LOCUS       NM_022017               3247 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            V, member 4 (Trpv4), mRNA.
ACCESSION   NM_022017
VERSION     NM_022017.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Tang,Y., Zhou,Y., Ren,J., Wang,Y., Li,X., Qi,M., Yang,Y., Zhu,C.,
            Wang,C., Ma,Y., Tang,Z. and Yu,G.
  TITLE     TRPV4-beta-catenin axis is a novel therapeutic target for dry
            skin-induced chronic itch
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167491 (2024)
   PUBMED   39218273
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Mou,A., Sun,F., Tong,D., Wang,L., Lu,Z., Cao,T., Li,L., You,M.,
            Zhou,Q., Chen,X., Xiang,J., Liu,D., Gao,P., He,H. and Zhu,Z.
  TITLE     Dietary apigenin ameliorates obesity-related hypertension through
            TRPV4-dependent vasorelaxation and TRPV4-independent adiponectin
            secretion
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167488 (2024)
   PUBMED   39218272
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Schaller,L., Gudermann,T. and Dietrich,A.
  TITLE     TRPV4 Mediates Alveolar Epithelial Barrier Integrity and Induces
            ADAM10-Driven E-Cadherin Shedding
  JOURNAL   Cells 13 (20), 1717 (2024)
   PUBMED   39451235
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Hernandez-Vega,A.M., Llorente,I., Sanchez-Hernandez,R., Segura,Y.,
            Tusie-Luna,T., Morales-Buenrostro,L.E., Garcia-Villegas,R.,
            Islas,L.D. and Rosenbaum,T.
  TITLE     Identification and Properties of TRPV4 Mutant Channels Present in
            Polycystic Kidney Disease Patients
  JOURNAL   Function (Oxf) 5 (5) (2024)
   PUBMED   38984987
  REMARK    GeneRIF: Identification and Properties of TRPV4 Mutant Channels
            Present in Polycystic Kidney Disease Patients.
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Kashio,M., Derouiche,S., Yoshimoto,R.U., Sano,K., Lei,J., Kido,M.A.
            and Tominaga,M.
  TITLE     Involvement of TRPV4 in temperature-dependent perspiration in mice
  JOURNAL   Elife 13, 92993 (2024)
   PUBMED   38963781
  REMARK    GeneRIF: Involvement of TRPV4 in temperature-dependent perspiration
            in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Voets,T., Prenen,J., Vriens,J., Watanabe,H., Janssens,A.,
            Wissenbach,U., Bodding,M., Droogmans,G. and Nilius,B.
  TITLE     Molecular determinants of permeation through the cation channel
            TRPV4
  JOURNAL   J Biol Chem 277 (37), 33704-33710 (2002)
   PUBMED   12093812
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Watanabe,H., Davis,J.B., Smart,D., Jerman,J.C., Smith,G.D.,
            Hayes,P., Vriens,J., Cairns,W., Wissenbach,U., Prenen,J.,
            Flockerzi,V., Droogmans,G., Benham,C.D. and Nilius,B.
  TITLE     Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
  JOURNAL   J Biol Chem 277 (16), 13569-13577 (2002)
   PUBMED   11827975
  REMARK    GeneRIF: Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol
            derivatives.
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Wissenbach,U., Bodding,M., Freichel,M. and Flockerzi,V.
  TITLE     Trp12, a novel Trp related protein from kidney
  JOURNAL   FEBS Lett 485 (2-3), 127-134 (2000)
   PUBMED   11094154
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Liedtke,W., Choe,Y., Marti-Renom,M.A., Bell,A.M., Denis,C.S.,
            Sali,A., Hudspeth,A.J., Friedman,J.M. and Heller,S.
  TITLE     Vanilloid receptor-related osmotically activated channel (VR-OAC),
            a candidate vertebrate osmoreceptor
  JOURNAL   Cell 103 (3), 525-535 (2000)
   PUBMED   11081638
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Strotmann,R., Harteneck,C., Nunnenmacher,K., Schultz,G. and
            Plant,T.D.
