LOCUS       NP_663495                331 aa            linear   ROD 30-APR-2024
DEFINITION  pseudouridylate synthase TRUB2, mitochondrial isoform a [Mus
            musculus].
ACCESSION   NP_663495
VERSION     NP_663495.3
DBSOURCE    REFSEQ: accession NM_145520.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (residues 1 to 331)
  AUTHORS   McIntyre,R.E., Nicod,J., Robles-Espinoza,C.D., Maciejowski,J.,
            Cai,N., Hill,J., Verstraten,R., Iyer,V., Rust,A.G., Balmus,G.,
            Mott,R., Flint,J. and Adams,D.J.
  TITLE     A Genome-Wide Association Study for Regulators of Micronucleus
            Formation in Mice
  JOURNAL   G3 (Bethesda) 6 (8), 2343-2354 (2016)
   PUBMED   27233670
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 331)
  AUTHORS   Dequeant,M.L., Glynn,E., Gaudenz,K., Wahl,M., Chen,J., Mushegian,A.
            and Pourquie,O.
  TITLE     A complex oscillating network of signaling genes underlies the
            mouse segmentation clock
  JOURNAL   Science 314 (5805), 1595-1598 (2006)
   PUBMED   17095659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK090004.1, AK167294.1, AL845323.18 and AK081579.1.
            
            On Mar 14, 2009 this sequence version replaced NP_663495.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015285.1, AK167294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.57 cM"
     Protein         1..331
                     /product="pseudouridylate synthase TRUB2, mitochondrial
                     isoform a"
                     /EC_number="5.4.99.25"
                     /note="probable tRNA pseudouridine synthase 2; TruB
                     pseudouridine (psi) synthase homolog 2; mitochondrial mRNA
                     pseudouridine synthase Trub2; psi55 synthase TRUB2; tRNA
                     pseudouridine 55 synthase TRUB2; truB pseudouridine
                     synthase homolog 2; pseudouridylate synthase TRUB2,
                     mitochondrial"
                     /calculated_mol_wt=36676
     Region          11..283
                     /region_name="PseudoU_synth_hTruB2_like"
                     /note="Pseudouridine synthase, humanTRUB2_like; cd02868"
                     /db_xref="CDD:211345"
     Site            order(95..98,236)
                     /site_type="active"
                     /note="probable active site [active]"
                     /db_xref="CDD:211345"
     Region          309..331
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WG3.1)"
     CDS             1..331
                     /gene="Trub2"
                     /gene_synonym="G430055L02Rik"
                     /coded_by="NM_145520.5:61..1056"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS15856.1"
                     /db_xref="GeneID:227682"
                     /db_xref="MGI:MGI:2442186"
ORIGIN      
        1 mgssglarlq glfavykppg lkwlhlretv elqllkglna qqppapdqrv rfllgpvegs
       61 eekkltlrat nvpsltthrl vrgpaftnlk igvghrldvq asgvlvlavg hgrslltdmy
      121 dahltkdytv rgllgkatdn fcedgrliek ttydhvtrer ldrilaviqg shqkalvmys
      181 nldlksqeay emavqgvirp mnkspmlisg irclhfappe fllevqcmhe tqqqlrklvh
      241 eiglelktsa vctqvrrtrd gffglddall rtqwdlhniq daiqaaaprv aaelqknlsl
      301 klghhqlpst gqpwglkdps stlelescsg q
//
