LOCUS       NM_207652               4601 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TSC22 domain family, member 1 (Tsc22d1), transcript
            variant 1, mRNA.
ACCESSION   NM_207652
VERSION     NM_207652.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4601)
  AUTHORS   Dusing,M., LaSarge,C.L., White,A., Jerow,L.G., Gross,C. and
            Danzer,S.C.
  TITLE     Neurovascular Development in Pten and Tsc2 Mouse Mutants
  JOURNAL   eNeuro 10 (2) (2023)
   PUBMED   36759189
  REMARK    GeneRIF: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4601)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4601)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   4  (bases 1 to 4601)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 4601)
  AUTHORS   Uchida,D., Kawamata,H., Omotehara,F., Miwa,Y., Horiuchi,H.,
            Furihata,T., Tachibana,M. and Fujimori,T.
  TITLE     Overexpression of TSC-22 (transforming growth factor-
            beta-stimulated clone-22) causes marked obesity, splenic
            abnormality and B cell lymphoma in transgenic mice
  JOURNAL   Oncotarget 7 (12), 14310-14323 (2016)
   PUBMED   26872059
  REMARK    GeneRIF: High TSC-22 expression is associated with obesity, splenic
            abnormality and B cell lymphoma.
REFERENCE   6  (bases 1 to 4601)
  AUTHORS   Soma,T., Dohrmann,C.E., Hibino,T. and Raftery,L.A.
  TITLE     Profile of transforming growth factor-beta responses during the
            murine hair cycle
  JOURNAL   J Invest Dermatol 121 (5), 969-975 (2003)
   PUBMED   14708594
REFERENCE   7  (bases 1 to 4601)
  AUTHORS   Kester,H.A., Ward-van Oostwaard,T.M., Goumans,M.J., van
            Rooijen,M.A., van Der Saag,P.T., van Der Burg,B. and Mummery,C.L.
  TITLE     Expression of TGF-beta stimulated clone-22 (TSC-22) in mouse
            development and TGF-beta signalling
  JOURNAL   Dev Dyn 218 (4), 563-572 (2000)
   PUBMED   10906776
REFERENCE   8  (bases 1 to 4601)
  AUTHORS   Dohrmann,C.E., Belaoussoff,M. and Raftery,L.A.
  TITLE     Dynamic expression of TSC-22 at sites of epithelial-mesenchymal
            interactions during mouse development
  JOURNAL   Mech Dev 84 (1-2), 147-151 (1999)
   PUBMED   10473130
REFERENCE   9  (bases 1 to 4601)
  AUTHORS   Shibanuma,M., Mashimo,J., Mita,A., Kuroki,T. and Nose,K.
  TITLE     Cloning from a mouse osteoblastic cell line of a set of
            transforming-growth-factor-beta 1-regulated genes, one of which
            seems to encode a follistatin-related polypeptide
  JOURNAL   Eur J Biochem 217 (1), 13-19 (1993)
   PUBMED   7901004
REFERENCE   10 (bases 1 to 4601)
  AUTHORS   Shibanuma,M., Kuroki,T. and Nose,K.
  TITLE     Isolation of a gene encoding a putative leucine zipper structure
            that is induced by transforming growth factor beta 1 and other
            growth factors
  JOURNAL   J Biol Chem 267 (15), 10219-10224 (1992)
   PUBMED   1587811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058660.1, AK147039.1 and AI841546.1.
            
            On Jul 17, 2015 this sequence version replaced NM_207652.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is also supported by available conservation
            data. The use of an alternative upstream would result in a protein
            that is 21 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058660.1, AF201285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4086              BC058660.1         1-4086
            4087-4582           AK147039.1         1231-1726
            4583-4601           AI841546.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.44 cM"
     gene            1..4601
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /note="TSC22 domain family, member 1"
                     /db_xref="GeneID:21807"
                     /db_xref="MGI:MGI:109127"
     exon            1..3189
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3496
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulatory protein Tsc22; Tgfb-stimulated clone 22
                     homolog; Tsc22-related inducible leucine zipper 1b;
