LOCUS       NM_145099               5708 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            V, member 3 (Trpv3), transcript variant 1, mRNA.
ACCESSION   NM_145099
VERSION     NM_145099.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5708)
  AUTHORS   Hu,Y., Zou,W., Zhang,L., Zhang,S., Hu,L., Song,Z., Kong,S., Gao,Y.,
            Zhang,J., Yang,Y. and Zheng,J.
  TITLE     TRPV3 facilitates lipolysis and attenuates diet-induced obesity via
            activation of the NRF2/FSP1 signaling axis
  JOURNAL   Free Radic Biol Med 221, 155-168 (2024)
   PUBMED   38777204
  REMARK    GeneRIF: TRPV3 facilitates lipolysis and attenuates diet-induced
            obesity via activation of the NRF2/FSP1 signaling axis.
REFERENCE   2  (bases 1 to 5708)
  AUTHORS   Martin,L.S., Josset-Lamaugarny,A., El Jammal,T., Ducreux,S.,
            Chevalier,F.P. and Fromy,B.
  TITLE     Aging is associated with impaired triggering of TRPV3-mediated
            cutaneous vasodilation: a crucial process for local heat exposure
  JOURNAL   Geroscience 46 (4), 3567-3580 (2024)
   PUBMED   37855862
  REMARK    GeneRIF: Aging is associated with impaired triggering of
            TRPV3-mediated cutaneous vasodilation: a crucial process for local
            heat exposure.
REFERENCE   3  (bases 1 to 5708)
  AUTHORS   Wei,Z., Gao,M., Liu,Y., Zeng,R., Liu,J., Sun,S., Li,S., Hu,L.,
            Xiang,R., Mo,R., Song,Z., Chen,Z., Bao,D., Hua,D., Zouboulis,C.C.,
            Feng,Y., Li,J. and Yang,Y.
  TITLE     TRPV3 promotes sebocyte inflammation via transcriptional modulating
            TLR2 in acne
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167195 (2024)
   PUBMED   38648901
  REMARK    GeneRIF: TRPV3 promotes sebocyte inflammation via transcriptional
            modulating TLR2 in acne.
REFERENCE   4  (bases 1 to 5708)
  AUTHORS   Pallotti,S., Picciolini,M., Deiana,G., Pediconi,D., Antonini,M.,
            Napolioni,V. and Renieri,C.
  TITLE     Whole genome sequencing analysis of alpaca suggests TRPV3 as a
            candidate gene for the suri phenotype
  JOURNAL   BMC Genomics 25 (1), 185 (2024)
   PUBMED   38365607
  REMARK    GeneRIF: Whole genome sequencing analysis of alpaca suggests TRPV3
            as a candidate gene for the suri phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5708)
  AUTHORS   Akizawa,H., Lopes,E.M. and Fissore,R.A.
  TITLE     Zn2+ is essential for Ca2+ oscillations in mouse eggs
  JOURNAL   Elife 12, 88082 (2023)
   PUBMED   38099643
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5708)
  AUTHORS   Watanabe,A., Takeuchi,M., Nagata,M., Nakamura,K., Nakao,H.,
            Yamashita,H., Makino,S., Harada,M. and Hirasawa,T.
  TITLE     Role of the Nh (Non-hair) mutation in the development of dermatitis
            and hyperproduction of IgE in DS-Nh mice
  JOURNAL   Exp Anim 52 (5), 419-423 (2003)
   PUBMED   14625409
REFERENCE   7  (bases 1 to 5708)
  AUTHORS   Chung,M.K., Lee,H. and Caterina,M.J.
  TITLE     Warm temperatures activate TRPV4 in mouse 308 keratinocytes
  JOURNAL   J Biol Chem 278 (34), 32037-32046 (2003)
   PUBMED   12783886
REFERENCE   8  (bases 1 to 5708)
  AUTHORS   Watanabe,A., Takeuchi,M., Nagata,M., Nakamura,K., Hirasawa,T.,
            Nakao,H., Makino,S. and Harada,M.
  TITLE     Spontaneous development of dermatitis in DS-Nh mice under specific
            pathogen-free conditions
  JOURNAL   Exp Anim 52 (1), 77-80 (2003)
   PUBMED   12638241
REFERENCE   9  (bases 1 to 5708)
  AUTHORS   Peier,A.M., Reeve,A.J., Andersson,D.A., Moqrich,A., Earley,T.J.,
            Hergarden,A.C., Story,G.M., Colley,S., Hogenesch,J.B., McIntyre,P.,
            Bevan,S. and Patapoutian,A.
