LOCUS       NP_083833                525 aa            linear   ROD 27-APR-2025
DEFINITION  tRNA-splicing endonuclease subunit Sen54 [Mus musculus].
ACCESSION   NP_083833 XP_001003234 XP_001003245 XP_001003252 XP_203352
            XP_920749 XP_998922 XP_998943
VERSION     NP_083833.1
DBSOURCE    REFSEQ: accession NM_029557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Ermakova,O., Orsini,T., Fruscoloni,P., Chiani,F., Gambadoro,A.,
            Putti,S., Cirilli,M., Mezzi,A., Kaciulis,S., Pasquini,M., Raspa,M.,
            Scavizzi,F. and Tocchini-Valentini,G.P.
  TITLE     Three-Dimensional X-ray Imaging of beta-Galactosidase Reporter
            Activity by Micro-CT: Implication for Quantitative Analysis of Gene
            Expression
  JOURNAL   Brain Sci 11 (6), 746 (2021)
   PUBMED   34199780
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Ermakova,O., Orsini,T., Gambadoro,A., Chiani,F. and
            Tocchini-Valentini,G.P.
  TITLE     Three-dimensional microCT imaging of murine embryonic development
            from immediate post-implantation to organogenesis: application for
            phenotyping analysis of early embryonic lethality in mutant animals
  JOURNAL   Mamm Genome 29 (3-4), 245-259 (2018)
   PUBMED   29170794
REFERENCE   4  (residues 1 to 525)
  AUTHORS   Stoller,J.Z., Huang,L., Tan,C.C., Huang,F., Zhou,D.D., Yang,J.,
            Gelb,B.D. and Epstein,J.A.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   5  (residues 1 to 525)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203746.1, AK002758.1 and BB273422.1.
            
            On or before Jun 12, 2006 this sequence version replaced
            XP_203352.3, XP_920749.1, XP_998943.1, XP_998922.1, XP_001003252.1,
            XP_001003245.1, XP_001003234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002758.1, SRR7652917.719757.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     Protein         1..525
                     /product="tRNA-splicing endonuclease subunit Sen54"
                     /note="tRNA splicing endonuclease 54 homolog; likely
                     ortholog of H. sapiens SEN54L; tRNA-intron endonuclease
                     Sen54"
                     /calculated_mol_wt=58952
     Region          1..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C2A2.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z6J9; propagated from
                     UniProtKB/Swiss-Prot (Q8C2A2.2)"
     Region          63..130
                     /region_name="tRNA_int_end_N2"
                     /note="tRNA-splicing endonuclease subunit sen54 N-term;
                     pfam12928"
                     /db_xref="CDD:463754"
     Region          <116..>169
                     /region_name="tRNA_int_end_N2"
                     /note="tRNA-splicing endonuclease subunit sen54 N-term;
                     cl46333"
                     /db_xref="CDD:480673"
     Site            178
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z6J9; propagated from
                     UniProtKB/Swiss-Prot (Q8C2A2.2)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z6J9; propagated from
                     UniProtKB/Swiss-Prot (Q8C2A2.2)"
     Region          220..273
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C2A2.2)"
     CDS             1..525
                     /gene="Tsen54"
                     /gene_synonym="0610034P02Rik"
                     /coded_by="NM_029557.1:26..1603"
                     /db_xref="CCDS:CCDS25648.1"
                     /db_xref="GeneID:76265"
                     /db_xref="MGI:MGI:1923515"
ORIGIN      
        1 mepepepgsv evpagrvlsa selraarsrs qklpqrshgp kdflpdgsea qaerlrlcrq
       61 elwqllaeer verlgslvaa ewkpeegfve ltspagkfwq tmgyseegrq rlhpeealyl
      121 lecgsiqlfy qdlplsiqea yqllltedtl sflqyqvfsh lkrlgyvvrr fqlssvvspy
      181 erqlnldgya qcledgsgkr krssscrsvn kkpkvlqnsl ppvslaasss pacdqssqyp
      241 eeksqdsspr qgselplqfl gssepcsdla redvgcdres hkiengakgt pklrwnfeqi
      301 sfpnmasdsr htflpapape llpanvigrg tdaeswcqkl nqrreklsrr dreqqavvqq
      361 fredvnadpe vrgcsswqey kellqrrqtq ksqprpphlw gqsvtplldp dkadcpaavl
      421 qhisvlqtth ladggyrlle ksgglqisfd vyqadavatf rknspgkpyv rmcisgfddp
      481 vpdlcslkcl tyqsgdvpli falvdhgdis fysfrdftlp rdlgh
//
