LOCUS       NM_001077364            2135 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus TSC22 domain family, member 3 (Tsc22d3), transcript
            variant 1, mRNA.
ACCESSION   NM_001077364
VERSION     NM_001077364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Grossi,L.C., Zaidan,I., Souza,J.A.M., Carvalho,A.F.S.,
            Sanches,R.C.O., Cardoso,C., Lara,E.S., Montuori-Andrade,A.C.M.,
            Bruscoli,S., Marchetti,M.C., Riccardi,C., Teixeira,M.M.,
            Tavares,L.P., Vago,J.P. and Sousa,L.P.
  TITLE     GILZ Modulates the Recruitment of Monocytes/Macrophages Endowed
            with a Resolving Phenotype and Favors Resolution of Escherichia
            coli Infection
  JOURNAL   Cells 12 (10), 1403 (2023)
   PUBMED   37408237
  REMARK    GeneRIF: GILZ Modulates the Recruitment of Monocytes/Macrophages
            Endowed with a Resolving Phenotype and Favors Resolution of
            Escherichia coli Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Linnenberger,R., Hoppstadter,J., Wrublewsky,S., Ampofo,E. and
            Kiemer,A.K.
  TITLE     Statins and Bempedoic Acid: Different Actions of Cholesterol
            Inhibitors on Macrophage Activation
  JOURNAL   Int J Mol Sci 22 (22), 12480 (2021)
   PUBMED   34830364
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Docq,M., Vetillard,M., Gallego,C., Jaracz-Ros,A., Mercier-Nome,F.,
            Bachelerie,F. and Schlecht-Louf,G.
  TITLE     Multi-Tissue Characterization of GILZ Expression in Dendritic Cell
            Subsets at Steady State and in Inflammatory Contexts
  JOURNAL   Cells 10 (11), 3153 (2021)
   PUBMED   34831376
  REMARK    GeneRIF: Multi-Tissue Characterization of GILZ Expression in
            Dendritic Cell Subsets at Steady State and in Inflammatory
            Contexts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Larrasa-Alonso,J., Villalba-Orero,M., Marti-Gomez,C.,
            Ortiz-Sanchez,P., Lopez-Olaneta,M.M., Rey-Martin,M.A.,
            Sanchez-Cabo,F., McNicoll,F., Muller-McNicoll,M., Garcia-Pavia,P.
            and Lara-Pezzi,E.
  TITLE     The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular
            Hypertrophy
  JOURNAL   Circ Res 129 (6), 669-683 (2021)
   PUBMED   34333993
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Flamini,S., Sergeev,P., Viana de Barros,Z., Mello,T., Biagioli,M.,
            Paglialunga,M., Fiorucci,C., Prikazchikova,T., Pagano,S.,
            Gagliardi,A., Riccardi,C., Zatsepin,T., Migliorati,G.,
            Bereshchenko,O. and Bruscoli,S.
  TITLE     Glucocorticoid-induced leucine zipper regulates liver fibrosis by
            suppressing CCL2-mediated leukocyte recruitment
  JOURNAL   Cell Death Dis 12 (5), 421 (2021)
   PUBMED   33927191
  REMARK    GeneRIF: Glucocorticoid-induced leucine zipper regulates liver
            fibrosis by suppressing CCL2-mediated leukocyte recruitment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Mittelstadt,P.R. and Ashwell,J.D.
  TITLE     Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ
  JOURNAL   J Biol Chem 276 (31), 29603-29610 (2001)
   PUBMED   11397794
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Ayroldi,E., Migliorati,G., Bruscoli,S., Marchetti,C., Zollo,O.,
            Cannarile,L., D'Adamio,F. and Riccardi,C.
  TITLE     Modulation of T-cell activation by the glucocorticoid-induced
            leucine zipper factor via inhibition of nuclear factor kappaB
  JOURNAL   Blood 98 (3), 743-753 (2001)
   PUBMED   11468175
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Riccardi,C., Bruscoli,S., Ayroldi,E., Agostini,M. and Migliorati,G.
  TITLE     GILZ, a glucocorticoid hormone induced gene, modulates T
            lymphocytes activation and death through interaction with NF-kB
  JOURNAL   Adv Exp Med Biol 495, 31-39 (2001)
   PUBMED   11774584
  REMARK    GeneRIF: GILZ, a glucocorticoid hormone induced gene, modulates T
            lymphocytes activation and death through interaction with NF-kB.
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Cho,S.Y., Jeon,J.W., Lee,S.H. and Park,S.S.
  TITLE     p67 isoform of mouse disabled 2 protein acts as a transcriptional
            activator during the differentiation of F9 cells
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 645-650 (2000)
   PUBMED   11104669
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   D'Adamio,F., Zollo,O., Moraca,R., Ayroldi,E., Bruscoli,S.,
            Bartoli,A., Cannarile,L., Migliorati,G. and Riccardi,C.
  TITLE     A new dexamethasone-induced gene of the leucine zipper family
            protects T lymphocytes from TCR/CD3-activated cell death
  JOURNAL   Immunity 7 (6), 803-812 (1997)
   PUBMED   9430225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683809.7.
