LOCUS       NM_032000              10210 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus transcriptional repressor GATA binding 1 (Trps1),
            transcript variant 2, mRNA.
ACCESSION   NM_032000 NM_175345 XM_904110 XM_918667 XM_918674
VERSION     NM_032000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10210)
  AUTHORS   Fujikawa,K., Socorro,M., Lukashova,L., Hoskere,P., Keskinidis,P.,
            Verdelis,K. and Napierala,D.
  TITLE     Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and
            Tooth Root Formation
  JOURNAL   Calcif Tissue Int 115 (5), 686-699 (2024)
   PUBMED   39177752
  REMARK    GeneRIF: Deficiency of Trps1 in Cementoblasts Impairs
            Cementogenesis and Tooth Root Formation.
REFERENCE   2  (bases 1 to 10210)
  AUTHORS   Saeki,N., Inui-Yamamoto,C., Ikeda,Y., Kanai,R., Hata,K., Itoh,S.,
            Inubushi,T., Akiyama,S., Ohba,S. and Abe,M.
  TITLE     Deletion of Trps1 regulatory elements recapitulates postnatal hip
            joint abnormalities and growth retardation of Trichorhinophalangeal
            syndrome in mice
  JOURNAL   Hum Mol Genet 33 (18), 1618-1629 (2024)
   PUBMED   38899779
  REMARK    GeneRIF: Deletion of Trps1 regulatory elements recapitulates
            postnatal hip joint abnormalities and growth retardation of
            Trichorhinophalangeal syndrome in mice.
REFERENCE   3  (bases 1 to 10210)
  AUTHORS   Tollot-Wegner,M., Jessen,M., Kim,K., Sanz-Moreno,A., Spielmann,N.,
            Gailus-Durner,V., Fuchs,H., Hrabe de Angelis,M. and von Eyss,B.
  TITLE     TRPS1 maintains luminal progenitors in the mammary gland by
            repressing SRF/MRTF activity
  JOURNAL   Breast Cancer Res 26 (1), 74 (2024)
   PUBMED   38702730
  REMARK    GeneRIF: TRPS1 maintains luminal progenitors in the mammary gland
            by repressing SRF/MRTF activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10210)
  AUTHORS   Abrar,M., Ali,S., Hussain,I., Khatoon,H., Batool,F., Ghazanfar,S.,
            Corcoran,D., Kawakami,Y. and Abbasi,A.A.
  TITLE     Cis-regulatory control of mammalian Trps1 gene expression
  JOURNAL   J Exp Zool B Mol Dev Evol 342 (2), 85-100 (2024)
   PUBMED   38369890
  REMARK    GeneRIF: Cis-regulatory control of mammalian Trps1 gene expression.
REFERENCE   5  (bases 1 to 10210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 10210)
  AUTHORS   Kaiser,F.J., Tavassoli,K., Van den Bemd,G.J., Chang,G.T.,
            Horsthemke,B., Moroy,T. and Ludecke,H.J.
  TITLE     Nuclear interaction of the dynein light chain LC8a with the TRPS1
            transcription factor suppresses the transcriptional repression
            activity of TRPS1
  JOURNAL   Hum Mol Genet 12 (11), 1349-1358 (2003)
   PUBMED   12761050
REFERENCE   7  (bases 1 to 10210)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 10210)
  AUTHORS   Malik,T.H., Von Stechow,D., Bronson,R.T. and Shivdasani,R.A.
  TITLE     Deletion of the GATA domain of TRPS1 causes an absence of facial
            hair and provides new insights into the bone disorder in inherited
            tricho-rhino-phalangeal syndromes
  JOURNAL   Mol Cell Biol 22 (24), 8592-8600 (2002)
   PUBMED   12446778
  REMARK    GeneRIF: Results implicate TRPS1 in regulation of bone and hair
            development and suggest that skeletal abnormalities emphasized in
            descriptions of TRPS are only the extreme manifestations of a
            generalized bone dysplasia.
