSHZ3) gene in human congenital anomalies of the kidney and
            urinary tract
  JOURNAL   Eur J Hum Genet 33 (1), 44-55 (2025)
   PUBMED   39420202
REFERENCE   2  (bases 1 to 5098)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5098)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   4  (bases 1 to 5098)
  AUTHORS   Caubit,X., Gubellini,P., Roubertoux,P.L., Carlier,M., Molitor,J.,
            Chabbert,D., Metwaly,M., Salin,P., Fatmi,A., Belaidouni,Y.,
            Brosse,L., Kerkerian-Le Goff,L. and Fasano,L.
  TITLE     Targeted Tshz3 deletion in corticostriatal circuit components
            segregates core autistic behaviors
  JOURNAL   Transl Psychiatry 12 (1), 106 (2022)
   PUBMED   35292625
  REMARK    Erratum:[Transl Psychiatry. 2022 May 23;12(1):211. doi:
            10.1038/s41398-022-01925-x.. PMID: 35606372]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5098)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   6  (bases 1 to 5098)
  AUTHORS   Manfroid,I., Caubit,X., Marcelle,C. and Fasano,L.
  TITLE     Teashirt 3 expression in the chick embryo reveals a remarkable
            association with tendon development
  JOURNAL   Gene Expr Patterns 6 (8), 908-912 (2006)
   PUBMED   16631416
REFERENCE   7  (bases 1 to 5098)
  AUTHORS   Li,M.Z., Wang,J.S., Jiang,D.J., Xiang,C.X., Wang,F.Y., Zhang,K.H.,
            Williams,P.R. and Chen,Z.F.
  TITLE     Molecular mapping of developing dorsal horn-enriched genes by
            microarray and dorsal/ventral subtractive screening
  JOURNAL   Dev Biol 292 (2), 555-564 (2006)
   PUBMED   16516881
REFERENCE   8  (bases 1 to 5098)
  AUTHORS   Muzio,L., Soria,J.M., Pannese,M., Piccolo,S. and Mallamaci,A.
  TITLE     A mutually stimulating loop involving emx2 and canonical wnt
            signalling specifically promotes expansion of occipital cortex and
            hippocampus
  JOURNAL   Cereb Cortex 15 (12), 2021-2028 (2005)
   PUBMED   15800025
REFERENCE   9  (bases 1 to 5098)
  AUTHORS   Caubit,X., Tiveron,M.C., Cremer,H. and Fasano,L.
  TITLE     Expression patterns of the three Teashirt-related genes define
            specific boundaries in the developing and postnatal mouse forebrain
  JOURNAL   J Comp Neurol 486 (1), 76-88 (2005)
   PUBMED   15834955
  REMARK    GeneRIF: role for mTsh genes in the establishment of regional
            identity and specification of cell types in the developing and
            adult forebrain
REFERENCE   10 (bases 1 to 5098)
  AUTHORS   Manfroid,I., Caubit,X., Kerridge,S. and Fasano,L.
  TITLE     Three putative murine Teashirt orthologues specify trunk structures
            in Drosophila in the same way as the Drosophila teashirt gene
  JOURNAL   Development 131 (5), 1065-1073 (2004)
   PUBMED   14973285
  REMARK    GeneRIF: three mouse Tsh genes are functionally equivalent to the
            Drosophila tsh gene when expressed in developing Drosophila embryos
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI413240.1 and AC129593.4.
            
            On Feb 17, 2018 this sequence version replaced NM_172298.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY063491.1, AK220396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AI413240.1         1-527
            528-5098            AC129593.4         183041-187611
FEATURES             Location/Qualifiers
     source          1..5098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 22.79 cM"
     gene            1..5098
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="teashirt zinc finger family member 3"
                     /db_xref="GeneID:243931"
                     /db_xref="MGI:MGI:2442819"
     exon            1..172
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..3378
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="zinc finger protein 537; teashirt 3"
                     /codon_start=1
                     /product="teashirt homolog 3"
                     /protein_id="NP_758502.1"
                     /db_xref="CCDS:CCDS39913.1"
                     /db_xref="GeneID:243931"
                     /db_xref="MGI:MGI:2442819"
                     /translation="MPRRKQQAPRRAAAYVSDELKAAALVEDDVEPEEQAADGEPSAK
                     YMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEETKEV
