LOCUS       NM_001382489            2981 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            V, member 2 (Trpv2), transcript variant 2, mRNA.
ACCESSION   NM_001382489 XM_030245930
VERSION     NM_001382489.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Yang,S., Du,Y., Li,Y., Tang,Q., Zhang,Y. and Zhao,X.
  TITLE     Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel
            tune microglial beta-amyloid peptide phagocytosis
  JOURNAL   J Neuroinflammation 21 (1), 218 (2024)
   PUBMED   39227967
  REMARK    GeneRIF: Tyrosine phosphorylation and palmitoylation of TRPV2 ion
            channel tune microglial beta-amyloid peptide phagocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2981)
  AUTHORS   Guo,Y.Y., Gao,Y., Zhao,Y.L., Xie,C., Gan,H., Cheng,X., Yang,L.P.,
            Hu,J., Shu,H.B., Zhong,B., Lin,D. and Yao,J.
  TITLE     Viral infection and spread are inhibited by the polyubiquitination
            and downregulation of TRPV2 channel by the interferon-stimulated
            gene TRIM21
  JOURNAL   Cell Rep 43 (4), 114095 (2024)
   PUBMED   38613787
  REMARK    GeneRIF: Viral infection and spread are inhibited by the
            polyubiquitination and downregulation of TRPV2 channel by the
            interferon-stimulated gene TRIM21.
REFERENCE   3  (bases 1 to 2981)
  AUTHORS   Li,C., Zhao,M., Liu,X., Li,Y., Xu,B., Zhou,L., Sun,X., Sun,W.,
            Kang,N., Ji,Z., Li,T., An,H., Wang,F., Wu,C., Ye,J.Y., Zhang,J.R.,
            Wang,Q., Zhao,X., Li,Z. and Liu,W.
  TITLE     Ion channel TRPV2 is critical in enhancing B cell activation and
            function
  JOURNAL   J Exp Med 221 (3) (2024)
   PUBMED   38353705
  REMARK    GeneRIF: Ion channel TRPV2 is critical in enhancing B cell
            activation and function.
REFERENCE   4  (bases 1 to 2981)
  AUTHORS   Peralvarez-Marin,A., Sole,M., Serrano,J., Taddeucci,A., Perez,B.,
            Penas,C., Manich,G., Jimenez,M., D'Ocon,P. and Jimenez-Altayo,F.
  TITLE     Evidence for the involvement of TRPV2 channels in the modulation of
            vascular tone in the mouse aorta
  JOURNAL   Life Sci 336, 122286 (2024)
   PUBMED   38007144
  REMARK    GeneRIF: Evidence for the involvement of TRPV2 channels in the
            modulation of vascular tone in the mouse aorta.
REFERENCE   5  (bases 1 to 2981)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2981)
  AUTHORS   Jahnel,R., Bender,O., Munter,L.M., Dreger,M., Gillen,C. and
            Hucho,F.
  TITLE     Dual expression of mouse and rat VRL-1 in the dorsal root ganglion
            derived cell line F-11 and biochemical analysis of VRL-1 after
            heterologous expression
  JOURNAL   Eur J Biochem 270 (21), 4264-4271 (2003)
   PUBMED   14622291
  REMARK    GeneRIF: analysis of glycosylation and localization in comparison
            to the endogenously expressed protein in F-11 cells
REFERENCE   7  (bases 1 to 2981)
  AUTHORS   Peier,A.M., Reeve,A.J., Andersson,D.A., Moqrich,A., Earley,T.J.,
            Hergarden,A.C., Story,G.M., Colley,S., Hogenesch,J.B., McIntyre,P.,
            Bevan,S. and Patapoutian,A.
  TITLE     A heat-sensitive TRP channel expressed in keratinocytes
  JOURNAL   Science 296 (5575), 2046-2049 (2002)
   PUBMED   12016205
REFERENCE   8  (bases 1 to 2981)
  AUTHORS   Boels,K., Glassmeier,G., Herrmann,D., Riedel,I.B., Hampe,W.,
            Kojima,I., Schwarz,J.R. and Schaller,H.C.
  TITLE     The neuropeptide head activator induces activation and
            translocation of the growth-factor-regulated Ca(2+)-permeable
            channel GRC
  JOURNAL   J Cell Sci 114 (Pt 20), 3599-3606 (2001)
   PUBMED   11707512
REFERENCE   9  (bases 1 to 2981)
  AUTHORS   Kanzaki,M., Zhang,Y.Q., Mashima,H., Li,L., Shibata,H. and Kojima,I.
