LOCUS       NM_023910               2308 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus Tsc22 domain family, member 4 (Tsc22d4), mRNA.
ACCESSION   NM_023910 XM_132432
VERSION     NM_023910.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Demir,S., Wolff,G., Wieder,A., Maida,A., Buhler,L., Brune,M.,
            Hautzinger,O., Feuchtinger,A., Poth,T., Szendroedi,J., Herzig,S.
            and Ekim Ustunel,B.
  TITLE     TSC22D4 interacts with Akt1 to regulate glucose metabolism
  JOURNAL   Sci Adv 8 (42), eabo5555 (2022)
   PUBMED   36269831
  REMARK    GeneRIF: TSC22D4 interacts with Akt1 to regulate glucose
            metabolism.
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Wolff,G., Sakurai,M., Mhamane,A., Troullinaki,M., Maida,A.,
            Deligiannis,I.K., Yin,K., Weber,P., Morgenstern,J., Wieder,A.,
            Kwon,Y., Sekar,R., Zeigerer,A., Roden,M., Bluher,M., Volk,N.,
            Poth,T., Hackert,T., Wiedmann,L., De Angelis Rigotti,F.,
            Rodriguez-Vita,J., Fischer,A., Mukthavaram,R., Limphong,P.,
            Tachikawa,K., Karmali,P., Payne,J., Chivukula,P., Ekim-Ustunel,B.,
            Martinez-Jimenez,C.P., Szendrodi,J., Nawroth,P. and Herzig,S.
  TITLE     Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD
            by impairing mitochondrial function
  JOURNAL   Mol Metab 60, 101487 (2022)
   PUBMED   35378329
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Ekim Ustunel,B., Friedrich,K., Maida,A., Wang,X., Krones-Herzig,A.,
            Seibert,O., Sommerfeld,A., Jones,A., Sijmonsma,T.P., Sticht,C.,
            Gretz,N., Fleming,T., Nawroth,P.P., Stremmel,W., Rose,A.J.,
            Berriel-Diaz,M., Bluher,M. and Herzig,S.
  TITLE     Control of diabetic hyperglycaemia and insulin resistance through
            TSC22D4
  JOURNAL   Nat Commun 7, 13267 (2016)
   PUBMED   27827363
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Lu,Y., Kitaura,J., Oki,T., Komeno,Y., Ozaki,K., Kiyono,M.,
            Kumagai,H., Nakajima,H., Nosaka,T., Aburatani,H. and Kitamura,T.
  TITLE     Identification of TSC-22 as a potential tumor suppressor that is
            upregulated by Flt3-D835V but not Flt3-ITD
  JOURNAL   Leukemia 21 (11), 2246-2257 (2007)
   PUBMED   17690703
  REMARK    GeneRIF: TSC-22 is a potential tumor suppressor that is upregulated
            by Flt3-D835V but not Flt3-ITD
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Fiol,D.F., Mak,S.K. and Kultz,D.
  TITLE     Specific TSC22 domain transcripts are hypertonically induced and
            alternatively spliced to protect mouse kidney cells during osmotic
            stress
  JOURNAL   FEBS J 274 (1), 109-124 (2007)
   PUBMED   17147695
  REMARK    GeneRIF: TSC22D4 is stably upregulated by hyperosmolality in mIMCD3
            cells and increased in renal papilla compared with cortex.
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Canterini,S., Mangia,F. and Fiorenza,M.T.
  TITLE     Thg-1 pit gene expression in granule cells of the developing mouse
            brain and in their synaptic targets, mature Purkinje, and mitral
            cells
  JOURNAL   Dev Dyn 234 (3), 689-697 (2005)
   PUBMED   15895388
  REMARK    GeneRIF: Thg-1 pit is relevant to specification,
            proliferation/migration, differentiation, and mature function of
            granule/interneuron cells in different brain districts [Thg-1 pit]
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   Fiorenza,M.T., Mukhopadhyay,M. and Westphal,H.
  TITLE     Expression screening for Lhx3 downstream genes identifies Thg-1pit
            as a novel mouse gene involved in pituitary development
  JOURNAL   Gene 278 (1-2), 125-130 (2001)
   PUBMED   11707329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125063.4.
