LOCUS       NM_001038996             890 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus trypsin 10 (Try10), mRNA.
ACCESSION   NM_001038996 XM_887638 XM_903629 XM_913771
VERSION     NM_001038996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Chen,F., Rowen,L., Hood,L. and Rothenberg,E.V.
  TITLE     Differential transcriptional regulation of individual TCR V beta
            segments before gene rearrangement
  JOURNAL   J Immunol 166 (3), 1771-1780 (2001)
   PUBMED   11160223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158659.6.
            
            On Sep 1, 2007 this sequence version replaced NM_001038996.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138698.1, AK133516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC158659.6         96079-96205         c
            128-287             AC158659.6         94699-94858         c
            288-541             AC158659.6         93534-93787         c
            542-678             AC158659.6         92844-92980         c
            679-890             AC158659.6         92366-92577         c
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.48 cM"
     gene            1..890
                     /gene="Try10"
                     /note="trypsin 10"
                     /db_xref="GeneID:436522"
                     /db_xref="MGI:MGI:3687012"
     exon            1..127
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..828
                     /gene="Try10"
                     /note="trypsinogen 10"
                     /codon_start=1
                     /product="trypsin 10 precursor"
                     /protein_id="NP_001034085.1"
                     /db_xref="CCDS:CCDS20046.1"
                     /db_xref="GeneID:436522"
                     /db_xref="MGI:MGI:3687012"
                     /translation="MSTLLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFIDAANIIKHPKFKKK
                     TLDNDIMLIKLSSPVTLNARVATVALPSSCAAAGTQCLISGWGNTLSSGVNNPDLLQC
                     LDAPLLPQADCEASYPGKITKNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGY
                     GCAQKDNPGVYTKVCNYVDWIQNTIAAN"
     exon            128..287
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            288..541
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            542..678
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            679..890
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      859..864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Try10"
                     /note="hexamer: AATAAA"
     polyA_site      880
                     /gene="Try10"
                     /note="major polyA site"
ORIGIN      
        1 gacggagccc tccccttagt atctccttct ccctgcactg gggtataaag gcaagctttc
       61 ccacagtgtt cactgcctgc tgtcacaatg agtacactcc tgttcctggc ccttgtggga
      121 gcagctgttg ctttccctgt ggatgatgat gacaagatag ttggaggata cacctgccga
      181 gagaattctg ttccctacca ggtgtccctg aactctggct accacttctg tggaggttcc
      241 ctcatcaatg accagtgggt ggtgtctgca gctcactgct acaagtcccg catccaagtg
      301 agactgggag agcacaacat caacgtcctg gagggcaatg agcagtttat cgatgctgcc
      361 aacatcatca agcatcctaa attcaaaaag aagactctgg acaatgacat catgctgatc
      421 aagctgtctt ctcctgtgac cctcaatgcc agagtggcca ctgtggctct gcccagctcc
      481 tgtgcagctg ctggcactca gtgcctcatc tctggctggg gcaacacctt gagctctggc
      541 gtgaacaacc cagacctgct ccagtgcctg gatgctccac tgctgcctca ggctgactgt
      601 gaggcctcct atcctggaaa gatcaccaag aacatgatct gtgttggctt cctggaggga
      661 ggcaaagatt cctgccaggg tgactctggt ggccctgtgg tctgcaatgg acagctccag
      721 ggcattgttt cttggggcta tggctgtgcc cagaaggaca accctggtgt gtacaccaag
      781 gtctgcaact atgtggactg gattcaaaac accattgctg caaactaagc atcctaatcc
      841 ctatgaagtc actatgccaa taaactgaat tttttcttac tttctgagtc
//
