LOCUS       NM_011646                815 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus trypsin 4 (Try4), mRNA.
ACCESSION   NM_011646
VERSION     NM_011646.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 815)
  AUTHORS   Scavuzzo,M.A., Chmielowiec,J., Yang,D., Wamble,K., Chaboub,L.S.,
            Duraine,L., Tepe,B., Glasgow,S.M., Arenkiel,B.R., Brou,C.,
            Deneen,B. and Borowiak,M.
  TITLE     Pancreatic Cell Fate Determination Relies on Notch Ligand
            Trafficking by NFIA
  JOURNAL   Cell Rep 25 (13), 3811-3827 (2018)
   PUBMED   30590051
REFERENCE   3  (bases 1 to 815)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 815)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 815)
  AUTHORS   Prevot,P.P., Augereau,C., Simion,A., Van den Steen,G., Dauguet,N.,
            Lemaigre,F.P. and Jacquemin,P.
  TITLE     Let-7b and miR-495 stimulate differentiation and prevent metaplasia
            of pancreatic acinar cells by repressing HNF6
  JOURNAL   Gastroenterology 145 (3), 668-78 (2013)
   PUBMED   23684747
REFERENCE   6  (bases 1 to 815)
  AUTHORS   Nemeth,B.C., Wartmann,T., Halangk,W. and Sahin-Toth,M.
  TITLE     Autoactivation of mouse trypsinogens is regulated by chymotrypsin C
            via cleavage of the autolysis loop
  JOURNAL   J Biol Chem 288 (33), 24049-24062 (2013)
   PUBMED   23814066
REFERENCE   7  (bases 1 to 815)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   8  (bases 1 to 815)
  AUTHORS   Chen,F., Rowen,L., Hood,L. and Rothenberg,E.V.
  TITLE     Differential transcriptional regulation of individual TCR V beta
            segments before gene rearrangement
  JOURNAL   J Immunol 166 (3), 1771-1780 (2001)
   PUBMED   11160223
REFERENCE   9  (bases 1 to 815)
  AUTHORS   Ohmura,K., Kohno,N., Kobayashi,Y., Yamagata,K., Sato,S.,
            Kashiwabara,S. and Baba,T.
  TITLE     A homologue of pancreatic trypsin is localized in the acrosome of
            mammalian sperm and is released during acrosome reaction
  JOURNAL   J Biol Chem 274 (41), 29426-29432 (1999)
   PUBMED   10506205
REFERENCE   10 (bases 1 to 815)
  AUTHORS   Stevenson,B.J., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     Sequence organisation and transcriptional regulation of the mouse
            elastase II and trypsin genes
  JOURNAL   Nucleic Acids Res 14 (21), 8307-8330 (1986)
   PUBMED   3641189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061135.1 and BC050120.1.
            
            On May 4, 2007 this sequence version replaced NM_011646.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061135.1, CF581317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-797               BC061135.1         1-797
            798-815             BC050120.1         779-796
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.41 cM"
     gene            1..815
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /note="trypsin 4"
                     /db_xref="GeneID:22074"
                     /db_xref="MGI:MGI:102757"
     exon            1..53
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..754
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /EC_number="3.4.21.4"
                     /codon_start=1
                     /product="trypsin-4 precursor"
                     /protein_id="NP_035776.1"
                     /db_xref="CCDS:CCDS20044.1"
                     /db_xref="GeneID:22074"
                     /db_xref="MGI:MGI:102757"
                     /translation="MRALLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFVNSAKIIKHPNFNSR
                     TLNNDIMLIKLASPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVNNPDLLQC
                     LDAPLLPQADCEASYPGKITNNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGY
                     GCALKDNPGVYTKVCNYVDWIQNTIAAN"
     exon            54..213
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /inference="alignment:Splign:2.1.0"
     exon            214..467
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /inference="alignment:Splign:2.1.0"
     exon            468..604
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /inference="alignment:Splign:2.1.0"
     exon            605..799
                     /gene="Try4"
                     /gene_synonym="0910001B19Rik; Td"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accttctgcc aaaatgagag cactcctgtt cctggccctt gtgggagctg ctgttgcttt
       61 ccctgtggat gatgatgaca agatcgttgg aggatacacc tgccgagaga attctgtccc
      121 ctaccaggtg tccctgaact ctggctacca cttctgtgga ggttccctca tcaatgacca
      181 gtgggtggtg tctgcagctc actgctacaa gtcccgcatc caagtgagac tgggagagca
      241 caacatcaat gtcctcgagg gcaatgagca gtttgtcaat tctgccaaga tcatcaagca
      301 tcccaacttc aatagcagga ccctgaacaa cgacatcatg ctgatcaaac tggcttcccc
      361 tgtgaccctc aatgccagag tggccactgt ggctctgccc agctcctgtg cacctgcagg
      421 cactcagtgt ctcatctctg gctggggcaa caccttgagc tttggtgtga acaacccaga
      481 cctgctccag tgcctggatg ccccactgct gcctcaggct gactgtgagg cctcctatcc
      541 tggaaagatc accaataaca tgatctgtgt tggcttccta gagggaggca aagattcctg
      601 ccagggtgac tctggtggcc ctgtggtctg caatggacag ctccagggca ttgtctcctg
      661 gggctatggc tgtgccctga aggacaaccc tggtgtgtac accaaggtct gcaactatgt
      721 ggactggatt caaaacacca ttgctgcaaa ctaagcatcc ctttgaagtc attatgtcaa
      781 taaagtgaat attcccttaa aaaaaaaaaa aaaaa
//
