LOCUS       NM_022413               2946 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            V, member 6 (Trpv6), mRNA.
ACCESSION   NM_022413 XM_977638
VERSION     NM_022413.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Jeong,K.H., Zhu,J., Park,S. and Kim,W.J.
  TITLE     Transient Receptor Potential Vanilloid 6 Modulates Aberrant Axonal
            Sprouting in a Mouse Model of Pilocarpine-Induced Epilepsy
  JOURNAL   Mol Neurobiol 61 (5), 2839-2853 (2024)
   PUBMED   37940780
  REMARK    GeneRIF: Transient Receptor Potential Vanilloid 6 Modulates
            Aberrant Axonal Sprouting in a Mouse Model of Pilocarpine-Induced
            Epilepsy.
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Beggs,M.R., Young,K., Plain,A., O'Neill,D.D., Raza,A.,
            Flockerzi,V., Dimke,H. and Alexander,R.T.
  TITLE     Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2
            Dependent Increases in Small Intestinal Calcium Permeability
  JOURNAL   Function (Oxf) 4 (5), zqad033 (2023)
   PUBMED   37575484
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Meena,A.S., Shukla,P.K., Rao,R., Canelas,C., Pierre,J.F. and Rao,R.
  TITLE     TRPV6 deficiency attenuates stress and corticosterone-mediated
            exacerbation of alcohol-induced gut barrier dysfunction and
            systemic inflammation
  JOURNAL   Front Immunol 14, 1093584 (2023)
   PUBMED   36817471
  REMARK    GeneRIF: TRPV6 deficiency attenuates stress and
            corticosterone-mediated exacerbation of alcohol-induced gut barrier
            dysfunction and systemic inflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2946)
  AUTHORS   Meena,A.S., Shukla,P.K., Bell,B., Giorgianni,F., Caires,R.,
            Fernandez-Pena,C., Beranova,S., Aihara,E., Montrose,M.H., Chaib,M.,
            Makowski,L., Neeli,I., Radic,M.Z., Vasquez,V., Jaggar,J.H.,
            Cordero-Morales,J.F. and Rao,R.
  TITLE     TRPV6 channel mediates alcohol-induced gut barrier dysfunction and
            systemic response
  JOURNAL   Cell Rep 39 (11), 110937 (2022)
   PUBMED   35705057
  REMARK    GeneRIF: TRPV6 channel mediates alcohol-induced gut barrier
            dysfunction and systemic response.
REFERENCE   5  (bases 1 to 2946)
  AUTHORS   Wartenberg,P., Lux,F., Busch,K., Fecher-Trost,C., Flockerzi,V.,
            Krasteva-Christ,G., Boehm,U. and Weissgerber,P.
  TITLE     A TRPV6 expression atlas for the mouse
  JOURNAL   Cell Calcium 100, 102481 (2021)
   PUBMED   34628109
  REMARK    GeneRIF: A TRPV6 expression atlas for the mouse.
REFERENCE   6  (bases 1 to 2946)
  AUTHORS   Fecher-Trost,C., Wissenbach,U., Beck,A., Schalkowsky,P.,
            Stoerger,C., Doerr,J., Dembek,A., Simon-Thomas,M., Weber,A.,
            Wollenberg,P., Ruppert,T., Middendorff,R., Maurer,H.H. and
            Flockerzi,V.
  TITLE     The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as
            methionine, upstream of canonical initiation at AUG
  JOURNAL   J Biol Chem 288 (23), 16629-16644 (2013)
   PUBMED   23612980
  REMARK    GeneRIF: A non-AUG start codon is used in both human and mouse,
            extending the N-terminus of the protein by 40 amino acids. The
            increased translation of the smaller TRPV6 cDNA version may
            overestimate the in vivo situation where translation efficiency may
            represent an additional mechanism to tightly control the
            TRPV6-mediated Ca(2+) entry to prevent deleterious Ca(2+) overload.
REFERENCE   7  (bases 1 to 2946)
  AUTHORS   Hoenderop,J.G., Voets,T., Hoefs,S., Weidema,F., Prenen,J.,
            Nilius,B. and Bindels,R.J.
  TITLE     Homo- and heterotetrameric architecture of the epithelial Ca2+
            channels TRPV5 and TRPV6
  JOURNAL   EMBO J 22 (4), 776-785 (2003)
   PUBMED   12574114
REFERENCE   8  (bases 1 to 2946)
  AUTHORS   Nilius,B., Prenen,J., Hoenderop,J.G., Vennekens,R., Hoefs,S.,
            Weidema,A.F., Droogmans,G. and Bindels,R.J.
