LOCUS       NM_011648               4332 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus thyroid stimulating hormone receptor (Tshr),
            transcript variant 1, mRNA.
ACCESSION   NM_011648
VERSION     NM_011648.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4332)
  AUTHORS   Zeng,S., Hu,H., Li,Z., Hu,Q., Shen,R., Li,M., Liang,Y., Mao,Z.,
            Zhang,Y., Zhan,W., Zhu,Q., Wang,F., Xiao,J., Xu,B., Liu,G.,
            Wang,Y., Li,B., Xu,S., Zhang,Z., Zhang,C., Wang,Z. and Liang,L.
  TITLE     Local TSH/TSHR signaling promotes CD8+ T cell exhaustion and immune
            evasion in colorectal carcinoma
  JOURNAL   Cancer Commun (Lond) 44 (11), 1287-1310 (2024)
   PUBMED   39285586
REFERENCE   2  (bases 1 to 4332)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   3  (bases 1 to 4332)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4332)
  AUTHORS   Ge,X., Weis,K. and Raetzman,L.
  TITLE     Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem
            cell-expressed gene associated with NOTCH2 signaling
  JOURNAL   Mol Cell Endocrinol 586, 112163 (2024)
   PUBMED   38246572
REFERENCE   5  (bases 1 to 4332)
  AUTHORS   Li,Y., Luan,S., Ruan,C., Li,W., Zhang,X., Ran,Z., Bi,W., Tong,Y.,
            Gao,L., Zhao,J., Li,Y. and He,Z.
  TITLE     TSHR signaling promotes hippocampal dependent memory formation
            through modulating Wnt5a/beta-catenin mediated neurogenesis
  JOURNAL   Biochem Biophys Res Commun 704, 149723 (2024)
   PUBMED   38430698
REFERENCE   6  (bases 1 to 4332)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   7  (bases 1 to 4332)
  AUTHORS   Akamizu,T., Ikuyama,S., Saji,M., Kosugi,S., Kozak,C., McBride,O.W.
            and Kohn,L.D.
  TITLE     Cloning, chromosomal assignment, and regulation of the rat
            thyrotropin receptor: expression of the gene is regulated by
            thyrotropin, agents that increase cAMP levels, and thyroid
            autoantibodies
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5677-5681 (1990)
   PUBMED   1696008
REFERENCE   8  (bases 1 to 4332)
  AUTHORS   Parmentier,M., Libert,F., Maenhaut,C., Lefort,A., Gerard,C.,
            Perret,J., Van Sande,J., Dumont,J.E. and Vassart,G.
  TITLE     Molecular cloning of the thyrotropin receptor
  JOURNAL   Science 246 (4937), 1620-1622 (1989)
   PUBMED   2556796
REFERENCE   9  (bases 1 to 4332)
  AUTHORS   Laffan,E.W., Lisciotto,C.A., Gapp,D.A. and Weldon,D.A.
  TITLE     Development of rotorod performance in normal and congenitally
            hypothyroid mutant mice
  JOURNAL   Behav Neural Biol 52 (3), 411-416 (1989)
   PUBMED   2590150
REFERENCE   10 (bases 1 to 4332)
  AUTHORS   Libert,F., Parmentier,M., Lefort,A., Dinsart,C., Van Sande,J.,
            Maenhaut,C., Simons,M.J., Dumont,J.E. and Vassart,G.
  TITLE     Selective amplification and cloning of four new members of the G
            protein-coupled receptor family
  JOURNAL   Science 244 (4904), 569-572 (1989)
   PUBMED   2541503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB645263.1 and BC086691.1.
