LOCUS       NM_001007572            2601 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            V, member 5 (Trpv5), mRNA.
ACCESSION   NM_001007572
VERSION     NM_001007572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Guan,N., Kobayashi,H., Ishii,K., Davidoff,O., Sha,F., Ikizler,T.A.,
            Hao,C.M., Chandel,N.S. and Haase,V.H.
  TITLE     Disruption of mitochondrial complex III in cap mesenchyme but not
            in ureteric progenitors results in defective nephrogenesis
            associated with amino acid deficiency
  JOURNAL   Kidney Int 102 (1), 108-120 (2022)
   PUBMED   35341793
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   De Clercq,K., Perez-Garcia,V., Van Bree,R., Pollastro,F.,
            Peeraer,K., Voets,T. and Vriens,J.
  TITLE     Mapping the expression of transient receptor potential channels
            across murine placental development
  JOURNAL   Cell Mol Life Sci 78 (11), 4993-5014 (2021)
   PUBMED   33884443
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Franken,G.A.C., Seker,M., Bos,C., Siemons,L.A.H., van der
            Eerden,B.C.J., Christ,A., Hoenderop,J.G.J., Bindels,R.J.M.,
            Muller,D., Breiderhoff,T. and de Baaij,J.H.F.
  TITLE     Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and
            developmental defects
  JOURNAL   Sci Rep 11 (1), 8217 (2021)
   PUBMED   33859252
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Li,S.H., Yin,H.B., Ren,M.R., Wu,M.J., Huang,X.L., Li,J.J.,
            Luan,Y.P. and Wu,Y.L.
  TITLE     TRPV5 and TRPV6 are expressed in placenta and bone tissues during
            pregnancy in mice
  JOURNAL   Biotech Histochem 94 (4), 244-251 (2019)
   PUBMED   30916584
  REMARK    GeneRIF: This study found that TRPV5 and TRPV6 are involved in
            calcium transport in the placenta and bone, and therefore play a
            role in calcium homeostasis during embryonic and fetal development.
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Hoenderop,J.G., van Leeuwen,J.P., van der Eerden,B.C.,
            Kersten,F.F., van der Kemp,A.W., Merillat,A.M., Waarsing,J.H.,
            Rossier,B.C., Vallon,V., Hummler,E. and Bindels,R.J.
  TITLE     Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in
            mice lacking TRPV5
  JOURNAL   J Clin Invest 112 (12), 1906-1914 (2003)
   PUBMED   14679186
  REMARK    GeneRIF: the key function of TRPV5 is in active Ca2+ reabsorption
            and it has an essential role in Ca2+ homeostasis
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   van de Graaf,S.F., Hoenderop,J.G., Gkika,D., Lamers,D., Prenen,J.,
            Rescher,U., Gerke,V., Staub,O., Nilius,B. and Bindels,R.J.
  TITLE     Functional expression of the epithelial Ca(2+) channels (TRPV5 and
            TRPV6) requires association of the S100A10-annexin 2 complex
  JOURNAL   EMBO J 22 (7), 1478-1487 (2003)
   PUBMED   12660155
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Hoenderop,J.G., Voets,T., Hoefs,S., Weidema,F., Prenen,J.,
            Nilius,B. and Bindels,R.J.
  TITLE     Homo- and heterotetrameric architecture of the epithelial Ca2+
            channels TRPV5 and TRPV6
  JOURNAL   EMBO J 22 (4), 776-785 (2003)
   PUBMED   12574114
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Hoenderop,J.G., Dardenne,O., Van Abel,M., Van Der Kemp,A.W., Van
            Os,C.H., St -Arnaud,R. and Bindels,R.J.
  TITLE     Modulation of renal Ca2+ transport protein genes by dietary Ca2+
            and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin
            D3-1alpha-hydroxylase knockout mice
  JOURNAL   FASEB J 16 (11), 1398-1406 (2002)
   PUBMED   12205031
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Nilius,B., Prenen,J., Hoenderop,J.G., Vennekens,R., Hoefs,S.,
            Weidema,A.F., Droogmans,G. and Bindels,R.J.
  TITLE     Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and
            ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located
            between transmembrane segments 2 and 3
  JOURNAL   J Biol Chem 277 (34), 30852-30858 (2002)
   PUBMED   12077127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC110555.1.