  TITLE     Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and
            ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located
            between transmembrane segments 2 and 3
  JOURNAL   J Biol Chem 277 (34), 30852-30858 (2002)
   PUBMED   12077127
REFERENCE   9  (bases 1 to 2946)
  AUTHORS   Hoenderop,J.G., Vennekens,R., Muller,D., Prenen,J., Droogmans,G.,
            Bindels,R.J. and Nilius,B.
  TITLE     Function and expression of the epithelial Ca(2+) channel family:
            comparison of mammalian ECaC1 and 2
  JOURNAL   J Physiol 537 (Pt 3), 747-761 (2001)
   PUBMED   11744752
  REMARK    GeneRIF: to characterize ECaC2 in more detail and to compare its
            properties with those of ECaC1 to obtain a better understanding of
            transcellular Ca2+ transport in epithelia.
REFERENCE   10 (bases 1 to 2946)
  AUTHORS   Peng,J.B., Chen,X.Z., Berger,U.V., Weremowicz,S., Morton,C.C.,
            Vassilev,P.M., Brown,E.M. and Hediger,M.A.
  TITLE     Human calcium transport protein CaT1
  JOURNAL   Biochem Biophys Res Commun 278 (2), 326-332 (2000)
   PUBMED   11097838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK168760.1, AK077234.1 and CF583712.1.
            
            On Dec 18, 2009 this sequence version replaced NM_022413.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168760.1, AK077234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 23612980
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AK168760.1         1-177
            178-2922            AK077234.1         108-2852
            2923-2946           CF583712.1         2-25                c
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.79 cM"
     gene            1..2946
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 6"
                     /db_xref="GeneID:64177"
                     /db_xref="MGI:MGI:1927259"
     exon            1..423
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2479
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /exception="alternative start codon"
                     /note="non-AUG (ACG) translation initiation codon;
                     epithelial calcium channel 2; osmosensitive transient
                     receptor potential channel 3; calcium transport protein 1"
                     /codon_start=1
                     /transl_except=(pos:176..178,aa:Met)
                     /product="transient receptor potential cation channel
                     subfamily V member 6"
                     /protein_id="NP_071858.3"
                     /db_xref="CCDS:CCDS20052.2"
                     /db_xref="GeneID:64177"
                     /db_xref="MGI:MGI:1927259"
                     /translation="MGPLQREDRPALGGANVAPGSSPVGVWHQPQPPKEPAFHPMGWS
                     LPKEKGLILCLWNKFCRWFHRQESWAQSRDEQNLLQQKRIWESPLLLAAKENDVQALS
                     KLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA
                     LHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEI
                     VRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPN
                     NQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLEL
                     IVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLK
                     PRITNRTNPRDNTLMQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLG
                     VTRFFGQTILGGPFHVIIITYAFMVLVTMVMRLTNVDGEVVPMSFALVLGWCNVMYFA
                     RGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYP
                     MALFSTFELFLTIIDGPANYDVDLPFMYSVTYAAFAIIATLLMLNLLIAMMGDTHWRV
                     AHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQR
                     IRRYAQAFQQQDGLYSEDLEKDSGEKLETARPFGAYLSFPTPSVSRSTSRSSTNWERL
                     RQGALRKDLRGIINRGLEDGEGWEYQI"
     exon            424..521
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            522..644
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            645..782
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..881
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1054
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1201
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1414
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1501
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1578
