LOCUS       NM_134252               6157 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus transient receptor potential cation channel, subfamily
            M, member 8 (Trpm8), mRNA.
ACCESSION   NM_134252
VERSION     NM_134252.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6157)
  AUTHORS   Cooper,A.H., Barry,A.M., Chrysostomidou,P., Lolignier,R., Wang,J.,
            Redondo Canales,M., Titterton,H.F., Bennett,D.L. and Weir,G.A.
  TITLE     Peripheral nerve injury results in a biased loss of sensory neuron
            subpopulations
  JOURNAL   Pain 165 (12), 2863-2876 (2024)
   PUBMED   39158319
REFERENCE   2  (bases 1 to 6157)
  AUTHORS   Jiang,H., Cui,H., Chen,M., Li,F., Shen,X., Guo,C.J., Hoekel,G.E.,
            Zhu,Y., Han,L., Wu,K., Holtzman,M.J. and Liu,Q.
  TITLE     Divergent sensory pathways of sneezing and coughing
  JOURNAL   Cell 187 (21), 5981-5997 (2024)
   PUBMED   39243765
REFERENCE   3  (bases 1 to 6157)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6157)
  AUTHORS   Landen,J.G., Vandendoren,M., Killmer,S., Bedford,N.L. and
            Nelson,A.C.
  TITLE     Huddling substates in mice facilitate dynamic changes in body
            temperature and are modulated by Shank3b and Trpm8 mutation
  JOURNAL   Commun Biol 7 (1), 1186 (2024)
   PUBMED   39304735
  REMARK    GeneRIF: Huddling substates in mice facilitate dynamic changes in
            body temperature and are modulated by Shank3b and Trpm8 mutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6157)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6157)
  AUTHORS   Hu,H.Z., Gu,Q., Wang,C., Colton,C.K., Tang,J., Kinoshita-Kawada,M.,
            Lee,L.Y., Wood,J.D. and Zhu,M.X.
  TITLE     2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2,
            and TRPV3
  JOURNAL   J Biol Chem 279 (34), 35741-35748 (2004)
   PUBMED   15194687
REFERENCE   7  (bases 1 to 6157)
  AUTHORS   Andersson,D.A., Chase,H.W. and Bevan,S.
  TITLE     TRPM8 activation by menthol, icilin, and cold is differentially
            modulated by intracellular pH
  JOURNAL   J Neurosci 24 (23), 5364-5369 (2004)
   PUBMED   15190109
REFERENCE   8  (bases 1 to 6157)
  AUTHORS   Story,G.M., Peier,A.M., Reeve,A.J., Eid,S.R., Mosbacher,J.,
            Hricik,T.R., Earley,T.J., Hergarden,A.C., Andersson,D.A.,
            Hwang,S.W., McIntyre,P., Jegla,T., Bevan,S. and Patapoutian,A.
  TITLE     ANKTM1, a TRP-like channel expressed in nociceptive neurons, is
            activated by cold temperatures
  JOURNAL   Cell 112 (6), 819-829 (2003)
   PUBMED   12654248
REFERENCE   9  (bases 1 to 6157)
  AUTHORS   Peier,A.M., Moqrich,A., Hergarden,A.C., Reeve,A.J., Andersson,D.A.,
            Story,G.M., Earley,T.J., Dragoni,I., McIntyre,P., Bevan,S. and
            Patapoutian,A.
  TITLE     A TRP channel that senses cold stimuli and menthol
  JOURNAL   Cell 108 (5), 705-715 (2002)
   PUBMED   11893340
REFERENCE   10 (bases 1 to 6157)
  AUTHORS   McKemy,D.D., Neuhausser,W.M. and Julius,D.
  TITLE     Identification of a cold receptor reveals a general role for TRP
            channels in thermosensation
  JOURNAL   Nature 416 (6876), 52-58 (2002)
   PUBMED   11882888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087780.19, FQ976922.1 and AC102505.8.
