LOCUS       NM_029557               1972 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tRNA splicing endonuclease subunit 54 (Tsen54), mRNA.
ACCESSION   NM_029557 XM_001003234 XM_001003245 XM_001003252 XM_203352
            XM_915656 XM_993828 XM_993849
VERSION     NM_029557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Ermakova,O., Orsini,T., Fruscoloni,P., Chiani,F., Gambadoro,A.,
            Putti,S., Cirilli,M., Mezzi,A., Kaciulis,S., Pasquini,M., Raspa,M.,
            Scavizzi,F. and Tocchini-Valentini,G.P.
  TITLE     Three-Dimensional X-ray Imaging of beta-Galactosidase Reporter
            Activity by Micro-CT: Implication for Quantitative Analysis of Gene
            Expression
  JOURNAL   Brain Sci 11 (6), 746 (2021)
   PUBMED   34199780
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Ermakova,O., Orsini,T., Gambadoro,A., Chiani,F. and
            Tocchini-Valentini,G.P.
  TITLE     Three-dimensional microCT imaging of murine embryonic development
            from immediate post-implantation to organogenesis: application for
            phenotyping analysis of early embryonic lethality in mutant animals
  JOURNAL   Mamm Genome 29 (3-4), 245-259 (2018)
   PUBMED   29170794
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Stoller,J.Z., Huang,L., Tan,C.C., Huang,F., Zhou,D.D., Yang,J.,
            Gelb,B.D. and Epstein,J.A.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203746.1, AK002758.1 and BB273422.1.
            
            On or before Jun 12, 2006 this sequence version replaced
            XM_203352.5, XM_915656.2, XM_993849.1, XM_993828.1, XM_001003252.1,
            XM_001003245.1, XM_001003234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002758.1, SRR7652917.719757.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY203746.1         6-21
            17-1957             AK002758.1         2-1942
            1958-1972           BB273422.1         167-181
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..1972
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /note="tRNA splicing endonuclease subunit 54"
                     /db_xref="GeneID:76265"
                     /db_xref="MGI:MGI:1923515"
     exon            1..81
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1603
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /note="tRNA splicing endonuclease 54 homolog; likely
                     ortholog of H. sapiens SEN54L; tRNA-intron endonuclease
                     Sen54"
                     /codon_start=1
                     /product="tRNA-splicing endonuclease subunit Sen54"
                     /protein_id="NP_083833.1"
                     /db_xref="CCDS:CCDS25648.1"
                     /db_xref="GeneID:76265"
                     /db_xref="MGI:MGI:1923515"
                     /translation="MEPEPEPGSVEVPAGRVLSASELRAARSRSQKLPQRSHGPKDFL
                     PDGSEAQAERLRLCRQELWQLLAEERVERLGSLVAAEWKPEEGFVELTSPAGKFWQTM
                     GYSEEGRQRLHPEEALYLLECGSIQLFYQDLPLSIQEAYQLLLTEDTLSFLQYQVFSH
                     LKRLGYVVRRFQLSSVVSPYERQLNLDGYAQCLEDGSGKRKRSSSCRSVNKKPKVLQN
                     SLPPVSLAASSSPACDQSSQYPEEKSQDSSPRQGSELPLQFLGSSEPCSDLAREDVGC
                     DRESHKIENGAKGTPKLRWNFEQISFPNMASDSRHTFLPAPAPELLPANVIGRGTDAE
                     SWCQKLNQRREKLSRRDREQQAVVQQFREDVNADPEVRGCSSWQEYKELLQRRQTQKS
                     QPRPPHLWGQSVTPLLDPDKADCPAAVLQHISVLQTTHLADGGYRLLEKSGGLQISFD