REFERENCE   9  (bases 1 to 10210)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   10 (bases 1 to 10210)
  AUTHORS   Malik,T.H., Shoichet,S.A., Latham,P., Kroll,T.G., Peters,L.L. and
            Shivdasani,R.A.
  TITLE     Transcriptional repression and developmental functions of the
            atypical vertebrate GATA protein TRPS1
  JOURNAL   EMBO J 20 (7), 1715-1725 (2001)
   PUBMED   11285235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142245.14, AC155307.2 and DV651380.1.
            
            On Feb 22, 2008 this sequence version replaced NM_032000.1.
            
            Transcript Variant: This variant (2) is alternatively spliced at
            the 5' end and uses an in-frame, downstream start codon compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no transcript from the reference
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.33557.1, BC099962.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC142245.14        142050-142487
            439-1367            AC142245.14        185149-186077
            1368-2497           AC142245.14        200133-201262
            2498-3101           AC142245.14        209383-209986
            3102-3224           AC155307.2         88470-88592         c
            3225-9420           AC155307.2         79324-85519         c
            9421-10210          DV651380.1         1-790
FEATURES             Location/Qualifiers
     source          1..10210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 19.18 cM"
     gene            1..10210
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /note="transcriptional repressor GATA binding 1"
                     /db_xref="GeneID:83925"
                     /db_xref="MGI:MGI:1927616"
     exon            1..438
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1367
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..4286
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger transcription factor Trps1; trichorhinophalangeal
                     syndrome I"
                     /codon_start=1
                     /product="zinc finger transcription factor Trps1 isoform
                     2"
                     /protein_id="NP_114389.2"
                     /db_xref="CCDS:CCDS27460.1"
                     /db_xref="GeneID:83925"
                     /db_xref="MGI:MGI:1927616"
                     /translation="MVRKKNPPLRNVASEGEGQTLEPTATESKVSGKNKELSADQMSE
                     NTDQSDVAELNSKEEHSTHGQEPSSSGKKDLQISGLSEKAGFNYESPSKGGSLVSFPH
                     DEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEEHKMSPKA
                     TEETGPVQSGQANCQGLSPVSVASKNPQVPSDGGVRLSKPKGDLLVNDNPDPAPLSPE
                     LQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHS
                     KDFQKVNRSVLSGVLQDISSSRPALLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFR
                     CKFCNFTYMGNSSTELEQHFLQTHPNKIKVSLPSSEGVKPSEKNSNKSIPALRASDSG