            
            On Nov 23, 2021 this sequence version replaced NM_134252.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117934.1, AF481480.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164133
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC087780.19        72249-72305         c
            58-150              AC087780.19        71138-71230         c
            151-272             AC087780.19        59954-60075         c
            273-346             AC087780.19        58103-58176         c
            347-503             AC087780.19        53502-53658         c
            504-681             AC087780.19        52458-52635         c
            682-854             AC087780.19        50717-50889         c
            855-1029            AC087780.19        48170-48344         c
            1030-1097           AC087780.19        46298-46365         c
            1098-1295           AC087780.19        41730-41927         c
            1296-1398           AC087780.19        37633-37735         c
            1399-1517           AC087780.19        35689-35807         c
            1518-1808           AC087780.19        30706-30996         c
            1809-1904           AC087780.19        29098-29193         c
            1905-2034           AC087780.19        28055-28184         c
            2035-2180           AC087780.19        27545-27690         c
            2181-2293           AC087780.19        24519-24631         c
            2294-2510           AC087780.19        23693-23909         c
            2511-2602           AC087780.19        19297-19388         c
            2603-2744           FQ976922.1         105-246             c
            2745-2916           AC087780.19        16958-17129         c
            2917-3094           AC087780.19        13823-14000         c
            3095-3285           AC087780.19        4601-4791           c
            3286-3385           AC102505.8         28490-28589
            3386-3419           AC102505.8         29719-29752
            3420-3510           AC102505.8         33413-33503
            3511-6157           AC102505.8         37291-39937
FEATURES             Location/Qualifiers
     source          1..6157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.57 cM"
     gene            1..6157
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 8"
                     /db_xref="GeneID:171382"
                     /db_xref="MGI:MGI:2181435"
     exon            1..57
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            58..150
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            151..272
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..3470
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /note="long transient receptor potential channel 6;
                     transient receptor potential p8; TRP ion channel TRPM8"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 8"
                     /protein_id="NP_599013.1"
                     /db_xref="CCDS:CCDS48316.1"
                     /db_xref="GeneID:171382"
                     /db_xref="MGI:MGI:2181435"
                     /translation="MSFEGARLSMRSRRNGTMGSTRTLYSSVSRSTDVSYSDSDLVNF
                     IQANFKKRECVFFTRDSKAMENICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDA
                     FGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPR
                     MRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWG
                     MVSNRDTLIRSCDDEGHFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAK
                     LRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQ
                     IADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSHLLT
                     VIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTND
                     RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRN
                     LQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFI
                     WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETR
                     AVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQW
                     YGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSW
                     NVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLW
                     NVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPK
                     IIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ
                     VPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLV
                     NLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFK
                     CCCKEKNMESNACCFRNEDNETLAWEGVMKENYLVKINTKANDNSEEMRHRFRQLDSK
                     LNDLKSLLKEIANNIK"
     exon            273..346
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            347..503