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1744
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1811
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2080
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2187
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2928
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /note="hexamer: AATAAA"
     polyA_site      2923
                     /gene="Trpv6"
                     /gene_synonym="Cac; CAT; CaT1; Ecac2; Otrpc3"
                     /note="major polyA site"
ORIGIN      
        1 gagggagtgc ccacatagct cctgctcact cccaacagga gctccagaga cacaagccca
       61 gcagatttcc agcccggcca agaggaacaa agcaggagcc ctcttcaggc tcctaggggc
      121 agccacggga agcctcagca gctccacagg tgaagtagga gacagaagac aggagacggg
      181 acctctacag agagaggaca ggccggctct tgggggtgcc aatgtggccc cagggtcgag
      241 cccagttggg gtctggcatc agcctcagcc ccccaaggaa ccagccttcc accccatggg
      301 gtggtccctg cccaaggaga aggggttaat actctgccta tggaacaagt tctgcagatg
      361 gttccacaga caagagtcct gggctcagag ccgagacgag cagaacctgc tgcagcagaa
      421 gaggatctgg gaatcacctc ttcttctagc tgccaaagaa aacgatgtcc aggctctgag
      481 caagctgctc aagtttgaag gatgtgaggt gcaccagaga ggagccatgg gggaaactgc
      541 acttcacata gcagccctct atgataacct ggaggctgca atggtgctaa tggaggctgc
      601 cccagaacta gtctttgagc ccatgacttc ggagctatat gaaggtcaga ctgcactaca
      661 cattgcagta ataaaccaga atgtaaactt ggtccgtgct ctgcttgccc gaggggccag
      721 tgtctctgcc agagctacag gctctgtctt ccactacagg cctcacaacc tcatttacta
      781 tggagagcac cctttgtcct ttgctgcctg tgtgggtagt gaggagattg ttagactgct
      841 cattgagcat ggagctgaca tccgtgccca ggactctctg ggaaatacag tactacacat
      901 actcatcctg cagcccaaca aaacctttgc ctgccagatg tacaacttgc tactgtccta
      961 tgatggggga gaccacctga agtccctgga acttgtgcca aataaccagg gactcacccc
     1021 cttcaagttg gctggggtgg aaggcaacat tgtgatgttc caacacctga tgcagaagcg
     1081 gaaacacatc cagtggacat atgggccatt gacctccaca ctgtatgacc tcactgagat
     1141 tgactcctca ggagatgatc aatccctact ggaacttatt gttactacca agaaacggga
     1201 ggctcgccag atcctggacc agacacctgt aaaggaactg gtgagcctca agtggaagag
     1261 gtatgggcgg ccctacttct gcgtgctggg tgccatctat gtgctgtaca tcatctgctt
     1321 taccatgtgc tgtgtctacc gcccgctcaa gcccaggatc actaaccgca ccaacccccg
     1381 ggacaacact ctgatgcaac agaagctcct tcaggaggcc tatgtgaccc ctaaggatga
     1441 cctccggttg gtgggggaac tcgtgagcat cgttggggct gtgatcatcc tgctggtgga
     1501 gattccagac atcttcaggt tgggggtcac tcgattcttt ggacagacca ttctcggggg
     1561 gccattccat gtcatcatta tcacttatgc cttcatggtg ctggtgacca tggtgatgcg
     1621 actcaccaat gtagatggag aagtggtgcc catgtccttt gctctggtgt tgggctggtg
     1681 caatgtcatg tactttgcca gaggattcca gatgctgggt cccttcacca tcatgattca
     1741 gaagatgatt tttggtgact tgatgcgatt ctgctggctg atggctgtgg taattctggg
     1801 atttgcttca gccttctata tcattttcca gacagaggat cccgatgagc tgggtcattt
     1861 ctatgactac cccatggcac tgttcagcac ctttgaactc ttcctcacca tcatcgatgg
     1921 ccctgccaac tatgacgtgg atctgccctt catgtacagc gttacctacg ctgcctttgc
     1981 catcatcgcc acactgctca tgcttaacct cctcattgcc atgatgggtg acactcactg
     2041 gagagttgcc catgagcgag atgagctctg gagagcacag gttgtggcca ccactgtgat
     2101 gttagagcgg aagctacctc gttgcctgtg gcctcgctct gggatatgtg ggcgagagta
     2161 tggtcttggc gaccgctggt tcttgagggt ggaagacagg caagatctca acagacaacg
     2221 catccgccgc tatgcacagg ccttccagca acaagatggc ctctactctg aggacttgga
     2281 aaaagattca ggagaaaaac tggagacagc acgtcccttt ggtgcctatc tgtcctttcc
     2341 tacaccctca gtatctcgaa gtacctcccg aagcagcacc aattgggaaa ggcttcgaca
     2401 aggggccctg aggaaggacc tgcgggggat aatcaaccgg ggcctagaag atggggaggg
     2461 ctgggagtac cagatctgaa tgttggctct caccaagcat cagaacagaa tgaaagaaag
     2521 acagctaagg tcatcctgcg agtccaaggg agaaggaaga ggaacatgcc aaggaatgta
     2581 cactgggaat aaatgctcca gggctccaca actcctttat cttggagcaa aaggaagacg
     2641 actctgtggt ccgtgcctca tccaagcttt ccttgttctc ttatggaagc tcccctgcac
     2701 accagagcac tttaaagaca ggcttcctat ctcaggcacc tgtctcctcc caggtctaat
     2761 aagtgggagg gcacagaact cttcccaggg tgctccagac gacggatgga gaacactgag
     2821 attgtgggaa ggtgtgtgat ggacagatac aggcaccagt ctaggggtgg ggaagctaga
     2881 ctgagccttg ccaccttcca ataaaatcat ttcctgatcc ccacccaaaa aaaaaaaaaa
     2941 aaaaaa
//