                     DVGKWQDKMTVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLK
                     LLEHYGKQHGAVQSGGLNPELNDKLPRGSVINQNDLAKSVEGEPLTKPEKGLSGAKKK
                     DFPSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPF
                     CPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGVAGSSRVKHQCHQCSFSTP
                     DVDVLLFHYETVHESQASDVKQEANHLLGSDGQQAVRDSKEHSCTKCDFITQVEEEIS
                     RHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQEITTANGEEGGHAIPTIKEEP
                     KIDLKVYSLLNPDSKMGETVPESIVKREKLDDKEGLKDKIWTESSTDDLRGVAWRGAD
                     ILRGSPSYTQASLGVLTPVSSSQEQTKTLRDSPNVEAAHLARPMYGLAVDTKGFLQGA
                     PAGSEKSASLTQQYPASGESKTKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGG
                     YVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSGE
                     EQVNGSPLERRSEDHLSESHPREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQALDIHK
                     RMQPLHIQIKSPQESTGDPGNSSSVSDGKGSSERGSPIEKYMRPAKHPNYSPPGSPIE
                     KYQYPLFGVPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPT
                     FNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPTVKNEGPLNVVKTEK
                     VDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHI
                     QRGLHRNNAQAEKNGKPKE"
     exon            1368..2497
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..3101
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3224
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..10204
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9742..9747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /note="hexamer: AATAAA"
     polyA_site      9763
                     /gene="Trps1"
                     /gene_synonym="D15Ertd586e"
                     /note="major polyA site"
ORIGIN      
        1 ggagagtgag gtcctgacaa gcgataacat ttctgataaa gacccgatct cattgcaatc
       61 tccagcgtcc tctttttcgc tgctgctcgg tggctccgga cctcgcgtcc tcctgatcgc
      121 tctctcgcct ttgcctattt ttttttttta aacaacaaca acaacaacaa aaaaccccaa
      181 caacaccccc tcccctcttc ccacccggca ccgggcacat cctagctcta tttcctttct
      241 ctttctctcg cgctctcttt ttttcctggg ggggggggga gggaagggaa agggggggag
      301 gcaggaaaga cctttttctc cccccccccc caataatcca agatcaactc tgcaaacaac
      361 agaagacggt tcatggctct ggccgccgcg ccaccatctt tcgggctgcg gagggtgttc
      421 ctgacgatta atcaacagat atggtccgga aaaagaaccc ccctctgaga aacgttgcta
      481 gtgaaggcga gggtcaaacc ctggagccaa cagctacaga gagcaaggta tctgggaaga
      541 acaaagaatt gtctgcagat cagatgtcag aaaatacaga tcagagtgat gttgcagagt
      601 tgaactcgaa ggaggaacac agcacgcatg gccaagagcc atcttccagc ggtaagaagg
      661 acttgcaaat ctcaggcctg agtgagaagg ctggcttcaa ttatgaaagc cccagtaagg
      721 gagggagcct tgtctccttc ccacatgatg aggtaacaga cagaaatatg ttggctttct
      781 catctccagc tgctggggga gtctgcgagc ccttgaagtc tcctcaaaga gcagaggcag
      841 atgaccctca agatatggcc tgcaccccat caggggattc attggagaca aaggaagagc