                     transforming growth factor beta 1 induced transcript 4"
                     /codon_start=1
                     /product="TSC22 domain family protein 1 isoform 1"
                     /protein_id="NP_997535.2"
                     /db_xref="CCDS:CCDS27285.2"
                     /db_xref="GeneID:21807"
                     /db_xref="MGI:MGI:109127"
                     /translation="MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALNAA
                     GTGVSGAAPSSEDFPPPSLLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGG
                     TQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLS
                     RATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPH
                     HLHHHHHPHHGHHLHHGHHHSSHAAVAGPSIPGGPPSSPVSRKLSTTGSSDGGVPVAP
                     PPAVPSSGLPASVMTNIRTPSTTGSLGINSVTGTSATNNVNIAAVGSFSPSVTNSVHG
                     NANINTSNIPNAASISGGPGVTSVVNSSILSGMGNGTVSSSPVANSVLNAAAGITVGV
                     VSSQQQQQQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAVPATEGVAVN
                     KVVETVKQTPTEASSSERESTSGSSVSSSVSTLSHYTESVGSGEMMGAPAVVAPQQPP
                     LPPAPPGLQGVALQQLEFSSPAPQSIAAVSMPQSISQSQMSQVQLQPQELSFQQKQTL
                     QPVPLQATMSAATGIQPSPVSVVGITAAVGQQPSVSSLAQPQLPYSQTAPPVQTPLPG
                     APPQQLQYGQQQPMVPAQIAPGHGQPVTQNPTSEYVQQQQQPIFQAALSSGQSSSTGT
                     GAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPIGQAQTAVSTVPTGGQIASIGQQ
                     ANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQ
                     STLVTVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNL
                     VPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIPLSSTQFSTQSLAQAIGSQ
                     MEDARRPAEPSLGGLPQTMSGDSGGMSAVSDGSSSSLAAPASLFPLKVLPLTTPLVDG
                     EDESSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNL
                     LKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGSTA"
     exon            3190..3238
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..4587
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /note="hexamer: AATAAA"
     polyA_site      4585
                     /gene="Tsc22d1"
                     /gene_synonym="Egr5; Gm19597; Tgfb1i4; Tsc; TSC-22; Tsc22"
                     /note="major polyA site"
ORIGIN      
        1 ctggaggggg aagtgaatgg cgaaggactg aaggggtccc ccttcggttc cccagccacc
       61 tggttcaccc ggttcatcct cccttcccga agttagccct cgaaggcacg agcagccggc
      121 gccttcggca gaggaggagg aggaggaggg atcgcgtcgg gcggagcttc aggtcctgtt
      181 cgtctctccg gcttctccat acaaagatta cggtgcagaa ggaaattgca cttgcctcct
      241 ccgccccccg gtacccagca caatgcacca gccgccggag tccaccgccg cggcggccgc
      301 tgctgcagac attagtgcta ggaagatggc gcacccggca atgttccctc gaaggggcag
      361 cggtggtggc agcgcctctg ctctcaatgc agcaggtacg ggcgtcagtg gtgctgctcc
      421 atcttctgaa gattttcctc ctccttcgct gctccagccg ccgcctcctg ctgcatcttc
      481 cacgcaggga ccccagcctc cgcctccaca aagcctgaac ctcctctcgc aggctcagct
      541 gcagggacag cctcttgcgc caggcggaac tcagatgaaa aagaaaagtg gcttccagat
      601 aactagcgtt actccggctc agatctctgc cagcatcagc tccaacaaca gcatcgcgga
      661 ggacaccgag agctacgacg atctggatga gtcgcacacg gaagatctct cctcttccga
      721 gatcctcgac gtctcccttt ccagggccac tgacttaggt gagcctgaac gaagctcctc
      781 agaggagact ctgaataact tccaggaagc tgagacacct ggggcagtct ctcctaacca
      841 gccccacctt cctcagcctc atttgcctca ccttccacaa cagaacgttg tgatcaatgg
      901 gaatgcccat ccccaccacc tccatcatca ccatcaccct catcatgggc accaccttca
      961 ccatgggcac catcattcat cacatgctgc tgtggccggt ccatccattc ccggagggcc
     1021 accctcgagc ccagtgtcca ggaaactctc tacaactgga agttctgatg gtggtgtgcc
     1081 agtcgcacct cctcctgcag taccatcgag tggcttacca gcatcagtga tgacgaacat
     1141 ccgtactcca agtactacag gaagcctagg tataaattcg gttactggca cgagcgctac
     1201 gaataatgtt aacattgctg ctgtgggtag tttcagtccc agtgtgacga acagcgtgca
     1261 tggtaatgct aatataaata caagcaatat ccctaatgct gctagcataa gtggtgggcc
     1321 tggagttacc agtgttgtta attcgagtat cttgagtggc atgggcaatg gtaccgtttc