  TITLE     A heat-sensitive TRP channel expressed in keratinocytes
  JOURNAL   Science 296 (5575), 2046-2049 (2002)
   PUBMED   12016205
  REMARK    GeneRIF: specifically expressed in keratinocytes;hence,skin cells
            are capable of detecting heat via molecules similar to those in
            heat-sensing neurons
REFERENCE   10 (bases 1 to 5708)
  AUTHORS   Haraguchi,M., Hino,M., Tanaka,H. and Maru,M.
  TITLE     Naturally occurring dermatitis associated with Staphylococcus
            aureus in DS-Nh mice
  JOURNAL   Exp Anim 46 (3), 225-229 (1997)
   PUBMED   9250484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663116.7 and AL645739.9.
            
            On Jun 21, 2019 this sequence version replaced NM_145099.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF510316.1, AB083654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL663116.7         69344-69486
            144-283             AL645739.9         2730-2869
            284-388             AL645739.9         10817-10921
            389-475             AL645739.9         11029-11115
            476-630             AL645739.9         12005-12159
            631-807             AL645739.9         12851-13027
            808-948             AL645739.9         14763-14903
            949-1229            AL645739.9         16682-16962
            1230-1406           AL645739.9         18951-19127
            1407-1565           AL645739.9         20440-20598
            1566-1667           AL645739.9         21257-21358
            1668-1741           AL645739.9         22324-22397
            1742-1907           AL645739.9         24658-24823
            1908-1974           AL645739.9         27022-27088
            1975-2249           AL645739.9         28284-28558
            2250-2362           AL645739.9         29518-29630
            2363-2442           AL645739.9         29817-29896
            2443-5708           AL645739.9         30192-33457
FEATURES             Location/Qualifiers
     source          1..5708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.25 cM"
     gene            1..5708
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 3"
                     /db_xref="GeneID:246788"
                     /db_xref="MGI:MGI:2181407"
     exon            1..143
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            144..283
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2540
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-hair; TRP ion channel TRPV3"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 3 isoform 1"
                     /protein_id="NP_659567.2"
                     /db_xref="CCDS:CCDS25004.1"
                     /db_xref="GeneID:246788"
                     /db_xref="MGI:MGI:2181407"
                     /translation="MNAHSKEMAPLMGKRTTAPGGNPVVLTEKRPADLTPTKKSAHFF
                     LEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNS
                     PSANLAKEEQRQKKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMH
                     KLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTA
                     LNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPE
                     IVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE
                     TMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSRKFTDWAYGPVSSSLYDL
                     TNVDTTTDNSVLEIIVYNTNIDNRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFF
                     YNITLTLVSYYRPREDEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLL
                     RPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYT
                     RGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGS
                     FSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVE
                     NVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWT
                     EWKTHVSFLNEDPGPIRRTADLNKIQDSSRSNSKTTLYAFDELDEFPETSV"
     exon            284..388
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            389..475
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            476..630