      901 ataaaatgtc accaaaggcc actgaggaaa cagggccagt gcagagtggt caagccaatt
      961 gtcaaggttt gagtccagtt tccgtggcct caaaaaaccc acaagtgcct tcagatgggg
     1021 gtgtcagact gagtaaaccc aaaggtgact tactggtgaa tgacaaccca gacccggcac
     1081 ctctgtctcc agagcttcag gactttaaat gcaatatctg tggatacggt tactatggca
     1141 atgaccccac agatctgatt aagcacttcc gaaagtatca cttaggactg cataatcgca
     1201 ccaggcagga tgctgagctg gacagcaaaa tcttggccct tcataacatg gtgcagttca
     1261 gccattccaa agacttccag aaggtcaacc gttctgtgct ttctggcgtg ctgcaggata
     1321 tcagctcttc acggcctgct ttactaaacg gaacctatga tgtacaggtc acttcaggag
     1381 gaactttcat tggcattgga cggaaaactc cagattgcca aggcaacacc aagtatttcc
     1441 gctgcaaatt ctgcaatttc acttatatgg gaaactcctc aactgaacta gagcaacatt
     1501 ttcttcagac gcacccgaat aaaatcaaag tgtctctccc gtcctccgag ggtgtgaaac
     1561 cttcagagaa aaactctaac aaatccatcc ctgcgcttcg agccagtgac tctggggatg
     1621 tgggaaagtg gcaggacaaa atgacagtca aagctggaga tgacacccct gtcggctact
     1681 cagtgcccat caagcccctc gattcctcac gacaaaatgg tacagaggcc accagttatt
     1741 actggtgtaa attttgtagt ttcagctgtg agtcatccag ctcccttaag ctgctagaac
     1801 attatggcaa gcagcacgga gcagtgcagt cgggcggcct taatccagag ttgaatgaca
     1861 agcttcccag gggctctgtc attaatcaga atgatctagc caaaagtgta gaaggagagc
     1921 cattgaccaa gccagaaaag ggcttgagtg gggctaaaaa gaaggacttc cccagcaagg
     1981 gagcagagga taatatggta acgagctata actgtcagtt ctgtgacttt agatattcca
     2041 aaagccatgg ccctgatgtg attgtagtgg gtccacttct ccgtcattat cagcaactcc
     2101 ataacatcca caagtgtacc attaagcact gtccattctg tcccagaggc ctttgcagcc
     2161 cagaaaagca ccttggagag attacttatc cgtttgcttg tagaaaaagt aattgttccc
     2221 actgtgcact gttgctgttg cacttgtctc ctggggtggc cggaagttcg agagtcaaac
     2281 accaatgcca ccagtgttcc ttctctaccc ccgatgtaga tgtgctcctc tttcactatg
     2341 agaccgtgca tgagtcccaa gcatcggatg tcaaacagga ggccaaccac ctgctaggat
     2401 ctgacgggca gcaggctgtc agggacagca aggagcactc gtgcaccaaa tgcgatttta
     2461 taacccaggt ggaagaagag atctcgagac actacaggag agcacacagc tgctataaat
     2521 gtcgtcagtg cagtttcaca gctgctgaca ctcagtcact attggagcac ttcaacacag
     2581 ttcactgcca ggaacaggaa atcactactg ctaatggcga agagggtggc catgccatac
     2641 ccaccatcaa agaagagccc aaaattgacc tcaaggtcta cagtctgcta aacccagact
     2701 ctaaaatggg agaaacagtt cccgagagca tagtcaagag agagaaactt gatgacaagg
     2761 aagggctgaa agataaaatc tggactgaga gttcaactga tgaccttcgt ggtgtggctt
     2821 ggagaggggc agacatccta cggggtagtc catcctacac tcaagcaagc ttaggggtct
     2881 tgacgcctgt gtccagctcc caagagcaga caaagactct gagggacagc cccaatgttg
     2941 aagctgccca cctggcacga cctatgtatg gcttggcagt agataccaag ggcttcctgc
     3001 aaggggctcc tgctggcagc gagaagtctg catctcttac ccagcagtat cctgcctccg
     3061 gagagagcaa gaccaaggat gaatcccagt cgctgttacg gaggcgaaga ggatctggtg
     3121 ttttttgtgc caattgcctg accacaaaga cctctctctg gcgaaagaat gcaaatggcg
