LOCUS       NM_025537               1180 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus Ts translation elongation factor, mitochondrial
            (Tsfm), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025537
VERSION     NM_025537.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Tomar,A., Gomez-Velazquez,M., Gerlini,R., Comas-Armangue,G.,
            Makharadze,L., Kolbe,T., Boersma,A., Dahlhoff,M., Burgstaller,J.P.,
            Lassi,M., Darr,J., Toppari,J., Virtanen,H., Kuhnapfel,A.,
            Scholz,M., Landgraf,K., Kiess,W., Vogel,M., Gailus-Durner,V.,
            Fuchs,H., Marschall,S., Hrabe de Angelis,M., Kotaja,N., Korner,A.
            and Teperino,R.
  TITLE     Epigenetic inheritance of diet-induced and sperm-borne
            mitochondrial RNAs
  JOURNAL   Nature 630 (8017), 720-727 (2024)
   PUBMED   38839949
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134329.3.
            
            On Nov 17, 2006 this sequence version replaced NM_025537.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057904.1, AK169164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC134329.3         54182-54252
            72-245              AC134329.3         54360-54533
            246-374             AC134329.3         55314-55442
            375-497             AC134329.3         56509-56631
            498-585             AC134329.3         59973-60060
            586-1180            AC134329.3         62070-62664
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..1180
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /note="Ts translation elongation factor, mitochondrial"
                     /db_xref="GeneID:66399"
                     /db_xref="MGI:MGI:1913649"
     exon            1..71
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..992
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /note="elongation factor Ts, mitochondrial"
                     /codon_start=1
                     /product="elongation factor Ts, mitochondrial precursor"
                     /protein_id="NP_079813.1"
                     /db_xref="CCDS:CCDS24222.1"
                     /db_xref="GeneID:66399"
                     /db_xref="MGI:MGI:1913649"
                     /translation="MSLLRSLRFFPVACTGRSARAVLLQPSQPWLTFHAGPSLSSAAS
                     SKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEDWLHKQAQKEGWSKAAKLHGRKTK
                     EGLIGLLQEGNTAVLVEVNCETDFVSRNLKFQQLVQQVALGTMAHCQNLTDRLSTYSK
                     GFLNSSELSELAAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVGSYVHG
                     VTQSPSLQNLVLGKYGALVICETPEQIANLEEVGRRLGQHVVGMAPLSVGSLDDEPGG
                     ETETRMLPQPYLLDPSITLGQYVQPQGVTVVDFVRFECGEDEQVAEAE"
     exon            72..245
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     exon            246..374
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     exon            375..497
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     exon            498..585
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     exon            586..1180
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /note="hexamer: AATAAA"
     polyA_site      1169
                     /gene="Tsfm"
                     /gene_synonym="2310050B20Rik; 9430024O13Rik; EF-TS;
                     EF-Tsmt"
                     /note="major polyA site"
ORIGIN      
        1 gcgggagggc cagagggatg tcgcttctgc ggtcgctgcg cttcttcccg gtcgcgtgca
       61 ccggccgctc ggcgagggct gtcctgctcc agccgtccca gccatggctc acgtttcacg
      121 ccggcccctc gctgtcctct gctgcctcca gcaaggagct ccttatgaaa ctgcggcgga
      181 aaaccggcta ctcctttgtc aactgcaaga aggctctgga gacttgtggc ggtgacctca
      241 agcaggcaga ggactggctg cacaaacagg cccagaagga aggatggagc aaagccgcca
      301 agctccacgg gaggaagact aaagaaggct tgattggact tctgcaggag ggaaacacag
      361 ctgttttagt agaggtaaac tgtgagacag attttgtctc cagaaattta aaatttcaac
      421 agttggtcca gcaagtagcc ctgggaacca tggcacactg tcagaacctg acggatcggc
      481 tctccacgta cagtaagggc tttctcaact cctctgagct ttctgaactt gcagctgggc
      541 ccgacaggga aggctctctc aaggatcagt tggccctagc gattggtaaa ctgggagaga
      601 acatgattct taagcgagct gcctgggtga aggtgccctc tgggttctat gtcggctctt
      661 atgtgcacgg agtgacgcag agcccctccc tccagaacct ggtgctgggg aagtacgggg
      721 ccctggtcat ctgtgagact cccgagcaga tcgcaaacct ggaggaggtt ggccgccgct
      781 tggggcagca cgtggtgggc atggcccctc tctctgtggg ctccctggac gatgagcctg
      841 ggggggagac ggagaccagg atgctgcccc agccgtacct cctggatcct tccattacac
      901 tggggcagta cgtgcagccc cagggcgtga ctgtagtgga cttcgtgcgc ttcgaatgtg
      961 gagaagacga acaggtggcc gaggctgaat aggtttttgg cctaagtgga aatatttaat
     1021 ttttatatct ggatttcctt ataaaaagtt attttctaaa cctcttcaac cctcaaattt
     1081 gttttttttt tttccttttt agtttaaaat gaagatatat aatcatgggt aaagttatta
     1141 aatggtgatg taataaagaa tttttctcat ttgtatagtg
//