     1381 ttcctctcct gttgctaaca gtgtccttaa tgcagctgca ggtatcactg tgggagtggt
     1441 ttccagtcag cagcagcagc agcagcagca gcaaccaaca gttaacacat cgaggttcag
     1501 ggttgtgaag ttagactcta cttctgaacc ctttaaaaaa ggtcgatgga cttgcacaga
     1561 attctatgag aaggaaaacg ctgtgccagc tacagaaggc gtggccgtca ataaagtggt
     1621 ggagacggtg aagcaaaccc ccacggaagc atcgtcctcg gagagggaga gcactagtgg
     1681 gagttctgtg agcagtagtg tgagcacact gagtcactac acggagagtg tgggaagtgg
     1741 agagatgatg ggagccccgg ctgtggtggc gccgcagcag ccgccgctac caccagcgcc
     1801 tccaggtctt caaggtgtgg ctctccaaca gctagagttc agtagccctg ctccacagag
     1861 tattgcggcg gttagtatgc cacagagtat ttctcagtca cagatgtcac aagtacagtt
     1921 acagcctcaa gagttgagct ttcagcagaa gcagactctt cagcctgtcc ctctgcaagc
     1981 caccatgagt gccgcaactg gtatccagcc ttcccctgtc agcgtggtcg gcatcacggc
     2041 ggctgtaggt cagcagcctt ctgtttccag cctggctcaa ccgcagctgc catattctca
     2101 gacagctcct cccgtgcaaa ctcctcttcc aggggcacca ccccagcagt tacaatatgg
     2161 gcagcagcaa ccaatggttc ctgcgcagat agccccaggc catggccagc cagtgactca
     2221 aaatccaact tcagagtatg tgcagcagca gcagcagcca atatttcaag cagcattgtc
     2281 ctctgggcag tccagttcca cgggcacggg ggcaggaata tcagtgattc ctgtggctca
     2341 ggcacagggg atccagctgc cagggcagcc cacagcagta caaacacaac ctgcaggggc
     2401 ggctgggcag cccattggcc aggctcaaac agcagtgtcc actgtaccaa ctggcggtca
     2461 gattgcaagt atcggtcaac aggcaaacat acccactgca gtacagcagc cctctaccca
     2521 agttacacct tcagttattc agcaaggtgc tcctccatct tcacaagtag tcctacctgc
     2581 tccaaccggg atcattcatc agggagttca aacccgtgct tcaagccttc cacaacaatt
     2641 ggtcattgca ccccagagta ccttggtaac tgtgcctccc cagccacagg gagtagaaac
     2701 cgtggcccaa ggggttgttt cccagcagtt gcccacaggc agtcctctgc cctctgctag
     2761 cactatttct gttacaaatc aggttagttc agccgctcct tctggaatgc cttctgtccc
     2821 aacaaactta gttccaccac agaatatagc acaaccccca gccacccaaa atggcagttt
     2881 ggttcaaagt gttagtcaat ctcccttgat agccactaac ataaatttgc ctttggcaca
     2941 acagatacca ctaagttcta ctcagttctc tacacaatca ttagctcagg ccattggaag
     3001 ccaaatggaa gatgccaggc gcccagcgga gccctcctta ggcggcttac ctcagactat
     3061 gagtggtgac agtgggggaa tgtcagcagt ttcagatggg agtagcagca gcctagcagc
     3121 ccctgcttct ctcttcccgt tgaaggtgct accgctgaca acacccctgg tggatggcga
     3181 ggacgagagc tctggtgcaa gtgtggtagc tatcgacaac aaaatagagc aagctatgga
     3241 tctggtgaaa agccatttga tgtatgcggt gagggaggaa gtggaagttc tgaaggagca
     3301 gatcaaagaa ctaatagaga aaaactccca gctggagcag gagaacaatc tgctgaagac
     3361 gctggccagt ccggagcagc tcgcccagtt tcaggcccag ctgcagactg gctcccctcc
     3421 ggccaccacg cagccacagg ggaccacaca gccccctgca cagccagcat cccagggctc
     3481 aggatcaacc gcatagcctc ctaggcccca acagaactgg ctgctgctgc tgctgtctga
     3541 actgaacaga ccgaagagat gtgctagaga gaagccgcct ccacagtcac ccatttcatt
     3601 gctgtctacg aaagagacgt gagactcaca cgctgttctc gctttctccc cagtattaag
     3661 cactcataag cttttggctt gaagaaatgt actagttgag tgaattaaag gttaatcaga
     3721 gagtgagcag ggatgtgccc tgtgcaacgt ggcagatgtc tgaggaatgg tttaattgac
     3781 cccgaggagc tctgtgcctt ttcaaccctc cccagccgcc caccctgctt ctgagagctc
     3841 gggcggctcg ccttcgtggg gctcgcctgc gtggggttcg gaaagtgggc tgctcctgga
     3901 ttctgcgctc tcttctcctt cccttcaaag aactcggaga ggccagaaac aagactgcaa
     3961 tggggggcgg ggggagggat gatgcagtcc ttatacaaaa ccgacaactg tcaccaaagc
     4021 ttataaaaca cgatagtact gtccctcttt tctgaaccat cagaagacac aaaactgtta
     4081 gtgacacaac ggtgacaggt agctgggacc taggctatct tattatgaag gttgttttgc
     4141 ttgttgtata tttgtgtatg tagtgtaacg aatttgtacc atagaggact gtccgtaact
     4201 actgtttagc ttctacacat tgaaatgtag atgtttcatt ggctgtctga aaaggtgtgg
     4261 cttgtccttc ctagagagat ctacttaaaa actgctttgt gacaaaaacc acacctgaag
     4321 aaattttaag aatttggccc agttagtcac tctgtgtaat cccggaatct agctgctgaa
     4381 gtcttgcgaa gtaaactccc cgtgaccgat gtcagttaag ctggtgatac ctggagaagt
     4441 ggtcagttgc taaggaagtg gatttcccag taggggtttc tgcacctcac ctgtatagtc
     4501 gttctgcgca tgtcccccac acagtcccca ctgtatttac ctgttctact tgtcaccttt
     4561 caataaagca tatcaaatgt tgatacaaaa aaaaaaaaaa a
//