                     QVPLEDTIVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSENNGGSSSSSSSSSSSC
                     GSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKD
                     CSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLK
                     CMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSP
                     DSTGGTPKATLSDASDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECG
                     SSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAAT
                     TFTSPSNTPASVSPKLAVEIKKEVDKEKAVPDEKPKEREKPSEEEEKYDISSKYHYLT
                     ENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGS
                     SGKSTPLKPMFGNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKV
                     EEKMKEPEGKLSPPKRATPSPCSSEQSEPIKMEASSDGSFKSQENSPSPPRDACKEAS
                     PSAEPVENGKELVKPLSGGLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPS
                     LPALDPMSMLFKMSNSLAEKAAVATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSD
                     KGCSLGSGLLSPTSTSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTE
                     SHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASL
                     RQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTG
                     HPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINNQIAQTKSPSEKLVT
                     SSPEEDLGTTYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLFVSELEKQ"
     exon            173..5098
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4993..4998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="hexamer: ATTAAA"
     polyA_site      5016
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="major polyA site"
     regulatory      5075..5080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="hexamer: ATTAAA"
     polyA_site      5098
                     /gene="Tshz3"
                     /gene_synonym="A630038G13Rik; mKIAA1474; teashirt3; Tsh3;
                     Zfp537"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgctc tccggggggg aggctgcgag caggcccgcc tcgccccccc cccgccgccc
       61 ctccctccct cggctcagcc cggcagcggc ggcggcggcg gcggcggcgg tggcagtcgc
      121 gggagaagca tcatgccgag gaggaagcag caggcgcccc ggcgcgcagc agcctatgtt
      181 tccgatgagt taaaggcagc tgccttggta gaagatgacg tagagccgga ggaacaagcg
      241 gcagatggag agccctcagc caagtacatg tgtccagaga aggaactcag caaggcctgc
      301 cctagctacc agaactcacc ggccgctgag ttctccagcc atgaaatgga cagcgagtct
      361 cacatcagtg agacgagtga ccggatggct gactttgaaa gcagttccat caagaatgag
      421 gaggagacca aggaggtcca ggtgcccctg gaggacacca tcgtgtctga tagcctggag
      481 cagatgaagg ccgtgtacaa caacttcctg tccaattcct attggtccaa cctcaacctg
      541 aacctgcacc agccctcctc cgagaacaat ggtggcagca gtagcagcag cagcagtagc
      601 agcagcagct gtggcagcgg gagctttgac tggcaccaga gtgccatggc gaagaccctg
      661 cagcaggtgt cccagaaccg aatgctgccg gagcccagcc tgttcagcac cgtgcagctg
      721 taccgccaga gcagcaagct gtacggctcc attttcaccg gggccagcaa gttccgttgc
      781 aaagactgta gcgccgccta cgacaccctg gtagagctga ccgtgcacat gaatgagaca
      841 ggtcactatc gcgatgacaa ccacgagacc gacaacaaca accccaagcg ctggtccaag
      901 cctcgcaaac ggtctttgtt ggagatggag gggaaggagg atgctcagaa ggtgctcaag
      961 tgtatgtact gtggccactc ctttgagtcc ctccaagacc tgagcgtcca tatgatcaaa
     1021 actaaacact accaaaaagt gcctctcaag gaacctgtca cacccgttgc agccaaaatc
     1081 atccctgctg ctcggaagaa accttctctg gagctggagc tgcctagctc ccctgattcc
     1141 acaggtggaa cccccaaagc caccctgtct gatgccagcg acgccctgca gaagaactcc
     1201 aacccttaca tcacgccaaa taatcggtac ggccaccaga acggggccag ctatgcatgg
     1261 cacttcgagg cccgaaagtc tcagatcctc aaatgcatgg agtgtggaag ctcccatgac
     1321 acgctccagg agctcacagc tcacatgatg gtcactggcc actttatcaa ggtcacaaac
     1381 tcggccatga agaaggggaa gcccatcatg gagacaccgg tcacgcccac catcaccacc
     1441 ttgctggacg agaaggtgca gtctgtgcca ctggcagcca ccacattcac gtctccctcc
     1501 aatacgcccg cgagtgtctc cccgaagctg gcggtggaga tcaaaaagga agtggacaag
     1561 gagaaagcag tcccggatga gaaacccaag gagagagaga agcccagtga agaggaggag
     1621 aagtatgata tttcttccaa gtaccactat ttgactgaaa acgacctaga agagagccct
     1681 aaaggtggac tagatatcct caaatccctt gagaacacag taacgtctgc catcaacaag