            
            On Jan 31, 2022 this sequence version replaced NM_001077364.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU818782.1, AF201289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AL683809.7         80381-80452         c
            73-503              AL683809.7         78072-78502         c
            504-555             AL683809.7         22049-22100         c
            556-2135            AL683809.7         19472-21051         c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..2135
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /note="TSC22 domain family, member 3"
                     /db_xref="GeneID:14605"
                     /db_xref="MGI:MGI:1196284"
     exon            1..72
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     exon            73..503
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..795
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /note="isoform 1 is encoded by transcript variant 1; delta
                     sleep inducing peptide, immunoreactor; TSC22 domain family
                     protein 3; TSC22-related inducible leucine zipper 3; long
                     glucocorticoid-induced leucine zipper protein"
                     /codon_start=1
                     /product="TSC22 domain family protein 3 isoform 1"
                     /protein_id="NP_001070832.1"
                     /db_xref="CCDS:CCDS41150.1"
                     /db_xref="GeneID:14605"
                     /db_xref="MGI:MGI:1196284"
                     /translation="MAQPKTECRSPVGLDCCNCCLDLANRCELQKEKSGESPGSPFVS
                     NFRQLQEKLVFENLNTDKLNNIMRQDSMEPVVRDPCYLINEGICNRNIDQTMLSILLF
                     FHSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELLEKNSQLERENTL
                     LKTLASPEQLEKFQSRLSPEEPAPEAPETPETPEAPGGSAV"
     exon            504..555
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2135
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /note="hexamer: AATAAA"
     polyA_site      2135
                     /gene="Tsc22d3"
                     /gene_synonym="DIP; Dsip1; Gilz; Tilz3; TSC-22R"
                     /note="major polyA site"
ORIGIN      
        1 actctgcgtg cgtgcgggct gctgggcaag tctctcgagg ggtcgacgga gccggtttac
       61 ctgaagtggc agcttgtttt tccgggcacc ctggagtccc aaaaggctag ctccgcaggt
      121 gcgcacctgc cggccgcccc cgacctccct gagcaggccg ccgccgccgc tgcctccaag
      181 ccggagaaga tggcccagcc caagaccgag tgccgctcac ctgttggcct cgactgctgc
      241 aactgctgcc tcgacctggc caaccgctgc gagctccaga aggagaagag cggggagagc
      301 ccgggcagcc ccttcgtgag caactttcgg cagctgcagg agaagctcgt cttcgagaac
      361 ctcaacactg acaagctgaa caacataatg cgccaggatt ccatggagcc cgtggtgcgc
      421 gacccctgct acctgatcaa tgagggcatc tgcaaccgca acatagacca gaccatgctc
      481 tccattctac ttttcttcca cagtgcctcc ggagccagtg tggtggccct agacaacaag
      541 attgagcagg ccatggacct cgtgaagaac cacctgatgt acgctgtgag agaggaggtg
      601 gaggtcctaa aggagcagat tcgtgagctg cttgagaaga actcccagct ggagcgcgag
      661 aacaccctcc tgaagacgct ggcaagcccc gagcaactgg aaaagttcca gtcccggctg
      721 agccctgaag agccagcacc tgaagcccca gaaaccccgg aaaccccgga agcccctggt
      781 ggttctgcgg tgtaagtggc tctgtcctta gggtgggcag agccacatct tgttctacct
      841 agttctttcc agtttgtttt tggctcccca agcgtcatct catgtggaga actttacacc
      901 taacatagct ggtgccaaga gatgtcccaa ggacatgccc atctgggtcc actccagtga
      961 cagacccctg acaaagagca ggtctctgga gactaagttg catggggcct agtaacacca
     1021 agccagtgag cctgtcgtgt caccgggccc tgggggctcc cagggcctgg gcaacttagt
     1081 tacagctgac caaggagaaa gtagttttga gatgtgatgc cagtgtgctc cagaaagtgt
     1141 aaggggtctg tttttcattt ccatggacat cttccacagc ttcacctgac aatgactgtt
     1201 cctatgaaga agccacttgt gttctaagca gaagcaacct ctctcttctt ctctgtcttt
     1261 tccaggcagg ggcagagatg ggagagattg agccaaatga gccttctgtt ggttaatact
     1321 gtataatgca tggctttgtg cacagcccag tgtggggtta cagctttggg atgactgctt
     1381 ataaagttct gtttggttag tattggcatc gtttttctat atagccataa tgcgtatata
     1441 tacccatagg gctagatcta tatcttaggg tagtgatgta tacatataca catacaccta
     1501 catgttgaag ggcctaacca gctttgggag tactgactgg tctcttatct cttaaagcta
     1561 agtttttgac tgtgctaatt taccaaattg atccagtttg tcctttagat taaataagac
     1621 tcgatatgag ggagggaggg gagaccagcc tcacaatgcg gccacagatg ccttgctgct
     1681 gcagtcctcc ctgatctgtc cactgaagac atgaagtcct cttttgaatg ccaaacccac
     1741 cattcattgg tgctgactac atagaatggg gttgagagaa gatcagtttg gacttcacat
     1801 ttttgtttta agttttaggt tgtttttttt tggttttgtt tgtttgtttg tttgtttgtt
     1861 tttgtttttt gtttttcttt tttttaagtt cttgtgggaa actttggggt taatcaaagg
     1921 atgtagtcct gtggtagacc agaggagtaa ctagttttga tccctttggg gtgtggaaaa
     1981 tgtacccagg aagcttgtgt aaggaggttc tgtgacagtg aacactttcc actttctgac
     2041 acctcatcct gctgtacgac tccaggattt ggatttggat ttttcaaatg tagcttgaaa
     2101 tttcaataaa ctttgctcct ttttctaaaa ataaa
//