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            504..681
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            682..854
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1029
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1097
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1295
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1398
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1517
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1808
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1904
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2034
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2180
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2293
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2510
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2602
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2744
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2916
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3094
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3285
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3385
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3419
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3510
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..6157
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3823
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /note="major polyA site"
     polyA_site      3832
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /note="major polyA site"
     regulatory      6136..6141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
                     /note="hexamer: AATAAA"
     polyA_site      6157
                     /gene="Trpm8"
                     /gene_synonym="CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8"
ORIGIN      
        1 gagacaagca ggctctttga ggagagagaa gctcttggct gattgagcag ctccacgtcc
       61 tggctgtccc ggagcttgat acatagaaaa gactgacctc agatacacag agatccttct
      121 gcttctgtct cccaagtgct gggatcacag gcaagatgtc cttcgaggga gccaggctca
      181 gcatgaggag ccgcagaaat ggtactatgg gcagcacccg gaccctgtac tccagtgtat
      241 ctcggagcac agacgtgtcc tacagtgaca gtgatttggt gaattttatt caggcaaatt
      301 ttaaaaaacg agaatgtgtc ttctttacca gagactccaa ggccatggag aacatatgca
      361 agtgtggtta tgcccagagc cagcacatcg aaggcaccca gatcaaccaa aatgagaagt
      421 ggaactacaa aaaacatacc aaggagtttc caacagacgc cttcggggac attcagtttg
      481 agactctggg gaagaaaggc aagtacttac gcttgtcctg tgacaccgac tctgaaactc
      541 tctacgaact gctgacccag cactggcacc tcaaaacacc caacctggtc atttcagtga
      601 cgggtggagc caaaaacttt gctttgaagc cacgcatgcg caagatcttc agcaggctga
      661 tttacatcgc acagtctaaa ggtgcgtgga ttctcactgg aggcactcac tacggcctga
      721 tgaagtacat aggcgaggtg gtgagagaca acaccatcag caggaactca gaagagaaca
      781 tcgtggccat tggcatcgca gcatggggca tggtctccaa cagggacacc ctcatcagga
      841 gctgtgatga tgagggacat ttttcagctc aatacatcat ggatgacttt accagagacc
      901 ctctatacat cctggacaac aaccataccc acctgctgct tgtggacaac ggttgtcatg
      961 gacaccccac agtggaagcc aagctccgga atcagctgga aaagtacatc tctgagcgca
     1021 ccagtcaaga ttccaactat ggtggtaaga tccccatcgt gtgttttgcc caaggaggtg
     1081 gaagagagac tctaaaagcc atcaacacct ctgtcaaaag caagatccct tgtgtggtgg
     1141 tggaaggctc ggggcagatt gctgatgtga tcgccagcct ggtggaggtg gaggatgttt
     1201 taacctcttc catggtcaaa gagaagctgg tacgcttttt accacgcact gtgtcccggc
     1261 tgcctgaaga ggaaattgag agctggatca aatggctcaa agaaattctt gagagttctc
     1321 acctactcac agtaattaag atggaagagg ctggagatga gattgtgagc aacgccattt
     1381 cctatgcgct gtacaaagcc ttcagcacta atgagcaaga caaggacaac tggaatggac
     1441 agctgaagct tctgctggag tggaaccagt tggaccttgc cagtgatgag atcttcacca
     1501 atgatcgccg ctgggagtct gccgaccttc aggaggtcat gttcacggct ctcataaagg
     1561 acagacccaa gtttgtccgc ctctttctgg agaatggcct gaatctgcag aagtttctca
     1621 ccaatgaagt cctcacagag ctcttctcca cccacttcag caccctagtg taccggaatc
     1681 tgcagatcgc caagaactcc tacaatgacg cactcctcac ctttgtctgg aagttggtgg
     1741 caaacttccg tcgaagcttc tggaaagagg acagaagcag cagggaggac ttggatgtgg
     1801 aactccatga tgcatctctc accacccggc acccgctgca agctctcttc atctgggcca
     1861 ttcttcagaa caagaaggaa ctctccaagg tcatttggga gcagaccaaa ggctgtactc
     1921 tggcagcctt gggggccagc aagcttctga agaccctggc caaagttaag aatgatatca
     1981 acgctgctgg ggaatcggag gaactggcca atgaatatga gacccgagca gtggagttgt
     2041 tcaccgagtg ttacagcaat gatgaagact tggcagaaca gctactggtc tactcctgcg
     2101 aagcctgggg tgggagcaac tgtctggagc tggcagtgga ggctacagat cagcatttca
     2161 tcgctcagcc tggggtccag aatttccttt ctaagcaatg gtatggagag atttcccgag
     2221 acacgaagaa ctggaagatt atcctgtgtc tattcatcat ccccttagtg ggctgtggcc
     2281 tcgtatcatt taggaagaaa cccattgaca agcacaagaa gctgctgtgg tactatgtgg