  TITLE     Translocation of a calcium-permeable cation channel induced by
            insulin-like growth factor-I
  JOURNAL   Nat Cell Biol 1 (3), 165-170 (1999)
   PUBMED   10559903
REFERENCE   10 (bases 1 to 2981)
  AUTHORS   Caterina,M.J., Rosen,T.A., Tominaga,M., Brake,A.J. and Julius,D.
  TITLE     A capsaicin-receptor homologue with a high threshold for noxious
            heat
  JOURNAL   Nature 398 (6726), 436-441 (1999)
   PUBMED   10201375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596181.10.
            
            On May 13, 2020 this sequence version replaced XM_030245930.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1076231.1,
                                           SRR5189676.130388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AL596181.10        98026-98524         c
            500-792             AL596181.10        95556-95848         c
            793-926             AL596181.10        92846-92979         c
            927-1217            AL596181.10        91018-91308         c
            1218-1516           AL596181.10        89477-89775         c
            1517-1690           AL596181.10        84327-84500         c
            1691-1846           AL596181.10        83833-83988         c
            1847-1945           AL596181.10        83146-83244         c
            1946-2016           AL596181.10        81855-81925         c
            2017-2182           AL596181.10        81235-81400         c
            2183-2249           AL596181.10        79932-79998         c
            2250-2578           AL596181.10        78900-79228         c
            2579-2706           AL596181.10        77114-77241         c
            2707-2786           AL596181.10        75838-75917         c
            2787-2981           AL596181.10        73848-74042         c
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.48 cM"
     gene            1..2981
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 2"
                     /db_xref="GeneID:22368"
                     /db_xref="MGI:MGI:1341836"
     exon            1..499
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..792
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2875
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     osm-9-like TRP channel 2; growth factor-regulated calcium
                     channel; vanilloid receptor-like protein 1; growth factor
                     regulated channel"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 2 isoform 2"
                     /protein_id="NP_001369418.1"
                     /db_xref="GeneID:22368"
                     /db_xref="MGI:MGI:1341836"
                     /translation="MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDR
                     NFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLT
                     DSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGH
                     SALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQW
                     DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARL
                     CPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVR
                     VSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNF
                     ACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWY
                     FWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLL
                     YYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDS
                     NTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAY
                     VLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGR
                     LLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKN
                     SASEEDHLPLQVLQSH"
     exon            793..926
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1217
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1516
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1690
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1846
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1945
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2016
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2182
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2249