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..807
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..948
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1229
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1406
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1565
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1667
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1741
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1907
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1974
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2249
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2362
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2442
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..5708
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5684..5689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /note="hexamer: AATAAA"
     polyA_site      5708
                     /gene="Trpv3"
                     /gene_synonym="1110036I10Rik; Nh; VRL3"
                     /note="major polyA site"
ORIGIN      
        1 gcctcattcc agctgtcagc tatctctgtg cctacgatga gagcctctgg ccacctcagc
       61 caccttcccg acggtgggtt ttgggcccca gacatgcggt gatctcaagg caaggactgc
      121 caccaccatc tggaacctgc cagcatatgc cttaggctcc agcaatgaat gcccactcca
      181 aggagatggc gcccctcatg ggcaaaagaa ccacggcacc tggcgggaac cctgttgtac
      241 tgacagagaa gaggccagca gatctcaccc ccaccaagaa gagtgcacac ttcttcctgg
      301 agatagaagg atttgagccc aaccccacgg tcaccaagac ctctccaccc atcttctcca
      361 agccgatgga ctccaacatc cggcagtgcc tctctggcaa ctgtgatgac atggactctc
      421 cccagtctcc tcaggatgat gtgacagaga ccccatccaa tcccaacagt ccgagcgcaa
      481 acctggccaa ggaagaacag aggcagaaga agaagcgact gaagaagcgc atcttcgcgg
      541 ctgtgtccga gggctgcgtg gaggagctgc gggaactcct acaggatctg caggacctct
      601 gcaggaggcg ccgcggcctg gatgtgcctg acttcctcat gcacaagctg acagcctcag
      661 acaccgggaa gacctgcctg atgaaggctt tgctcaacat caatcccaac accaaagaga
      721 tcgtgcggat tctgcttgcc ttcgctgagg agaacgacat cctggacagg ttcatcaacg
      781 ctgagtacac ggaagaggcc tatgaagggc agacagcgct gaacatcgcc atcgagcggc
      841 gccagggaga catcacagca gtgcttatag cagcgggtgc tgacgtcaat gctcacgcca
      901 agggggtctt cttcaacccc aaataccagc atgaaggctt ctattttggc gagacacccc
      961 tggctttggc agcgtgtact aaccagcctg agattgtgca gctgctgatg gagaatgagc
     1021 agacagacat cacttcccag gattcccggg gaaacaacat cctgcacgcg ctggtgacag
     1081 tggctgagga cttcaagact cagaatgact tcgttaagcg catgtatgac atgatcctgc
     1141 tgaggagtgg caactgggag ctggagacca tgcgcaacaa cgatgggctc acaccactgc
     1201 agctggctgc caagatgggc aaggctgaga tcctgaagta catcctcagc cgcgagatca
     1261 aggagaagcc tctccggagc ttgtccagga agttcacgga ctgggcgtat gggcctgtgt
     1321 catcctcact ctatgacctc accaatgtag acacaacgac ggataactct gtgctggaaa
     1381 tcatcgtcta caacaccaac attgataacc gacatgagat gctgaccctg gagcctctgc
     1441 atacgctgct acacacgaaa tggaagaaat ttgccaagta catgttcttc ttgtccttct
     1501 gcttctattt cttctacaac atcaccctga cccttgtctc ttactaccgt cctcgggaag
     1561 atgaggatct cccacacccc ttggccctga cacacaaaat gagttggctt cagctcctag
     1621 ggaggatgtt tgtcctcatc tgggccacat gcatctctgt gaaagaaggc attgccattt
     1681 tcctgctgag accctccgat cttcagtcca tcctgtcaga tgcctggttt cactttgtct
     1741 tttttgtcca agctgtactt gtgatactgt ctgtattctt gtacttgttt gcctacaaag
     1801 aatacctcgc ctgcctcgtg ctggccatgg ccctgggctg ggcgaacatg ctctactaca
     1861 cgagaggctt ccagtctatg ggcatgtaca gcgtcatgat ccagaaggtc attttgcatg
     1921 atgtcctcaa gttcttgttt gtttacatcc tgttcttact tggatttgga gtagcgctgg
     1981 cctcactgat tgagaagtgc tccaaggaca aaaaggactg cagttcctat ggcagcttca
     2041 gcgacgcggt gctggagctc ttcaagctca ccataggcct gggcgacctg aacatccagc
     2101 agaactccac ctaccccatc ctctttctct tcctactcat cacctatgtc atcctcacct
     2161 tcgtcctcct cctcaacatg ctcattgccc tgatggggga gacggtggag aacgtctcca
     2221 aagaaagtga gcggatctgg cgcttgcaga gagccaggac catcttggag tttgagaaaa
     2281 tgttaccaga atggctgaga agcagattcc gcatgggcga gctgtgcaaa gtagcagatg
     2341 aggacttccg gctgtgtctg cggatcaacg aggtgaagtg gacggaatgg aaaacacacg
     2401 tgtccttcct taatgaagac ccgggaccca taagacggac agcagattta aacaagattc