            
            On Jan 13, 2008 this sequence version replaced NM_011648.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086691.1, BC092523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BB645263.1         1-71
            72-4332             BC086691.1         1-4261
FEATURES             Location/Qualifiers
     source          1..4332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 44.51 cM"
     gene            1..4332
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /note="thyroid stimulating hormone receptor"
                     /db_xref="GeneID:22095"
                     /db_xref="MGI:MGI:98849"
     exon            1..262
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2387
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; thyrotropin receptor; TSH-R"
                     /codon_start=1
                     /product="thyrotropin receptor isoform 1 precursor"
                     /protein_id="NP_035778.3"
                     /db_xref="CCDS:CCDS26088.1"
                     /db_xref="GeneID:22095"
                     /db_xref="MGI:MGI:98849"
                     /translation="MRPGSLLLLVLLLALSRSLRGKECASPPCECHQEDDFRVTCKEL
                     HRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSK
                     MTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDIFFILEITD
                     NPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTAIDN
                     DAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSLSFLHLTRAD
                     LSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNILRGPIYQEYEEDPGDNS
                     VGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFGQELKNPQEETLQAFESHYDYTVCGD
                     NEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYKLTVPR
                     FLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELS
                     VYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKV
                     SICLPMDTDTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNPQYNPRDKDTKIAK
                     RMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFT
                     KAFQRDVFILLSKFGICKRQAQAYQGQRVCPNNSTGIQIQKIPQDTRQSLPNMQDTYE
                     LLGNSQLAPKLQGQISEEYKQTAL"
     exon            263..334
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            335..409
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            410..484
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            485..559
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            560..637
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            638..706
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            707..784
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            785..973
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     exon            974..4312
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /note="hexamer: TATAAA"
     polyA_site      3681
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /note="major polyA site"
     regulatory      4289..4294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
                     /note="hexamer: ATTAAA"
     polyA_site      4312
                     /gene="Tshr"
                     /gene_synonym="hypothroid; hyt; pet"
ORIGIN      
        1 tgcacccggg tctcttccag cgtcagacgc agggcactga gaatgtggcg acagcgcgca
       61 acgatgaagt agcccagagg gtcccttgga aaatgaggcc agggtccctg ctgctgcttg
      121 ttctgctgct cgccctgtcc aggagcctgc ggggcaaaga gtgtgcgtct ccaccctgtg
      181 agtgtcacca ggaggacgac ttcagagtca cctgcaagga gctccaccga atccccagcc
      241 tgccgcccag cacccagact ctgaagctca tcgagactca tctgaagacc atacccagtc
      301 ttgcattttc gagtctgccc aatatttcca ggatctattt atctatagat gcaactctgc
      361 agcggctgga accacattct ttctacaatt tgagtaaaat gactcacata gaaatccgga
      421 acaccagaag cttaacctat atagaccctg atgccttgac agagctcccc ttgctcaagt
      481 ttcttggcat tttcaatact ggacttagaa tattccctga cttgaccaaa atttattcca
      541 cggacatatt ctttatactt gaaatcacag acaaccctta catgacttcg gtccctgaaa
      601 acgcattcca gggcctatgc aatgaaacct tgaccctgaa actgtacaac aatggattta
      661 cttcagtcca aggacatgct ttcaatggaa caaagctgga tgctgtttac ctaaacaaga
      721 ataaatacct gacagctata gacaacgatg cctttggagg agtatacagt ggaccaactt
      781 tgctagatgt gtcttccacc agcgtcactg cccttccttc caaaggcctg gagcacctca