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2578
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2706
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2786
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2981
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /note="hexamer: TATAAA"
     polyA_site      2981
                     /gene="Trpv2"
                     /gene_synonym="GRC; OTRPC2; VRL-1; Vrl1"
                     /note="major polyA site"
ORIGIN      
        1 atcccattct tctctccctt gggtcggaca gtgatgaacc aaatggccgg gggagggcac
       61 acggtgttaa gaatcaggag gggtgggcgt cagtgtttta gggcatgaat cccacacctg
      121 tgccagcttc cacccaagcc taggtcccac caccccagaa cttcctctga ctgccccagg
      181 ggcttctctg gctacagttg tgggtggaag tgcaccgatg gaggagcagg gcgtgtctcg
      241 cgaaagcagg gtgtggccag tggtcctgat gatcagccca gtggccagtc actggtcctt
      301 gacaggttgg cgttaagccc gcactatcca ctgtgtgcga cgaacaggtg gagggtggac
      361 gatacagaga aagctacggc cagctacgga ggcttccgcg gcacttcctc tctcaatccc
      421 cgctgctgga gagtcccgct aggcttggtg atcctggctt gtagtctgct gccgctacgc
      481 cttgacttca gcctgagggg tcccagccag gcctacccca ctgcggtatg agagagagag
      541 gggaacctta agatctccat ctccacagaa gtttcagcga taaggagcac cctcctctct
      601 caggatgact tcagcctcca accccccagc ttttaggctg gagacgtccg atggagatga
      661 agaaggcagt gctgaggtga acaaaggaaa gaatgagcca ccccccatgg agtctccctt
      721 ccagggagag gaccggaact tctcccctca gattaaagtg aatctcaact accgaaaggg
      781 actgggtccc agccaacagg acccaaatcg gtttgaccgt gaccgactct tcagtgtggt
      841 ctcccggggt gtccccgagg agctgactgg actgctagag tacctgcgcc ggaccagcaa
      901 gtacctcact gactcggcat acacagaagg ctccactgga aagacgtgcc tgatgaaggc
      961 tgtgctgaac cttcaggatg gggtcaatgc ctgtatcctg ccgctgctgc agattgacag
     1021 ggattccggc aatcctcagc cccttgtcaa tgcccagtgc accgatgagt tctaccgagg
     1081 ccacagtgcg ctgcacatcg ccatagagaa gaggagcctg tggtgcgtga agctgctggt
     1141 agagaatgga gcgaatgttc acatccgagc ctgtggccgc ttcttccaaa agcaccaagg
     1201 aacttgtttc tattttggag agctacctct ttctctggca gcgtgcacca agcagtggga
     1261 tgtggtgacc tacctcctgg agaacccaca ccagcctgcc agcctggagg ccaccgactc
     1321 cctgggcaac acagtcctgc atgctctggt aatgattgca gacaactcac ctgagaacag
     1381 tgcgctggtg atccacatgt atgacagcct tctccaaatg ggggcccgcc tctgccccac
     1441 tgtacagctt gaggatatct gcaaccatca aggcctcaca cccctgaagt tggctgccaa
     1501 ggaaggtaaa attgagatct tcaggcacat cctgcagcgg gagttctcag ggctgtacca
     1561 gcccctttcc cgaaagttca ccgagtggtg ctacggtcct gtccgagtgt cactgtacga
     1621 cctgtcctct gtggacagtt gggaaaagaa ctcggtcctg gaaatcatcg ctttccattg
     1681 caagagcccg caccggcacc gcatggtggt tttagagcca ctgaacaagc ttctgcagga
     1741 gaaatgggat cggctcatcc caagattctt cttcaacttc gcctgttact tggtctacat
     1801 gatcatcttc accatagttg cctaccacca gccttccctg gagcagccag ccattccctc
     1861 atcaaaagcg acttttgggg actccatgct gctgttgggc cacattctga tcctgcttgg
     1921 gggtatttac ctcttactgg gccagctgtg gtacttttgg cggcggcgcc tgttcatctg
     1981 gatctcgttc atggacagtt actttgaaat cctcttcctt gtccaggcgc tgctcacagt
     2041 gctgtcccag gtgctgcgct tcgtggagac tgaatggtac ctccccctgt tagtgtcatc
     2101 cctagtgctg ggctggctga acctgcttta ttatacacgt ggctttcagc acacaggcat
     2161 ctacagtgtc atgatccaaa aggtcattct gcgagacctg ctccgcttcc tgctggtcta
     2221 cctagtcttc cttttcggct ttgctgtagc cctagtaagc ttgagccggg aggcccgaag
     2281 tcccaaagcc cctgaagata gcaacaccac tgtgacggaa aagcccacgc tgggtcagga
     2341 ggaggagcca gtcccatatg ggggcattct ggatgcctcc ctagagctgt tcaagttcac
     2401 cattggtatg ggtgagctgg ctttccagga acagctgcgc tttcgtgggg tggtgctgct
     2461 gttgctgttg gcctacgtcc tcctcaccta cgtcctactg ctcaacatgc tcattgccct
     2521 catgagtgag actgtcaaca gcgttgccac tgacagctgg agcatctgga agttgcagaa
     2581 agccatctct gtcttggaga tggagaatgg ttactggtgg tgcaggagga aaaggcatcg
     2641 cgcagggagg ctgctgaaag ttggcaccaa aggggatggt atacctgatg agcgctggtg
     2701 cttcagggtg gaggaagtaa actgggctgc atgggagaag acccttccca ccttatctga
     2761 ggatccatca ggggcaggca tcactggtta taaaaagaac ccaacctcta aacctgggaa
     2821 gaacagtgcc tcagaggaag accatctgcc tcttcaggtc ctccagtccc actgacggtc
     2881 cagatgcggc agcagcaggc tggcagggta gagtagggaa ttttgccagc cacacccgag
     2941 gctactgaat tttggtggaa atataaatat tttttgcata a
//