                     VYQADAVATFRKNSPGKPYVRMCISGFDDPVPDLCSLKCLTYQSGDVPLIFALVDHGD
                     ISFYSFRDFTLPRDLGH"
     exon            82..246
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..310
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            311..394
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..493
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..546
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            547..645
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            646..1274
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1335
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1452
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1972
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1939..1944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1959
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcagcc gcagacagcg gcccgatgga gcccgaaccc gaacccgggt cggtggaggt
       61 tcccgcgggg cgtgtgctca gcgcctcgga gctccgcgcc gcgcgctcgc ggtcccagaa
      121 gctaccacag cggtcgcatg gccccaagga cttcctcccg gacggctcgg aggcccaggc
      181 ggagcggctg cgcctgtgtc gccaagagct gtggcagctg ctggcggagg agcgcgtgga
      241 gcgcctgggc agcttggtgg ccgcggagtg gaaaccagaa gagggctttg tggagttgac
      301 gtctcctgcg gggaaattct ggcagaccat gggctactca gaggaaggac ggcagcgact
      361 tcaccccgaa gaggctttgt atctgctgga gtgtggttcg attcagctct tctaccaaga
      421 cctcccactg tctatccaag aggcatacca gctgctgctg acagaggaca ccttgagttt
      481 cctgcagtac caggtcttca gccacctgaa gagactgggc tatgtggttc gtcggttcca
      541 gctaagctct gtcgtgtcac cttacgagcg gcagcttaat ttggatggtt atgcccagtg
      601 cctggaggat gggtctggca agaggaagag gagttccagc tgtcggtctg ttaataagaa
      661 gcccaaggtc ctgcagaact ccctgccgcc cgtcagcctg gcagcctcca gctcacctgc
      721 ctgtgaccag agtagccaat acccagagga gaagtctcag gactcaagcc ccaggcaggg
      781 ctcagagctc cccttgcagt tcctggggtc ctcagagcct tgctctgatc tggccaggga
      841 agacgtgggg tgtgaccgag agagtcacaa aatagagaat ggagctaagg gaacccctaa
      901 gctacgctgg aactttgagc agatctcatt ccccaacatg gcctctgata gtcgccacac
      961 tttcctgcct gctccagccc cagagctgct cccagccaat gtcattgggc gagggacaga
     1021 tgctgagtcc tggtgccaaa agctgaacca gcggagggag aagctctccc gtagagaccg
     1081 ggaacagcaa gcagtggtcc agcagttccg ggaggatgtt aacgcagatc ccgaggtgcg
     1141 gggctgctcc agctggcagg agtacaagga gctgctgcag aggcgacaga cgcagaagag
     1201 ccagccccgg cctccacacc tatggggcca gtccgttacc cccttgctcg accctgataa
     1261 agccgattgt ccagccgcgg tcctgcaaca tatctctgta ctgcagacga cacaccttgc
     1321 tgatggaggt taccggctgc tggagaagtc tggaggcttg cagatcagct tcgatgttta
     1381 ccaggctgac gctgtggcga cgttccgaaa aaacagccct ggcaaaccct atgtgcgaat
     1441 gtgcattagt gggtttgatg accctgtccc agacctctgc agcctcaagt gcttgaccta
     1501 ccagagtggg gatgttcccc tgatctttgc tctagtggac cacggtgaca tctccttcta
     1561 cagcttcaga gacttcacac tgcccaggga tctgggccac tgaatacagc tctggggatg
     1621 gcttgctctg ggggggcctg gactgctctc aggggccgtg ccagctgtct ctcatatagg
     1681 actcacctgg atggaaccgt ccaggccatt ggggtctgtg atcctaggtg tcttctgttt
     1741 gtagggacgt gcacaccctc ttgcctggcc actgtgcttt caagcccact gcctggaagt
     1801 gctgcctgac agtgacgccc ccacccccac cccccttgga actcaggact tgttttcaga
     1861 ggcccaggac ttgggttagg agaaaggact gtgcctttat tcaagggggt gcttgcttcg
     1921 tgccataaag ccaaagccat taaaaaaata tatattttct gctgtggttc aa
//