  TITLE     OTRPC4, a nonselective cation channel that confers sensitivity to
            extracellular osmolarity
  JOURNAL   Nat Cell Biol 2 (10), 695-702 (2000)
   PUBMED   11025659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002735.1, AF279672.1 and BC127052.1.
            
            On Nov 21, 2009 this sequence version replaced NM_022017.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279672.1, AF208026.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AK002735.1         1-149
            150-379             AF279672.1         134-363
            380-2812            BC127052.1         345-2777
            2813-3247           AF279672.1         2797-3231
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..3247
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 4"
                     /db_xref="GeneID:63873"
                     /db_xref="MGI:MGI:1926945"
     exon            1..80
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            81..497
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2727
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /note="osmosensitive transient receptor potential channel
                     4; trpv4 channel; osm-9-like TRP channel 4; vanilloid
                     receptor-like channel 2; vanilloid receptor-like protein
                     2; vanilloid receptor-related osmotically-activated
                     channel; transient receptor potential protein 12"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 4"
                     /protein_id="NP_071300.2"
                     /db_xref="CCDS:CCDS19568.1"
                     /db_xref="GeneID:63873"
                     /db_xref="MGI:MGI:1926945"
                     /translation="MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEE
                     GSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKA
                     PMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSR
                     GSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAE
                     RTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPK
                     DEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADN
                     TRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRR
                     EVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEML
                     AVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDY
                     LRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAAL
                     YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF
                     MIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGD
                     LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT
                     ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINED
                     PGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGH
                     QQGYAPKWRTDDAPL"
     exon            498..670
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            671..823
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            824..964
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1263
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1443
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1602
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1695
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1769
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1935
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2002
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2319
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2447
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2569
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..3226
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3204..3209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /note="hexamer: AATAAA"
     polyA_site      3226
                     /gene="Trpv4"
                     /gene_synonym="0610033B08Rik; OTRPC4; Trp12; VR-OAC;
                     VRL-2; VROAC"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgcgg ccgaagcgca gcaggaggag gacgcggccg gagggatcag gaagcggcgg