     3181 gatatgtatg caatgcatgt ggtctctacc agaaacttca ctcgactccc aggcctttaa
     3241 acatcattaa acaaaacaac ggcgagcaga ttattagaag acggacaaga aagcgcctta
     3301 acccagaggc acttcaggct gagcagctca acaaacagca gaggggaagt ggggaggagc
     3361 aggtcaatgg aagcccctta gagaggaggt cagaagatca cttaagtgaa agtcatccga
     3421 gagaaattcc acttccgagc ctgagtaaat acgaagccca gggttcattg actaaaagcc
     3481 attctgctca gcagccagtc ctggtcagcc aagctctgga tatccacaaa aggatgcagc
     3541 ctttgcacat tcagataaaa agtcctcagg aaagtactgg agatccagga aatagttcat
     3601 ccgtatctga tgggaaagga agttctgaaa gaggcagccc catcgaaaag tacatgagac
     3661 ctgcaaaaca ccccaactat tctccaccag gcagccccat cgaaaagtac caatacccgc
     3721 tttttggagt tccttttgta cataatgact tccagagtga agctgattgg ctacggttct
     3781 ggagtaaata taagctctcc gttcctggga atccgcacta cttgagtcat gtgcctggct
     3841 taccaaatcc ttgccaaaac tatgtgcctt atcccacctt caatctgcct cctcatttct
     3901 cagctgttgg atcagacaat gacattcctc tagatttggc gatcaagcat tccagacctg
     3961 ggccaactgc aaatggtgcc tccaaggaga aaaccaaggc accaccaact gtaaaaaatg
     4021 aaggtccctt gaatgtagtt aagacggaga aagttgacag aagcactcaa gatgaacttt
     4081 caacgaaatg tgtgcactgt ggcattgttt ttctggatga agtgatgtat gctttgcata
     4141 tgagttgcca tggtgacagt ggacctttcc agtgcagcat atgccagcat ctttgcacgg
     4201 acaaatatga cttcacaaca catatccaga ggggcctgca taggaacaat gcacaagcag
     4261 aaaaaaatgg aaaacctaaa gagtaaaacc ttagcactta gcacaattaa atagaaatag
     4321 gttttcttga tgggaattca atagcttgta atgtcttatg aagacctatt aaaaaaataa
     4381 ttcatagagc ctgccttatc caacataaaa ttcctttttt tttttaaatt ctttcttttg
     4441 atgagtaggt taccaagatt ttaaaatgaa acatatggtc agtgagaaag aatgaaatta
     4501 atagataatt aaaaaaaaag aaaaaaagga aatctagagt gaaaactatc ttacctaatg
     4561 tatactgcgg aatctctata cagaggtcca ccaaattata gttattttgt ttgtaaagaa
     4621 tgctctctag aattcgaaag agtttacata ctatcatatg acagcagtat taggctggct
     4681 attggcccat ccattcagaa acctgcaata ggttgtctac atctaaaact atcataaaat
     4741 tctagccaaa tgagaagaaa atgaatctcc agggcaatgg aagaaaaaaa aatggcacct
     4801 ctcaaattag tctcctctca ttgaccatgt ttcagattta gacctcaaaa tgtgaactgt
     4861 ggttaggctt gttgaacgag cagtaagaat cgtgacagtt ggtggcacaa tgttttttgg
     4921 gccagccctg cctgtacata cacatacaca ccctctttga tatttttgtc ctttagatgt
     4981 tccagtactt ggtagtcatt ttgttcgcag tttagattca ttttgttcaa atatattcat
     5041 tcttaaaaca atgtcctcag tgcttatgta gtaactttat tttagccaga tatttctttc
     5101 ttgttgatga tgaaccggtt tggaattttt taaacctcct gttggtcact aatctcactt
     5161 ggcacattgt aactaaagca atcccttcac ttcaaaagac tagataaata caaatgtcag
     5221 gccatggctt taatttgctg agaacacatg gtatttctct acaaggtaac ctgctgtatt
     5281 tatttatttt cttttggtta aatataatgt ccaaactttg tggtcaggca gcatgcaagg
     5341 ttacgttacc acagactgac agttggtata tgtaccaatc aatcccttca ttagatttat
     5401 acagatttag ttaagtagca ttaagtaggc ttcttagaag tatgtcttca tagtcctttt
     5461 aatacttaag gctttgtaaa aactatccat gaagggagag ctcctcggca taactgctca