            
            On Aug 6, 2021 this sequence version replaced NM_023910.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018735.2, AK040534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC125063.4         139594-139996       c
            404-1415            AC125063.4         138149-139160       c
            1416-1576           AC125063.4         134640-134800       c
            1577-1625           AC125063.4         127276-127324       c
            1626-2308           AC125063.4         126259-126941       c
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.64 cM"
     gene            1..2308
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /note="Tsc22 domain family, member 4"
                     /db_xref="GeneID:78829"
                     /db_xref="MGI:MGI:1926079"
     exon            1..403
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1415
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1576
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1625
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..2308
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /note="hexamer: ATTAAA"
     polyA_site      2308
                     /gene="Tsc22d4"
                     /gene_synonym="0610009M14Rik; 1700023B23Rik; AI415410;
                     Spacdr; Thg-1pit; Tilz2"
                     /note="major polyA site"
ORIGIN      
        1 agaccgagac ggagcggagc tgaggagctg agagatacat ccagtggggc cacgtgggag
       61 gagccttgag agagagccac tcaagggact ggagccagcg gggggctgag ccgccccctc
      121 ccacagcaac agggaagacc cgtggagtgt taaccgaggc tgcgcctggg ctcccccgtg
      181 gaagcgctgg tttcttctcg tctcaactgc aaactttcca ccgagatgcc tcgcagagtg
      241 agatgcggac gccagagaac actgggtagc ccttgattgc tgcctgccgt ggcctgctct
      301 aggccgcctt aggatttaaa aaaaaaagag agagagagag agagagagat cttagtcccc
      361 caggtcttct ctccagctca gctcggtggc cgaggcccga gagtttgcaa gctcagcttt
      421 ggggtttcag cggcgacagc agcaggaaaa acctgcccct gcccccccct cctgccacct
      481 cccctctgta ctccagtcac taaccaggca cccccaagtt cccacaaggc cctcctgcca
      541 tgtcggaccc agacgtcccc aggggccccg atgtccctgc catgtggccc ccttgttcca
      601 gaggtgcctg agcccctctc caggagccca gcccctcccc cacccgagcc cagtccggag
      661 ccccagggac catgagtggt ggtaagaaga aaagtagttt tcagatcacc agcgtcacca
      721 cggactatga gggcccagga agcccagggg cttcggattc ccctgtccca ccggctctcg
      781 ctgggccccc gccccgcctc cccaatgggg accccaaccc tgatccaggg ggcaggggca
      841 ccccccggaa tggctctccg ccacctggag cccctgcctc ccgtttccgg gtggtgaagc
      901 tgccccaagg tttgggagag ccttatcgtc gaggtcggtg gacgtgtgtg gatgtttacg
      961 agagagatct ggagcctcca agcttcggtc ggcttctgga gggcattcga ggggcctctg
     1021 gaggcaccgg aggcagatca ttggattcta ggttggagct ggctagtttg ggcataagca
     1081 cccctatccc gcagccaggc ctgtctcagg gccccacctc ttggctccgc ccgcccccta
     1141 cttctcctgg accacaggcc cgctccttca caggggggct gggccagctg gcaggacctg
     1201 gcaaggctaa ggtggagaca cccccgctgt cagcatctcc accccagcag cgccccccag
     1261 ggcctgggac tggagatagt gctcagaccc tgccctctct gagggtagaa gtggagtctg
     1321 ggggttcagc agccgcaacc cctccactgt cacggagaag agatggagca gttcggctga
     1381 ggatggagtt agttgctcca gcggagacag gaaaggtacc tcccaccgac tctcgcccca
     1441 actccccagc cctctacttc gatgccagcc tggtccataa gtctccagac ccatttggag
     1501 ccgcagcagc ccagagcctc agcctggccc gttccatgtt ggctatcagc ggtcacctgg
     1561 acagcgatga cgatagtggt tccggaagcc tggttggcat tgacaacaag attgaacaag
     1621 ccatggactt ggtgaagtcc cacctcatgt ttgccgtgcg agaagaggtg gaggtgctga
     1681 aggagcagat ccgagacctg gcagagcgga acgctgcatt ggagcaggag aatggattgc
     1741 tgcgcgccct ggccagcccg gagcagctgg cccagctgcc atcctcgggg ctccccaggc
     1801 tcgggccctc tgcacccaat gggccctcca tctgagcctt ctttccctca caatgtgcct
     1861 ttggggggct gccactggct gttgcgcctt gtgccggcag cctgccccct cttcctatgt
     1921 agctttaatg cccatgccca actccagtgc ccagggatgg gagttgaagg ctcaatattg
     1981 gcctgtccca tcccgctcgg tctccccaga gtcctcaggc cttgccggaa gagaaacagc
     2041 tcgggagagg gtatttatct gaagcccctc gtccgtggaa gaacccagcc ctgcctccta
     2101 ccccgggtat cagtgttctg gggagcccct cagcaatagg tggcctggaa agatttggag
     2161 gttccctggc aggcctcacc ccgttctctt caagtgcccc ctctcctctg ccaagggagg
     2221 gtgtatggac agtatcttca acttctcgga ttcaggttgt tgttaaaata ataattataa
     2281 ttaaaaaaaa aatctgaaga aacttgaa
//