     1741 gctcagaatg gcactcccag ctggggcggc tatcccagca tccacgctgc ctaccagctc
     1801 cccaacatga tgaagttgtc cctgggttcc tcggggaaga gcacgcccct gaaacccatg
     1861 tttggcaaca gcgaaatcgt gtctcccaca aaaacccaga ccctggtctc tccacccagc
     1921 agccagacct ctcccatgcc caagacaaac tttcacgcca tggaggaact ggtgaaaaaa
     1981 gtcacggaga aagttgccaa agttgaggag aaaatgaaag agccagaagg caagctctcg
     2041 ccacccaagc gggccacgcc gtccccgtgc agcagcgagc agagcgaacc catcaagatg
     2101 gaggcctcca gcgacggcag cttcaaaagt caggagaata gccccagccc accaagagat
     2161 gcgtgcaagg aggcgagccc ctccgcagag cccgtagaga atggcaagga gctggtgaag
     2221 cccctgagcg gaggtctcag cggcagcaca gccattatca cggaccaccc accagaacag
     2281 ccttttgtga accccctgag tgccctgcag tcggtcatga acatccacct gggcaaggcc
     2341 gccaagccct cgctgcctgc gctggacccc atgagcatgc ttttcaagat gagcaacagt
     2401 ctggccgaga aggcagctgt ggccacccca ccaccccttc aggccaagaa ggcggagcat
     2461 ctggaccgct atttctacca cgtcaacaat gaccagccca tagacttgac aaaagggaag
     2521 agcgacaaag gttgctcttt aggttcaggg cttttgtccc ccacgtccac atccccggca
     2581 acttcctcat ccacggtgac aacggcaaag acatctgccg tcgtatcatt catgtcaaac
     2641 tcgccgctgc gtgagaatgc cttgtcagat atatccgata tgttgaagaa cttgacagag
     2701 agccacacgt caaaatcctc cactccttcc agcatctctg agaagtctga cattgacggg
     2761 gccaccctgg aagaggccga ggagtcgact ccggcgcaga agaggaaagg ccgccagtca
     2821 aactggaatc ctcagcacct gctaatcctg caggcgcagt ttgcagctag cctgcggcag
     2881 acttcagaag ggaagtacat catgtccgat ctgagccccc aggagcgcat gcacatctcc
     2941 aggttcaccg gtctctccat gaccaccatc agccattggc tggccaatgt gaagtaccaa
     3001 cttcgaagga caggtggaac aaagttcctc aaaaacttgg acactggaca cccagtgttc
     3061 ttttgtaacg actgtgcgtc acaaatcagg actccttcca cgtacatcag ccacctagag
     3121 tcacatctgg gcttccggct acgggactta tcaaaattgt ccaccgaaca gattaacaat
     3181 caaatagcac aaaccaagtc gccgtctgaa aaactggtga catcctcccc ggaggaggat
     3241 ctggggacca cctaccagtg caaactttgt aatcggacct ttgcgagcaa gcatgctgtt
     3301 aaacttcacc ttagcaaaac ccacgggaaa tcaccggaag accacctcct gttcgtttct
     3361 gaattggaga agcagtagcg tttgctccag agcggaaatg actggaggag aaaatgctga
     3421 aggcacctta aagcccctct ctgtcttgtt cttggcacac gttcttatgt tcactgcaga
     3481 ggattgttct gggctggact gttcggtcta actgtacagt gtttaataga gaggtgcata
     3541 taatcagctg ttgttactgg taaaataacg aaggttaaaa cgcagtgcta agtgtttgga
     3601 actttgtgta aatgggattt aattgtgagc atcccctcga tgcttcaagc tgcatgcatt
     3661 aacagacggt ttaattaagc atttataagg aaaccaggca cactttttcc atgagacttg
     3721 ggtgtgctgg catttcccac cctttcatct ttagccctct gagtactacg aagcactttt
     3781 gcattaattt ggttaataaa aaaaagataa taataaaaca aaataataat gaataataat
     3841 aatgtatgaa actctgtttt taaaactcgt taccagctta gttataagga atattaggaa
     3901 cctccattta tgcaggggta tgacacgcct tgaaatttaa aagaatatta ttttcacatt
     3961 gaaacataga tgtatatatt gtatagattt caaactctta tgggaaaatg tgactggtta
     4021 aatgaccctt tctttcttgc atttataaca agtgttttat gtatctgcta tactctgggc
     4081 acaagccatg cctctgtata gtgtatattt ccttatcttt ttcttttttt ttaaggttta
     4141 tggttttttt tttacatgca aacattgtaa attatacaga aaataccaca gatagcattt
     4201 ataaaatata cagaagcatt atctcaaagc aaggtatgat gtttgttttg ctatacggca
     4261 catctatatt gatagagggt tcatgtttaa attatacata tttattagca ttctattatc
     4321 atttgttttg aggtcaggaa atccatccct ggcaggcatc ataactattt tgcacatggt
     4381 tcttaaaggt atttattaga aattaaagga tgctcaaagt aaactcagtg ctcaaagggt
     4441 taagtctatt cgaaaaggaa aaaaaaagat taaaaaaaaa aacccaactt gtactgtatt
     4501 tcctgaacat tgataaagcc tttaaaatgt ttgtactgta atcctttgct taaaagtcaa
     4561 gagtcgttct gtgggacagc cccttcactt atttataagc cctctcggtt gctagttcat
     4621 aatgtgggat ttttttccct ttctcttttt tcttttcttt tctttctttc tttctttttt
     4681 ttttttttta atttcaatcg gtaactttgt tttgttcctc ctaattattc tcccaagatc
     4741 ccacactgca gttttatctt taggcttatg aaaggtaacc cgtggtaacc ggctctccaa
     4801 gccattcttg tctccatttc tggcagttaa tttgcagaaa taactgacag ctgacaccat
     4861 atgagaacct atgtataaaa tattggcatg taaacaccac agacaccgtg acacactctg
     4921 tgccctgttt tgttgttgac gatggcacac catgatgtga ctcttcatat aacccttttt
     4981 ttctacggca gcattaaaat tgtctttttg ctataatttt gtgttgcgtt cacaattatg
     5041 tctgagatgt gctacgacta acgagcacat taaaattaaa ttgtatgcga tctgttta
//