     5521 gggaaatagg gctaaataat tgaacattaa ataattggtt taaggtgctg ttagtcgagc
     5581 ctcaatgctt gctacaagga tgtatgtaca aggactgact ttaataattt gcattatatt
     5641 gtcccaacca gtagtttatt ttttgccacg gagatgtaga agatattaca agctactgga
     5701 tgcactgtca gattaactta tttcattaaa gaagttggga gaacaaatag gaaaaaaaaa
     5761 cttatttttc tagtaaatat taatgtatta catttcaaat aatggtgcct gacatattga
     5821 ataattattt tctacagtgt acgtatgcaa caaagatatt ccatcatgca ttagagtcag
     5881 ttctggctct gcctagctgt ttacatttgc aaatgtagca aacaaggtaa tgaagcaact
     5941 atttctattg cagtaggtat ctctagtgtg tatgtgtgcg tgtgtgtatg tgtgcattaa
     6001 agttgtaaac ggtaacatga aacaaaggaa gttctcagtg taatggtgtg gaaaacaaga
     6061 aggaaatgaa aatattttta tgcctactta ggatacaagg gtagcactat tcattccaag
     6121 tacttttttt ttttttaatt ttaagctctt aactcccatt gttatgctta agatgataaa
     6181 catatattct ctttttattg ctttgtctgt ttcagatgaa acatttcaga aattattttg
     6241 atatgtgttg ctggaatccg cagcacggat gttcttattg cattctgtag tggcgtttgc
     6301 actccagttt tacattaatt cgcagttgct tttgtattgt tttgttgggt tggggttggc
     6361 ttctttctca gatgcgggag tctcattgct tagagtttgg atggcaggta gagttaacca
     6421 gtctgtgact gttccagcaa atgaagttca aattaccttc ctgatgctat gttgtcctca
     6481 tcttcattct tgcatttttt tttgtttatt ttcatgtttt aaaaaaaaat ggaaaaagaa
     6541 aagaaaaaaa aaagaagatc gagagaaaga aaatcaggac taaggcctct gctttggttt
     6601 cattgttaaa ggaccctgtt ttaatctcac ctgtctgtgg catagctcaa atgttcacaa
     6661 gaacggaaat aaagaggtgg aatgaggagc tttgacattc aaatgacttg atataattta
     6721 tctttcttag gattttggtg gctgcatctc agaataaaga gggcaatctg agaggagtca
     6781 aagatctgaa aaggaaattt cccaaacaac atatttaact tccttagtaa cacgaatatc
     6841 aaagtgcact gtactgatcc tcaaggctca ttatgtgtgg actgcccaat tcaacaacat
     6901 gccagaaatt tgatcaactt gggcaatatt gcacattaca tctttgatat ccttatgcaa
     6961 tgtcttcagt gtgttagaca caagtagagt tttcattgtt ggcatgtatg ccttttgttt
     7021 tttcattcca ttttttttct cagtcagaca tagtagcaat gattagcatt gaaaatacat
     7081 atcactgtgc ttggaatatt tatggtcagt ctactttcag tagattatct tttggatagc
     7141 attggcgtat tagatcttat tccgtattcc tttattagta attactttta ttttcctgtt
     7201 tgtttatgtt atgcatattt tggttgagaa aagttgggcc ttaaaaaatg atggacattt
     7261 ataataacac taaaatactc atttttttga tgacctaaag ttttgattcc atgtttcaaa
     7321 atgtattaca aaaatgagtt atatttttaa aggcatttga agacttttgt cttaaattgt
     7381 gaaggatttt aagtgaggta tttaggtact taaccttttt cgaaggactt tcaagatgat
     7441 tttgaaactt ttctctcttg gaaaagtctt ctggagatac caactaaagt actgtgccat
     7501 ttcaaccctg ccattcttct caagttattt gtcacttcta tactgagctt tggcttcaac
     7561 actgggccag agtcaactca tgcacgtcct tccttttcct acatctctct caccttctct
     7621 cacccccagg aaagtactgt tgtttgggat ataaaaccat aaggagccag cccacctcag
     7681 agcattgtgg cctgggagac actacacgac tctaagtaca tgagaacggg aaggagctca
     7741 cagagttaat atattctctc tgttgtttag acgacaaaga gttggcccgt tctctctaca
     7801 tgacatattg agatgggttt tttttttgtt tgtttgtttg ttttgttaaa tccactttta
