LOCUS       NP_001277650             690 aa            linear   ROD 29-JUL-2024
DEFINITION  testis-specific gene 10 protein isoform 3 [Mus musculus].
ACCESSION   NP_001277650
VERSION     NP_001277650.1
DBSOURCE    REFSEQ: accession NM_001290721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 690)
  AUTHORS   Luo,G., Hou,M., Wang,B., Liu,Z., Liu,W., Han,T., Zhang,D., Zhou,X.,
            Jia,W., Tan,Y., Wu,Y., Wang,J. and Zhang,X.
  TITLE     Tsga10 is essential for arrangement of mitochondrial sheath and
            male fertility in mice
  JOURNAL   Andrology 9 (1), 368-375 (2021)
   PUBMED   32790169
  REMARK    GeneRIF: Tsga10 is essential for arrangement of mitochondrial
            sheath and male fertility in mice.
REFERENCE   2  (residues 1 to 690)
  AUTHORS   Tajaddini Mahani,S., Behnam,B., Abbassi,M., Asgari,H., Nazmara,Z.,
            Shirinbayan,P., Joghataei,M.T. and Koruji,M.
  TITLE     Tsga10 expression correlates with sperm profiles in the adult
            formalin-exposed mice
  JOURNAL   Andrologia 48 (10), 1092-1099 (2016)
   PUBMED   26791599
  REMARK    GeneRIF: This study also shows that Tsga10 expression protects
            sperm dysfunction in formalin plus manganese-exposed mice resulting
            in better preservation of spermatozoa and improvement of male
            fertility.
REFERENCE   3  (residues 1 to 690)
  AUTHORS   Hagele,S., Behnam,B., Borter,E., Wolfe,J., Paasch,U., Lukashev,D.,
            Sitkovsky,M., Wenger,R.H. and Katschinski,D.M.
  TITLE     TSGA10 prevents nuclear localization of the hypoxia-inducible
            factor (HIF)-1alpha
  JOURNAL   FEBS Lett 580 (15), 3731-3738 (2006)
   PUBMED   16777103
  REMARK    GeneRIF: HIF-1alpha nuclear localization and HIF-1 transcriptional
            activity were significantly affected by overexpressed TSGA10
REFERENCE   4  (residues 1 to 690)
  AUTHORS   Behnam,B., Modarressi,M.H., Conti,V., Taylor,K.E., Puliti,A. and
            Wolfe,J.
  TITLE     Expression of Tsga10 sperm tail protein in embryogenesis and neural
            development: from cilium to cell division
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1102-1110 (2006)
   PUBMED   16643851
  REMARK    GeneRIF: Tsga10 expression starts in 4.5-7.5 dpc mouse embryos and
            continues throughout embryogenesis.
REFERENCE   5  (residues 1 to 690)
  AUTHORS   Modarressi,M.H., Behnam,B., Cheng,M., Taylor,K.E., Wolfe,J. and van
            der Hoorn,F.A.
  TITLE     Tsga10 encodes a 65-kilodalton protein that is processed to the
            27-kilodalton fibrous sheath protein
  JOURNAL   Biol Reprod 70 (3), 608-615 (2004)
   PUBMED   14585816
  REMARK    GeneRIF: Tsga10 plays a role in the sperm tail fibrous sheath.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ046680.1, AK030254.1, BC053407.1, AC123068.4, CK789086.1 and
            BX637247.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            an alternate 3' structure and 3' terminal exon, compared to variant
            1. The encoded protein (isoform 3) has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF530050.3, SRR7974084.3373.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.88 cM"
     Protein         1..690
                     /product="testis-specific gene 10 protein isoform 3"
                     /note="testis-specific gene 10 protein"
                     /calculated_mol_wt=80219
     Region          <135..467
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <361..>652
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          556..688
                     /region_name="Interaction with HIF1A.
                     /evidence=ECO:0000269|PubMed:16777103"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NY15.1)"
     Region          656..684
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NY15.1)"
     Site            687
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z220; propagated from
                     UniProtKB/Swiss-Prot (Q6NY15.1)"
     CDS             1..690
                     /gene="Tsga10"
                     /gene_synonym="4933432N21Rik; Gm217; Mtsga10"
                     /coded_by="NM_001290721.1:529..2601"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS78571.1"
                     /db_xref="GeneID:211484"
                     /db_xref="MGI:MGI:2685063"
ORIGIN      
        1 mmrnrskspr rpsptsraan cdvellksta rdreelkcml ekyerhlaei qgnvkvltse
       61 rdktfllyeq aqeeiarlrr emmksckspk sttahailrr veterdvaft dlrrmtterd
      121 slrerlkiaq etafnekahl eqrieelect vhnldderme qmanmtlmke tittvekemk
      181 slarkamdte selgrqkaen nslrllyent ekdlsdtqrh lakkkyelql tqekimclde
      241 kidnftrqni aqreeisilg atlndlakek eclqacldkk seniaslges lamkektisg
      301 mkniiaemeq asrqsteali mceqdisrmr rqldetndel gqiarerdil ahendnlqeq
      361 fakvkqenqa lskklndthn elsdikqkvq dtnlevnklk nilkseesen rqimeqlrka
      421 nedaenwenk arqteaennt lklelitaea egnrlkekvd alnreveqhl naersyksqi
      481 atlhkslvkm eeelqkvqfe kvsaladlss trelciklds skellnrqlv akdqeiemme
      541 neldsarsei ellrsqmtne rismqnleal lvanrdkeyq sqialqekes eiqllkehlc
      601 laenkmaiqs rdvaqfrnvv tqleadldit krqlgterfe reravqelrr qnyssnaynl
      661 gpmkpntkch sperahhrsp drgldrslee
//