     2461 aagattcttc caggagcaat agcaaaacca ccctctatgc gtttgatgaa ttagatgaat
     2521 tcccagaaac gtcggtgtag atgcctggct taaggcggat gtgaaccctg tggtttgatg
     2581 ctgcaggctg agccctggtg tgctgaagtg ctatgcagag tgctaaacta gaagcaaaat
     2641 gctcctcaca tagactggtg gctgctgagg agtggcagtc aggatctgaa agggaagcac
     2701 cttgggttgt gtgactccag aggtcaggac aattccaagg ccagcggttc tgagtctgga
     2761 agtctcctga tgccccatgt gaggaacctg caggttggct tggctccaag acatacgtgc
     2821 tggagaagga aggaactggg gtctgaggag tggggagagt ggtctcctct ctactacgat
     2881 ctgttgttgg ggccagcttc tgcccacaga ctccttcctc ctttatctcc ccaactatga
     2941 ctgtgcttcc tgaatttgta ggggaccctg tcccagcgtg tgtagaggac ctgagctaag
     3001 ttgggtctac ttgggtgaag aggggaatga gctacagaat gcccttactg agcctccagg
     3061 aaacaggaaa ctggactcta tccttggatt gaaatccaag gctaaaccta tctccaactg
     3121 agagatgctt aaatagtgta actgacacaa agtttttatt tttagttcag aaaagccatt
     3181 tcagttttga atgaaattta cttcagatga agtaggcaac tttaaaagct aagaaacaga
     3241 ttttgggctt ttggactgaa tgtaagtatt atatactagg cttcaggtgg ccaggatcag
     3301 gacaataaac gtttctacac acacacacac acacacacac acacacaaag cctgagggag
     3361 acaggctgtg atctggggga aaggtttggg gtccatcctc tttgagtctc atccagtgct
     3421 ggcctcactt tatctgagtc agaaatagca gctgacctat tgagagggtc ttaaaactca
     3481 gagatggcta gcaagcactc cagtgtttcc cactggggaa atcagcagat gcctaaaaca
     3541 cactgctagt ttttgtttac tgtgaatatt gaaactgtac aagaggcttc tgaggggaga
     3601 atatctgcca gacttagggc ttatttcaga tcctcagcct cagatttttt ttttttctcc
     3661 ttgaaatttc agagtcagtt tggtagagta gaggtggaga ttggagaatt tctccaatga
     3721 ctagaactga aatagtctcc cctgtccaac tccctctctt ctaacctaca ctctcctcca
     3781 acctacactc ttctgttatt tagtaaaagg attcatgtag aaagatttga gatggaacta
     3841 tagatgacta tgaagatttt tttatgttaa atgggttgga aataagttgg gcctttacaa
     3901 aacttggcaa ttgttgagct aatcagacta gagaccagac aaagaaagca gtccactctg
     3961 gcaggtttct ccattctaga aagttccaag taccagcata gctggacagg tgaaaagttg
     4021 gtcattccat cctgaatggc ctggtgggag agatggtggt ggatggtaca gcatggacag
     4081 ctgcccagtc tgcagcagcc actacctgca caaccttctg gattctctat tgctcaaaga
     4141 tcacactcaa gtaggggaag atgacaaagc atgtgtcttt ggaaaagcaa aaacctgagg
     4201 gggacatcat gggaagaagg agaagaagtg ctcctgatgg gcagaaatag tgagagaact
     4261 ggtttgagat tttggttcag ttcagtagac agctgcttca ggagtttaga agagttcaag
     4321 aaatgggcta gtacttgttg ggaagatgtt gaagaaagca actaggtgaa tcttaagatg
     4381 ctgagacatt ctacagacca gtattccata gctggagtct ccttgagtta tcctgaacag
     4441 aagtccctgt ttaaagggca accgctggtt ccagggagct gggattccag ctttgcattg
     4501 ccttggaagg cagtagttca aaccacgtag ctttgcattt cccacttgga tggaaggtgt
     4561 ggcaagttgg gcagatagaa ataactagct tctcaagtgt tgtggagact gttttctgtg
     4621 gatctggatg gaatttgttg gcaaacccat ttctgaattg gctattcatc taaatgtggg
     4681 accccacccc ccaagatgaa ggctttcacc ccagagggtc aagctaagaa ggctcatcaa
     4741 agcaaggaaa ggcatctcaa caaatggtgt cctgctcaaa agggccaaat ccctcattat
     4801 acatgtggag actcaggctc tggaatgaac atagacttgt tcaaagtcat gtcagagcag
     4861 gtgaggctag gataccctga tttctgggcc acagggatat ttctgcagtt tttaatcatt
     4921 gggtcttttt gtagttgcca cattaggggg tagttttttt ttttttttct tttctcttat
     4981 gatttggaag ttatcattgt ccttacaacc taatgacaag tctaaagatc caatgtgcct
     5041 aaagccacac aataacaaca aagatagcaa gaatacacac acaccactga ctcttgttgg
     5101 cctatcagga catcttaaaa ctccatgatt tacatttcag taatttaggg ggaagaggtt
     5161 ttctggggat gggcctgagc atgcttcggt agtagttaca agccctggtt tacacctcag
     5221 gaagagtttt gtattgcaga cattatgcca tgtgtctgtt tagaataaca tgggtgcttc
     5281 cttccttcct ggtgtgggga gaaggaataa aagctgtact gtgaagtcat tgagctctca
     5341 ggcatctgcc cacgagagtg cagtattact gtggttcctt tccttcctca gggcctggtg
     5401 actgctcccc ctttgctctg gatgaggcac agggagacag gccctcacca gagtctgtaa
     5461 gccatacttg acttctgcgt tgatttacat gttgttattt tatatgtact gtgatcttgg
     5521 ttccagacac agaattattg tcgtattctc acgagatgtg ctgatcattg tataacttaa
     5581 cttatagaat tgtttttagt gttgtttgtg tgaaactaca tgctcaagaa atcataaaga
     5641 gttaagacta ctttggtctc attgaaatac tgttttgatt tccaataaat atttattttg
     5701 tcatgtta
//