     2341 ccttcttcac gtcgcccttc gtggtcttct cctggaacgt ggtcttctac atcgccttcc
     2401 tcctgctgtt tgcctatgtg ctgctcatgg acttccactc agtgccacac acccccgagc
     2461 tgatcctcta cgccctggtc ttcgtcctct tctgtgatga agtgaggcag tggtacatga
     2521 acggagtgaa ttatttcacc gacctatgga acgttatgga caccctggga ctcttctact
     2581 tcatagcggg tattgtattc cggctccact cttctaataa aagctcgttg tactctgggc
     2641 gcgtcatttt ctgtctggat tacattatat tcacgctaag gctcatccac attttcaccg
     2701 tcagcaggaa cttgggaccc aagattataa tgctgcagcg gatgctgatc gacgttttct
     2761 tcttcctgtt cctctttgct gtgtggatgg tggcctttgg cgtggccaga caggggatcc
     2821 taaggcaaaa tgaacagcgc tggagatgga tcttccgctc tgtcatctat gagccctacc
     2881 tggccatgtt tggccaggtt cccagtgacg tggatagtac cacatatgac ttctcccact
     2941 gtaccttctc gggaaatgag tccaagccac tgtgtgtgga gctggatgag cacaacctgc
     3001 cccgcttccc tgagtggatc accattccgc tggtgtgcat ctacatgctc tccaccaata
     3061 tccttctggt caacctcctg gtcgccatgt ttggctacac ggtaggcatt gtacaggaga
     3121 acaacgacca ggtctggaaa ttccagcggt acttcctggt gcaggagtac tgcaaccgcc
     3181 taaacatccc cttccccttc gttgtcttcg cttatttcta catggtggtg aagaagtgtt
     3241 tcaaatgctg ctgtaaagag aagaatatgg agtctaatgc ctgctgtttc agaaatgagg
     3301 acaatgagac tttggcgtgg gagggtgtca tgaaggagaa ttaccttgtc aagatcaaca
     3361 cgaaagccaa cgacaactca gaggagatga ggcatcggtt tagacaactg gactcaaagc
     3421 ttaacgacct caaaagtctt ctgaaagaga ttgctaataa catcaagtaa ggctggcgat
     3481 gcttgtgggg agaaaccaaa tcacaatgag gtcacagcaa ccacctggat gtggaggctc
     3541 atgggacact gatggacagt actgctaatg acttctaaag gagacatttt caggtccctg
     3601 agcacagggt ggatgactct tagtcaccct caagggcata ggtcagggag caaagtgtac
     3661 agaggacttt acacctgaag aggggtgcaa aggaccatgt tcttctgtga aggtgcctgt
     3721 gttttctgca tctcagagcc ttgtcctgat gctgagggat taagtgttga cactcctttc
     3781 ccacgactgt gactctggcc ctgattttat acttatactg ctattgtgtc tatttccttt
     3841 tctgcagtgt gtgatgaatt cgtcgacaca ctgtcaaaga gtcctacccc atcccaaaga
     3901 aaaataaggc cagattctaa aacacctaag ggcaacctct cctttctcac atgtcaaaca
     3961 ggggtggggt ggggaacact gaggcaatga cttctttctc tggggctcac cagaacttcc
     4021 gctgaaggga ccacccaaaa ggaattcttg agtggtgtac cttgcttctc cccccacccc
     4081 caggagtgtg cccctcctcc actctttcat tatttcccca ttaaaaatag tgactggatc
     4141 tcacaggagg ctagaggaca tagaggacac aaatgtatgt aaacccctcc cactcatgta
     4201 gtcgttgctc acacttctga gtgtttgctc aattccagcc ttttctatgc atgcactttt
     4261 aacaacctta tgtgacatca tcacctgcac atacagtttt ctataggctt tcccatcaac
     4321 tattttacct gagatgtttt cttcacagtc tttacaagca ttatcagtaa ctcagtagta
     4381 ttcaaacctc tagcaatttc catactgtag gtcgctgata gctggctcca cctagccatt
     4441 gaaatgaatg tctctgtgca cgtcttctct ttgcattaag aacaccaaga aatcgcctat
     4501 gtagagtatt agattctttg gaatatctgt tgattatcaa accacttgca aggctttttt
     4561 tcatcaatgt atagcaaaat aggctttagt aacttgtgca taagacataa gctacatggc
     4621 gctctctcta gtaagacata tccgacttca ctttcacttt aggaagaaga caacactctt
     4681 atttaggcat tgtggagcat gtgggtgttg gtgcagacac tgagtgattg tctgcctgaa
     4741 cactccaccc ctgcccttct ccagagctgt ggtatctgtg ctcaaaagag cttggcagag
     4801 ggagcataag gccgctttaa gtattgaaag tgaaaagttt ttcaactttt tcataaacca
     4861 tacactcagc aactgaagga gcgaccctca gcaggaagct gttgactgaa tgtttaggta
     4921 gaagaatgac tgacgcatta acccagatgt gtttattttt atttggtctg gctatccaca
     4981 cgctgcaaat ggaagcagag aggggcagaa caaaggctgc ctggcctttt tttttaaatg
     5041 tttgcccact gttttattta tttattttat ttatttattt ttattttttg agaagaaaac
     5101 atttaactag ctttttaaaa aaattttccc aattttatta ggtattttct tcatttacat
     5161 ttcaaatgct atctcgaaag tcccccatac cctccccccc tcccctaccc acccactccc
     5221 acttcttggc cctggcgttc ccctgtactg gggcatataa actttgcaag tccaaggggc
     5281 gtctctttcc agtgatggcc gactaggcca tcttctgcta catatgcagc cagagacaag
     5341 agctctgggg ctactggtta gttcatattg ttgttccacc tatagggttg caaactcctt
     5401 tagctccttg ggtactttct ctagctcccg acttttaaag ccatcctggc ctcataggtc
     5461 tctaactcac tggggtttca gaagcagaga gtggatggaa cacatttgca taatgaaaat
     5521 ggccaacagg tggaaagttg aacatttcac tgttagtgag agcatttcac ttccatttta
     5581 ccctgatgac caaggtgctt gccatgtctg aaaccaccag gaggaagggt ctggcctcta
     5641 catagggact tgtaaaaaat gaaatgtaag acagcacact gactgttcag acagaaaaac
     5701 agtcagagcc tcaccttcaa ctcaagtaag gaactggact agaagaagca aacaagactt
     5761 agcctagtct atctgccaac ccccacttaa tcagagtgtt cacatgttca tatttccaca
     5821 ccatgtctcc accagcttaa gaaaacagtc tctgtacatg gaatgttcct gttgaccctg
     5881 aagaagagtt agacgatgct tagaatttgc ttacatggtt aatctacagg atgtgtgctc
     5941 ctgtgacgtc actatttcta acgtagctcc tgaaaagagc tcatttgtca agtcaaaggt
     6001 gctgcatctg ttggtctggt tctaaccatc tgtagacttg tccccagaga ctcctgcatc
     6061 atggcgtcag tgtgagcaca ttaaaccatg gaggaattgt catgtttatg tgtggcattc
     6121 tagtgagagt aaaaaaataa aagtcactct ttgctga
//