      841 aagaactgat cgcaaaagac acctggactc tcaaaaagct cccgctgtcg ttgagtttcc
      901 tccacctcac tcgggctgac ctctcttacc cgagccactg ctgcgctttt aagaaccaga
      961 agaaaatcag gggaatcctg gagtctttga tgtgtaatga gagcagtatc cggaaccttc
     1021 gtcaaaggaa atcagtgaac atcttgaggg gtcccatcta ccaggaatat gaagaagatc
     1081 cgggtgacaa cagtgttggg tacaaacaaa actccaagtt ccaggagagc ccaagcaact
     1141 ctcactatta cgtcttcttt gaagaacaag aggatgaggt cgttggtttc ggccaagagc
     1201 tcaaaaatcc tcaggaagag actctccaag ccttcgagag ccactatgac tacacggtgt
     1261 gtggggacaa cgaggacatg gtgtgtaccc ccaagtcgga cgagtttaac ccctgtgaag
     1321 atatcatggg ctacaggttc ctgagaatcg tggtgtggtt tgtcagtctg ctggctctcc
     1381 tgggcaatat cttcgtcctg ctcattctgc taaccagcca ctacaaattg accgtgccgc
     1441 ggttcctcat gtgcaacttg gcctttgcag atttctgcat gggggtatac ctgcttctca
     1501 ttgcctctgt agacctgtac acacactctg agtactacaa ccacgccatc gactggcaga
     1561 cgggccctgg gtgcaacacg gctggcttct tcactgtttt cgccagtgag ttatcagtgt
     1621 acacactgac ggtcatcacc ctggagcgat ggtacgccat caccttcgcc atgcgcctgg
     1681 ataggaagat ccgcctcagg cacgcgtaca ccatcatggc tgggggctgg gtttcctgct
     1741 tccttctcgc cctgctcccg atggtgggaa tcagcagcta tgccaaggtc agcatctgcc
     1801 tgccaatgga caccgacacc cctcttgcac tcgcatacat tgtcctcgtt ctgctgctca
     1861 atgttgttgc ctttgttgtc gtctgttcct gctatgtgaa gatctacatc acggtccgaa
     1921 atccccagta caaccctcga gataaagaca ccaagattgc caagaggatg gctgtgttga
     1981 tcttcactga cttcatgtgc atggcgccca tctccttcta tgcgctgtcg gcacttatga
     2041 acaagcctct aatcactgtt actaactcca aaatcttgtt ggttctcttc taccccctca
     2101 actcctgtgc caatccgttt ctctatgcta ttttcaccaa ggccttccag agggacgtgt
     2161 tcatcctgct cagcaagttt ggcatctgca aacgccaggc ccaggcctat cagggtcaga
     2221 gagtctgtcc caacaatagc actggtattc agatccaaaa gattccccag gacacgaggc
     2281 agagtctccc caacatgcaa gatacctatg aactgcttgg aaactcccag ctagctccaa
     2341 aactgcaggg acaaatctca gaagagtata agcaaacagc cttgtaaagg aaaggctacg
     2401 ctagtcacag tgagacttac aaaaggctgg tttcttgaac atgcgttcca gtcccgtgac
     2461 atgtgaacac ataggttcat gcaggtgatg attcataggg tcagagttca tctctagaaa
     2521 gtattgcctc taagaaggaa gagacgctat cagcatatct gagtcctagg tgatatgaca
     2581 atcgcctatg ctcgctggga gatttgcttg ttgcttgtct atgatgccat gcaacatgtt
     2641 ccacagacac cagttgaacc attcccacat cttgcttctc cattttatgt agtgttttat
     2701 actaaagact caacaactgg ccagtgttca tcatactcca tattagcacc cctgaaagaa
     2761 ccaaagaaat gtttttattc cttaaaaata aaatgccaag gtaaaatctg gactgttaat
     2821 aaaaaaagat taaataaaat taaataaata aataaaatgc cacacttgga aggtggaggt
     2881 aggggaatcc agttcatact tagccacata gagaattcca agccaacttg tgctacctga
     2941 agctccacct caagctacca aaagaagcct ggaaagccaa acatatagat gtcacataat
     3001 tgcttttatt aaactgaaaa aaagagcacg tctagttttg agaggttttt ctttgttttt
     3061 cttccttaga ctctgaatca atcatcacca ggctctgcct gccgtgaccc agctgttaca
     3121 cgctgactgg agaaactgcc aaggtttcag cttttgtggc tgagcaaact taagaattat
     3181 cttctcatat aaaacatgag ctccgggaga gatttctaag gaccacatgg gaatgaggac
     3241 agggcacact tggccacgtg ttgaataaga caactatata ccagttaact tgtcgggctt
     3301 tgagcaagtc tctggacctc taaattctgt agaaatgggg ggatttgatg ccctcttcca
     3361 ttaaaaaaca aaaacaaaaa aacctaggta tatatccccc tcaaaagata tgtgtgacaa
     3421 agacaaagaa aacactactt aagtagactc ggttttttct accttgtgac gctgctgtct
     3481 acttctttta ggaaccagga catgtgaccc aagatgcttt ttctttattt cattctgatc
     3541 atcgtgtctg aaccaaaagt tctattgagt gactgactat gtggagccag atcctaacta
     3601 ttcatctaaa ttattgtatc tatactactg tcaagtccaa gacatactgg aatttatata
     3661 aactgttaat aatacagccc agctcatgtg gtgcacgcct ttaatttcag cactggggag
     3721 gcagaggcag gtagatctct gaatttgagg ctagcctggc ctaagacagc caagtgtaca
     3781 cagagaaacc ctgtttcaaa gaaaaaaaca aaacaaaata gactactaat agagttaata
     3841 tgtgactatg taggctcact ttcaaacatt taactcgttc ttcttctttt ttttaagctc
     3901 tcctgggctc acaccacact aacactgtca agagagaaat ctctttactg acactgccag
     3961 tcccttctaa ccctgccagt cactgacata aaacatgtgt gtcccaagag ttgccttgct
     4021 tcaaacagga actgcatctc caggtgtacc ctccaggtag ccagtctggt caggctcttt
     4081 accacattgt tacggagtcc ccaagcagat ctggcatgct cttctcagtg ctcatgagcc
     4141 aaagcaggaa ctataagggg ctcgccactt tcagcctatg aagtagggtt tatgggtcac
     4201 ctgacatggc tcctatctgc ctggcctggg actctgtcac ggtctcacaa gcaccggctt
     4261 ccccagcagt tcacgtgtaa ctactgaaat taaataactg tgctaccctg tgaaaaaaaa
     4321 aaaaaaaaaa aa
//
