LOCUS       NM_009432                645 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus thyroid stimulating hormone, beta subunit (Tshb),
            transcript variant 1, mRNA.
ACCESSION   NM_009432
VERSION     NM_009432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 645)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 645)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 645)
  AUTHORS   Lu,C., Zhang,J., Wang,B., Gao,Q., Ma,K., Pei,S., Li,J. and Cui,S.
  TITLE     Casein kinase 1alpha is required to maintain murine hypothalamic
            pro-opiomelanocortin expression
  JOURNAL   iScience 26 (5), 106670 (2023)
   PUBMED   37168577
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 645)
  AUTHORS   Gonzalez-Meljem,J.M., Ivins,S., Andoniadou,C.L., Le Tissier,P.,
            Scambler,P. and Martinez-Barbera,J.P.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 645)
  AUTHORS   Bando,H., Brinkmeier,M.L., Castinetti,F., Fang,Q., Lee,M.S.,
            Saveanu,A., Albarel,F., Dupuis,C., Brue,T. and Camper,S.A.
  TITLE     Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone
            deficiency in mouse and man
  JOURNAL   Hum Mol Genet 32 (3), 367-385 (2023)
   PUBMED   35951005
REFERENCE   6  (bases 1 to 645)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   7  (bases 1 to 645)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   8  (bases 1 to 645)
  AUTHORS   Todd,J.A., Aitman,T.J., Cornall,R.J., Ghosh,S., Hall,J.R.,
            Hearne,C.M., Knight,A.M., Love,J.M., McAleer,M.A., Prins,J.B. et
            al.
  TITLE     Genetic analysis of autoimmune type 1 diabetes mellitus in mice
  JOURNAL   Nature 351 (6327), 542-547 (1991)
   PUBMED   1675432
REFERENCE   9  (bases 1 to 645)
  AUTHORS   Aitman,T.J., Hearne,C.M., McAleer,M.A. and Todd,J.A.
  TITLE     Mononucleotide repeats are an abundant source of length variants in
            mouse genomic DNA
  JOURNAL   Mamm Genome 1 (4), 206-210 (1991)
   PUBMED   1794049
  REMARK    Review article
REFERENCE   10 (bases 1 to 645)
  AUTHORS   Kingsmore,S.F., Moseley,W.S., Watson,M.L., Sabina,R.L., Holmes,E.W.
            and Seldin,M.F.
  TITLE     Long-range restriction site mapping of a syntenic segment conserved
            between human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 7 (1), 75-83 (1990)
   PUBMED   1970802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134871.3.
            
            On Sep 30, 2009 this sequence version replaced NM_009432.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M54943.1, J00644.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC134871.3         88643-88709
            68-114              AC134871.3         88861-88907
            115-155             AC134871.3         89255-89295
            156-318             AC134871.3         93045-93207
            319-645             AC134871.3         93633-93959
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..645
                     /gene="Tshb"
                     /note="thyroid stimulating hormone, beta subunit"
                     /db_xref="GeneID:22094"
                     /db_xref="MGI:MGI:98848"
     exon            1..67
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     exon            68..114
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     exon            115..155
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     exon            156..318
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     exon            319..645
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      623..628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tshb"
                     /note="hexamer: AATAAA"
     polyA_site      640
                     /gene="Tshb"
                     /note="major polyA site"
ORIGIN      
        1 atcctgaagg gtataaaatg aacggagagt gggtcatcac agcagtaact cactcatgca
       61 aagtaagatc ctgcagtagt gggtggagaa gagtgagcgc atacgagtgg agagaaaaat
      121 attctgcttc agtgaagagc tggggttgtt caaagcatga gtgctgccgt cctcctctcc
      181 gtgctttttg ctcttgcttg tgggcaagca gcatcctttt gtattcccac tgagtataca
      241 atgtacgtgg ataggagaga gtgtgcctac tgcctgacca tcaacaccac catctgtgct
      301 gggtattgta tgacacggga tatcaatggc aaactgtttc ttcccaaata tgcactctct
      361 caggatgtct gtacatacag agacttcatc tacagaacgg tggaaatacc aggatgcccg
      421 caccatgtta ctccttattt ctccttccct gtcgccataa gctgcaagtg tggcaagtgt
      481 aatactgaca acagtgactg catacacgag gctgtcagaa ccaactactg caccaagccg
      541 cagtctttct atctgggggg attttctgtt taacttcaat agcagtgcaa tctggttaaa
      601 tgtgtttacc tggaatagaa cgaataaaat accattgaga cgtct
//