       61 cgctgcgccc gcgtcctgag gccgagaagt acaaacagat ctgggtccag tatggcagat
      121 cctggtgatg gtccccgtgc agcgcctggg gaggtggctg agccccctgg agatgagagt
      181 ggtacctctg gtggggaggc cttccccctc tcttccctgg ccaatctgtt tgagggggag
      241 gaaggctcct cttctctttc cccggtggat gctagccgcc ctgctggccc tggcgatgga
      301 cgtccaaacc tgcgtatgaa gttccagggc gctttccgca agggggttcc caaccccatt
      361 gacctgttgg agtccaccct gtacgagtcc tcagtagtgc ctgggcccaa gaaagcgccc
      421 atggattcct tgttcgacta cggcacttac cgtcaccacc ccagtgacaa caagagatgg
      481 aggagaaagg tcgtggagaa gcagccacag agccccaaag ctcctgcacc ccagccaccc
      541 cccatcctca aagtcttcaa tcggcccatc ctctttgaca ttgtgtcccg gggctccact
      601 gcggacctag atggactgct ctccttcttg ttgacccaca agaagcgcct gactgatgag
      661 gagttccggg agccgtccac ggggaagacc tgcctgccca aggcgctgct gaacctaagc
      721 aacgggcgca acgacaccat cccggtgttg ctggacattg cggagcgcac cggcaacatg
      781 cgtgaattca tcaactcgcc cttcagagac atctactacc gaggccagac atccctgcac
      841 attgccatcg aacggcgctg caagcactac gtggagctgc tggtggccca gggagccgac
      901 gtgcacgccc aggcccgcgg ccgcttcttc cagcccaagg atgagggagg ctacttctac
      961 tttggggagc tgcccttgtc cctggcagcc tgcaccaacc agccgcacat cgtcaactac
     1021 ctgacagaga accctcacaa gaaagctgac atgaggcgac aggactcgag ggggaacacg
     1081 gtgctgcacg cgctggtggc catcgccgac aacacccgag agaacaccaa gtttgtcacc
     1141 aagatgtacg acctgctgct tctcaagtgt tcacgcctct tccccgacag caacctggag
     1201 acagttctca acaatgatgg cctttcgcct ctcatgatgg ctgccaagac aggcaagatc
     1261 ggggtctttc agcacatcat ccgacgtgag gtgacagatg aggacacccg gcatctgtct
     1321 cgcaagttca aggactgggc ctatgggcct gtgtattctt ctctctacga cctctcctcc
     1381 ctggacacat gcggggagga ggtgtccgtg ctggagatcc tggtgtacaa cagcaagatc
     1441 gagaaccgcc atgagatgct ggctgtagag cccattaacg aactgttgag agacaagtgg
     1501 cgtaagtttg gggctgtgtc cttctacatc aacgtggtct cctatctgtg tgccatggtc
     1561 atcttcaccc tcaccgccta ctatcagcca ctggagggca cgccacccta cccttaccgg
     1621 accacagtgg actacctgag gctggctggc gaggtcatca cgctcttcac aggagtcctg
     1681 ttcttcttta ccagtatcaa agacttgttc acgaagaaat gccctggagt gaattctctc
     1741 ttcgtcgatg gctccttcca gttactctac ttcatctact ctgtgctggt ggttgtctct
     1801 gcggcgctct acctggctgg gatcgaggcc tacctggctg tgatggtctt tgccctggtc
     1861 ctgggctgga tgaatgcgct gtacttcacg cgcgggttga agctgacggg gacctacagc
     1921 atcatgattc agaagatcct cttcaaagac ctcttccgct tcctgcttgt gtacctgctc
     1981 ttcatgatcg gctatgcctc agccctggtc accctcctga atccgtgcac caacatgaag
     2041 gtctgtgacg aggaccagag caactgcacg gtgcccacgt atcctgcgtg ccgcgacagc
     2101 gagaccttca gcgccttcct cctggacctc ttcaagctca ccatcggcat gggagacctg
     2161 gagatgctga gcagcgccaa gtaccccgtg gtcttcatcc tcctgctggt cacctacatc
     2221 atcctcacct tcgtgctcct gttgaacatg cttatcgccc tcatgggtga gaccgtgggc
     2281 caggtgtcca aggagagcaa gcacatctgg aagttgcagt gggccaccac catcctggac
     2341 atcgagcgtt ccttccctgt gttcctgagg aaggccttcc gctccggaga gatggtgact
     2401 gtgggcaaga gctcagatgg cactccggac cgcaggtggt gcttcagggt ggacgaggtg
     2461 aactggtctc actggaacca gaacttgggc atcattaacg aggaccctgg caagagtgaa
     2521 atctaccagt actatggctt ctcccacacc gtggggcgcc ttcgtaggga tcgttggtcc
     2581 tcggtggtgc cccgcgtagt ggagctgaac aagaactcaa gcgcagatga agtggtggta
     2641 cccctggata acctagggaa ccccaactgt gacggccacc agcagggcta cgctcccaag
     2701 tggaggacgg acgatgcccc actgtagggg ccgtgccaga gctcgcacag atagtccagg
     2761 cttggccttc gctcccacct acatttaggc atttgtccgg tgtcttccca cacccgcatg
     2821 ggaccttgga ggtgagggcc tctgtggcga ctctgtggag gccccaggac cctctggtcc
     2881 ccgccaagac ttttgccttc agctctactc cccacatggg ggggcggggc tcctggctac
     2941 ctgtctcgct cgctcccatg gagtcaccta agccagcaca aggcccctct cctcgaaagg
     3001 ctcaggcccc atccctcttg tgtattattt attgctctcc tcaggaaaat ggggtggcag
     3061 gagtccaccc gcggctggaa cctggccagg gctgaagctc atgcagggac gctgcagctc
     3121 cgacctgcca cagatctgac ctgctgcagc cctggctagt gtgggtcttc tgtactttga
     3181 agagatcggg gccgctggtg ctcaataaat gtttattctc ggtggaaaaa aaaaaaaaaa
     3241 aaaaaaa
//