     7861 agatagtgat gttctgttct aaactgttct cttttagtaa aggtagagtt taggaaacaa
     7921 gcatggggat tcttttctaa gttaataagg aggagaaaac agtgattatc ttcaagagct
     7981 ttttgtggaa gcctgtggta gcacatcctg tttatgattg cacatgtgca cataatctat
     8041 tatgatctaa tgcaaataca gctcccaaaa cattaaatgt acatacatat attttaattg
     8101 cctggggaaa tgtttttctt aataaactaa agatgatcca tattgctatc aaaataaata
     8161 ttaccctctt gccttgtggc tgtaaaacat cacaaagtga cctgtcttga gacttttgta
     8221 ctgtctgcct acctagttaa caaacattaa catcttttat aagtgggaat atctgccctc
     8281 tggaggtgga actatggaga gactatgctg gtagtctggt ggtcatgctg tctctaggcc
     8341 atagtccagc ctcttaccca tacttgagat caattacact ctttgggttg agggctgcac
     8401 caaaaaatac tatgtgacat ctttgtttag ctggtaggtt aaaggctttc tgactttgct
     8461 agataagtgg ggctgaggaa ctgtacacct tgaatatgaa actaaatgta ctaaccaaag
     8521 aaacgtacgg ttaagtgtac caggctactg agtattaact aacagttaat ggtggttaga
     8581 aatagacgca tggagagcag agctctcatt gatttggcca gtgctaagat atattggctt
     8641 cttgcagggt gtttccttgt ggttgttgct tgctagttcg gagtgttctc atgtgtttct
     8701 gatcatagtg caacagtttc tcaagcattt cccacttaca tagattcatt gggccctctg
     8761 gaagatgcca gggcagagat gtaccaaggc agggatgaag aagaggtaaa aatccacaac
     8821 aatccaccta gttcaatgga taaagtatgc tcacatattc tctcaaaaga aatgttagca
     8881 tggtgagctt atgctgtcct gcacccgagc aaagcaagga taacaaccat aaaaaacaat
     8941 gcttaacctt tctcagaccc acaagtccca aacctggatc ccagttttat cccataattt
     9001 cttcaataca acaactgcaa agtagaactc tttctttctg cgcctcaggt tcctcagctg
     9061 taaaatggaa agtatattaa taataataat aatattaaaa ataataatgg taatgtagta
     9121 cttgtttgta acgcactttg agatccttgg ttggagggca ccataagagt gtcaagtatt
     9181 attatgtggc caagggggtt atttaaaact ctggttccca cgggccgaga aagtttggca
     9241 tcatttttat taaagatgag ctgtaaatat cttttctaag cagcctatag tgttggctat
     9301 gaagaggcaa gactataacc aggctgataa gaccatagtt ttttaatggc taccaaaaag
     9361 gcacgtgtca caataacaaa tgctgaattc tttagggtgt aatatttgac aacatgattg
     9421 atctggggga ggggatgggt ggaaaaaaac atctcaaaat gccaatgtaa aactaacagc
     9481 aatattcacc agcagaaaat gtctttcata tggaatgatt tcatgttgat aagaaaaagc
     9541 attcaatttg tagtcctgat ttgaacacca gactgtgggg tataatagtt ctgtttttac
     9601 aacacatgga attttttttt cattttattt cattttgttt tcatagtgca tgttcatttc
     9661 gactcacaac atgttcttgg tgtatttctt atgcaaacaa tcttcaggca gcaaagatgt
     9721 ctgttacatc taaacttgaa taataaagtt ttaccaccag ttatccatga cggctttggt
     9781 atggtttata tggatctacg ttcatccagg cagcaacaga agctacggat ccttaacata
     9841 tcaatgagct ctgaacttaa ataataaaac tgaaaccagg tcacctatta aaaaaaaagt
     9901 cactaagatg tactaagctg gattcttttc aacttgattt ttcattaacc aatctgttac
     9961 aggtagattt ttctgctaaa aaaaaattat actatatttt taggaaggtt aatgatactc
    10021 ttgtttattt caaaaggatt ctgaacatca gactttgagt gttgcatatt gatctgctaa
    10081 taataccttt cagtgtgtaa atacttcctt ttaagaacta taactttgat tctattcagt
    10141 atccccatgt gcatgtgaaa tgaagatcct gataaatatc gcaaattaaa ttcgtatttt
    10201 aaaaaaaaaa
//