            
            On Aug 6, 2006 this sequence version replaced NM_001007572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110554.1, AK085479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.83 cM"
     gene            1..2601
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 5"
                     /db_xref="GeneID:194352"
                     /db_xref="MGI:MGI:2429764"
     exon            1..178
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2240
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /note="epithelial calcium channel 1; OTRPC3; osm-9-like
                     TRP channel 3; calcium transport protein 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 5"
                     /protein_id="NP_001007573.1"
                     /db_xref="CCDS:CCDS20053.1"
                     /db_xref="GeneID:194352"
                     /db_xref="MGI:MGI:2429764"
                     /translation="MGAKTPWIQLQKLLNWWVRDQDWNQHVDQLHMLQQKSIWESPLL
                     RAAKENDMCTLKKLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMEAAPYLVTE
                     STLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHP
                     LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDG
                     GDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKRIQWSFGPLTSSLYDLTEI
                     DSWGEELSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGALYIFYMV
                     CFTTCCVYRPLKFRDANRTHVRDNTIMEQKSLQEAYVTYQDKIRLVGELVTVIGAVII
                     LLLEIPDIFRVGASRYFGQTVLGGPFHVIIITYASLVLLTMAMRLTNVNGEVVPMSMA
                     LVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTE
                     DPDNLGEFSDYPTAMFSTFELFLTIIDGPANYRVDLPFMYSVTYATFAIIATLLMLNL
                     FIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFL
                     RVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLS
                     RTTSLSSNSHRGWEILRRNTLGHLNLGLDPGEGDGEEIYQF"
     exon            179..276
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..399
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..537
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..636
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..809
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..956
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1169
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1256
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1333
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1499
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1566
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1835
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1942
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2600
                     /gene="Trpv5"
                     /gene_synonym="CAT2; D630033B11; ECAC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcctctgtc atcctagact ggctccttcc atgagatttg aacaagttgt aagtacgtgc
       61 aagaagacat gggggctaaa actccttgga tccaacttca gaaacttctc aattggtggg
      121 tcagagacca agactggaac cagcacgtgg atcagctaca tatgctacag caaaaaagta
      181 tttgggagtc tccactgctt agagcagcca aggaaaatga tatgtgcaca cttaagaaac
      241 ttcagcatga ccagaactgt gacttccggc aaagaggagc tctgggagag acagcactgc
      301 atgtagctgc cctctatgat aacctggatg ctgctataat gctgatggag gctgctccat
      361 acttggtcac agagtccaca ctgtgtgagc catttgtagg tcagactgca ctgcacatcg
      421 cagtcatgaa ccagaatgtg aacctagtcc gtgccctgtt ggcccgaggg gccagtgcct
      481 ccgccagagc tacaggctcc gccttccatc gaagttcaca caacctcatc tactatggag
      541 aacacccttt gtcctttgct gcctgtgtgg gtagtgagga gattgttagg ttgctcattg
      601 agcatggagc tgacatccgt gcccaggact ccctgggaaa tacagtacta cacatacttg
      661 tcctgcagcc caacaaaacc tttgcctgtc agatgtacaa cctgctactg tcctatgatg
      721 gaggagacca cctgaagtcc ctggagcttg tgcccaacaa ccagggactc acccccttca
      781 agttggctgg ggtggaaggc aacacagtga tgtttcaaca tctaatgcag aaacggaagc
      841 gcatccagtg gtcctttggg cccctaacat cttccctcta tgacctcaca gagattgact
      901 cctggggtga ggagctgtcc tttctggagc ttgtggtttc ctccaagaag aaagaggctc
      961 gacagattct agaacagacc ccagtgaagg agctggtgag cctgaagtgg aagaaatatg
     1021 gacagcctta tttctgcctc ctgggtgctc tgtacatctt ctacatggtc tgcttcacca
     1081 catgctgtgt ttaccgcccc ctcaagttcc gagatgccaa ccgtacacat gttcgagata
     1141 acaccatcat ggaacagaaa tcactacagg aagcatatgt gacttaccag gataagatcc
     1201 ggctggtcgg ggagttggtg acagtcattg gggctgtaat tattctactc ctagagatcc
     1261 cagacatctt cagagttggt gcctctcgct actttggaca aacagttctt gggggcccat
     1321 tccatgtcat catcattaca tatgcctccc ttgtgctact gactatggca atgaggctta
     1381 ccaatgtgaa tggcgaggta gtgcccatgt ccatggccct ggtgctgggc tggtgtagtg
     1441 tcatgtactt cgcccgagga ttccagatgc tgggcccctt cacaatcatg attcagaaga
     1501 tgatttttgg agacctactg cgcttctgct ggctaatggc tatggtcatc ctgggatttg
     1561 cctcagcctt ctatatcatt ttccagacag aggatccaga taatctgggg gaattctccg
     1621 actaccccac agcaatgttc agcacctttg agctgttcct caccatcatt gacggacctg
     1681 ccaattacag agtggatctg cccttcatgt acagtgttac ctatgccacc tttgccatca
     1741 tcgccacact gctcatgctc aacttgttca ttgccatgat gggcgacact cactggcgag
     1801 tggcccagga gagggacgag ctctggagag cacaagttgt agccaccaca gtgatgctgg
     1861 agaggaaaat gcctcgtttc ctgtggcctc gctctggtat ctgtggttgc gaatacggcc
     1921 tgggagaccg ttggttctta cgggttgaac accaccagga gcagaatcct tatcgagtac
     1981 ttcgatatgt ggaagctttc aaatcttcag acaaagagga agtacaagag cagctatctg
     2041 agaaacaacc ttctgggact gagactggga ctttagctag aggctctgtg gttctccaaa
     2101 cacctccttt gtccaggact acatccctaa gcagcaatag ccaccgtgga tgggaaattc
     2161 tccgtcgaaa caccctggga catttgaatc ttggactaga ccctggtgaa ggggatgggg
     2221 aagagatcta ccagttctga agagaatcct gtttctgtag acttagcccc aagtaggcca
     2281 aggtgtgaga aagggggttg ggggtagttg aaggtgggca gggagaagag agctgctttg
     2341 caagagtttg aattctatgg ttatgaatag ctggatgata tacacaaaat attctctaag
     2401 cagcaatatt tcacatttga gcatttgtag agatgggcaa tggtcatcaa gtgttgtatg
     2461 taccttttca gttcctctaa agctcatatc ctgagagcct ggcaactaag gatataaaat
     2521 gggggctaat tgacatttct ggttgacatc tggaccatct ttcttatgcc ttgaacagaa
     2581 ggcagaaggc agcaagccag a
//
